Abstract: The present invention relates to isolated promoter sequences responsive to germ infection and functioning in plants; vectors and DNA comprising the promoter sequences are also disclosed. The invention further relates to methods of transforming plants with a DNA construct comprising a germ responsive promoter operably linked to a pathogen resistant gene.

Abstract: It is intended to provide a means of diagnosing genetic risk of restenosis after coronary angioplasty which shows a high accuracy and a high estimation ratio. The risk of restenosis after coronary angioplasty is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 6 gene polymorphisms proved as relating to restenosis after balloon expansion or 5 gene polymorphisms proved as relating to restenosis after stent insertion; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of restenosis after coronary angioplasty form the genotype thus determined.

Abstract: A hydrogenation promoter of the present invention is produced by reacting an alkyne compound or an alkene compound, a palladium compound represented by a general formula Pd(II)XjLk (where L represents a monodentate ligand or a polydendate ligand other than a phosphorus-containing ligand (when two or more Ls are present in the compound, the Ls may be the same or different), X represents an anionic group, j represents a value determined according to the valence of X so that Xj has a valence of ?2 as a whole, and k represents an integer in the range of 0 to 4), and a base in an organic solvent. Specifically, The hydrogenation promoter of the invention includes palladium nanoparticles containing the alkyne compound or the alkene compound as an agglomeration-preventing agent.

Abstract: A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan, and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive sequences in the promoter region of UGT1 gene and two types of polymorphisms (bases at the 211- and 686-positions) on the basis of single nucleotide polymorphisms in the exon 1 are analyzed. Based on the analytical data, the risk of the expression of an adverse drug reaction caused by the administration of irinotecan is estimated. Further, the administration doses of irinotecan is designed for individual patients depending on the risk of the expression of the adverse drub reaction, thereby reducing the adverse drug reaction caused by the administration of irinotecan.

Abstract: A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol.

Abstract: A monoclonal antibody falling within the category of human IgM which specifically recognizes HIV-infected cells and induces apoptosis is obtained. Using the obtained antibody, it is intended to provide a remedy for patients suffering from HIV-infection, which contains as the active ingredient a human IgM antibody capable of specifically reacting with HIV-infected cells, inducing apoptosis in the infected cells and thus disrupting the cells, etc.

Abstract: It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.

Abstract: It is intended to provide a means of predicting genetic risk for hypertension at a high accuracy and high prediction possibility. Namely, risk for hypertension is predicted by a method involving the following steps: (i) the step of analyzing two or more polymorphisms selected from among 4 gene polymorphisms having been revealed as relating to hypertension; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of predicting the genetic risk for hypertension from the genotype thus determined.

Abstract: According to an image signal cancel-type heterodyne reception method, I-phase and Q-phase intermediate-frequency signals can be modulated using two orthogonal signals, superimposed one on the other, amplified by one amplifier, and modulated using two modulated orthogonal signals, thereby amplifying I-phase and Q-phase signals by one amplifier. Therefore, it is possible to obtain a high image signal cancellation ratio with no difference in gain for both of the phases. According to a direct conversion orthogonal frequency division reception method, on the other hand, two-phase base-band signals can be amplified respectively by one amplifier to eliminate a difference in gain between amplifications of the two-phase base-bands, thereby realizing high non-interference between sub-carriers.

Abstract: It is intended to provide a means of diagnosing myocardial infarction which shows a high accuracy and a high predictability. The risk of myocardial infarction is diagnosed by a method comprising the following steps: (i) the step of analyzing 2 or more polymorphisms among 10 gene polymorphisms or 5 gene polymorphisms proved as relating to myocardial infarction; (ii) the step of determining the genotype of a nucleic acid sample based on the polymorphism data obtained in the above step; and (iii) the step of determining the genetic risk of myocardial infarction from the genotype thus obtained.

Abstract: A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol.

Abstract: It is intended to provide a model animal faithfully reproducing the pathogenic conditions of spinal and bulbar muscular atrophy, a method of screening a remedy for polyglutamine disease using the same, and a remedy for spinal and bulbar muscular atrophy. Namely, a nonhuman animal having the following characteristics (1) to (5) in its conditions or pathological findings: (1) showing progressive myoatrophy; (2) showing lowering in muscular power; (3) in immunostaining with the use of an anti-polyglutamine antibody, showing nuclear diffuse staining and nuclear inclusions; (4) in immunostaining with the use of an anti-androgen receptor antibody, showing nuclear diffuse staining and nuclear inclusions; and (5) showing a neurogenic change. A remedy for polyglutamine disease is screened by administering a test substance to this nonhuman animal and examining changes in its conditions or pathological findings.

