Patents Assigned to Nanjing University
  • Patent number: 9187394
    Abstract: Provided in the present invention is a method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: November 17, 2015
    Assignees: Nanjing University of Technology, Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Chunlei Lv, Shiqing Pi, Jianhui Chen, Dingqiang Lu, Pingkai Ouyang
  • Patent number: 9182332
    Abstract: A device for testing a corrosion inhibitor, the device including: a circulating cooling water tank; a circulating water pump; a flowmeter; a five-port glass tube; a working electrode; a reference electrode; an auxiliary electrode; a heating rod; and an electrochemical workstation. The circulating water pump is connected to the circulating cooling water tank. The heating rod is fixed inside the circulating cooling water tank. The water inlet of the flowmeter is connected to the circulating water pump. The water outlet of the flowmeter is connected to the water inlet of the five-port glass tube. The water outlet of the five-port glass tube is connected to the circulating cooling water tank. The working electrode the reference electrode, and the auxiliary electrode are connected to the electrochemical workstation; and the electrochemical workstation is connected to a host computer.
    Type: Grant
    Filed: April 28, 2013
    Date of Patent: November 10, 2015
    Assignee: Nanjing University
    Inventors: Hongqiang Ren, Zhanhui Shen, Jinju Geng, Ke Xu, Xinkun Ren
  • Patent number: 9116300
    Abstract: Technologies are generally described for techniques useful in an interferometer system. In some examples, a system may include a first waveguide effective to propagate a first wave in a first mode. In some examples, the system may include a second waveguide effective to, in response to the first wave, propagate second and third waves in second and third modes, respectively. In some examples, the second waveguide may be effective to reflect the second and third waves off a reflection surface to produce first, second, third and fourth reflected waves. In some examples, the second waveguide may be effective to propagate the first and third reflected waves in the second mode and propagate the second and fourth reflected waves in the third mode.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: August 25, 2015
    Assignee: Nanjing University
    Inventors: Yanqing Lu, Shuyi Zhang, Qi Zhong, Fei Xu, Xiaowen Lin, Wei Hu
  • Patent number: 9108897
    Abstract: The present invention provides a method for desorbing and regenerating a butanol-adsorbing hydrophobic macroporous polymer adsorbent, comprising: successively eluting the hydrophobic macroporous polymer adsorbent with butanol adsorbed therein using a water soluble low-boiling-point polar solvent and water. The method provided in the present invention has a simple process, a short separation time, easy, fast and complete desorption and regeneration, low equipment investment and pollution, and reduced energy consumption, and therefore production is easy on a large scale.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: August 18, 2015
    Assignee: Nanjing University of Technology
    Inventors: Hanjie Ying, Xiaoqing Lin, Jiansheng Fan, Jinglan Wu, Yong Chen, Xiaochun Chen, Jingjing Xie, Jian Xiong, Jianxin Bai
  • Patent number: 9090489
    Abstract: A method for removing antibiotic resistance genes (ARGs). The method includes the following steps: 1) coagulation and sedimentation of waste water; 2) biochemical treatment; 3) disinfection by peracetic acid; 4) sterilization by high pressure CO2; 5) photocatalysis by nano-titanium dioxide (TiO2); and 6) depositing.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: July 28, 2015
    Assignee: Nanjing University
    Inventors: Jinju Geng, Hongqiang Ren
  • Patent number: 9066870
    Abstract: The present invention provides preparation methods of protein nanoparticles for in vivo delivery of pharmacologically active agents, wherein said methods are to encase pharmaceutically active agents into proteins or peptides to form nanoparticles by unfolding the protein, and subsequently refolding or assembling the protein to produce a pharmacologically active agent encased within a protein nanoparticle.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: June 30, 2015
    Assignees: Nanjing University, Nanjing Effect Pharm Drug Development Corporation
    Inventors: Yiqiao Hu, Jinhui Wu, Dawei Ding, Guangming Gong, Xiaolei Tang, Chunhui Tong, Yan Zhu, Shaoling Li
  • Patent number: 9062159
    Abstract: A method for synthesizing a medical grade biodegradable material, poly(lactic-co-glycolic acid), copolycondensation of lactic acid and glycolic acid catalyzed by biomass creatinine. The present invention uses commercialized creatinine (a type of biomaterial organic guanidine compounds—the arginine metabolite creatinine (CR) in human body) as the catalyst and industrial lactic acid (LA, mass content 85%, aqueous solution) and glycolic acid (GA, 95%) as the monomer to synthesize the high biosafety of medical poly(lactic-co-glycolic acid) in terms of two steps polycondensation without solvent.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: June 23, 2015
