Patents Assigned to National Research Council of Canada
  • Publication number: 20220241786
    Abstract: A centrifugal microfluidic chip is provided that allows an on-chip chamber to provide humidification control, or more generally, gas composition control, to another chamber of the chip. This allows for microfluidic incubation using low-cost and efficient centrifugal devices such as multi-port pneumatic chip controllers, single or multi-port pneumatic slip rings, and articulated centrifugal blades with a pneumatic slip ring. The device may be used for cell culturing, microorganism testing, or production of chemical species from biological samples with a controlled microenvironment.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 4, 2022
    Applicant: National Research Council of Canada
    Inventors: Lidija Malic, Teodor VERES, Liviu CLIME, Jamal DAOUD
  • Patent number: 11396610
    Abstract: Disclosed is a method of printing an ultranarrow line of a functional material. The method entails providing a substrate having an interlayer on the substrate and printing the ultranarrow line by depositing ink on the interlayer of the substrate, the ink comprising the functional material and a solvent mixture that partially dissolves the interlayer on the substrate to cause the ink to shrink and sink into the interlayer on the substrate thereby reducing a width of the line.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: July 26, 2022
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Ta-Ya Chu, Zhiyi Zhang, Ye Tao
  • Patent number: 11384141
    Abstract: The present document describes an antibody or an antigen-binding fragment that bind to serum albumin comprising three complementarity determining regions (CDR1, CDR2 and CDR3), for half-life extension of biologics. The present invention also relates to pharmaceutical compositions, nucleic acid vectors, cells comprising the nucleic acid vectors, and methods of removing molecules from serum.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: July 12, 2022
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Gregory Hussack, Jamshid Tanha, Kevin Henry, Traian Sulea
  • Patent number: 11387507
    Abstract: An apparatus and method for initiating thermal runaway in a battery cell are provided. The apparatus and method may be used in safety research of battery cells and packs to initiate thermal runaway. The apparatus comprises a resistive heating element for positioning in thermal contact with the battery cell for transferring heat to a region of the battery cell. An energy source is electrically coupled to the resistive heating element. A switch selectively forms a circuit to send a current pulse through the resistive heating element to generate a power pulse at the resistive heating element to heat the region of the battery cell for initiating thermal runaway. Alternatively, the heating element is heated and held at a predetermined temperature until thermal runaway is initiated. The heat generation rate may be designed to be comparable to that of an internal short circuit within a cell, which is much faster than many existing slow heating methods used to initiate thermal runaway.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: July 12, 2022
    Assignee: National Research Council of Canada
    Inventors: Steven Recoskie, Dean MacNeil, Giulio Torlone, Oltion Kodra, Joel Perron
  • Patent number: 11370822
    Abstract: The present disclosure relates to bioactive self-assembling peptides, nanofibers and hydrogels for activating human mast cells. The peptides, nanofibers and hydrogels comprise a self-assembling peptide that mediates self-assembly linked to a MrgX2 agonist peptide; for example, (RADA)4 linked to proadrenomedullin-12 (PAMP-12).
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: June 28, 2022
    Assignees: The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Larry D. Unsworth, Lei Lu, Marianna Kulka
  • Patent number: 11359939
    Abstract: Provided is an optical waveguide with an inscribed Bragg grating, where the Bragg grating is stable at high temperature, has low scattering loss and high reflectivity. Also provided is a method for inscribing a Bragg grating in an optical waveguide, the method comprising irradiating the optical waveguide with electromagnetic radiation from an ultrashort pulse duration laser of sufficient intensity to cause a permanent change in an index of refraction within a core of the optical waveguide, where the irradiating step is terminated prior to erasure of a Bragg resonance, and heating the optical waveguide to a temperature and for a duration sufficient to substantially remove a non-permanent grating formed in the optical waveguide by the irradiating step.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: June 14, 2022
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Dan Grobnic, Stephen Mihailov, Robert Walker, Ping Lu, Huimin Ding, David Coulas, Cyril Hnatovsky
  • Publication number: 20220169702
    Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-beta) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
    Type: Application
    Filed: November 10, 2021
    Publication date: June 2, 2022
    Applicant: National Research Council of Canada
    Inventors: John C. Zwaagstra, Traian Sulea, Maria L. Jaramillo, Maureen D. O'Connor, Anne E.G. Lenferink
  • Publication number: 20220173433
    Abstract: A biodegradable solid aqueous electrolyte composition, an electrochemical device incorporating the electrolyte composition, and methods for the same are provided. The electrolyte composition may include a rubber-like hydrogel including a copolymer and a salt. The copolymer may include at least two polycaprolactone chains coupled with a polymeric center block. The polymeric center block may include polyvinyl alcohol. The hydrogel may be biodegradable. The electrochemical device may include an anode, a cathode, and the electrolyte composition disposed between the anode and the cathode.
