Abstract: Provided is the use of compounds of Formula I, as well as certain specific compounds, or a pharmaceutically acceptable salt, solvate or derivative thereof, in the preparation of a medicament to treat or prevent a disease condition that is associated with increased KCa3.1 or altered activity, such as stroke.

Abstract: According to examples, a method comprises obtaining a digital representation of a three-dimensional object, mapping the digital representation on to a sphere of a pre-determined radius and generating a descriptor of the digital representation based on a spherical harmonic decomposition of an output of the mapping.

Abstract: The present invention relates to a polypeptide comprising at least one at least one deletion selected from the group consisting of ?HNH (?775-909), ARuvCIII-b (?1002-1074), AREC1-a (?510-655), AREC1-b (?525-587), AREC1-c (?662-710), AREC2 (?180-308), AREC2-a (?212-244), AREC2-b (?244-276), AREC2-c (?276-308), AREC2-d (?199-283), AREC2-e (?198-257), AREC2-f (?235-286), AREC2-g (?217-266), AREC3 (?498-712) and combinations thereof, wherein the position numbering is in accordance with SEQ ID NO: 1 encoding for S. pyogenes Cas9, and wherein the polypeptide has CRISPR-Cas DNA-binding activity. The polypeptide may further comprises a missense mutations selected from G12R, T13K, T13R, N14K, N497K, T657K, T657R, N767K, T770K, T770R, Q920K, Q920R, S1109R, D1135K, D1135R, S1338R and combinations thereof. Also claimed are nucleic acid molecules encoding for said polypeptides, compositions and method of site-directed engineering of a target DNA thereof.

Abstract: According to embodiments of the present invention, a photodiode detector is provided. The photodiode detector includes an optical cavity including an overlying light-receiving portion and an underlying minor; and a GeSn absorption layer. The GeSn absorption layer may be disposed within the optical cavity and arranged between the overlying light-receiving portion and the underlying mirror. The overlying light-receiving portion may be configured to receive light to be detected by the photodiode detector. According to further embodiments of the present invention, a method of fabricating a photodiode detector is also provided.

Abstract: A receiver includes a differential signal generator receiving a single-ended signal, and generating differential signals having a positive signal and a negative signal based on the single-ended signal, a reference signal, and a pair of compensation signals, a pair of charging circuits charging first and second nodes to a power level in a logic low period of a clock signal, a pair of discharging circuits discharging the first and second nodes according to a level of the positive signal and a level of the negative signal, respectively, in a logic high period of the clock signal, a comparator comparing signal levels of the first and second nodes and outputting an offset detection signal of the differential signals, and an offset compensator outputting the reference signal and the pair of compensation signals, each adjusted based on the offset detection signal, to the differential signal generator.

Abstract: The invention concerns a compound of formula (Ia) or (lb) wherein R1 is hydrogen or a methyl group; R2 is an unsubstituted or substituted alkyl group; R3 is an aryl group or a heteroaryl group, optionally substituted by one or more groups selected from halogen, alkyl or alkoxy; and, in Formula (Ia), X is CH or N and Y is NH, S or O, or, in Formula (Ib), X is NH, S or O and Y is CH or N. The invention further concerns a method of synthesizing the inventive compound, a composition comprising the inventive compound or a pharmaceutically acceptable salt thereof and bedaquiline (BDQ), an analogue of bedaquiline (BDQ) or a mixture thereof, and the use of said composition or compound for the treatment of tuberculosis.

Abstract: The present disclosure provides a device for patterning extracellular matrix (ECM) hydrogel comprising a first layer surface patterned to define a microchannel, a second layer comprising a loading channel in fluid communication with loading ports to receive an ECM hydrogel, wherein the first layer is attached over the second layer such that the patterned surface faces the loading channel to define an open chamber with regions of reduced cross-sectional area, and wherein the ECM hydrogel is confined to fill said regions, thereby forming a perfusable channel in the open chamber. The present disclosure also provides the same device wherein the second layer is a substrate without a loading channel and is optically pervious; and additionally provides a method of patterning ECM hydrogel comprising use of the aforementioned device. Importantly, ECM patterning is achieved by surface tension between the ECM hydrogel and the first layer at the boundaries of the microchannel.

Abstract: The present invention relates to a method of ligating a first peptide via its C-terminus to the N-terminus of a second peptide, wherein the reaction is catalyzed by an asparagine/aspartate (Asx) peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1. Further encompassed are a method of preparing a dimer, oligomer, or multimer of one or more peptides of interest and a method of modifying or tagging the surface of a target cell by one or more peptides of interest. Also encompassed in the invention are the ligated peptides and/or tagged target cells obtainable according to any of the methods, the peptide ligase OaAEPI Cys247Ala having the amino acid sequence of SEQ ID NO: 1, as well as kits comprising said peptide ligase.

Abstract: A generative adversarial network performs face anonymization. In a first step, an input image showing a face to be anonymized is received. Furthermore, an input vector with control data for face anonymization is received. The generative adversarial network then generates an output image in which the face is anonymized in accordance with the control data of the input vector.

Abstract: A cryogenic energy system for cooling and powering an indoor environment includes a cryogenic open loop comprising a cryogen source to supply a cryogen and at least one transfer-expansion stage in fluid connection with the cryogen source, each transfer-expansion stage comprising at least one heat exchanger for heat transfer therein from a hot fluid to the cryogen and a power unit for expansion therein of the cryogen that has been heated in the at least one heat exchanger to generate electricity, the at least one heat exchanger including an evaporator; and a heat supply open loop configured to provide the hot fluid for heat exchange with the cryogen in the at least one heat exchanger; the cryogenic energy system configured to perform heat removal from a first heat transfer loop of a conventional cooling system, the first heat transfer loop transferring heat obtained from air in the indoor environment.

