Patents Assigned to Nanyang Technological University
  • Publication number: 20220255298
    Abstract: According to embodiments of the present invention, a laser source is provided. The laser source includes a photonic crystal structure including a first domain having a plurality of first holes defined therein, the first domain being associated with a first set of Chern numbers, and a second domain having a plurality of second holes defined therein, the second domain being associated with a second set of Chern numbers, wherein the plurality of first holes and the plurality of second holes are arranged to define an interface region between the first domain and the second domain, the interface region defining an optical cavity for lasing. According to further embodiments of the present invention, a method for forming a laser source is also provided.
    Type: Application
    Filed: July 13, 2020
    Publication date: August 11, 2022
    Applicant: Nanyang Technological University
    Inventors: Yongquan Zeng, Udvas Chattopadhyay, Baile Zhang, Yi Dong Chong, Qijie Wang
  • Patent number: 11406610
    Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: August 9, 2022
    Assignee: Nanyang Technological University
    Inventors: Ho Sup Yoon, Sreekanth Rajan, Hui Ting Toh, Xuewei Liu, Hui Yao
  • Patent number: 11406731
    Abstract: According to the present disclosure, a bioadhesive formulation is provided. The bioadhesive formulation comprises a polycaprolactone dendrimer having a dendrimer core and a plurality of polycaprolactone chains extending from the dendrimer core, wherein at least one of the polycaprolactone chains has an end which is covalently attached with a diazirine, and wherein the diazirine converts to a carbene or a diazoalkyl when a stimulant is applied to the bioadhesive formulation. Methods of forming the bioadhesive formulation are also provided. The bioadhesive could be used in (i) the prevention of thrombosis from tissue fixation and/or (ii) the relief of discomfort and/or pain during and/or after surgery. Preferably, the bioadhesive formulation further comprises a hygroscopic additive, an antithrombotic agent, and/or an anaesthetic agent.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: August 9, 2022
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Terry W. J. Steele, Ivan Djordjevic
  • Patent number: 11411000
    Abstract: A high voltage logic circuit for high voltage system application comprises a first device layer formed from a first semiconductor material and comprises a low voltage logic circuit; and a second device layer formed from a second different semiconductor material and comprising one or more components of an additional circuit for generating a high voltage logic output from a low voltage logic input from the low voltage logic circuit; wherein the first and second device layers are integrally formed.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: August 9, 2022
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Pilsoon Choi, Chirn-Chye Boon, Li-Shiuan Peh
  • Patent number: 11407849
    Abstract: A method for manufacturing a graft polymer, that ensures more stable progress of a living radical polymerization by using a monomer structural unit containing an iodine initiating group as an initiator, includes performing a living radical polymerization of a compound with a vinyl monomer by an organic catalyst to manufacture the graft polymer. The compound has a recurring unit represented by a formula (1) below in a main chain: where, R1: linking group (linear, branched, or cyclic alkylene group having 1 to 30 carbon atoms that may contain an ether bond, an amide bond, or an ester bond, an aromatic group), R2, R3, R4, R5, R6: an aromatic group, an aliphatic group, a hydrogen atom, an aliphatic group, and n=1 to 5.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: August 9, 2022
    Assignees: GODO SHIGEN CO., LTD, NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Yoshinobu Tsujii, Keita Sakakibara, Atsushi Goto, Michihiko Miyamoto, Hiroto Komatsu, Takuya Jitsukawa
  • Patent number: 11396531
    Abstract: The present disclosure relates to a peptide comprising at least five amino acid residues, wherein at least one amino acid residue is modified to an epsilon-lysine, delta-ornithine, gamma-2,4-diaminobutyric acid, beta-2,3-diaminopropionic acid, with the peptide also comprising at least one non-epsilon lysine, non-delta-ornithine, non-gamma-2,4-diaminobutyric acid or non-beta-2,3-diaminopropionic acid, and wherein the peptide displays a reduced or no cytotoxicity when compared to an equivalent non-modified peptide. In a preferred embodiment, the modifications are to the melittin or mastoparan B peptides, and comprise the substitution of at least one a-lysine residue for an ?-lysine residue, and the modified peptides display antimicrobial activity.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: July 26, 2022
    Assignees: Singapore Health Services Pte Ltd, Nanyang Technological University
    Inventors: Lakshminarayanan Rajamani, Venkatesh Mayandi, Tze Leng Eunice Goh, Roger Wilmer Beuerman, Navin Kumar Verma
  • Patent number: 11397088
