Patents Assigned to National Institute of Radiological Sciences
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Publication number: 20080149835Abstract: Dosimeters 140 are housed in dosimeter housing pockets 130 of a dosimeter fitting wear including: wear main bodies 120, 150 which cover measuring positions on at least subject bodies 100, 102, and 110, and can be detachably fitted on the subject bodies, and the dosimeter housing pockets 130 provided at positions that come to the measuring positions when the wear main bodies are fitted on the subject bodies, and then the wear main bodies are fitted on the subject bodies. Thereby, a number of dosimeters can be easily fitted on or detached from the surfaces of subject bodies without hindering medical activities, and set positions of the dosimeters can be easily reproduced.Type: ApplicationFiled: February 16, 2006Publication date: June 26, 2008Applicants: National Institute of Radiological Sciences, Chiyoda Technol CorporationInventors: Takashi Moritake, Saburo Fujisaki, Yasuhiro Koguchi, Hiroshi Mizushima, Kiyoshi Matsuno, Takashi Uchida
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Publication number: 20080123816Abstract: An X-ray flux irradiation intensity distribution which is nonuniform due to a heel effect can be made uniform, and a subject can be prevented from being unnecessarily exposed. In addition, image quality of image data obtained with an X-ray CT scanner can be made uniform and improved in a body axis direction. A heel effect compensation filter is configured to have a thickness distribution that uniforms an X-ray intensity angular distribution that is nonuniform in the body axis direction of a subject in an X-ray flux irradiated space. The space is formed by an X-ray flux diverging from an anode in a body width direction of the subject and diverging in a shape of an approximate sector in the body axis direction due to the heel effect, when the X-ray flux generated on the anode by irradiating a thermoelectron beam flux from a cathode to the anode is irradiated on the subject. The thickness distribution can be obtained using a predetermined formula.Type: ApplicationFiled: March 29, 2005Publication date: May 29, 2008Applicant: National Institute of Radiological SciencesInventors: Shinichirou Mori, Masahiro Endo
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Publication number: 20080104723Abstract: To comprehensively modify genome, it is intended to develop a transposition system of the copy and paste type which has an improved efficiency. This object has been achieved by the finding that an LTR retrotransposon is partly usable in a transposition system. Namely, a technique of efficiently transferring a foreign gene into a cell by using a transposon. More specifically speaking, a complete IPA element and a functional promoter sequence are found out. It is clarified that, without a combination of them, a retrotransposon cannot exert its function.Type: ApplicationFiled: November 19, 2004Publication date: May 1, 2008Applicants: Osaka Industrial Promojtion Organization c/o Mydom, National Institute of Radiological SciencesInventors: Junji Takeda, Hyoji Horie, Kosuke Yusa, Hiroshi Ishihara
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Publication number: 20080019946Abstract: An integration-type low-dose radiation-inducible viral vector comprising a DNA sequence comprising a p53 target gene promoter sequence and a therapeutic gene sequence. The vector of the present invention is useful for gene therapy.Type: ApplicationFiled: April 19, 2007Publication date: January 24, 2008Applicant: National Institute of Radiological SciencesInventors: Mitsuru Nenoi, Kazuhiro Daino
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Patent number: 7262565Abstract: According to the present invention, a non-isochronous magnetic field distribution in which the magnetic field increases as the radius increases is formed and a distribution of fixed-frequency accelerating RF voltage is formed, said non-isochronous magnetic field distribution and said distribution of fixed-frequency accelerating RF voltage being formed so that a harmonic number defined as a ratio of the particle revolution period to the period of the accelerating RF voltage decreases in integer for every particle revolution.Type: GrantFiled: April 3, 2006Date of Patent: August 28, 2007Assignee: National Institute of Radiological SciencesInventor: Takashi Fujisawa
