Patents Assigned to National Research Council of Canada
  • Publication number: 20240076389
    Abstract: AXL-specific antibodies and uses therefor are described, including monoclonal and single domain antibodies. Such antibodies bind to cell surface expressed human AXL at an epitope in an immunoglobulin-like (IgL) domain of the AXL ectodomain. The antibody may be used in an antibody-drug conjugate (ADC), for example in the treatment, detection or staging of cancer. The antibody may be biparatopic.
    Type: Application
    Filed: June 27, 2023
    Publication date: March 7, 2024
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Kevin HENRY, Maria Luz JARAMILLO, Colin Roger MACKENZIE, Anne MARCIL
  • Publication number: 20240076406
    Abstract: The present disclosure relates to a single domain antibody that specifically binds to the epitope in the catalytic domain of carbonic anhydrase IX (CA-IX). The single domain antibody has a dissociation constant (KD) of 1×10?7 or lower for a monomeric form of human CA-IX and/or a dimeric form of human CA-IX.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 7, 2024
    Applicant: National Research Council of Canada
    Inventors: Anne EG LENFERINK, Mehdi ARBABI GHAHROUDI, Nazanin ROHANI LARIJANI, Scott MCCOMB
  • Publication number: 20240053300
    Abstract: Described are various embodiments of an ultrasonic structural health monitoring device, system and method. In one embodiment, an ultrasonic structural health monitoring device is described to monitor a structure. The device comprises a bottom electrode disposable on the structure; a piezoelectric medium disposed on the bottom electrode; a top electrode disposed on the piezoelectric medium; an acoustic insulation layer; and a connector to bring electrical excitation for the piezoelectric medium and to collect a generated electric response therefrom representative of structural health.
    Type: Application
    Filed: August 20, 2021
    Publication date: February 15, 2024
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Silvio Elton KRUGER, David ROCHELEAU, Zhigang SUN, Kuo-Ting WU
  • Publication number: 20240010686
    Abstract: Methods and compositions for increasing the production of large amounts of empty capsids of the foot-and-mouth disease virus (FMDV) in a stable manner in mammalian cells by regulating the expression of FMDV 3C protease. The instant methods and compositions are based on the fact that a decreased expression of 3C protease results in a reduced cell toxicity and an increased synthesis of viral capsid proteins, as well as production of recombinant empty capsids. The invention provides recombinant plasmids that direct the expression of P1, 3C, and the use of the plasmids for producing new stable cell lines capable of generating high titers of FMDV empty capsids. The invention provides methods for regulating the expression of the FMDV 3C protease gene at a transcriptional and translational level in order to achieve the required process level of 3C protease for the selection process, as well as the production process.
    Type: Application
    Filed: November 9, 2021
    Publication date: January 11, 2024
    Applicants: Instituto Nacional de Tecnologia Agropecuaria, National Research Council of Canada
    Inventors: Ana Clara Mignaqui, Andres Wigodorovitz, Yves Durocher
  • Patent number: 11867320
    Abstract: In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: January 9, 2024
    Assignee: National Research Council of Canada
    Inventors: Kebin Li, Keith Morton, Teodor Veres
  • Patent number: 11866481
    Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-?) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: January 9, 2024
    Assignee: National Research Council of Canada
    Inventors: Anne E. G. Lenferink, John C. Zwaagstra, Traian Sulea, Maureen D. O'Connor-McCourt
  • Publication number: 20240001565
    Abstract: The use of an unctuous sealing material (high viscosity liquid bordering on, or having, solid behavior at low shear forces) for sealing open pore, highly crushable suction cups allows for increased surface conformation for fast secure vacuum gripping, and maintenance of the pressure differential with lower energy in view of the seal. Furthermore, fast grasping is demonstrated if the unctuous sealing material protrudes from the lip.
    Type: Application
    Filed: December 2, 2021
    Publication date: January 4, 2024
    Applicant: National Research Council of Canada
    Inventors: Charles VIDAL, Alexis GERARD, Martin DE MONTIGNY, Bruno MONSARRAT, Iraj MANTEGH, Bruno CHAPDELAINE
  • Patent number: 11845234
    Abstract: A vacuum bag system (VBS) for forming pre-consolidated composite blanks has a blank enclosure for sealing around a periphery of the blank, while leaving a second side of the blank exposed, an articulated forming caul (AFC) with at least two facets, each facet effectively jointedly coupled to an adjacent facet, and having a respective, independently controlled, heater integrated with, or coupled to the facet. The VBS further has a forming enclosure for sealing around a periphery of a tool. The blank enclosure brings the blank and the facets into uniform thermal contact resistance and mechanical contact; and permits the articulated AFC to distribute thermal and mechanical load across the blank during forming, even as the facets move to align to faces of the mold.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: December 19, 2023
    Assignee: National Research Council of Canada
    Inventors: Ali Yousefpour, Drazen Djokic, Simon Hind, Meysam Rahmat, Steven Roy, Marc-Andre Octeau, Jihua Chen
  • Patent number: 11837681
    Abstract: An avalanche photodiode with a diffused junction and the method for its fabrication are disclosed. The method comprising forming, on a substrate, a first high-doped region and a low-doped region; performing selective area growth (SAG) with in-situ etchant on the low-doped region to grow a SAG structure; and diffusing through the SAG structure to form a second high-doped region in the low-doped region.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: December 5, 2023
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Oliver Pitts, Omid Salehzadeh Einabad
  • Patent number: 11820975
