Patents Assigned to National Research Council of Canada
  • Patent number: 10981817
    Abstract: A technique for wastewater treatment involves ensuring that all paths for wastewater must pass through at least one porous microbial support to go from the inlet to the outlet, and allowing a biofilm to grow on the porous microbial support under microaerobic conditions (concentration of oxygen between 0.05 and 0.35 mg/L). The biofilm formed comprises a population of anaerobic microbes for digesting organics in the wastewater including methanogenic microbes, and an aerobic methanotrophic and heterotrophic population that catabolizes methane from the methanogenic microbes, and oxygen from the injector, to produce heat. The support may be an electrode, and the technique is applied in a microbial electrolysis cell, with substantial COD removal rates.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: April 20, 2021
    Assignee: National Research Council of Canada
    Inventors: Boris Tartakovsky, Yehuda Kleiner
  • Publication number: 20210087298
    Abstract: The present invention relates to compounds, compositions, and methods are provided for covalently linking a cargo molecule, such as a therapeutic or a diagnostic agent, to a glycan in the Fab region of an antibody. Also provided are methods of modeling and producing antibodies having de novo Fab glycosylation sites. Also provided are antibody carrier conjugates, methods of using the conjugates.
    Type: Application
    Filed: November 8, 2018
    Publication date: March 25, 2021
    Applicant: National Research Council of Canada
    Inventors: Michel GILBERT, Traian SULEA, Maria L. JARAMILLO, Yves DUROCHER, Maurizio ACCHIONE
  • Publication number: 20210087102
    Abstract: The present application relates to boron nitride nanotube (BNNT)-silicate glass composites and to methods of preparing such composites. The methods comprise mixing BNNTs that are coated with a glass former such as boron oxide with a silicate glass precursor to create a mixture; heating the mixture under conditions to obtain a molten silicate glass; and cooling the molten silicate glass under conditions to obtain the BNNT-silicate glass composite.
    Type: Application
    Filed: August 1, 2018
    Publication date: March 25, 2021
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Benoit SIMARD, Yadienka MARTINEZ-RUBI, Christopher Thomas KINGSTON, Keun Su KIM, Morag CLARK-HEPTINSTALL, Maxime GAUTHIER
  • Publication number: 20210079248
    Abstract: A flake-less molecular ink suitable for printing (e.g. screen printing) conductive traces on a substrate has 30-60 wt % of a C8-C12 silver carboxylate and 0.1-10 wt % of a polymeric binder, or 5-75 wt % of bis(2-ethyl-1-hexylamine) copper (II) formate, bis(octylamine) copper (II) formate or tris(octylamine) copper (II) formate and 0.25-10 wt % of a polymeric binder, and balance of at least one organic solvent, wherein the binder has ethyl cellulose, and the ethyl cellulose has an average weight molecular weight in a range of 60,000-95,000 g/mol and a bimodal molecular weight distribution.
    Type: Application
    Filed: November 24, 2020
    Publication date: March 18, 2021
    Applicants: National Research Council of Canada, Groupe Graham International Inc.
    Inventors: Arnold J. KELL, Sylvie LAFRENIÈRE, Chantal PAQUET, Patrick MALENFANT, Olga MOZENSON
  • Patent number: 10921579
    Abstract: A security device that elicits at least one dynamic response upon acceleration, or upon change of orientation with respect to gravity, wherein the dynamic response continues after cessation of the acceleration or the change of orientation. In addition, the dynamic response can be optical, such that it is visually observable by an unaided human eye. Alternatively, the response can be machine readable. In some cases, the dynamic response has duration of from about 0.01 s to about 100 s, or from about Is to about 10 s.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: February 16, 2021
    Assignees: National Research Council of Canada, Bank of Canada
    Inventors: Daniel Brassard, Lidija Malic, Keith J. Morton, Teodor Veres, Charles D. MacPherson, Theodoros Garanzotis
  • Patent number: 10906973
    Abstract: The present invention relates, in general, to polypeptides capable of transmigrating the blood-brain barrier, and uses thereof. More specifically, the present invention relates to polypeptides derived by site-directed mutagenesis of an existing antibody fragment and uses thereof, and methods of making such molecules. The polypeptides of the present invention show enhanced blood-brain barrier crossing and brain exposure levels in vitro and in vivo.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 2, 2021
    Assignees: National Research Council of Canada, Cephalon, Inc.
    Inventors: Danica Stanimirovic, Traian Sulea, Kristin Kemmerich, David Wilson, Jennifer Stratton, Matthew Pollard, Adam Clarke
  • Publication number: 20210023597
    Abstract: A metallic extruded profile has two parallel skins interconnected by a set of at least two webs running between extrusion edges of the profile and snap-fit features on joining edges permitting two instances of the profile to snap fit together along the joining edges, where a first web that is closest to snap-fit features of a first joining edge, is a curved web viewed from the extrusion edges. The curvature allows for both the curved web and skins to participate in snap-fit deformation, allowing for the deformation to be distributed over a large area, for a stiffer snap fit, and reduced plastic deformation.