    Abstract: A simultaneous localization and mapping method and corresponding system are disclosed. The method comprises: receiving a frame of three dimensional point cloud data from a three dimensional point cloud sensor coupled to a robot; receiving inertial measurement data indicative of a change in pose of the three dimensional point cloud sensor; using the inertial measurement data to estimate a rotation between the received frame of three dimensional point cloud data and a key frame of three dimensional point cloud data; applying a rotation to the received frame of three dimensional point cloud data to obtain an aligned frame of three dimensional point cloud data, the aligned frame of three dimensional point cloud data having an orientation aligned with the key frame of three dimensional point cloud data; and estimating a translation of the aligned frame of three dimensional point cloud data from the key frame of three dimensional point cloud data.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: July 26, 2022
    Assignee: Nanyang Technological University
    Inventors: Lihua Xie, Chen Wang, Junsong Yuan
  • Patent number: 11399449
    Abstract: A server rack cooling arrangement may include a server rack enclosure defining a single undivided interior volume of space and configured to be sealable; two or more open-frame-server-units disposed within the interior volume of space and arranged in a multi-level arrangement, wherein heat-producing-electronic-components may be exposed to environmental conditions of the interior volume of space; a central condenser disposed towards a rear; a coolant reservoir for collecting condensate from the central condenser; at least one nozzle in fluid communication with the coolant reservoir and configured to deliver fine coolant droplets into the interior volume of space for impingement on the heat-producing-electronic-components; and a fan configured to generate an airflow through the two or more open-frame-server-units from a front to the rear in a manner so as to carry coolant vapour generated from impingement of the fine coolant droplets on the heat-producing-electronic-components to the central condenser.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: July 26, 2022
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Teck Neng Wong, Ranjith Kandasamy, Kok Chuan Toh, Jin Yao Ho
  • Patent number: 11392672
    Abstract: Methods and systems for obfuscating computer program code are disclosed. In an embodiment, a method of generating obfuscated binary code from input source code for execution on a target processor comprises: generating a set of random obfuscation transform selections; and iteratively optimizing the obfuscation transform selections until a termination criterion is met. The obfuscation transformation selections may comprise indications of custom instructions which are executable on the co-processor in order to reduce side channel leakage.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: July 19, 2022
    Assignee: Nanyang Technological University
    Inventors: Siew Kei Lam, Hung Thinh Pham, Alexander Fell, Veeranna Nandeesha
  • Patent number: 11390867
    Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: July 19, 2022
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Anh Tuan Phan, Kah Wai Lim, Vee Vee Cheong, Christopher Brian Henry Jacques Lech, Brahim Heddi
  • Publication number: 20220207218
    Abstract: Methods and apparatus for extracting one or more mechanical properties for a material based on one or more indentation parameters for the material. The method comprises receiving load-displacement data from one or more instrumented indentation tests on the material, determining, by at least one computer processor, the indentation parameters for the material based, at least in part, on the received load-displacement data, providing as input to a trained neural network, the indentation parameters for the material, determining, based on an output of the trained neural network, the one or more mechanical properties of the material, and displaying an indication of the determined one or more mechanical properties of the material to a user of the computer system.
    Type: Application
    Filed: March 6, 2020
    Publication date: June 30, 2022
    Applicants: Nanyang Technological University, Massachusetts Institute of Technology, Brown University
    Inventors: Lu Lu, Ming Dao, Subra Suresh, George Karniadakis
  • Patent number: 11372271
    Abstract: According to embodiments of the present invention, an optical modulator is provided. The optical modulator includes a substrate, and a waveguiding arrangement on the substrate, the waveguiding arrangement having a waveguide, and at least one graphene layer arranged to interact with light propagating in the waveguiding arrangement, wherein the waveguide is designed such that the light interacting with the at least one graphene layer has a maximum intensity overlapping with the at least one graphene layer. According to further embodiments of the present invention, a method for forming the optical modulator, and a method for controlling the optical modulator are also provided.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: June 28, 2022
    Assignee: Nanyang Technological University
    Inventors: Xiaonan Hu, Guozhen Liang, Bo Meng, Qijie Wang
  • Patent number: 11357651
    Abstract: Various embodiments relate to a stent assembly comprising a stent; a swellable coating disposed on at least a portion of an exterior surface of the stent; optionally, a carrier dispersed in the swellable coating and/or disposed on at least a portion of an exterior surface of the stent; and an active agent comprised in at least one of the swellable coating or the carrier, if present. Use of the stent assembly as a ureteric stent, and method of preparing a stent assembly are also provided.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: June 14, 2022
    Assignees: Nanyang Technological University, Singapore Health Services Pte. Ltd.