    Abstract: An in vitro population of human brain endothelial cells (hBECs) expressing claudin-5, occludin, ZO-1 and GLUT-1 and expressing one or more of FZD7, WNT7A, WNT7B, APCDD1, STRA6 and ZO-3 is provided. A blood brain barrier (BBB) comprising the hBECs and use of the BBB for analyzing permeability characteristics of a test agent are provided.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: November 21, 2023
    Assignee: National Research Council of Canada
    Inventors: Mahmud Bani, Danica Stanimirovic, Maria Ribecco-Lutkiewicz
  • Patent number: 11819021
    Abstract: Novel activators of the APC complex and methods and uses of these activators are provided. In particular, the activators are used for increasing resistance to stress and/or increasing lifespan in a plant or mammalian cell, in a plant or mammalian embryo or in a plant or subject. The activators are also used for treating cancer in a subject.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: November 21, 2023
    Assignee: University of Saskatchewan & National Research Council of Canada
    Inventors: Troy Harkness, Terra Gayle Arnason, Pankaj Bhowmik
  • Publication number: 20230357566
    Abstract: Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer matrix comprising a first polymer material and a second polymer material that are immiscible with each other, and a plurality of piezoelectric particles located in at least a portion of the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
    Type: Application
    Filed: March 22, 2022
    Publication date: November 9, 2023
    Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Sarah J. VELLA, Alexandros VASILEIOU, Yujie ZHU, Edward G. ZWARTZ, Chantal PAQUET, Silvio E. KRUGER, Mohammad RAFIEE, Yujie ZHANG, Thomas LACELLE, Derek ARANGUREN VAN EGMOND, Claudie ROY
  • Publication number: 20230361637
    Abstract: An electrical machine, which may be a motor and/or a generator has a rotor mounted to rotate about an axis. A plurality of magnetic poles are spaced circumferentially around the rotor in the bore. The rotor comprises a shell shaped to provide a toroidal bore centered on the axis. A slit extends circumferentially around the rotor. The slit penetrates through the shell into the bore. The electrical machine also includes a stator that is supported in the bore by one or more supports extending through the slit of the rotor. The stator carries plural windings that are spaced apart around the bore.
    Type: Application
    Filed: September 16, 2021
    Publication date: November 9, 2023
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Maged IBRAHIM, Fabrice BERNIER, Jean-Michel LAMARRE
  • Patent number: 11795190
    Abstract: Heptose-1-monophosphate-7-derivatives are modifiable immunomodulators that can be used to prepare clinically active conjugate compounds. Such conjugate compounds are useful in modulating an immune response in a subject.
    Type: Grant
    Filed: December 29, 2018
    Date of Patent: October 24, 2023
    Assignees: NATIONAL RESEARCH COUNCIL OF CANADA, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Janelle Sauvageau, Andrew Cox, Xinyi Guo, Scott Gray-Owen
  • Publication number: 20230331788
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Application
    Filed: May 30, 2023
    Publication date: October 19, 2023
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Luke MASSON, Melanie ARBOUR, Marie-Anne GAURIAT
  • Patent number: 11753485
    Abstract: The present application relates to polymer microparticle-metal nanoparticle composites, to methods of preparing polymer microparticle-metal nanoparticle composites and to uses of such composites. The methods comprise introducing into a microfluidic device, a composition comprising: a cationic metal nanoparticle precursor; a polymer microparticle precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: September 12, 2023
    Assignee: National Research Council of Canada
    Inventors: Lidija Malic, Xuefeng Zhang, Keith Morton, Teodor Veres
  • Publication number: 20230282880
    Abstract: An electrochemical device is disclosed, which may include an anode, a cathode, and a molded electrolyte composition disposed between the anode and the cathode. Implementations of the electrochemical device may include where the cathode and/or the anode are disposed in a stacked geometry. The electrolyte composition may include a gel polymer electrolyte, which can include a hydrogel of a copolymer and a salt dispersed in the hydrogel of a copolymer. The electrolyte composition may alternatively include a crosslinker or a photoinitiator.
    Type: Application
    Filed: March 1, 2022
    Publication date: September 7, 2023
    Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Naveen CHOPRA, Gregory McGUIRE, Nan-Xing HU, Alexis LAFORGUE, Robert BLACK
  • Patent number: 11749558
    Abstract: A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed.
    Type: Grant
    Filed: December 13, 2021
    Date of Patent: September 5, 2023
    Assignees: Quantum Silicon Inc., The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Bruno Vieira Da Cunha Martins, Robert A. Wolkow, Marco Taucer, Jason Pitters
  • Patent number: 11744884
    Abstract: The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: September 5, 2023
    Assignees: UNIVERSITY OF MARYLAND, BALTIMORE, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: James E. Galen, Thanh Pham, Dacie R. Bridge, Jin Yuan Wang, Wangxue Chen
  • Patent number: 11744924
    Abstract: A stretchable multiple-layer nanocomposite material is provided and includes at least a nanocomposite material layer comprising a network of nanotubes modified with an elastomeric polymer; and at least one additional layer laminated with the nanocomposite material layer. The number of nanocomposite layers and additional layers, the nature and composition thereof, may be varied in a surface direction and/or a thickness direction so as to provide tailored mechanical and physico-chemical properties to a resulting skin that can be used to produce morphing or deployable structures.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: September 5, 2023
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Behnam Ashrafi, Michael Jakubinek, Kurtis Laqua, Yadienka Martinez-Rubi, Benoit Simard