    Type: Application
    Filed: July 23, 2020
    Publication date: January 28, 2021
    Applicant: National Research Council of Canada
    Inventors: Jean-Francois BELAND, Francois Nadeau
  • Publication number: 20210013424
    Abstract: The development of air-stable unipolar n-type semiconductors with good solubility in organic solvents at room temperature remains a critical issue in the field of organic electronics. Moreover, most of the existing semiconducting materials exhibit LUMO energy levels higher than ?4.0 eV, making electron transport sensitive to both moisture and oxygen. Bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are disclosed herein. More specifically, bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof for use in organic electronics are disclosed. A process for the preparation of bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide and derivatives is also disclosed. The bis(2-oxoindolin-3-ylidene)benzodifurandione dicyanide or derivatives thereof are characterized by high electron mobilities and are suitable for use as n-type semiconductors in organic electronics.
    Type: Application
    Filed: March 13, 2019
    Publication date: January 14, 2021
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Jianping LU, Afshin DADVAND, Mark BORTOLUS, Salima ALEM, Ye TAO, Yuning LI, Jesse QUINN
  • Publication number: 20210001972
    Abstract: A bridging structure for a deforming foil, such as a morphing wing, that provides a fluid-dynamic surface throughout foil deformation that forms a curved fluid-dynamic surface with a relatively low drag. A high extent of foil deformation can be provided, with lower actuation force, providing a fluid-dynamic surface with a simple or complex curve in one direction, by providing a set of rail-mounted members that are joined at one end to a deforming sheet. By coupling the members with high elongation, resilient bodies, adjacent members can support each other, while permitting extension, and accommodating curvature.
    Type: Application
    Filed: July 3, 2020
    Publication date: January 7, 2021
    Applicant: National Research Council of Canada
    Inventors: Jaye MANGIONE, Amin FEREIDOONI, Yong CHEN, Viresh WICKRAMASINGHE, Jan MARCHWICA
  • Patent number: 10883011
    Abstract: A flake-less molecular ink suitable for printing (e.g. screen printing) conductive traces on a substrate has 30-60 wt % of a C8-C12 silver carboxylate or 5-75 wt % of bis(2-ethyl-1-hexylamine) copper (II) formate, bis(octylamine) copper (II) formate or tris(octylamine) copper (II) formate, 0.1-10 wt % of a polymeric binder (e.g. ethyl cellulose) and balance of at least one organic solvent. Conductive traces formed with the molecular ink are thinner, have lower resistivity, have greater adhesion to a substrate than metal flake inks, have better print resolution and are up to 8 times less rough than metal flake inks. In addition, the shear force required to remove light emitting diodes bonded to the traces using Loctite 3880 is at least 1.3 times stronger than for commercially available flake-based inks.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: January 5, 2021
    Assignees: Groupe Graham International Inc., National Research Council of Canada
    Inventors: Arnold Kell, Sylvie Lafreniere, Chantal Paquet, Patrick Malenfant, Olga Mozenson
  • Publication number: 20200408332
    Abstract: In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area.
    Type: Application
    Filed: March 4, 2019
    Publication date: December 31, 2020
    Applicant: National Research Council of Canada
    Inventors: Kebin LI, Keith MORTON, Teodor VERES
  • Publication number: 20200407565
    Abstract: A composite includes a plastic substrate and an electrical insulator layer formed on the plastic substrate. The electrical insulator layer contains boron nitride nanotubes (BNNTs), which may be unmodified or modified BNNTS. The composite is suitable for use in making printed electronic devices. A process includes providing a plastic substrate and forming on at least a portion of a surface of the plastic substrate a layer that contains the BNNTs. A metallic ink trace is formed on a portion of the layer, such that the metallic ink trace is spaced-apart from the substrate. Using photonic or thermal sintering techniques, the metallic ink trace is then sintered.
    Type: Application
    Filed: October 26, 2018
    Publication date: December 31, 2020
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Chantal PAQUET, Jacques LEFEBVRE, Jingwen GUAN, Patrick Roland Lucien MALENFANT, Benoit SIMARD, Yadienka MARTINEZ-RUBI, Arnold KELL, Xiangyang LIU
  • Publication number: 20200411855
    Abstract: A nickel hydroxide includes stacked nickel hydroxide layers. Each of the nickel hydroxide layers includes Ni2+ and OH?. At least one of the nickel hydroxide layers further includes a type of polyatomic anions. The polyatomic anions include a type of anions that are not SO42? or CO32?.
