Patents Assigned to National Research Council of Canada
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Publication number: 20250144174Abstract: Described herein are BBB-transporting fusion proteins, polynucleotides encoding the fusion proteins and mammalian cells genetically modified to express and secrete the fusion proteins, as well as compositions, implantable devices and device preparations comprising the fusion proteins or genetically modified cells secreting the fusion proteins, and methods of making and using the same for treating various CNS diseases and conditions, e.g., any mucopolysaccharidosis type with CNS manifestations.Type: ApplicationFiled: January 27, 2023Publication date: May 8, 2025Applicant: National Research Council of CanadaInventors: Elina Makino, Erika Pearson, Gregory Hussack, Danica Stanimirovic
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Patent number: 12286347Abstract: The present application relates to boron nitride nanotube (BNNT)-nanoparticle composites, to methods of preparing such composites and their use, for example, in metal/ceramic matrix composites and/or macroscopic assemblies. For example, the methods comprise subjecting a source of hydrogen, a source of boron, a source of nitrogen and a nanoparticle precursor to a stable induction thermal plasma and cooling the reaction mixture to obtain the composite.Type: GrantFiled: September 18, 2018Date of Patent: April 29, 2025Assignee: National Research Council of CanadaInventors: Keun Su Kim, Benoit Simard, Christopher Thomas Kingston, Homin Shin
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Publication number: 20250114996Abstract: Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer material comprising at least one thermoplastic polymer, at least one polymer precursor, or any combination thereof, and a plurality of piezoelectric particles dispersed in at least a portion of the polymer material. The piezoelectric particles may interact non-covalently with at least a portion of the polymer material, be covalently bonded to at least a portion of the polymer material, and/or be reactive with at least a portion of the polymer material. The compositions may be extrudable and formable into a self-standing three-dimensional structure upon being extruded. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer.Type: ApplicationFiled: March 22, 2022Publication date: April 10, 2025Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADAInventors: Sarah J. VELLA, Alexandros VASILEIOU, Yujie ZHU, Edward G. ZWARTZ, Chantal PAQUET, Silvio E. KRUGER, Yujie ZHANG, Derek ARANGUREN VAN EGMOND, Thomas LACELLE, Mohammad RAFIEE, Claudie ROY
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Publication number: 20250110087Abstract: Examples are disclosed herein relating to detecting a change in a substrate. A system can include a transducer that can be frequency matched to a substrate and to provide an electrical signal that can characterize a reflected sound wave by the substrate. The system can include an acoustic wave analysis system to detect a change in a physical characteristic of the substrate.Type: ApplicationFiled: October 2, 2023Publication date: April 3, 2025Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADAInventors: Sarah J. VELLA, Silvio E. KRÜGER, Edward G. ZWARTZ, Alexandros VASILEIOU, Johann JUNGINGER, Hamed O. TABRIZI
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Patent number: 12263956Abstract: An aircraft with an aircraft fuselage, and a passenger cabin and a cockpit, where the aircraft includes a center-forward attendant space between the passenger cabin and the cockpit. A cabin crew member of the aircraft can stand in the center-forward attendant space for monitoring progress of an emergency evacuation of the aircraft. The aircraft has one or more emergency exits for providing egress of passengers from the aircraft fuselage during the emergency evacuation. The aircraft also has a situational awareness monitoring (SAM) system for use in evacuating the passengers from the aircraft during the emergency evacuation. The SAM system includes one or more imaging devices and one or more display modules, each of which displays within the passenger cabin images captured by a corresponding one of the one or more imaging devices.Type: GrantFiled: December 21, 2022Date of Patent: April 1, 2025Assignees: Airbus Americas, Inc., Airbus Operations GmbH, National Research Council of CanadaInventors: Joyce S. T. Tan, Tina Kay Griffin, Patrick Alexander Rollfink, Christophe J. P. J. Legare, Natalia Cooper, John Russell Thomas, Shelley M. Roberts, Caidence S. Paleske
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Publication number: 20250101105Abstract: The present document describes antibodies or antigen-binding fragments that bind specifically to a target antigen, wherein the antibodies or antigen-binding fragments comprise complementarity determining regions (CDR1, CDR2 and CDR3) and an added O-glycosylation sequon glycosylated with an O-glycan having the general formula (I): wherein R1 is an initial N-acetylgalactosamine (GalNAc); n=1, or 2; R2 are each independently absent, galactose (Gal), GalNAc, N-Acetylglucosamine (GlcNAc), or a sialic acid; R3 are each independently absent, Gal or a sialic acid; and R4 are each independently absent or a sialic acid. Also described are compounds comprising the antibodies or antigen-binding fragments comprising a functional moiety operably linked to said O-glycan, compositions comprising the same, and methods of preparing such compounds.Type: ApplicationFiled: March 21, 2023Publication date: March 27, 2025Applicant: National Research Council of CanadaInventors: Michel Gilbert, Yves Durocher, Warren Wakarchuk