    Assignee: Nanjing University
    Inventors: Hong Li, Quanxing Zhang, Wei Jiang, Bingcai Pan
  • Patent number: 9058169
    Abstract: Disclosed are a method and a system for remote wake-up and status check, with a wake-up signal generating unit generating and transmitting a wake-up signal to wake up an electricity supply unit of a remote device to operate normally and provide electricity for the remote device. The wake-up signal has an assigned electric voltage with specific characteristics for detection by the electricity supply unit while in power-off mode and, upon signal detection, the electricity supply unit wakes up to provide normal electric voltage output. The wake-up signal generating unit determines, according to an electric current on a wake-up signal feed line, whether the remote device is in an active mode. A low wake-up energy consumption enables system wake-up and a true powered-off sleep mode.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: June 16, 2015
    Assignee: Nanjing University
    Inventors: Xiangning Chen, Jie Zhang, Lifang Hao
  • Patent number: 9029497
    Abstract: This disclosure provides a method of making polylactic acid using carbon dioxide adducts of carbenes, wherein the adducts of carbenes have a structure represented by formula (I) as follows:
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: May 12, 2015
    Assignee: Nanjing University of Technology
    Inventors: Zhenjiang Li, Pingkai Ouyang, He Huang
  • Patent number: 9010735
    Abstract: A contact reaction tower, including: a central cylinder; and an outer cylinder. Lift pipes and a water inlet pipe(s) are installed in the central cylinder, reflux windows are formed on the wall of the central cylinder, and the water flow circulation between the central cylinder and the outer cylinder is realized through the lift pipes, the water inlet pipe(s), and the reflux windows, such that the water flow internal circulation of the whole contact reaction tower is realized. The contact reaction tower is sealed in its entirety from the outside environment, and a gas guide pipe is installed at the top of the contact reaction tower.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: April 21, 2015
    Assignee: Nanjing University
    Inventors: Hongqiang Ren, Ke Xu, Lili Ding, Xinkun Ren, Yanru Wang
  • Patent number: 8993810
    Abstract: Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: March 31, 2015
    Assignees: Nanjing University of Technology, Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory
    Inventors: Chunlei LV, Shiqing Pi, Jianhui Chen, Dingqiang Lu, Pingkai Ouyang
  • Patent number: 8988671
    Abstract: A BOTDA system that combined optical pulse coding techniques and coherent detection includes a narrow linewidth laser, two polarization-maintaining couplers, microwave generator, two electro-optic modulators (EOMs), fiber under test, an optical circulator, a 3 dB coupler, a polarization scrambler, a pulse generator, a balance photodetector, an electrical spectrum analyzer, digital signal processing unit and a frequency shifter. The optical pulse coding techniques and coherent detection are simultaneously used in the invented system, which can be enhance the signal-to-noise ration (SNR), the measuring accuracy and the sensing distance of BOTDA. Moreover, the proposed system has the capacity of break interrogation.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 24, 2015
    Assignee: Nanjing University
    Inventors: Xuping Zhang, Junhui Hu, Lan Xia
  • Patent number: 8946407
    Abstract: Provided are a fructosylated mangiferin, a preparation method therefor and a use thereof, wherein the fructosylated mangiferin has a structural formula represented by the following formula (I), the method for preparing the fructosylated mangiferin includes adding a substance with fructosylating enzymatic activity to a transformed liquid containing mangiferin for biotransformation reaction, so as to convert the mangiferin into the fructosylated mangiferin, wherein the transformed liquid contains the mangiferin and a glycosyl donor; as well as a use of the fructosylated mangiferin in preparation of a medicament for treatment of tumor-related diseases.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: February 3, 2015
    Assignee: Nanjing University of Technology
    Inventors: Bingfang He, Xueming Wu, Jianlin Chu, Bin Wu, Sen Zhang, Pingkai Ouyang
  • Patent number: 8871048
    Abstract: The present invention provides a flexible nanoimprint mold which can fabricate sub-15 nm ultra fine structures on either planar or curved substrates. The mold comprises a top ultra-thin rigid layer of imprint patterning features and a bottom thick flexible layer of polymer elastomer. The two distinct layers are preferably integrated via chemically bonding. The top layer of the mold enables a sub-15 nm resolution of pattern fabrication and the bottom layer affords a conformal contact to planar or curved surface of substrates. The methods for fabricating the same are disclosed.
