Patents Assigned to National Research Council of Canada
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Patent number: 12103130Abstract: A base attachment module (BAM) of a small aerial vehicle (SAV) for attaching the SAV to an unprepared work surface has a surface meeting docking assembly (DA) with contact points for contacting the work surface, and a contracting suction cup (CSC) in a position surrounded by the contact points such that it extends beyond a plane (or other surface contour) of the points in a fully extended operating position, and is retracted below the plane in a retracted position. Actuation of the CSC when in contact with the surface, allows for the DA to be brought into contact with the contact points in a controlled manner, for a high stiffness attachment, as is needed for deployment of robotic tasks from a SAV.Type: GrantFiled: October 18, 2019Date of Patent: October 1, 2024Assignee: National Research Council of CanadaInventors: Bruno Monsarrat, Charles Vidal, Martin De Montigny, Iraj Mantegh
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Publication number: 20240301381Abstract: The present invention relates, in general, to polypeptides capable of neutralizing SARS-CoV-2 and providing ACE2 enzymatic activity, and uses of these polypeptides for treating disorders related coronaviral infections (COVID-19) and the accompanying acute respiratory distress syndrome (ARDS) and major organ injuries, and methods of making such molecules.Type: ApplicationFiled: January 25, 2022Publication date: September 12, 2024Applicant: National Research Council of CanadaInventors: Traian SULEA, Yves DUROCHER
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Patent number: 12084510Abstract: Herein described are antibodies to epidermal growth factor receptor (EGER) having an EGER binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.Type: GrantFiled: February 21, 2020Date of Patent: September 10, 2024Assignees: Gilead Sciences, Inc., National Research Council of CanadaInventors: Ilia Alexandre Tikhomirov, Maria L. Jaramillo, Maureen D. O'Connor-McCourt, Traian Sulea, Renald Gilbert, Bruno Gaillet, Jason Baardsnes, Myriam Banville, Suzanne Grothe
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Publication number: 20240270826Abstract: Described herein are antibodies that specifically recognize the SARS-CoV-2 spike (S) polypeptide, compositions comprising said antibodies, uses thereof, and methods employing said antibodies. Each antibody specifically recognizes the S1-RBD domain, S1-NTD domain, or S2 subunit of the SARS-CoV-2 spike polypeptide. Some antibodies are cross-reactive with variants of SARS-CoV-2 and other coronavirus spike polypeptides, such as SARS-CoV S, pangolin CoV S, bat SARS-like CoV S, and civet SARS-CoV S.Type: ApplicationFiled: April 22, 2022Publication date: August 15, 2024Applicant: National Research Council of CanadaInventors: Jamshid TANHA, Martin A. ROSSOTTI
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Patent number: 12055740Abstract: There is described a multilayer optical thin film structure comprising multiple optically absorbing layers and multiple optically non-absorbing layers. The optically absorbing layers and the optically non-absorbing layers are configured such that light incident on the structure is reflected with a red colour at a first angle, and light incident on the structure is reflected with a yellow colour at a second angle. There is also described an item having applied thereto such a multilayer structure.Type: GrantFiled: April 3, 2019Date of Patent: August 6, 2024Assignee: National Research Council of CanadaInventor: Penghui Ma
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Patent number: 12036229Abstract: Phosphorylated heptose compounds are useful in modulating an immune response in a subject. Also, the compounds are useful as adjuvants.Type: GrantFiled: May 11, 2018Date of Patent: July 16, 2024Assignees: National Research Council of Canada, The Governing Council of the University of TorontoInventors: Andrew Cox, Janelle Sauvageau, Scott Gray-Owen, Xinyi Guo
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Patent number: 12040367Abstract: An ohmic contact includes a first semiconductor layer a second semiconductor layer, and a heterointerface between the first semiconductor layer and the second semiconductor layer. The second semiconductor layer has a two-dimensional electron sheet region in which a two-dimensional electron sheet is formed. The ohmic contact further includes a metal terminal covering the first semiconductor layer and filling a plurality of direct access pathways that provide direct lateral contact with the two-dimensional electron sheet region. The semiconductor device is fabricated by providing the semiconductor layers, etching the direct access pathways, and depositing metal material to fill the direct access pathways and cover the semiconductor layers.Type: GrantFiled: September 14, 2022Date of Patent: July 16, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Alireza Loghmany, Jean-Paul Noel, Elias Al-Alam