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Patent number: 12259296Abstract: An apparatus, method and system are set forth for detection of fluids using Bragg grating sensors, wherein the Bragg grating sensing element comprises an optical fiber having a Bragg grating inscribed therein characterized by optical properties that are dependent upon the periodicity and effective refractive index of the grating, and a package for subjecting the Bragg grating to a change in strain when contacted by a fluid such that periodicity and effective refractive index of the grating changes, whereby when interrogated with laser light any such change in periodicity and effective refractive index may be detected.Type: GrantFiled: January 10, 2020Date of Patent: March 25, 2025Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Cyril Hnatovsky, Dan Grobnic, Stephen Mihailov, Ping Lu, Kasthuri De Silva, Huimin Ding, David Coulas, Robert Walker
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Publication number: 20250085203Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.Type: ApplicationFiled: March 9, 2022Publication date: March 13, 2025Applicant: National Research Council of CanadaInventors: Byeong-Ui MOON, Liviu CLIME, Daniel Brassard, Keith MORTON, Teodor VERES
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Patent number: 12240916Abstract: The present document describes an alpha-(1,6)-fucosyltransferase (FUT8) antibody, antigen binding domain thereof, or a fusion protein thereof, operable to inhibit FUT8 activity in a cell, and methods of producing recombinant proteins, in particular antibodies, having reduced fucosylation. The present document also describes methods of inhibiting expression and/or activity of a protein in a cell by expressing an antibody and/or a fusion protein operable to inhibit expression and/or activity of the protein. The antibody, antigen binding domain thereof, or fusion protein thereof may comprise a transmembrane domain of a protein resident in an endoplasmic reticulum (ER), a cis Golgi apparatus, a trans Golgi apparatus, or a combination thereof.Type: GrantFiled: September 20, 2019Date of Patent: March 4, 2025Assignee: National Research Council of CanadaInventors: Yves Durocher, Simon Joubert
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Publication number: 20250018642Abstract: Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles dispersed in at least a portion of a polymer matrix comprising first polymer material and a sacrificial material, the sacrificial material being removable from the polymer matrix to define a plurality of pores in the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The sacrificial material may comprise a second polymer material. The compositions may define a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer and introducing porosity therein.Type: ApplicationFiled: September 27, 2024Publication date: January 16, 2025Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADAInventors: Sarah J. VELLA, Alexandros VASILEIOU, Yujie ZHU, Edward G. ZWARTZ, Chantal PAQUET, Silvio E. KRUGER, Mohammad RAFIEE, Yujie ZHANG, Thomas LACELLE, Derek ARANGUREN VAN EGMOND, Claudie ROY
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Publication number: 20240425875Abstract: Provided are methods, expression systems, kits, and vectors for constitutive and/or cumate-inducible expression of a gene of interest in CHO cells. The expression systems and methods described herein employ CHO cells that are stably transfected with a nucleic acid molecule encoding a reverse cumate transactivator (rcTA), the expression of which is regulated by a cymene repressor (CymR). for constitutive and/or cumate-inducible expression of a gene of interest.Type: ApplicationFiled: September 12, 2022Publication date: December 26, 2024Applicant: National Research Council of CanadaInventors: Yves DUROCHER, Simon JOUBERT, Sylvie PERRET, Martin LOIGNON, Jean-Sebastien MALTAIS, Simon LORD-DUFOUR
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Patent number: 12175051Abstract: A method and apparatus are provided for effecting an RFID-based finger input sensing system using a transmission line connected to at least two RFID tags, by analyzing a plurality of features relating to the number of spikes in the derivatives of the RSS, timing of maximum RSS and the spikes of the RSS derivatives, relative RSS magnitude between the at least two RFID tags, and increase/decrease trend of the RSS, thereby eliminating the need for calibration and training.Type: GrantFiled: November 5, 2021Date of Patent: December 24, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Ju Wang, Omid Salehi-Abari, Daniel Vogel, Keiko Katsuragawa
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Patent number: 12174370Abstract: A synthesized grating is provided comprising a substrate/layer, and a plurality of alternating aperiodic non-uniform low and high index profiles on a surface of the substrate/layer defining a transmission/reflection spectrum for one of either single or multi-frequency operation of said grating in an optical cavity. A method is also provided for designing the synthesized grating, comprising determining a grating structure of given profiles through analysis of an optimized weighted sum and mapping the grating profile to said surface with the plurality of alternating non-uniform low and high index profiles.Type: GrantFiled: April 30, 2020Date of Patent: December 24, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Mohamed Rahim, Greg Pakulski, Philip Poole, Zhenguo Lu
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Patent number: 12174218Abstract: A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging.Type: GrantFiled: August 31, 2020Date of Patent: December 24, 2024Assignees: National Research Council of Canada, The Governors of the University of AlbertaInventors: Robert A. Wolkow, Jason Pitters, Mark Salomons