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Publication number: 20070138088Abstract: Radionuclide can be easily removed from a solution under aerobic condition by culturing Euglena in contact with radionuclide in a solution that is suitable for viability Euglena to thus transfer said radionuclide to Euglena and separating said Euglena comprising radionuclide from said solution.Type: ApplicationFiled: October 20, 2006Publication date: June 21, 2007Applicant: National Institute of Radiological SciencesInventors: Nobuyoshi Ishii, Shigeo Uchida
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Patent number: 7091490Abstract: A depth of interaction detector with uniform pulse-height comprises a multi-layer scintillator obtained by coupling at least two scintillator cells on a plane and then stacking the planar coupled scintillator cells, in layers, up to at least two stages and a light-receiving element connected to the bottom face of each scintillator cell of this multi-layer scintillator, wherein the detector is provided with a means for discriminating the position of a scintillator cell, which receives radiant rays and emits light rays and a means for making, uniform, the quantity of the light emitted from each scintillator cell and received by the light-receiving element.Type: GrantFiled: October 15, 2003Date of Patent: August 15, 2006Assignees: Hitachi Chemical Co., Ltd., National Institute of Radiological Sciences, Hamamatsu Photonics K.K.Inventors: Keiji Sumiya, Hiroyuki Ishibashi, Hideo Murayama, Naoko Inadama, Takaji Yamashita, Tomohide Omura
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Patent number: 7087905Abstract: The radiation three-dimensional position detector of the present invention comprises a scintillator unit (10), a light receiving element (20) and an operation section (30). The scintillator unit is disposed on the light incident plane of the light receiving element, wherein the scintillator unit is comprised of four layers of scintillator arrays, each layer being composed of scintillator cells arrayed in 8 row ?8 column matrix. The scintillator cell produces scintillation light corresponding to the radiation absorbed thereby. The optical characteristic of a partition material for separating neighboring scintillator cells, which faces at least one same side face is different between a scintillator cell Ck1,m,n included in one scintillator array layer (k1-th layer) and a scintillator cell Ck2,m,n included in the other scintillator array layer (k2-th layer).Type: GrantFiled: February 26, 2004Date of Patent: August 8, 2006Assignees: National Institute of Radiological Sciences, Shimadzu Corporation, Hamamatsu Photonics K.K.Inventors: Hideo Murayama, Naoko Inadama, Keishi Kitamura, Takaji Yamashita
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Publication number: 20050181424Abstract: The present invention provides a method for preparing a gene expression profile with a high precision, by carrying out the annealing of primers to templates in the temperature range of TmMAX+6° C. to TmMAX+14° C. of the primer in a PCR step of a HiCEP method.Type: ApplicationFiled: March 21, 2005Publication date: August 18, 2005Applicant: National Institute of Radiological SciencesInventor: Masumi Abe
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Publication number: 20050183149Abstract: A non-human mammal, especially a mouse exhibiting a characteristic of Rothmund-Thomson syndrome prepared by introducing a mutation into exon 13 of RECQL4 gene; and method of preparation thereof are provided.Type: ApplicationFiled: March 21, 2005Publication date: August 18, 2005Applicant: National Institute of Radiological SciencesInventor: Masumi Abe
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Patent number: 6924929Abstract: A microscope apparatus has a sample table for supporting a sample and being mounted to undergo movement in a horizontal direction. A line sensor acquires a line image for each of a series of measuring positions of the sample in accordance with movement of the sample at a constant speed by one measuring width of the line sensor in the horizontal direction. An image processing device produces an image of the sample based on the line images acquired by the line sensor. A focusing device has a light-projecting member for projecting light onto the sample at a position forward of a leading side of an imaging range of the line sensor in the horizontal direction to prevent light reflected by the sample as a result of the projected light from being incident on and interfering with the line images acquired by the line sensor.Type: GrantFiled: March 28, 2003Date of Patent: August 2, 2005Assignees: National Institute of Radiological Sciences, Seiko Precision Inc.Inventors: Nakahiro Yasuda, Yoshihiro Honma
