Abstract: Disclosed is an optical cylinder of a corneal prosthesis comprising: a) an optical cylinder comprising a solid polymer, and b) a plurality of nanoparticles forming a substantially uniform layer on a circumference of the solid polymer surface of the optical cylinder. Also disclosed are methods of surface treatment of optical cylinders of corneal prostheses, and corneal prostheses thereof.

Abstract: Methods and apparatus for extracting one or more mechanical properties for a material based on one or more indentation parameters for the material. The method comprises receiving load-displacement data from one or more instrumented indentation tests on the material, determining, by at least one computer processor, the indentation parameters for the material based, at least in part, on the received load-displacement data, providing as input to a trained neural network, the indentation parameters for the material, determining, based on an output of the trained neural network, the one or more mechanical properties of the material, and displaying an indication of the determined one or more mechanical properties of the material to a user of the computer system.

Abstract: Disclosed herein are polymers containing repeating units of formula (I) or copolymers containing the repeating units of formula (I) and (II), where R1 to R12, m, n, p, q, x and y are as defined herein. The polymers and copolymers have an antimicrobial effect and may be used therapeutically or in formulations intended for use as detergents.

Abstract: An arrangement for non-destructive testing of a component part, which may include a first end surface and a second opposite end surface. The arrangement may include a plurality of discrete piezoelectric transduction elements arranged in a circular array on the first end surface, and an electric wave signal transmitting and receiving unit electrically coupled to the piezoelectric transduction elements. The electric wave signal transmitting and receiving unit may be able to generate an electric excitation wave signal and to receive an electric response wave signal. The piezoelectric transduction elements may deform, upon an application of the electric excitation wave signal, in an in-phase shearing motion parallel to the first end surface and in respective tangential direction with respect to the circular array so as to generate a corresponding structure-borne wave in the component part at the first end surface such that said structure-borne wave can propagate in the component part.

Abstract: There is provided an optical remote sensing system including: an emission channel mount having mounted thereto input ends of an array of emission fiber channels; a beam steering device configured to scan a light beam from a light source across the input ends of the array of emission fiber channels; a plurality of sensor portions, each sensor portion configured to be exposed to a corresponding scene and having connected thereto: an output end of a corresponding emission fiber channel of the array of emission fiber channels; and an input end of a corresponding first collection fiber channel of an array of first collection fiber channels; a first photodetector arranged to detect the backscattered light beams that propagated through the array of first collection fiber channels for sensing a property with respect to the corresponding scenes associated with the plurality of sensor portions; and a fiber channel hub configured for the array of emission fiber channels and the array of first collection fiber channels t

Abstract: According to embodiments of the present invention, a laser source is provided. The laser source includes a photonic crystal structure including a first domain having a plurality of first holes defined therein, the first domain being associated with a first set of Chern numbers, and a second domain having a plurality of second holes defined therein, the second domain being associated with a second set of Chern numbers, wherein the plurality of first holes and the plurality of second holes are arranged to define an interface region between the first domain and the second domain, the interface region defining an optical cavity for lasing. According to further embodiments of the present invention, a method for forming a laser source is also provided.

Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.

Abstract: According to the present disclosure, a bioadhesive formulation is provided. The bioadhesive formulation comprises a polycaprolactone dendrimer having a dendrimer core and a plurality of polycaprolactone chains extending from the dendrimer core, wherein at least one of the polycaprolactone chains has an end which is covalently attached with a diazirine, and wherein the diazirine converts to a carbene or a diazoalkyl when a stimulant is applied to the bioadhesive formulation. Methods of forming the bioadhesive formulation are also provided. The bioadhesive could be used in (i) the prevention of thrombosis from tissue fixation and/or (ii) the relief of discomfort and/or pain during and/or after surgery. Preferably, the bioadhesive formulation further comprises a hygroscopic additive, an antithrombotic agent, and/or an anaesthetic agent.

Abstract: A method for manufacturing a graft polymer, that ensures more stable progress of a living radical polymerization by using a monomer structural unit containing an iodine initiating group as an initiator, includes performing a living radical polymerization of a compound with a vinyl monomer by an organic catalyst to manufacture the graft polymer. The compound has a recurring unit represented by a formula (1) below in a main chain: where, R1: linking group (linear, branched, or cyclic alkylene group having 1 to 30 carbon atoms that may contain an ether bond, an amide bond, or an ester bond, an aromatic group), R2, R3, R4, R5, R6: an aromatic group, an aliphatic group, a hydrogen atom, an aliphatic group, and n=1 to 5.

Abstract: A high voltage logic circuit for high voltage system application comprises a first device layer formed from a first semiconductor material and comprises a low voltage logic circuit; and a second device layer formed from a second different semiconductor material and comprising one or more components of an additional circuit for generating a high voltage logic output from a low voltage logic input from the low voltage logic circuit; wherein the first and second device layers are integrally formed.

