Patents Assigned to National Research Council of Canada
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Publication number: 20250144174Abstract: Described herein are BBB-transporting fusion proteins, polynucleotides encoding the fusion proteins and mammalian cells genetically modified to express and secrete the fusion proteins, as well as compositions, implantable devices and device preparations comprising the fusion proteins or genetically modified cells secreting the fusion proteins, and methods of making and using the same for treating various CNS diseases and conditions, e.g., any mucopolysaccharidosis type with CNS manifestations.Type: ApplicationFiled: January 27, 2023Publication date: May 8, 2025Applicant: National Research Council of CanadaInventors: Elina Makino, Erika Pearson, Gregory Hussack, Danica Stanimirovic
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Patent number: 12286347Abstract: The present application relates to boron nitride nanotube (BNNT)-nanoparticle composites, to methods of preparing such composites and their use, for example, in metal/ceramic matrix composites and/or macroscopic assemblies. For example, the methods comprise subjecting a source of hydrogen, a source of boron, a source of nitrogen and a nanoparticle precursor to a stable induction thermal plasma and cooling the reaction mixture to obtain the composite.Type: GrantFiled: September 18, 2018Date of Patent: April 29, 2025Assignee: National Research Council of CanadaInventors: Keun Su Kim, Benoit Simard, Christopher Thomas Kingston, Homin Shin
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Patent number: 12263956Abstract: An aircraft with an aircraft fuselage, and a passenger cabin and a cockpit, where the aircraft includes a center-forward attendant space between the passenger cabin and the cockpit. A cabin crew member of the aircraft can stand in the center-forward attendant space for monitoring progress of an emergency evacuation of the aircraft. The aircraft has one or more emergency exits for providing egress of passengers from the aircraft fuselage during the emergency evacuation. The aircraft also has a situational awareness monitoring (SAM) system for use in evacuating the passengers from the aircraft during the emergency evacuation. The SAM system includes one or more imaging devices and one or more display modules, each of which displays within the passenger cabin images captured by a corresponding one of the one or more imaging devices.Type: GrantFiled: December 21, 2022Date of Patent: April 1, 2025Assignees: Airbus Americas, Inc., Airbus Operations GmbH, National Research Council of CanadaInventors: Joyce S. T. Tan, Tina Kay Griffin, Patrick Alexander Rollfink, Christophe J. P. J. Legare, Natalia Cooper, John Russell Thomas, Shelley M. Roberts, Caidence S. Paleske
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Publication number: 20250101105Abstract: The present document describes antibodies or antigen-binding fragments that bind specifically to a target antigen, wherein the antibodies or antigen-binding fragments comprise complementarity determining regions (CDR1, CDR2 and CDR3) and an added O-glycosylation sequon glycosylated with an O-glycan having the general formula (I): wherein R1 is an initial N-acetylgalactosamine (GalNAc); n=1, or 2; R2 are each independently absent, galactose (Gal), GalNAc, N-Acetylglucosamine (GlcNAc), or a sialic acid; R3 are each independently absent, Gal or a sialic acid; and R4 are each independently absent or a sialic acid. Also described are compounds comprising the antibodies or antigen-binding fragments comprising a functional moiety operably linked to said O-glycan, compositions comprising the same, and methods of preparing such compounds.Type: ApplicationFiled: March 21, 2023Publication date: March 27, 2025Applicant: National Research Council of CanadaInventors: Michel Gilbert, Yves Durocher, Warren Wakarchuk
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Publication number: 20250085203Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.Type: ApplicationFiled: March 9, 2022Publication date: March 13, 2025Applicant: National Research Council of CanadaInventors: Byeong-Ui MOON, Liviu CLIME, Daniel Brassard, Keith MORTON, Teodor VERES
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Patent number: 12240916Abstract: The present document describes an alpha-(1,6)-fucosyltransferase (FUT8) antibody, antigen binding domain thereof, or a fusion protein thereof, operable to inhibit FUT8 activity in a cell, and methods of producing recombinant proteins, in particular antibodies, having reduced fucosylation. The present document also describes methods of inhibiting expression and/or activity of a protein in a cell by expressing an antibody and/or a fusion protein operable to inhibit expression and/or activity of the protein. The antibody, antigen binding domain thereof, or fusion protein thereof may comprise a transmembrane domain of a protein resident in an endoplasmic reticulum (ER), a cis Golgi apparatus, a trans Golgi apparatus, or a combination thereof.Type: GrantFiled: September 20, 2019Date of Patent: March 4, 2025Assignee: National Research Council of CanadaInventors: Yves Durocher, Simon Joubert
