Abstract: The invention relates to a method of activating a T cell in a subject and to a method of treating a cancer in a subject with a bispecific antibody and IL-15. The invention also relates to a pharmaceutical composition and to a kit comprising the bispecific antibody and IL-15. The invention further relates to a bispecific antibody for use in activating a T cell in a subject, to a bispecific antibody for use in the manufacture of a medicament for activating a T cell in a subject and to a product comprising a bispecific antibody and the mentioned IL-15.

Abstract: An ablation catheter (100) for ablative treatment of ventricular tachycardia is provided. The catheter comprises a shaft (102) which is capable of being guided to the tissue to be ablated. An ablation element (104) for ablating tissue is mounted on the shaft. The catheter further comprises a plurality of ultrasound transducer arrays (106) for obtaining images of myocardial tissue. The arrays are positioned separately from each other around the circumference of the shaft. The catheter can adopt a folded configuration and a deployed configuration. In the folded configuration, the arrays are positioned against or close to the shaft thereby facilitating insertion and guiding of the catheter. In the deployed configuration, the arrays are more separated from the shaft than in the folded configuration. Further provided is a catheter arrangement including the ablation catheter, and a system for providing ablative treatment comprising the ablation catheter or catheter arrangement.

Abstract: A sigma-delta modulator includes an N-bit quantization circuit that generates a stream of N-bit code words and a feedback signal path with an N-bit DAC circuit, having a non-ideal operation due to mismatch error, that converts the stream of N-bit code words to generate a feedback signal. A digital DAC copy circuit provides a digital replication of the N-bit DAC circuit. The digital replication accounts for the non-ideal operation of the N-bit DAC circuit 126 due to mismatch error, and converts the stream of N-bit code words to generate a stream of P-bit code words, where P>N, that are functionally equivalent to the feedback signal output from the N-bit DAC circuit.

Abstract: A monitoring system includes an implantable intra-vascular support device for positioning against a vessel wall and an implantable sensor-actuator mounted to the support device. The sensor-actuator is drivable between a non-deployed position in which it is against the support device and a deployed position in which it is displaced away from the support device. Sensor signals are generated when in the deployed position. This system is able to monitor flow away from the edge of a vessel by deploying the sensor-actuator towards the center of the vessel. When flow monitoring does not need to take place, it can be non-deployed so that it does not present an occlusion to the flow.

Abstract: A monitoring device is for monitoring breast milk consumption during breastfeeding. The monitoring devices comprises a breast stiffness monitoring unit (22) which includes a deformation sensor (30) and a force or pressure applicator (28), and a controller (24). The controller is adapted to monitor stiffness changes resulting from breast milk expression thereby to determine the breast milk consumption.

Abstract: A voltage controlled oscillator (VCO) circuit generates an output signal having a frequency which is dependent on a control voltage. A current is generated which is itself dependent on an amplitude of the VCO circuit. The generated current accordingly tracks, to an extent, the temperature behavior of the oscillator within the VCO circuit. The oscillator is driven by the sum of the generated current and a control current dependent on the control voltage. The control voltage may, for example, be generated by a phase lock loop (PLL).

Abstract: The present invention relates to a nozzle arrangement (10) of a cleaning device (100) for cleaning a surface (20), comprising: —a nozzle housing (28); —a rotating brush (12) that is rotatable about a brush axis (14) and comprises a substantially cylindrical core element (52) with flexible brush elements (16) that are arranged on a circumferential surface (56) of the core element (52), wherein said brush elements (16) are configured to contact the surface to be cleaned (20) and pick up dirt and liquid particles (22, 24) from the surface to be cleaned (20) during a rotation of the rotating brush (12); —a drive for driving the rotating brush (12); —a liquid supplying arrangement (58) for supplying a cleansing liquid (68) to the rotating brush (12); —a wiping element (32) for wiping dirt and liquid particles (22, 24) across or off the surface to be cleaned (20), wherein said wiping element (32) extends along a longitudinal direction (48), which is arranged substantially parallel to the brush axis (14), and wherei

Abstract: A host device (300) provides wireless docking to a dockee device (250). The host has a remote client unit (210) for providing at least one audio/video (AV) rendering function to an application (252) via remote server unit (251) in a dockee device. The host has transfer units (211,212,213,214) arranged for enabling transmitting a downstream of first AV data to the dockee device, and receiving an upstream of second AV data to be rendered from the dockee device. The host device has an AV router (310) for processing the downstream and the upstream so as to replace first AV data in the downstream by a predetermined pattern before transmitting the downstream to the dockee device, and replace at least part of second AV data in the upstream by at least part of the first AV data after receiving the upstream from the dockee device and before rendering the AV data. Advantageously required bandwidth is reduced in the wireless communication.

Abstract: The present invention relates to a selector unit (10) for selectively feeding beans (20), in particular coffee beans, from a plurality of storage containers (16, 18) to an outlet opening (22). The selector unit comprises a shutter (26) associated to the outlet opening, wherein the shutter is movably mounted and movable in at least two different positions for feeding the beans from at least one selected storage container of the plurality of storage containers to the outlet opening. The selector unit further comprises a lever (30) including an actuation portion (36, 38) associated to the shutter for actuating the shutter in order to move the shutter in the at least two different positions, wherein the lever is formed separately from the shutter and movable with respect to the shutter.