Abstract: A tert-alkyl ketone, pinacolone was hydrogenated under pressurized hydrogen in the presence of a ruthenium complex (S)-1 and a base, and corresponding (S)-3,3,-dimethyl-2-butanol was thereby obtained in 100% yield and 97% ee

Abstract: A broadband optical spectrum generating apparatus 20 includes a ultrashort pulsed fiber laser 22 that generates pulsed light having a pulse width in the unit of picosecond to femtosecond, and broadband optical spectrum-generating optical fibers 24 that are connected with the ultrashort pulse fiber laser 22 via a lens 26 and have characteristics of normal dispersion, that is, a nonlinear coefficient of not less than 10 [W?1km?1] and a magnitude of wavelength dispersion of not greater than a value 0 [ps/km/nm] with regard to a wavelength of the pulsed light. The resulting output is super continuum that is widely broadened to a wavelength band of 1400 nm to 1750 nm and is chirped to a linear characteristic.

Abstract: A semiconductor radiation detector 10 comprises a Si substrate 11 of an N-ype of low resistance, an arsenic coating layer 12 formed on the Si substrate, and a CdTe growth layer 13 of a P-type of high resistance laminated and formed thereon by the MOVPE method, which is divided into multiple plane elements of a hetero junction structure by means of division grooves 15 extending from the CdTe growth layer surface to the Si substrate. The Si substrate is heated in a hydrogen reducing atmosphere of a high temperature, and its surface is cleaned. On this Si substrate, GaAs powder or GaAs crystals are thermally decomposed, and coated by arsenic molecule to an extent at about one molecular layer, and an arsenic coating layer is thereby formed. On the Si substrate forming the arsenic coating layer, a CdTe growth layer is formed by the MOVPE method to a film thickness of about 0.2 to 0.5 mm in an atmosphere of about 450 to 500 deg. C.

Abstract: A hydrogenation promoter of the present invention is produced by reacting an alkyne compound or an alkene compound, a palladium compound represented by a general formula Pd(II)XjLk (where L represents a monodentate ligand or a polydendate ligand other than a phosphorus-containing ligand (when two or more Ls are present in the compound, the Ls may be the same or different), X represents an anionic group, j represents a value determined according to the valence of X so that Xj has a valence of ?2 as a whole, and k represents an integer in the range of 0 to 4), and a base in an organic solvent. Specifically, The hydrogenation promoter of the invention includes palladium nanoparticles containing the alkyne compound or the alkene compound as an agglomeration-preventing agent.

Abstract: An optical tactile sensor has a touch pad and a CCD camera for imaging behavior of the touch pad. A CPU processes image information from the CCD camera, extracts information on the size, shape, and center of gravity of a contact region, and extracts information on the size of a fixation region. The CPU obtains a normal force from the size of the contact region, obtains a tangential force from the shape of the contact region and the center of gravity of the contact region, and obtains a friction coefficient from the ratio of the size of the fixation region to the size of the contact region.

Abstract: The invention presents a method of manufacturing a multi-pitch screw having desired threads and pitches by rolling. A trace of general (even lead angle) spiral screw is formed by even pitch protrusions 610 and 620 of an existing rotating dies 61 and 62, and it is combined with a trace of stair step screw formed by stair step protrusions 632 of a rotating die 63 of uneven lead angle, and multi-pitch screw threads are formed efficiently. Herein, only one rotating die 61 of uneven lead angle is used, and screw threads are not flattened out by stair step protrusions of the plurality of rotating dies of uneven lead angles.

Abstract: To present a method of manufacturing a multipitch screw easily by using flat dies suited to mass production. A flat die 4 includes linear ordinary screw threads 40a, and multipitch screw threads 40b consecutive to the ordinary screw threads 40a, slightly shorter in height than the ordinary screw threads 40a, with both side walls formed alternately and consecutively, alternating between a section departing from the central line 40c of screw threads and an approaching section along a central line 40c, and symmetrically to the central line 40c of screw threads. After forming the tacks of a constant lead angle screw on the outer circumference of a shaft-like blank piece by the ordinary screw threads 40a, tracks of a multipitch screw are formed by the multipitch screw threads 40b, and therefore the tracks of a multipitch screw varying in the force applied at the time of rolling can be formed easily.

Abstract: The histamine detection method of the invention includes: a reaction step of causing a sample solution possibly containing histamine to react with 2,3-naphathalene dicarboxylaldehyde at PH of less than 10; and a detection step of detecting histamine based on a color change in the reaction step. The arrangement of this histamine detection method ensures the good color development in a visible region and thus enables easy and quick detection of histamine.