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Patent number: 6870069Abstract: A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1): wherein X1 and X2 are same or different and each is hydrogen atom or halogen atom; R1 and R2 are same or different and each is hydrogen atom, an alkyl group having 1 to 10 carbon(s) or a halogen-substituted alkyl group having 1 to 10 carbon(s); and R3 is a halogen-substituted alkyl group having 1 to 5 carbon(s), or a radioisotope thereof.Type: GrantFiled: November 4, 2003Date of Patent: March 22, 2005Assignees: National Institute of Radiological Sciences, Taisho Pharmaceutical Co., Ltd., Nihon Nohyaku Co., Ltd.Inventors: Kazutoshi Suzuki, Ming-Rong Zhang, Tetsuya Suhara, Atsuro Nakazato, Makoto Goto
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Publication number: 20040178347Abstract: The radiation three-dimensional position detector of the present invention comprises a scintillator unit (10), a light receiving element (20) and an operation section (30). The scintillator unit is disposed on the light incident plane of the light receiving element, wherein the scintillator unit is comprised of four layers of scintillator arrays, each layer being composed of scintillator cells arrayed in 8 row—8 column matrix. The scintillator cell produces scintillation light corresponding to the radiation absorbed thereby. The optical characteristic of a partition material for separating neighboring scintillator cells, which faces at least one same side face is different between a scintillator cell Ck1,m,n included in one scintillator array layer (k1-th layer) and a scintillator cell Ck2,m,n included in the other scintillator array layer (k2-th layer).Type: ApplicationFiled: February 26, 2004Publication date: September 16, 2004Applicants: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES, SHIMADZU CORPORATION, HAMAMATSU PHOTONICS K.K.Inventors: Hideo Murayama, Naoko Inadama, Keishi Kitamura, Takaji Yamashita
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Patent number: 6768407Abstract: A permanent-magnet-type magnetic field generator (10) capable of generating a strong magnetic field not weaker than 3 T in a magnetic field generation space (12) is provided. The magnetic field generator (10) has an axially central portion serving as the magnetic field generation space (12), and includes a first magnetic circuit (14) provided by a Halbach array at an outer central portion, and a second magnetic circuit (16) formed inside the first magnetic circuit (14) to surround the magnetic field generation space (12). The first magnetic circuit (14) is provided by permanent magnets (20a)-(20f) and central portions (A) of permanent magnets (22a)-(22f). The second magnetic circuit (16) is provided by a pair of pole pieces (24a) and (24b) each having a saturation magnetism not smaller than 1.6 T, and central portions (B) of permanent magnets (26a)-(26d) which provides magnetic interconnection between the pole pieces (24a) and (24b).Type: GrantFiled: January 9, 2004Date of Patent: July 27, 2004Assignees: Sumitomo Special Metals Co., Ltd., National Institute of Radiological SciencesInventors: Tsutomu Kohda, Masayuki Kumada
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Publication number: 20040138310Abstract: A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1): 1Type: ApplicationFiled: November 4, 2003Publication date: July 15, 2004Applicants: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES, TAISHO PHARMACEUTICAL CO., LTD., NIHON NOHYAKU CO., LTD.Inventors: Kazutoshi Suzuki, Ming-Rong Zhang, Tetsuya Suhara, Atsuro Nakazato, Makoto Goto
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Patent number: 5452337Abstract: A rotational drive sensor 31 which allows a radiation source 10 and a twomensional sensor 20 which are caused to be in one body to turn round a subject 50. An X-ray vessel 13 irradiates X-rays to the subject 50 in a pulsated manner. An X-ray/light conversion element 21 converts an X-ray transmitted image to an optical image. A CCD camera 23 picks up this optical image. An information processing unit 40 reconstructs a three-dimensional pictorial image on the basis of two dimensional pictorial images in plural directions obtained, and a display monitor 46 displays this three-dimensional pictorial image. A controller 39 controls the distance between the X-ray vessel 13 and the X-ray/light conversion element 21 and the focal size of the X-ray vessel 13 on the basis of the size of the subject 50.Type: GrantFiled: November 30, 1993Date of Patent: September 19, 1995Assignees: Sony Corporation, National Institute of Radiological Science, Science and Technology AgencyInventors: Masahiro Endo, Yukio Tateno, Masao Jinbo, Masahiro Kusakabe, Kazumasa Sato, Tsutomu Okazaki