    Type: Grant
    Filed: February 26, 2009
    Date of Patent: October 28, 2014
    Assignee: Nanjing University
    Inventors: Yanfeng Chen, Haixiong Ge, Zhiwei Li, Changsheng Yuan, Minghui Lu
  • Patent number: 8864987
    Abstract: Disclosed is an internal circulation resin ion exchange adsorption reactor with a mechanical stirrer. The upper part ?˜? of the reactor main body is an open cylinder and the lower part ?˜? is a cone-shaped body with a slope of 30°±10°. A bell-jar shaped reaction slot with a turbine water stirrer inside is located in the center of the reactor main body. The reactor main body is equipped with a cylindrical guide plate. A water collection weir, an inclined tube separator and an annular resin collection hopper are located between the shell of the reactor main body and the guide plate. The reactor is equipped with a water inlet pipe and a water outlet pipe. A resin removal pipe is connected with the annular resin collection hopper and a resin desorption slot respectively, and a regenerated resin reflux pipe is connected to the bell-jar shaped reaction slot.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: October 21, 2014
    Assignees: Nanjing University, Nanjing University Yancheng Environmental Protection Technology and Engineering Research Institute
    Inventors: Chao Long, Jun Fan, Aimin Li, Chendong Shuang
  • Patent number: 8867254
    Abstract: This invention describes the structure and the fabrication method of a flexible memory. The flexible memory includes eight layers. The three function layers are a flexible layer of hall unit, a flexible layer of horizontal lines, and a flexible layer of vertical lines. The main fabrication process of the flexible memory includes the following: the function layers are made on the hard substrates by the traditional nano-micro methods, and then the function layers are transferred on the flexible substrates, finally the whole layers are packaged to form the flexible memory.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: October 21, 2014
    Assignee: Nanjing University
    Inventors: Yi Zhao, Yi Shi, Xiangdong Ye
  • Patent number: 8859689
    Abstract: Polymer compositions based on polyaniline and carbonyl-functionalized polysilicones, and methods for making these polymer compositions are disclosed in the present application. The polymer compositions have, for example, good solubility, processability, mechanical performance and conductivity.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: October 14, 2014
    Assignee: Nanjing University
    Inventors: Yun Lu, Hongjuan Wang
  • Patent number: 8847948
    Abstract: Techniques for comparing 3D models are provided. A method for comparing 3D models includes obtaining a first skeleton of a first 3D model, obtaining a second skeleton of a second 3D model, and calculating similarity between the first and the second 3D models based on distance, angle, and inter-position related global constraints of the first and the second skeletons.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: September 30, 2014
    Assignee: Nanjing University
    Inventor: Tong Lu
  • Patent number: 8846853
    Abstract: A direct polycondensation method for medical biodegradable polylactic acid (PLA). The invention uses commercialized creatinine (a type of biomaterial organic guanidine compounds—the arginine metabolite creatinine in human body) as the catalyst and industrial lactic acid (mass content 85-90%, aqueous solution) as the monomer to synthesize the PLA in terms of second polycondensation without solvent. Instead of tin catalysts having cytotoxicity, the catalyst used in the invention has high biocompatibility and biosafety. The synthesized PLA does not contain any metal and other toxic components; therefore, it can be used as the carrier for targeting drugs and controlled release drugs. The green catalyst and green processing method (no solvent applied and no toxic products produced) are used to synthesize the green biodegradable PLA with high biosafety. The molecular weight distribution for all synthesized products is narrow and the molecular weight is controllable within 1.5-3.0×104.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: September 30, 2014
    Assignee: Nanjing University
    Inventors: Hong Li, Quanxing Zhang, Wei Jiang, Wei Huang, Bingcai Pan
  • Publication number: 20140275582
    Abstract: Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicants: Texas Tech University, Nanjing University, Institute of Chemistry and Biomedical Sciences
    Inventor: Guigen LI