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Publication number: 20240425875Abstract: Provided are methods, expression systems, kits, and vectors for constitutive and/or cumate-inducible expression of a gene of interest in CHO cells. The expression systems and methods described herein employ CHO cells that are stably transfected with a nucleic acid molecule encoding a reverse cumate transactivator (rcTA), the expression of which is regulated by a cymene repressor (CymR). for constitutive and/or cumate-inducible expression of a gene of interest.Type: ApplicationFiled: September 12, 2022Publication date: December 26, 2024Applicant: National Research Council of CanadaInventors: Yves DUROCHER, Simon JOUBERT, Sylvie PERRET, Martin LOIGNON, Jean-Sebastien MALTAIS, Simon LORD-DUFOUR
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Patent number: 12174218Abstract: A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging.Type: GrantFiled: August 31, 2020Date of Patent: December 24, 2024Assignees: National Research Council of Canada, The Governors of the University of AlbertaInventors: Robert A. Wolkow, Jason Pitters, Mark Salomons
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Patent number: 12153988Abstract: A tag detection system comprising a source for producing an interrogation signal having a first frequency; a harmonic radar tag comprising: an antenna structure; a tunneling junction electrically and integrally coupled to the antenna; and wherein the harmonic radar tag when stimulated by the interrogation signal having the first frequency, and the harmonic radar tag produces a response signal at a second frequency different from the first frequency.Type: GrantFiled: December 18, 2020Date of Patent: November 26, 2024Assignee: National Research Council of CanadaInventors: Nikola Pekas, Adam Johan Bergren
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Patent number: 12140032Abstract: Methods and systems for determining a change in condition of a rock bolt. Some methods may comprise, at a first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a first time of flight for each of the shear and longitudinal waves, at a second point in time after the first point in time, propagating shear and longitudinal ultrasonic waves along the rock bolt to measure a second time of flight for each of the shear and longitudinal waves, and using the relative changes of the first and second time of flights, determining the change in condition of the rock bolt section.Type: GrantFiled: February 10, 2023Date of Patent: November 12, 2024Assignee: National Research Council of CanadaInventors: Zhigang Sun, Kuo-Ting Wu, Silvio Elton Kruger
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Publication number: 20240341108Abstract: A composition for use in a photo-active device has: a charge transfer network of single walled carbon nanotubes (SWCNT) having at least 95 wt % of semiconducting single walled carbon nanotubes (sc-SWCNT) based on total weight of the SWCNT, the sc-SWCNT containing at least 30 wt % of one chiral type of sc-SWCNT based on total weight of the sc-SWCNT; and, a solution processible electron trapping material of a fullerene compound, the electron trapping material in contact with the charge transfer network of SWCNT. The composition is readily prepared from solution processible components and is highly sensitive in a narrow wavelength band. The composition is particularly useful in photoconductors and phototransistors that operate on the infrared region of the electromagnetic spectrum.Type: ApplicationFiled: August 8, 2022Publication date: October 10, 2024Applicant: National Research Council of CanadaInventors: Zhao LI, Jianying OUYANG, Jianfu DING, Patrick R. L. MALENFANT
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Patent number: 12114515Abstract: The present application relates to thin film transistors having a semiconducting channel comprising a network of carbon nanotubes that are electrically coupled to a source electrode and a drain electrode and electrically insulated from, but capacitively coupled to, a gate electrode, wherein a polymeric layer encapsulates the carbon nanotubes. The polymeric layer can comprise a first monomeric unit and optionally a second monomeric unit, wherein the first monomeric unit, the second monomeric unit and the relative amounts thereof are optionally selected to provide at least one target electrical property of the thin film transistor. The present application also relates to methods for manufacturing such thin film transistors as well as a methods of selecting a polymeric layer to provide a desired threshold voltage for such thin film transistors.Type: GrantFiled: December 17, 2019Date of Patent: October 8, 2024Assignee: National Research Council of CanadaInventors: Jacques Lefebvre, Francois Lapointe, Zhao Li, Jianfu Ding, Patrick Roland Lucien Malenfant