Abstract: There is provided a method of forming a 3-dimensional structure from a hydrogel, the process comprising the steps of: (a) placing a hydrogel polymerisation solution into a reaction vessel, and (b) allowing the hydrogel polymerisation solution to react without mixing for a period of time at ambient temperature, while introducing a polymerisation modulator to the reaction solution through a reaction solution/polymerisation modulator interface, wherein over the period of time, a modulation effect gradient is established in the reaction solution, where the modulation effect has a maximal value at the reaction solution/polymerisation modulator interface and a minimal value at a point furthest away from said interface. The said method additionally includes the use of physical constraint members such as wires and/or threads.

Abstract: Systems and methods for simultaneously recovering and separate sounds from multiple sources using Impulse Radio Ultra-Wideband (IR-UWB) signals are described. In one embodiment, a device can be configured for generating an audio signal based on audio source ranging using ultrawideband signals. In an embodiment the device includes, a transmitter circuitry, a receiver circuitry, memory and a processor. The processor configured to generate a radio signal. The radio signal including an ultra-wideband Gaussian pulse modulated on a radio-frequency carrier. The processor further configured to transmit the radio signal using the transmitter circuitry, receive one or more backscattered signals at the receiver circuitry, demodulate the one or more backscattered signals to generate one or more baseband signals, and generate a set of data frames based on the one or more baseband signals.

Abstract: A first object for assembly with a second object, the first object comprising: a body having a first mating portion; and a first electronic element fabricated on the body; wherein the first electronic element is provided to establish an electrical coupling with a second electronic element fabricated on one of: the body and the second object, wherein a second mating portion is provided on the second object, and wherein the electrical coupling is configured to provide a measurable output for positioning the first mating portion at a desired position relative to the second mating portion according to an analysis of the measurable output against a predetermined reference output.

Abstract: An is disclosed. The apparatus comprises a two-dimensional perovskite having a polaronic emission Stokes' shifted by at least 50 nm to minimise loss due to re-absorption.

Abstract: The microfluidic board comprises a plurality of matrix units, wherein each matrix unit is a stacked arrangement comprising a driving portion comprising an actuator, a pump portion in contact with the driving portion and comprising a pump, a channel portion in contact with the pump portion and comprising one or more channels, and a chamber portion in contact with the channel portion and comprising a chamber, wherein the one or more channels are configured to direct fluid between the pump and the chamber, and wherein the actuator is configured to generate a force to drive the pump upon receiving of an input energy.

Abstract: Disclosed herein is a process for the treatment of wastewater for biosolids reduction and biogas (i.e. methane) generation where a wastewater is provided to a first reactor which is operated under anaerobic conditions, a hydraulic/solids retention time of from 0.1 to 1 day, a temperature of from 30 to 70° C. and a pH of from 6.5 to 10, with the effluent of the first reactor passing to a second reactor which is operated under anaerobic conditions, a hydraulic/solids retention time of from 3 to 10 days and a temperature of from 30 to 70° C. The process may further comprise feeding an effluent produced from the second reactor to a third reactor operated under anaerobic conditions, a hydraulic/solids retention time of from 3 to 20 days and a temperature of from 30 to 70° C.

Abstract: Various embodiments may provide an integrated circuit layout cell. The integrated circuit layout cell may include a doped region of a first conductivity type, a doped region of a second conductivity type opposite of the first conductivity type, and a further doped region of the first conductivity type at least partially within the doped region of the second conductivity type, and continuous with the doped region of the first conductivity type. The integrated circuit cell may include a first transistor having a control terminal, a first controlled terminal, and a second controlled terminal. The first controlled terminal and the second controlled terminal of the first transistor may include terminal regions of the second conductivity type formed within the further doped region of the first conductivity type. The integrated circuit cell may also include a second transistor.

Abstract: According to the present disclosure, the use of a nanoliposome in the manufacture of a medicament for the prophylaxis and/or treatment of anterior segment ocular diseases is provided. The nanoliposome comprises a plurality of unsaturated and/or saturated lipids forming at least one lipid bilayer encapsulating a hydrophobic drug comprising tacrolimus, wherein the hydrophobic drug and the plurality of unsaturated and/or saturated lipids have a weight ratio of up to 0.2. The present disclosure also provides for such a nanoliposome and a method of preventing and/or treating anterior segment ocular diseases based on the nanoliposomes.

Abstract: An offset detector circuit includes a digital signal register storing M unit digital signals received in latest M signal periods, M being a natural number, among digital signals generated based on a single-ended PAM-N signal, N being an odd number, a comparator outputting a comparison signal of a pair of signals included in differential signals generated from a differential signal generator based on the single-ended PAM-N signal, a comparison result register storing M unit comparison signals corresponding to the latest M signal periods among the comparison signals, a pattern detector outputting a detection signal when the M unit digital signals match a predetermined signal pattern, and an offset checker checking patterns of the M unit comparison signals in response to the detection signal, and outputting an offset detection signal when the patterns of the M unit comparison signals match a predetermined offset pattern.

Abstract: A receiver includes a differential signal generator receiving a single-ended signal, and generating differential signals having a positive signal and a negative signal based on the single-ended signal, a reference signal, and a pair of compensation signals, a pair of charging circuits charging first and second nodes to a power level in a logic low period of a clock signal, a pair of discharging circuits discharging the first and second nodes according to a level of the positive signal and a level of the negative signal, respectively, in a logic high period of the clock signal, a comparator comparing signal levels of the first and second nodes and outputting an offset detection signal of the differential signals, and an offset compensator outputting the reference signal and the pair of compensation signals, each adjusted based on the offset detection signal, to the differential signal generator.