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Patent number: 12034053Abstract: An ohmic contact includes a first semiconductor layer a second semiconductor layer, and a heterointerface between the first semiconductor layer and the second semiconductor layer. The second semiconductor layer has a two-dimensional electron sheet region in which a two-dimensional electron sheet is formed. The ohmic contact further includes a metal terminal covering the first semiconductor layer and filling a plurality of direct access pathways that provide direct lateral contact with the two-dimensional electron sheet region. The semiconductor device is fabricated by providing the semiconductor layers, etching the direct access pathways, and depositing metal material to fill the direct access pathways and cover the semiconductor layers.Type: GrantFiled: May 8, 2020Date of Patent: July 9, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Alireza Loghmany, Jean-Paul Noel, Elias Al-Alam
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Publication number: 20240213834Abstract: A permanent magnet (PM) for use in an electric machine including at least one cavity containing a phase change material (PCM) integrated with said PM, the PCM having a phase transition temperature between about 80° C. to about 200° C.Type: ApplicationFiled: May 20, 2022Publication date: June 27, 2024Applicant: National Research Council of CanadaInventors: Jean-Michel Lamarre, Maged Ibrahim, Fabrice Bernler, Roger Pelletier
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Patent number: 12017155Abstract: Provided herein are phase separation devices and methods for performing phase separation of an aqueous mixture. Said devices and methods may include a cavitation component for cavitating the aqueous mixture to produce a cavitated aqueous mixture; and an electrosorption component for performing an electrosorptive phase separation of the cavitated aqueous mixture. Such devices and methods may be used for phase separation of aqueous mixtures including algal aqueous mixtures and/or mining or waste water aqueous mixtures, for example.Type: GrantFiled: March 13, 2018Date of Patent: June 25, 2024Assignee: National Research Council of CanadaInventor: Deepak M. Kirpalani
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Patent number: 12017392Abstract: The present application relates to overmoulded printed electronic parts as well as to methods for preparing overmoulded printed electronic parts using conductive trace inks such as molecular inks, thermoset resins, and reinforcing materials such as glass microspheres and glass fabric.Type: GrantFiled: August 7, 2019Date of Patent: June 25, 2024Assignees: NATIONAL RESEARCH COUNCIL OF CANADA, E2IP TECHNOLOGIES INC.Inventors: Paul Arthur Trudeau, Arnold Jason Kell, Xiangyang Liu, Olga Mozenson
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Publication number: 20240178490Abstract: An electrochemical device is disclosed and may include an electrolyte composition disposed between the anode and the cathode and a water vapor barrier which may include a biodegradable material, where the water vapor barrier is disposed to prevent water vapor escaping from the electrochemical device. The water vapor barrier further may include poly lactic acid or a metalized coating. The water vapor barrier further may further include multiple layers and have a water vapor transmission rate (WVTR) less than or equal to 2 wt % over 24 hours. Embodiments of the water vapor barrier may also include a polymeric biodegradable material or a metalized coating disposed onto the biodegradable material. The water vapor barrier may also include multiple layers and may have a water vapor transmission rate (WVTR) less than or equal to 1 mg per cm2 over 24 hours.Type: ApplicationFiled: March 30, 2022Publication date: May 30, 2024Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADAInventors: Gregory McGuire, Naveen Chopra, Nan-Xing Hu, Alexis Laforgue, Nathalie Chapleau
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Publication number: 20240178793Abstract: Methods and systems for reducing solar cell degradation are provided. The methods and systems related to frequently applying large reverse bias current-voltage (J-V) sweeps to the cell to reduce the rates of internal degradation of the solar cells. The frequent sweeps serve to detrap charge carriers formed in the cell due to photo-oxidative damage. This detrapping reduces the rate of power conversion efficiency (PCE) degradation throughout the life of the solar cell.Type: ApplicationFiled: November 24, 2022Publication date: May 30, 2024Applicant: National Research Council of CanadaInventors: Salima ALEM, Ye TAO, Jianping LU, Badrou Reda AICH, Neil GRADDAGE, Zhiyi (Frank) ZHANG