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Patent number: 12103130Abstract: A base attachment module (BAM) of a small aerial vehicle (SAV) for attaching the SAV to an unprepared work surface has a surface meeting docking assembly (DA) with contact points for contacting the work surface, and a contracting suction cup (CSC) in a position surrounded by the contact points such that it extends beyond a plane (or other surface contour) of the points in a fully extended operating position, and is retracted below the plane in a retracted position. Actuation of the CSC when in contact with the surface, allows for the DA to be brought into contact with the contact points in a controlled manner, for a high stiffness attachment, as is needed for deployment of robotic tasks from a SAV.Type: GrantFiled: October 18, 2019Date of Patent: October 1, 2024Assignee: National Research Council of CanadaInventors: Bruno Monsarrat, Charles Vidal, Martin De Montigny, Iraj Mantegh
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Publication number: 20240301381Abstract: The present invention relates, in general, to polypeptides capable of neutralizing SARS-CoV-2 and providing ACE2 enzymatic activity, and uses of these polypeptides for treating disorders related coronaviral infections (COVID-19) and the accompanying acute respiratory distress syndrome (ARDS) and major organ injuries, and methods of making such molecules.Type: ApplicationFiled: January 25, 2022Publication date: September 12, 2024Applicant: National Research Council of CanadaInventors: Traian SULEA, Yves DUROCHER
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Patent number: 12084510Abstract: Herein described are antibodies to epidermal growth factor receptor (EGER) having an EGER binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.Type: GrantFiled: February 21, 2020Date of Patent: September 10, 2024Assignees: Gilead Sciences, Inc., National Research Council of CanadaInventors: Ilia Alexandre Tikhomirov, Maria L. Jaramillo, Maureen D. O'Connor-McCourt, Traian Sulea, Renald Gilbert, Bruno Gaillet, Jason Baardsnes, Myriam Banville, Suzanne Grothe
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Publication number: 20240270826Abstract: Described herein are antibodies that specifically recognize the SARS-CoV-2 spike (S) polypeptide, compositions comprising said antibodies, uses thereof, and methods employing said antibodies. Each antibody specifically recognizes the S1-RBD domain, S1-NTD domain, or S2 subunit of the SARS-CoV-2 spike polypeptide. Some antibodies are cross-reactive with variants of SARS-CoV-2 and other coronavirus spike polypeptides, such as SARS-CoV S, pangolin CoV S, bat SARS-like CoV S, and civet SARS-CoV S.Type: ApplicationFiled: April 22, 2022Publication date: August 15, 2024Applicant: National Research Council of CanadaInventors: Jamshid TANHA, Martin A. ROSSOTTI
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Patent number: 12055740Abstract: There is described a multilayer optical thin film structure comprising multiple optically absorbing layers and multiple optically non-absorbing layers. The optically absorbing layers and the optically non-absorbing layers are configured such that light incident on the structure is reflected with a red colour at a first angle, and light incident on the structure is reflected with a yellow colour at a second angle. There is also described an item having applied thereto such a multilayer structure.Type: GrantFiled: April 3, 2019Date of Patent: August 6, 2024Assignee: National Research Council of CanadaInventor: Penghui Ma
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Patent number: 12036229Abstract: Phosphorylated heptose compounds are useful in modulating an immune response in a subject. Also, the compounds are useful as adjuvants.Type: GrantFiled: May 11, 2018Date of Patent: July 16, 2024Assignees: National Research Council of Canada, The Governing Council of the University of TorontoInventors: Andrew Cox, Janelle Sauvageau, Scott Gray-Owen, Xinyi Guo
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Publication number: 20240213834Abstract: A permanent magnet (PM) for use in an electric machine including at least one cavity containing a phase change material (PCM) integrated with said PM, the PCM having a phase transition temperature between about 80° C. to about 200° C.Type: ApplicationFiled: May 20, 2022Publication date: June 27, 2024Applicant: National Research Council of CanadaInventors: Jean-Michel Lamarre, Maged Ibrahim, Fabrice Bernler, Roger Pelletier
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Patent number: 12017155Abstract: Provided herein are phase separation devices and methods for performing phase separation of an aqueous mixture. Said devices and methods may include a cavitation component for cavitating the aqueous mixture to produce a cavitated aqueous mixture; and an electrosorption component for performing an electrosorptive phase separation of the cavitated aqueous mixture. Such devices and methods may be used for phase separation of aqueous mixtures including algal aqueous mixtures and/or mining or waste water aqueous mixtures, for example.Type: GrantFiled: March 13, 2018Date of Patent: June 25, 2024Assignee: National Research Council of CanadaInventor: Deepak M. Kirpalani