Abstract: Continuity of therapy associated with a respiratory treatment device may be measured. Information relating to therapy administered via the respiratory treatment device to a subject during a therapy session may be received. Based on the received information, a quantity of therapy interruption events that occurred during the therapy session may be determined. A continuity indicator may be determined based on the quantity of therapy interruption events that occurred during the therapy session. The continuity indicator is indicative of continuity of therapy associated with the respiratory treatment device during the therapy session.

Abstract: A particle sensor includes an aperture for receiving a gas flow with entrained particles, an electrostatic particle charging section, a parallel-plate particle precipitation section; and a sensor for detecting precipitated particles to produce a sensor signal. The sensor signal Isensor is related to an apparent particle number concentration of the particles in the gas flow entering the charging section by a calibration constant S1, such that Isensor=f(Napp, S1), the calibration constant being dependent on a count mean diameter of the particles in the gas flow entering the charging section according to a first relationship. The particle sensor includes a pre-filter positioned upstream from the charging section, the pre-filter filtering a part of the particles from the gas flow entering the pre-filter, a fractional degree of particle filtering depending on the count mean particle diameter of the particles entering the pre-filter according to a second relationship.

Abstract: The current disclosure provides microorganisms, such as lactic acid bacteria (e.g., Lactococcus lactis) containing an exogenous nucleic acid encoding an IL-10 polypeptide and an exogenous nucleic acid encoding a T1D-specific antigen (e.g., a proinsulin) polypeptide, wherein both exogenous nucleic acids are integrated into the bacterial chromosome. Such microbial strains are suitable for human therapy. The disclosure further provides compositions (e.g., pharmaceutical compositions) methods of using the microorganisms and compositions, e.g., for the treatment of type 1 diabetes (T1D), including those with residual beta-cell function, e.g., recent-onset T1D. The microorganism may be administered orally, delivers the microorganism into the gastrointestinal tract, where it is released and expresses the bioactive polypeptides, The methods of the present disclosure are particularly well suited for subjects possessing residual beta-cell function, e.g., for subjects with recent-onset T1D.

Abstract: Methods and systems for managing data analytics are provided. The methods and systems entail obtaining a configuration file that includes steps. Each step includes at least one parameter that identifies a source of input data, a transformation that corresponds to business logic to be applied to the input data, and/or a sink of output data resulting from a transformation to the input data. A directed acyclic graph is generated based on the configuration file. The directed acyclic graph is then executed by invoking an application programming interface (API) of a data transformation engine to apply the transformations to the input data, and then returning an indication of completion to a source of the configuration file.

Abstract: The present disclosure pertains to a system configured to detect slow wave sleep and/or non-slow wave sleep in a subject during a sleep session based on a predicted onset time of slow wave sleep and/or a predicted end time of slow wave sleep that is determined based on changes in cardiorespiratory parameters of the subject. Cardiorespiratory parameters in a subject typically begin to change before transitions between non-slow wave sleep and slow wave sleep. Predicting this time delay between the changes in the cardiorespiratory parameters and the onset and/or end of slow wave sleep facilitates better (e.g., more sensitive and/or more accurate) determination of slow wave sleep and/or non-slow wave sleep.

Abstract: An exhaust gas-purifying three-way catalyst containing: (i) base material particles of a Nd-solid dissolved zirconia-based complex oxide comprising Nd and Zr as constituent metal elements in the following mass proportions: ZrO2 50 to 75% by mass; and Nd2O3 25 to 50% by mass, in terms of oxides; and (ii) Pd catalyst particles supported on the base material particles, wherein the Nd-solid dissolved zirconia-based complex oxide further contains at least one or more rare earth elements selected from the group consisting of yttrium, scandium, lanthanum, and praseodymium, as a constituent metal element, in an amount of a total of more than 0% by mass to 20% by mass or less in terms of an oxide.

Abstract: An illuminable pointer assembly for an instrument panel includes a transparent or translucent base, a transparent or translucent pointer blade, and a hub mounted on the base and supporting the pointer blade. The assembly is miniaturized or capable of being miniaturized by integrating reflectors into a lower surface of the pointer blade to internally reflect light propagated upwardly through the base in a lateral direction to uniformly illuminate the pointer blade.

Abstract: The present invention relates to a method to produce mutated microorganisms which resist the phenomenon of lactose killing and to the microorganisms obtainable via said method. Such engineered microorganisms can be applied for the production of specialty products, such as but not limited to specialty carbohydrates, glycolipids and galactosylated compounds.

Abstract: A computer-implemented system and method configure a payment processing system to interpret image data from scanned payment coupons. A screen display is generated for presentation to a recipient of payments, such as a business. The screen display shows a sample payment coupon. Configuration information is received that is generated based on user inputs. The user inputs designate a region of the sample payment coupon and define how scanned information in the designated region is to be interpreted.