    Inventors: Subramaniam Venkatraman, Yingying Huang, Wei Shan Lim, Tsung Wen Chong
  • Patent number: 11357884
    Abstract: The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: June 14, 2022
    Assignees: Nanyang Technological University, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Terry W. J. Steele, Daniel Mandler
  • Patent number: 11356094
    Abstract: A circuit arrangement is provided, having a first circuit configured to receive an input signal, and a second circuit configured to provide an output signal, wherein the first circuit includes a first pull-up network having a first transistor of a first conductivity type and a second transistor of a second conductivity type electrically coupled to each other, and a first pull-down network having a first transistor of the first conductivity type and a second transistor of the second conductivity type electrically coupled to each other, wherein the second circuit includes a second pull-up network having a first transistor of the first conductivity type, and a second pull-down network having a second transistor of the second conductivity type, wherein the first pull-up network and the second pull-down network are electrically coupled to each other, and wherein the first pull-down network and the second pull-up network are electrically coupled to each other.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 7, 2022
    Assignee: Nanyang Technological University
    Inventors: Joseph Sylvester Chang, Kwen Siong Chong, Ne Kyaw Zwa Lwin, Sivaramakrishnan Hariharakrishnan
  • Patent number: 11344873
    Abstract: Disclosed herein is a multi-layered composite thin film material formed from graphene quantum dots (GQDs) and metal nanocrystals in a layer-by-layer design, wherein the metal nanocrystals can be selected from the group consisting of Ru, Rh, Os, Ir, Pd, Au, Ag and Pt. In a preferred embodiment, the multi-layered composite thin film material is prepared via a facile, green, and easily accessible layer-by-layer (LbL) self-assembly strategy. In this strategy, positively charged GOQDs and negatively charged metal nanocrystals are alternately and uniformly integrated with each other in a “face-to-face” stacked fashion under substantial electrostatic attractive interaction, and then the obtained GOQDs/metal composite thin film is calcined into GQDs/metal composite thin film. The composite thin film material disclosed herein may be used to catalyse a wide range or reactions, including selective reduction of aromatic nitro compounds in water and electrocatalytic oxidation of methanol at ambient conditions.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: May 31, 2022
    Assignee: Nanyang Technological University
    Inventors: Thatt Yang Timothy Tan, Zhiping Zeng
  • Patent number: 11306097
    Abstract: The present invention relates to a method for synthesizing a compound of Formula (I) as defined herein, comprising: (i) activating a compound of Formula (II) as defined herein, by reacting said compound of Formula (II) with a compound of Formula (III) as defined herein, in the presence of a base, to obtain a compound of Formula (IV) as defined herein; and (ii) reacting the compound of Formula (IV) with an electrophile to obtain the compound of Formula (I). The present invention further relates to the organocatalysts used in the described methods and their respective uses.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: April 19, 2022
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Yonggui Chi, Zhenqian Fu
  • Patent number: 11303316
    Abstract: An apparatus and method for wireless communication, and a method of fabricating the apparatus. The apparatus comprises two or more transceiver array groups, each transceiver array group comprising one or more radio frequency, RF, circuits, and one or more RF front end, RF FE, circuits; wherein the transceiver array groups are configured to operate at different frequencies; wherein the transceiver array groups are configured to be connected to one corresponding digital baseband processor; and wherein the transceiver array groups comprise at least one first transceiver array group configured to operate at cm wavelength or larger. Preferably, the transceiver array groups comprise at least one second transceiver array group configured to operate at mm wavelength.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: April 12, 2022
    Assignees: Nanyang Technological University, Massachusetts Institute of Technology
    Inventors: Pilsoon Choi, Dimitri Antoniadis, Chirn Chye Boon, Eugene A. Fitzgerald
  • Patent number: 11300656
    Abstract: Example embodiments describe a radar sensor, whereby the radar sensor comprises a pair of continuous wave (CW) radar transceivers that each has a leaky wave antenna that are provided adjacent to each other. Each CW radar transceiver comprises a microwave frequency transmission circuit configured to transmit and receive signals reflected off a nearby object. The transmitted and received signals are then processed by the radar sensor to determine a relative displacement between the detected object and the radar sensor. This determined relative displacement may then be used with machine learning techniques to identify dynamic gestures made within the radar sensor's range of detection.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: April 12, 2022
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Karthik Thothathri Chandrasekaran, Arokiaswami Alphones, Muhammad Faeyz Karim, Ashita Priya Thomas
  • Patent number: 11296552
    Abstract: Various embodiments may provide a transmitter device. The transmitter device may include an oscillator configured to operate at a variable oscillation frequency to generate an oscillator signal. The transmitter device may also include a transmitter antenna configured to transmit power to a receiver device via magnetic coupling based on the oscillator signal. The transmitter device may further include a feedback arrangement configured to generate a feedback to the oscillator based on a resonant frequency of the magnetic coupling between the transmitter antenna and a receiver antenna of the receiver device such that the variable oscillation frequency of the oscillator is adjusted towards the resonant frequency.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: April 5, 2022
    Assignee: NANYANG TECHNOLOGICAL UNIVERSITY
    Inventors: Ji-Jon Sit, Guangyin Feng