    Type: Application
    Filed: February 18, 2022
    Publication date: June 2, 2022
    Applicants: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Naveen CHOPRA, Nan-Xing HU, Gregory McGUIRE, Robert BLACK, Alexis LAFORGUE, Edmond LAM, Chi Woon LEUNG, Yali LIU, Sophie REGNIER
  • Publication number: 20220162337
    Abstract: The present invention is directed to anti-Her2 antibodies and fragments thereof, compositions, and uses thereof. The antibodies and fragments thereof bind to Her2-expressing cells in a pH-dependent manner, with low affinity at the physiological pH typical of normal cells and tissues, and with high affinity at the slightly acidic pH characteristic to solid tumors. Furthermore, the antibodies inhibit the growth of tumor spheroids at a level comparable to that of the benchmark anti-Her2 antibody Herceptin at acidic pH, whereas these effects were significantly reduced at physiological pH. This pH selectivity of cellular growth inhibition is maintained upon antibody conjugation to cytotoxic drugs. The invention also includes methods of treating solid tumors, methods of detecting solid tumors, and methods of pH-dependent capturing of the Her-2 ectodomain.
    Type: Application
    Filed: March 30, 2020
    Publication date: May 26, 2022
    Applicant: National Research Council of Canada
    Inventors: Traian Sulea, Jason Baardsnes, Christopher R. Corbeil, Maria L. Jaramillo, Enrico O. Purisima, John C. Zwaagstra, Nazanin Larijani Rohani
  • Patent number: 11306335
    Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: April 19, 2022
    Assignees: NATIONAL RESEARCH COUNCIL OF CANADA, UNIVERSITY OF SASKATCHEWAN
    Inventors: Jonathan E. Page, Steve Gagne
  • Patent number: 11306007
    Abstract: Provided herein are processes for the removal and/or recovery of a target metal from a liquid sample, said process comprising: [1] applying acoustic cavitation to the liquid; and [2] adding an iron (II) salt, or a precursor form thereof, to the liquid sample and allowing Fenton oxidation reaction to occur between the iron and hydrogen peroxide in the liquid, thereby producing hydroxyl radicals; thereby producing a target metal salt or metal oxide having a reduced solubility in the liquid sample, leading to removal of the target metal from the liquid sample. The use of metal ligands in such processes is also described, as well as systems for performing such processes. Methods, processes, and systems for removing organic contaminants from a liquid sample are also described.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: April 19, 2022
    Assignee: National Research Council of Canada
    Inventors: Deepak M. Kirpalani, Dipti Prakash Mohapatra
  • Publication number: 20220102197
    Abstract: A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Applicants: Quantum Silicon Inc., The Governors of the University of Alberta, National Research Council of Canada
    Inventors: Bruno Vieira Da Cunha Martins, Robert A. Wolkow, Marco Taucer, Jason Pitters
  • Publication number: 20220093815
    Abstract: An avalanche photodiode with a diffused junction and the method for its fabrication are disclosed. The method comprising forming, on a substrate, a first high-doped region and a low-doped region; performing selective area growth (SAG) with in-situ etchant on the low-doped region to grow a SAG structure; and diffusing through the SAG structure to form a second high-doped region in the low-doped region.
    Type: Application
    Filed: December 9, 2019
    Publication date: March 24, 2022
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Oliver PITTS, Omid SALEHZADEH EINABAD
  • Publication number: 20220090115
    Abstract: Methods are provided for modulating an abiotic stress response to drought in a plant, for example by introducing a heritable change to the plant, which alters the expression in the plant of an endogenous or exogenous protein that is a member of a particular gene family, the Kanghan genes. Similarly, plants and plants cells having such heritable changes are provided.