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Patent number: 11993643Abstract: Polypeptides with biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human heavy and light chain variable domains (VHs and VLs), are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human VHs and VLs are identified, which may be useful for immunotherapy or as diagnostic agents. Multimer complexes of human VHs and VLs are also identified. The VHs and VLs identified may be used to create further libraries for identifying additional polypeptides. Further, the VHs and VLs may be subjected to DNA shuffling to select for improved biophysical properties.Type: GrantFiled: July 12, 2021Date of Patent: May 28, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventor: Jamshid Tanha
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Patent number: 11993719Abstract: A composite includes a plastic substrate and an electrical insulator layer formed on the plastic substrate. The electrical insulator layer contains boron nitride nanotubes (BNNTs), which may be unmodified or modified BNNTS. The composite is suitable for use in making printed electronic devices. A process includes providing a plastic substrate and forming on at least a portion of a surface of the plastic substrate a layer that contains the BNNTs. A metallic ink trace is formed on a portion of the layer, such that the metallic ink trace is spaced-apart from the substrate. Using photonic or thermal sintering techniques, the metallic ink trace is then sintered.Type: GrantFiled: October 26, 2018Date of Patent: May 28, 2024Assignee: National Research Council of CanadaInventors: Chantal Paquet, Jacques Lefebvre, Jingwen Guan, Patrick Roland Lucien Malenfant, Benoit Simard, Yadienka Martinez-Rubi, Arnold Kell, Xiangyang Liu
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Patent number: 11966076Abstract: An optical fiber transducer usable in environments of extreme operating temperature features a stationary support, a movable body displaceable back and forth relative thereto, and an optical fiber connected between the support and the movable body. The fiber has a Fiber Bragg Grating in an intermediate region thereof between the support and movable body. To accommodate varying coefficients of thermal expansion (CTEs) among these components, one or more tubes close circumferentially around the fiber. Each tube has a CTE that is greater than that of the fiber, and less than that of the constituent material of the support and movable body. The fiber is bonded to an interior of the tube(s), while an exterior of the tube(s) is bonded to the support and movable body.Type: GrantFiled: February 19, 2021Date of Patent: April 23, 2024Assignee: National Research Council of CanadaInventors: Richard Green, Lixue Wu, Michael Bakaic
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Patent number: 11958048Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.Type: GrantFiled: February 27, 2022Date of Patent: April 16, 2024Assignee: National Research Council of CanadaInventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
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Patent number: 11955172Abstract: An atomic orbital based memory storage is provided that includes a plurality of surface atoms forming dangling bonds (DBs) and a subset of the plurality of surface atoms passivated with spatial control to form covalent bonds with hydrogen, deuterium, or a combination thereof. The atomic orbital based data storage that can be rewritten and corrected as needed. The resulting data storage is also archival and capable of high data densities than any known storage as the data is retained in a binary storage or a given orbital being passivated or a dangling bond (DB). A method of forming and reading the atomic orbital data storage is also provided. The method including selectively removing covalent bonds to form dangling bonds (DBs) extending from a surface atom by hydrogen lithography and imaging the covalent bonds spatially to read the atomic orbital data storage.Type: GrantFiled: November 28, 2022Date of Patent: April 9, 2024Assignees: National Research Council of Canada, Quantum Silicon Inc., The Governors of the University of AlbertaInventors: Roshan Achal, Robert A. Wolkow, Jason Pitters, Martin Cloutier, Mohammad Rashidi, Marco Taucer, Taleana Huff
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Patent number: 11945858Abstract: The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.Type: GrantFiled: May 17, 2019Date of Patent: April 2, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Marzia Martina, Balu Chakravarthy, Yves Durocher, Mehdi Arbabi-Ghahroudi, Anne Marcil, Danica Stanimirovic, Traian Sulea, Maria Moreno, Umberto Banderali
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Publication number: 20240101641Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-?) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.Type: ApplicationFiled: August 29, 2023Publication date: March 28, 2024Applicant: National Research Council of CanadaInventors: Anne E.G. LENFERINK, John C. Zwaagstra, Traian Sulea, Maureen D. O'Connor-McCourt