Abstract: To enable practical and quick generation of a family of good looking HDR gradings for various displays on which the HDR image may need to be shown, we describe a color transformation apparatus (201) to calculate resultant colors (R2, G2, B2) of pixels of an output image (IM_MDR) for a display with a display peak brightness (PB_D) starting from input colors (R, G, B) of pixels of an input image (Im_in) having a maximum luma code corresponding to a first image peak brightness (PB_IM1) which is different from the display peak brightness, characterized in that the color transformation apparatus comprises: —a color transformation determination unit (102; 2501) arranged to determine a color transformation (TMF; g) as defined in color processing specification data (MET_1) comprising at least one tone mapping function (CC) received via a metadata input (116), which color transformation specifies how the luminances of pixels of the input image are to be converted into luminances for those pixels of a second image (IM_

Abstract: A circuit includes a frequency detector generating a comparison signal as a function of a comparison between a reference signal and a feedback signal. An oscillator generates an output signal as a function of the comparison signal. A frequency divider, in operation, divides the output signal by a division value to produce the feedback signal as having a frequency that is a multiple of a frequency of the reference signal. A frequency counter circuit measures the frequency of the reference signal and generates a count signal based thereupon. A control circuit adjusts the division value used by the frequency divider, in operation, based upon the count signal.

Abstract: The present invention relates to a pump arrangement (1) for a double breast pump (2). The pump arrangement (1) comprises first and second terminals (23, 24) for connecting first and second expression kits (3, 4) having first and second breast shields (5, 6) and at least one container (7) for collecting breast milk (8) in fluidic connection with the expression kits (3, 4), a pump (9) for generating reduced pressure within said breast shields, a plurality of conduits (10, 11, 14, 15, 16), a suction valve (12) connected to the pump (9) by a connection conduit (14) and to the first and second terminals (23, 24) by respective air conduits (10, 11), and a venting valve (13) connected to the first and second terminals (23, 24) by venting conduits (15, 16), wherein the venting valve (13) comprises an opening (17) to the environment. The pump (9) is alternatingly connected to the first and second terminals (23, 24) by alternate opening and closing of the suction valve (12) and the venting valve (13).

Abstract: This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay).

Abstract: The invention provides a treatment plate (10) for a garment treatment appliance (100), the treatment plate (10) having a contact surface (13) that in use slides on a garment (200) being treated, the contact surface (13) comprising a coating (20) comprising a metal oxide coating (21), the metal oxide coating (21) comprising: —first metal ions selected from the group consisting of titanium (Ti), zirconium (Zr), hafnium (Hf), scandium (Sc), and yttrium (Y); and—second metal ions selected from the group consisting of cerium (Ce), manganese (Mn), and cobalt (Co). This invention provides a favorable gliding behavior.

Abstract: A continuous time Delta-Sigma (CT-??) modulator has an input node configured to receive an input signal and an output node configured to output a digital output signal. The CT-?? modulator includes a feedback loop with a summation circuit configured to sum the digital output signal with a jitter perturbed test signal to generate a signal supplied to an input of a digital to analog converter circuit. A single tone signal is injected with a jitter error of a clock signal to generate the jitter perturbed test signal. A processing circuit processes the digital output signal to detect a signal to noise ratio of the CT-?? modulator. The detected signal to noise ratio is indicative of presence of jitter in the clock signal.

Abstract: A method of cropping an image containing an image of a human face includes detecting a region occupied by the image of the human face within the image, evaluating a plurality of candidate crops of the image, and selecting a crop of the image from the plurality of candidate crops of the image based on the results of the evaluation. The evaluating step includes applying a penalty to a candidate crop of the image in which the detected region occupied by the image of the human face is excluded or only partially included.

Abstract: The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.

Abstract: The present application relates to a device for treating skin using non-thermal plasma. It comprises a housing having a skin interface electrode for application to skin during treatment, a generator for generating non-thermal plasma at the skin interface electrode; and an isolating element to isolate a region surrounding said skin interface electrode other than during treatment so that non-thermal plasma generated at the skin interface electrode within said region sterilises the skin interface electrode.

Abstract: A system, method and non-transitory computer readable storage medium for monitoring a perfusion of a patient. The system, method and computer readable storage medium receive an indication of a voltage applied across a chest of the patient via a first electrode, receive a measurement of a current across the chest of the patient, resulting from the applied voltage via a second electrode, generate an impedance-based respiratory rate waveform based on the applied voltage and the measured current, generate a Fourier Transform of the respiratory rate waveform relative to a heartbeat of the patient, isolate cardiac artifacts in the Fourier Transform and generate a perfusion waveform indicating a perfusion of a chest cavity of the patient based on the isolated cardiac artifacts.