Abstract: The present disclosure relates to a peptide comprising at least five amino acid residues, wherein at least one amino acid residue is modified to an epsilon-lysine, delta-ornithine, gamma-2,4-diaminobutyric acid, beta-2,3-diaminopropionic acid, with the peptide also comprising at least one non-epsilon lysine, non-delta-ornithine, non-gamma-2,4-diaminobutyric acid or non-beta-2,3-diaminopropionic acid, and wherein the peptide displays a reduced or no cytotoxicity when compared to an equivalent non-modified peptide. In a preferred embodiment, the modifications are to the melittin or mastoparan B peptides, and comprise the substitution of at least one a-lysine residue for an ?-lysine residue, and the modified peptides display antimicrobial activity.

Abstract: A simultaneous localization and mapping method and corresponding system are disclosed. The method comprises: receiving a frame of three dimensional point cloud data from a three dimensional point cloud sensor coupled to a robot; receiving inertial measurement data indicative of a change in pose of the three dimensional point cloud sensor; using the inertial measurement data to estimate a rotation between the received frame of three dimensional point cloud data and a key frame of three dimensional point cloud data; applying a rotation to the received frame of three dimensional point cloud data to obtain an aligned frame of three dimensional point cloud data, the aligned frame of three dimensional point cloud data having an orientation aligned with the key frame of three dimensional point cloud data; and estimating a translation of the aligned frame of three dimensional point cloud data from the key frame of three dimensional point cloud data.

Abstract: A server rack cooling arrangement may include a server rack enclosure defining a single undivided interior volume of space and configured to be sealable; two or more open-frame-server-units disposed within the interior volume of space and arranged in a multi-level arrangement, wherein heat-producing-electronic-components may be exposed to environmental conditions of the interior volume of space; a central condenser disposed towards a rear; a coolant reservoir for collecting condensate from the central condenser; at least one nozzle in fluid communication with the coolant reservoir and configured to deliver fine coolant droplets into the interior volume of space for impingement on the heat-producing-electronic-components; and a fan configured to generate an airflow through the two or more open-frame-server-units from a front to the rear in a manner so as to carry coolant vapour generated from impingement of the fine coolant droplets on the heat-producing-electronic-components to the central condenser.

Abstract: The present invention relates to conjugates comprising (a) an antisense oligonucleotide (ASO) and (b) at least one G-quadruplex structure, wherein the ASO and the at least one G-quadruplex structure are heterologous to each other. The G-quadruplex of the conjugate may be further conjugated with ligands or functional moieties for addressable delivery and enhanced properties including potency and therapeutic index. Further encompassed are such conjugates for use as a medicament, a method of modulating the stability, translation, splicing, cleavage, or activity of a target nucleic acid molecule using such conjugates, and use of G-quadruplex in stabilizing antisense oligonucleotides.

Abstract: Methods and systems for obfuscating computer program code are disclosed. In an embodiment, a method of generating obfuscated binary code from input source code for execution on a target processor comprises: generating a set of random obfuscation transform selections; and iteratively optimizing the obfuscation transform selections until a termination criterion is met. The obfuscation transformation selections may comprise indications of custom instructions which are executable on the co-processor in order to reduce side channel leakage.

Abstract: Methods and apparatus for extracting one or more mechanical properties for a material based on one or more indentation parameters for the material. The method comprises receiving load-displacement data from one or more instrumented indentation tests on the material, determining, by at least one computer processor, the indentation parameters for the material based, at least in part, on the received load-displacement data, providing as input to a trained neural network, the indentation parameters for the material, determining, based on an output of the trained neural network, the one or more mechanical properties of the material, and displaying an indication of the determined one or more mechanical properties of the material to a user of the computer system.

Abstract: According to embodiments of the present invention, an optical modulator is provided. The optical modulator includes a substrate, and a waveguiding arrangement on the substrate, the waveguiding arrangement having a waveguide, and at least one graphene layer arranged to interact with light propagating in the waveguiding arrangement, wherein the waveguide is designed such that the light interacting with the at least one graphene layer has a maximum intensity overlapping with the at least one graphene layer. According to further embodiments of the present invention, a method for forming the optical modulator, and a method for controlling the optical modulator are also provided.

Abstract: Various embodiments relate to a stent assembly comprising a stent; a swellable coating disposed on at least a portion of an exterior surface of the stent; optionally, a carrier dispersed in the swellable coating and/or disposed on at least a portion of an exterior surface of the stent; and an active agent comprised in at least one of the swellable coating or the carrier, if present. Use of the stent assembly as a ureteric stent, and method of preparing a stent assembly are also provided.

Abstract: The present invention relates to electrochemically initiated bioadhesive compositions comprising biocompatible polymers containing derivatives of diazonium, arylsulfonium, or diaryliodonium in general, and to their use in tissue fixation, in particular.

Abstract: A circuit arrangement is provided, having a first circuit configured to receive an input signal, and a second circuit configured to provide an output signal, wherein the first circuit includes a first pull-up network having a first transistor of a first conductivity type and a second transistor of a second conductivity type electrically coupled to each other, and a first pull-down network having a first transistor of the first conductivity type and a second transistor of the second conductivity type electrically coupled to each other, wherein the second circuit includes a second pull-up network having a first transistor of the first conductivity type, and a second pull-down network having a second transistor of the second conductivity type, wherein the first pull-up network and the second pull-down network are electrically coupled to each other, and wherein the first pull-down network and the second pull-up network are electrically coupled to each other.