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Patent number: 5285166Abstract: A method of extracting a strong, charged particle beam, that is, a large current from an accelerator, and an accelerator capable of carrying out the method utilizes charged particles which are extracted from the accelerator. The equilibrium orbit of charged particles in one of a bending magnet and a magnet having multipole components greater than sextuple components, is shifted by a constituent element of the accelerator other than these magnets, to change the tune of charged particles. The adjustment of this tune based upon the shift of the equilibrium orbit in the above magnet for extracting charged particles, can keep the gradient of orbit of the extracted beam substantially constant. Accordingly, beam extraction is readily controlled, and a large current can be extracted from the accelerator.Type: GrantFiled: March 26, 1992Date of Patent: February 8, 1994Assignees: Hitachi, Ltd., Director General of National Institute of Radiological SciencesInventors: Kazuo Hiramoto, Masatsugu Nishi, Akifumi Itano
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Patent number: 4426699Abstract: A plurality of input signals are applied to input terminals of first and second priority encoders according to the order of priority in ascending and descending orders, respectively. The encoded output signals of the first and second priority encoders are exclusive-ORed for each corresponding pair of significant bits. A single event detection is executed only if exclusive OR is effected for all the corresponding pairs of significant bits.Type: GrantFiled: February 28, 1980Date of Patent: January 17, 1984Assignees: The Director of the National Institute of Radiological Sciences, Science and Technology Agency, Tokyo Shibaura Denki Kabushiki KaishaInventors: Eiichi Tanaka, Norimasa Nohara, Takehiro Tomitani, Mineki Nishikawa
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Patent number: 4394576Abstract: An apparatus for a detecting the location of incident radiation comprises at least one pair of assembly comprised of a scintillation crystal consisting of a plurality of crystal segments, a pair of photo-multiplier tubes optically coupled to the scintillation crystal so as to be able to detect a scintillation produced in any one of these crystal segments. These plural crystal segments are coupled to each other in such manner that any scintillation produced in any single crystal segment will cause the photo-multiplier tubes to deliver substantially a same output irrespective of the illuminating position within this crystal segment, and also that scintillations produced in the respective crystal segments will cause the photo-multiplier tubes to deliver outputs which are different in level for the respective crystal segments.Type: GrantFiled: September 29, 1980Date of Patent: July 19, 1983Assignees: National Institute of Radiological Sciences, Hitachi Medical CorporationInventors: Eiichi Tanaka, Norimasa Nohara, Hideo Murayama, Kenji Ishimatsu, Akira Ogushi, Katsumi Takami
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Patent number: 4352018Abstract: An apparatus for effecting positron emission computed tomography comprises rows of a plurality of arrays of detectors arranged rotatably around a center of rotation in such way that at least one of the detectors in each array is disposed at an irregular position relative to the rest of detectors in the array, and that, for each revolution of the row through an angle of 360.degree./n (wherein: n represents an odd number of 3 or larger), each array of detectors will assume exactly the position occupied by its adjacent array till the revolution takes place.Type: GrantFiled: March 25, 1980Date of Patent: September 28, 1982Assignees: National Institute of Radiological Sciences, Hitachi Medical CorporationInventors: Eiichi Tanaka, Norimasa Nohara, Takehiro Tomitani, Mikio Yamamoto, Kenji Ishimatsu, Katsumi Takami