    Type: Application
    Filed: August 31, 2021
    Publication date: March 24, 2022
    Applicant: National Research Council of Canada
    Inventors: Jitao Zou, Wenyun Shen, Peng Gao
  • Patent number: 11278890
    Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: March 22, 2022
    Assignee: National Research Council of Canada
    Inventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
  • Publication number: 20220072816
    Abstract: A vacuum bag system (VBS) for forming pre-consolidated composite blanks has a blank enclosure for sealing around a periphery of the blank, while leaving a second side of the blank exposed, an articulated forming caul (AFC) with at least two facets, each facet effectively jointedly coupled to an adjacent facet, and having a respective, independently controlled, heater integrated with, or coupled to the facet. The VBS further has a forming enclosure for sealing around a periphery of a tool. The blank enclosure brings the blank and the facets into uniform thermal contact resistance and mechanical contact; and permits the articulated AFC to distribute thermal and mechanical load across the blank during forming, even as the facets move to align to faces of the mold.
    Type: Application
    Filed: January 24, 2020
    Publication date: March 10, 2022
    Applicant: National Research Council of Canada
    Inventors: Ali YOUSEFPOUR, Drazen DJOKIC, Simon HIND, Meysam RAHMAT, Steven ROY, Marc-Andre OCTEAU, Jihua CHEN
  • Publication number: 20220063038
    Abstract: A base attachment module (BAM) of a small aerial vehicle (SAV) for attaching the SAV to an unprepared work surface has a surface meeting docking assembly (DA) with contact points for contacting the work surface, and a contracting suction cup (CSC) in a position surrounded by the contact points such that it extends beyond a plane (or other surface contour) of the points in a fully extended operating position, and is retracted below the plane in a retracted position. Actuation of the CSC when in contact with the surface, allows for the DA to be brought into contact with the contact points in a controlled manner, for a high stiffness attachment, as is needed for deployment of robotic tasks from a SAV.
    Type: Application
    Filed: October 18, 2019
    Publication date: March 3, 2022
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Bruno MONSARRAT, Charles VIDAL, Martin DE MONTIGNY, Iraj MANTEGH
  • Publication number: 20220040914
    Abstract: Functional and/or functional precursor products, formulations for making the products, methods of making the products (e.g. functional coatings, concentrated gradients, and/or composites), and uses thereof are provided. In an aspect, a method for making a product is provided, the method comprising: a) combining at least one first component and at least one polymerizable component to form a composition; and b) polymerizing the at least one polymerizable component to form at least one polymer, wherein at least two phases are formed from the at least one first component and the at least one polymer. The at least one first component comprises at least one functional component, at least one functional precursor component, or combinations thereof, and the product is a functional product, a functional precursor product, or a combination of a functional and functional precursor product.
    Type: Application
    Filed: October 18, 2019
    Publication date: February 10, 2022
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Bhavana DEORE, Chantal PAQUET, Patrick Roland Lucien MALENFANT, Thomas LACELLE, Stephane DENOMMEE
  • Patent number: 11232976
    Abstract: A method for treating a wafer is provided with a portion of a semiconductor layer is selectively removed from the wafer so as to create an inactive region of the wafer surrounding a first active region of the wafer. The inactive region of the wafer has an exposed portion of an insulator layer, but none of the semiconductor layer. The first active region of the wafer includes a first portion of the semiconductor layer and a first portion of the insulator layer. At least one conductor is formed in contact with the first portion of the semiconductor layer, such that the conductor and the first portion of the semiconductor layer form a portion of an electrical circuit. The first active region of the wafer is selectively treated to remove a native oxide layer from the first portion of the semiconductor layer. A resulting wafer is also disclosed.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: January 25, 2022
    Assignees: National Research Council of Canada, The Governors of the University of Alberta, Quantum Silicon Inc.
    Inventors: Bruno Vieira Da Cunha Martins, Robert A. Wolkow, Marco Taucer, Jason Pitters
  • Publication number: 20220017603
    Abstract: Polypeptides with biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human heavy and light chain variable domains (VHs and VLs), are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human VHs and VLs are identified, which may be useful for immunotherapy or as diagnostic agents. Multimer complexes of human VHs and VLs are also identified. The VHs and VLs identified may be used to create further libraries for identifying additional polypeptides. Further, the VHs and VLs may be subjected to DNA shuffling to select for improved biophysical properties.
    Type: Application
    Filed: July 12, 2021
    Publication date: January 20, 2022
    Applicant: National Research Council of Canada
    Inventor: Jamshid TANHA