    Type: Application
    Filed: June 26, 2020
    Publication date: December 31, 2020
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Kenji TAKAHASHI, Christina BOCK, Nafiseh EBRAHIMI, Olga NABOKA
  • Patent number: 10871450
    Abstract: Described are various embodiments of a system, method and device for laser induced breakdown spectroscopy (LIBS). In some embodiments, the LIBS system comprises a silicon photomultiplier (Si PM) operated in a time-gated photon counting mode. Some such embodiments allow for the provision of a portable LIBS device. Also provided are embodiments for the measurement of constituent carbon, gold and/or other precious metal group elements in a target sample.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: December 22, 2020
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Paul Bouchard, Mohamad Sabsabi, Christian Padioleau, Rene Heon, Peter John Hardman
  • Patent number: 10865222
    Abstract: N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant gonorrhea.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: December 15, 2020
    Assignees: National Research Council of Canada, University of Massachusetts Medical School
    Inventors: Ian Schoenhofen, Dennis M. Whitfield, Sanjay Ram
  • Patent number: 10866125
    Abstract: Provided is an optical waveguide with an inscribed Bragg grating, where the Bragg grating is stable at high temperature, has low scattering loss and high reflectivity. Also provided is a method for inscribing a Bragg grating in an optical waveguide, the method comprising irradiating the optical waveguide with electromagnetic radiation from an ultrashort pulse duration laser of sufficient intensity to cause a permanent change in an index of refraction within a core of the optical waveguide, where the irradiating step is terminated prior to erasure of a Bragg resonance, and heating the optical waveguide to a temperature and for a duration sufficient to substantially remove a non-permanent grating formed in the optical waveguide by the irradiating step.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 15, 2020
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Dan Grobnic, Stephen Mihailov, Robert Walker, Ping Lu, Huimin Ding, David Coulas, Cyril Hnatovsky
  • Patent number: 10858629
    Abstract: Disclosed is a new process for the production of recombinant proteins, by transient transfection of suspension-grown human embryonic kidney cells (293 cell line and its genetic variants) with an expression vector, using polyethylenimine (PEI) as a transfection reagent. In a preferred embodiment, the process uses 293E cells expressing the Epstein-Barr virus (EBV) EBNA 1 protein, in combination with an oriP-based episomal expression vector having an improved cytomegalovirus expression cassette comprising the CMV5 promoter. The process combines in a single step the cell growth, transfection and protein expression, is carried out without changing the culture medium, and allows to achieve high expression levels in a short period of time. The process may be carried out in a serum-free, low-protein culture medium, is easily scalable, compatible with continuous production processes, and fully adapted to high-throughput production of milligram quantities of recombinant proteins.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: December 8, 2020
    Assignee: National Research Council of Canada
    Inventors: Yves Durocher, Amine Kamen, Sylvie Perret, Phuong Pham
  • Publication number: 20200377838
    Abstract: A technique for producing an artificial biointerface involves providing a patterned microfluidic chip having: a chamber divided by a fluid-permeable fencing into a central region and two flanking channels; and at least 3 fluid paths, each of the paths extending across one of the central region and the two flanking channels. A porous packing of rigid beads is placed within the central region to define a bead bed, the beads being of a size to be retained by the fencing. A biowall can be grown on at least one segment of the fencing separating the central region from one flanking channel, the biowall formed at least in part by live cells cultured on the beads. Beads may be modified, coated or functionalized to improve cell attachment and growth, and for reporting, or dosing particles or molecules can be conveniently added to the bead bed.
    Type: Application
    Filed: February 18, 2019
    Publication date: December 3, 2020
    Applicant: National Research Council of Canada
    Inventors: Teodor VERES, Xuyen Dai HOA, Jamal DAOUD, Caroline MIVILLE-GODIN, Lidija MALIC
  • Patent number: 10844835
    Abstract: A perpendicular axis turbine having at least two blades, wherein the blades are longitudinally offset with respect to one another, reducing the effects of blade-vortex interaction and providing increased power generation. In one embodiment, the blades are longitudinally offset such that the attachment point of one blade is halfway between the attachment points for the other blade.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: November 24, 2020
    Assignee: National Research Council of Canada
    Inventors: Amin Fereidooni, Doma Seleman Hilewit, Edgar A. Matida, Fred Nitzsche
  • Patent number: 10836918
    Abstract: A smart ink, comprising microparticles, with each microparticle comprising: a) an exterior shell; b) a liquid encapsulated within the shell; and c) a Janus microparticle suspended in the liquid, wherein the Janus microparticle either comprises: i) two or more distinct assemblies of particles; or ii) a core loaded with particles, the core having a first surface portion and a second surface portion that is functionally distinct from the first surface portion. An apparatus and method for production of the microparticles are also provided.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: November 17, 2020
    Assignee: National Research Council of Canada
    Inventors: Lidija Malic, Xuefeng Zhang, Teodor Veres