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Fiber Bragg grating sensor in polymer-coated ultra-thin optical fibers and method for producing same
Patent number: 12164144Abstract: A method and apparatus for inscribing a Bragg grating in an optical waveguide, comprising: providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the electromagnetic radiation has a pulse duration of less than or equal to 5 picoseconds, and wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 microns (?m): providing cylindrical focusing optics corrected for spherical aberration: providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intense to cause the permanent change in the index of refraction in the core of the optical waveguide.Type: GrantFiled: May 13, 2020Date of Patent: December 10, 2024Assignee: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Cyril Hnatovsky, Nurmemet Abdukerim, Dan Grobnic, Stephen Mihailov, Rune Lausten, Ping Lu, Huimin Ding, David Coulas, Kasthuri De Silva -
Patent number: 12153988Abstract: A tag detection system comprising a source for producing an interrogation signal having a first frequency; a harmonic radar tag comprising: an antenna structure; a tunneling junction electrically and integrally coupled to the antenna; and wherein the harmonic radar tag when stimulated by the interrogation signal having the first frequency, and the harmonic radar tag produces a response signal at a second frequency different from the first frequency.Type: GrantFiled: December 18, 2020Date of Patent: November 26, 2024Assignee: National Research Council of CanadaInventors: Nikola Pekas, Adam Johan Bergren
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Patent number: 12140032Abstract: Methods and systems for determining a change in condition of a rock bolt. Some methods may comprise, at a first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a first time of flight for each of the shear and longitudinal waves, at a second point in time after the first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a second time of flight for each of the shear and longitudinal waves, and using the relative changes of the first and second time of flights, determining the change in condition of the rock bolt section.Type: GrantFiled: February 10, 2023Date of Patent: November 12, 2024Assignee: National Research Council of CanadaInventors: Zhigang Sun, Kuo-Ting Wu, Silvio Elton Kruger
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Publication number: 20240344995Abstract: Described are various embodiments of a refractory lance assembly and a composite refractory lance. In one embodiment, a refractory lance assembly is provided that comprises: an immersion tube having an immersion tip immersible within a melt and an extension tube coupled at an opposed end thereof to form a longitudinally extended composite tube therewith defining an optical path therein, wherein said longitudinally extended composite tube is injectable, in use. with an inert gas to form and probe an immersed melt surface. The assembly further comprises a shroud longitudinally encasing the composite tube and injectable with inert gas to mitigate fluid contamination of the composite tube and immersed melt surface.Type: ApplicationFiled: August 4, 2022Publication date: October 17, 2024Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: André MOREAU, André HAMEL, Mohamad SABSABI
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Publication number: 20240341108Abstract: A composition for use in a photo-active device has: a charge transfer network of single walled carbon nanotubes (SWCNT) having at least 95 wt % of semiconducting single walled carbon nanotubes (sc-SWCNT) based on total weight of the SWCNT, the sc-SWCNT containing at least 30 wt % of one chiral type of sc-SWCNT based on total weight of the sc-SWCNT; and, a solution processible electron trapping material of a fullerene compound, the electron trapping material in contact with the charge transfer network of SWCNT. The composition is readily prepared from solution processible components and is highly sensitive in a narrow wavelength band. The composition is particularly useful in photoconductors and phototransistors that operate on the infrared region of the electromagnetic spectrum.Type: ApplicationFiled: August 8, 2022Publication date: October 10, 2024Applicant: National Research Council of CanadaInventors: Zhao LI, Jianying OUYANG, Jianfu DING, Patrick R. L. MALENFANT
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Patent number: 12114515Abstract: The present application relates to thin film transistors having a semiconducting channel comprising a network of carbon nanotubes that are electrically coupled to a source electrode and a drain electrode and electrically insulated from, but capacitively coupled to, a gate electrode, wherein a polymeric layer encapsulates the carbon nanotubes. The polymeric layer can comprise a first monomeric unit and optionally a second monomeric unit, wherein the first monomeric unit, the second monomeric unit and the relative amounts thereof are optionally selected to provide at least one target electrical property of the thin film transistor. The present application also relates to methods for manufacturing such thin film transistors as well as a methods of selecting a polymeric layer to provide a desired threshold voltage for such thin film transistors.Type: GrantFiled: December 17, 2019Date of Patent: October 8, 2024Assignee: National Research Council of CanadaInventors: Jacques Lefebvre, Francois Lapointe, Zhao Li, Jianfu Ding, Patrick Roland Lucien Malenfant