Abstract: A wafer boat cooldown device comprising a bottom plate and a rotatable table that is rotatable between a number of index positions. The rotatable table comprises at least two wafer boat positions for supporting a wafer boat. A vertically extending wall structure is mounted on the rotatable table and creates, at each wafer boat position, a wafer boat chamber having a gas supply area and a gas discharge area. The wafer boat cooldown device further comprises a plenum chamber which extends under the bottom plate. The plenum chamber accommodates at least one gas/liquid heat exchanger.

Abstract: A computer-implemented method for customizing a user interface comprises receiving, from a touchpoint device, identification information entered by a user; accessing a record of the user from a database using the received identification information; determining whether the record has any application windows configured for the user interface on the touchpoint device; transmitting, by a server to the touchpoint device, at least a first financial application window and a second financial application window identified by the record of the user for display of the first financial application window and the second financial application window simultaneously on the user interface of the touchpoint device; receiving instructions from the user via the first financial application window to perform a financial transaction; and performing, by a server, the financial transaction while the touchpoint device displays at least the first financial application window and the second financial application window, wherein the firs

Abstract: A method of assisting in selection of a particular mask from among a plurality of masks, the method comprising: generating a plurality of augmented faces, each augmented face corresponding to a respective mask of the plurality of masks; and associating each augmented face with a respective mask of the plurality of masks.

Abstract: A memory includes error correction circuitry that receives a data packet, outputs a correctable error flag indicating presence or absence of a correctable error in the data packet, and outputs an uncorrectable error flag indicating presence or absence of an uncorrectable error in the data packet. A response manager, operating in availability mode, generates output indicating that a correctable error was present if the correctable error flag indicates presence thereof, and generates an output indicating that an uncorrectable error was present if the uncorrectable error flag indicates presence thereof. In a coverage mode, the response manager generates an output indicating that a correctable error was potentially present but should be treated as an uncorrectable error if the correctable error flag indicates presence of the correctable error, and generates an output indicating that an uncorrectable error was present if the uncorrectable error flag indicates presence thereof.

Abstract: The present invention relates to a system (100), a method (200) and a computer program for adapting power usage of a mobile unit (110) that is configured to communicate data to a base unit (120). In wearable/portable modules, the power needed by an ISM radio link between the wearable/portable mobile unit (110) and the (quasi-)stationary base unit (120) is determined primarily by the attenuation of the transmitted wave between transmitter and receiver. By monitoring the power setting needed for the transmitter to maintain the link, that information can be used to optimize the position of the base unit (120) for achieving lowest power consumption in the battery operated mobile unit (110).

Abstract: The present invention relates to a process for preparing two mixtures of epoxidized fatty acid esters, comprising in the order given a transesterification of an epoxidized vegetable oil, followed by a reduction of the volatile saturated non-epoxidized fraction by short path distillation of the transesterified epoxidized vegetable oil, followed by a selection on the one hand of the non-vaporized fraction (residue) of the previous process step as the first mixture of epoxidized fatty acid esters and a selection on the other hand of the vaporized fraction (distillate) as the second mixture of epoxidized fatty acid esters. The first mixture is in particular suitable as plasticizer in halogenated polymers, the second mixture being particularly suitable as plasticizer in non-halogenated polymers.

Abstract: An oral care appliance comprises: a fluid delivery system for producing discrete fluid bursts by means of a pump (130), a regulator (132) regulating liquid in a pressurized liquid tank (134) delivered via a valve (140) through a fluid delivery path (123) in an outlet member (124), directed to a nozzle assembly (126) from which the resulting fluid bursts are directed to the teeth.

Abstract: A device for measuring a physiological parameter of a user carrying the device that includes a sensor having at least two sensor elements for detecting a sensor signal, a carrier configured to carry the sensor, and electrical contacts of the sensor elements that lead on, into or through the carrier. One or more frames carried by the carrier are formed around the sensor and/or the individual sensor elements, and an insulator material is filled between the one or more frames and the sensor and/or the sensor elements surrounded by a respective frame without covering a top surface of a respective sensor element facing away from the carrier.

Abstract: A Dixon water/fat separation technique, in particular in combination with a single-point acquisition scheme, avoids swaps of water and fat signals in the reconstructed MR images due to imperfections of the main magnetic field B0. Echo signals are generated and acquired in a pre-scan by subjecting an object (10) to a two or more point imaging sequence. A fat fraction map is derived from the echo signals of the pre-scan. Echo signals are generated and acquired in a clinical scan by subjecting the object (10) to a single-point imaging sequence. A field map estimate is derived from the fat fraction map and from the echo signals of the clinical scan. An MR image is reconstructed from the echo signals of the clinical scan. Signal contributions from fat and water are separated on the basis of the field map estimate.

Abstract: The invention relates to an assembly comprising a main device and an accessory, which can be connected by a safe connector and a safe detection method. According to the invention, the assembly comprises: —a main device (2), —an accessory (3) connectable to the main device (2), —the accessory (3) comprising an accessory connector (4) for mating with a device connector (5) of the main device (2), —the accessory connector (4) and the device connector (5) each comprising one or more supply contacts (7) for transmitting electric power from the main device (2) to the accessory (3), —the main device (2) comprising a detection device (9), which, if connecting the accessory (3) to the main device (2), receives complex accessory data stored by the accessory (3) and which by positive evaluation of the complex data enables applying a supply voltage at the one or more supply contacts (7) of the device connector (5).