Patents Assigned to National Research Council of Canada
  • Patent number: 10100117
    Abstract: The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF 1R)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF 1R polypeptide. Humanized forms of the camelid VHH are also generated.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: October 16, 2018
    Assignee: National Research Council of Canada
    Inventors: Danica Stanimirovic, Kristin Kemmerich, Arsalan S. Haqqani, Traian Sulea, Mehdi Arbabi-Ghahroudi, Bernard Massie, Rénald Gilbert
  • Patent number: 10098973
    Abstract: The present invention relates to Tau-specific antibodies, fragments thereof, and uses thereof. More specifically, the present invention relates to Tau-specific antibodies, fragments thereof, and conjugates thereof with conjugated to a superparamagnetic nanoparticle. The molecules of the present invention may be used in visualizing damage from traumatic brain injury.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: October 16, 2018
    Assignee: National Research Council of Canada
    Inventors: Garnette R. Sutherland, Sanju Lama, Mehdi Arbabi-Ghahroudi
  • Patent number: 10094782
    Abstract: The invention discloses an apparatus and method for use with Laser Induced Breakdown Spectroscopy (LIBS) systems that can be applied to the real time analysis of various materials. The invention, in one aspect, provides a layer-by-layer method to remove the undesired coating layer of a material in which a pulsed laser is coupled with high speed scanning optics. To prepare the surface for LIBS, (i) a pulsed laser beam is scanned over an area of the surface to ablate the surface coating layer; (ii) the laser parameters are changed (i.e. pulse duration is made smaller) and the area scanned again to polish the surface; and (iii) the laser parameters are changed again (i.e. pulse duration is made smaller yet again) and the area scanned again with spectrometric analysis of the plasma plume created by the laser (i.e. LIBS is performed).
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: October 9, 2018
    Assignee: National Research Council of Canada
    Inventors: Francois Doucet, Mohamad Sabsabi, Lutfu-Celebi Ozcan, Jean-Francois Gravel, Francis Boismenu
  • Patent number: 10092644
    Abstract: Disclosed is the use of fluorinated cyclic dinucleotides and pharmaceutically acceptable salts thereof as an adjuvant for the preparation of an oral vaccine. Further disclosed is the use of fluorinated cyclic dinucleotides and pharmaceutically acceptable salts thereof for enhancing the immune response to an orally administered vaccine.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: October 9, 2018
    Assignees: Brock University, National Research Council of Canada
    Inventors: Hongbin Yan, Wangxue Chen, Rhonda Kuo Lee
  • Patent number: 10081672
    Abstract: The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof as well as their use in therapy or prophylaxis.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: September 25, 2018
    Assignee: National Research Council of Canada
    Inventors: Wei-Gang Hu, Laurel M. Negrych, Damon Chau, Junfei Yin, Scott J. Jager, John W. Cherwonogrodzky
  • Patent number: 10067745
    Abstract: A method of generating a random number that involves applying pulses of energy to amplify a quantum mechanical vacuum fluctuation to generate one or more macroscopic fields having one or more physical properties (e.g. phase or energy) that are random and measurable, and, measuring at least one of the physical properties to obtain a value for the physical property, the value of the physical property being a random number. Measuring the phase of a Stokes signal generated in a transient Raman scattering process is one way of generating the random number as the phase of the Stokes signal is random. This method can produce random numbers faster than prior art methods as the real numbers generated can be converted to binary to produce more than one random bit and the measurement process itself is faster permitting more rapid data collection rates and more rapid turn-on times.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: September 4, 2018
    Assignee: National Research Council of Canada
    Inventors: Benjamin J. Sussman, Philip J. Bustard
  • Patent number: 10059971
    Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: August 28, 2018
    Assignees: National Research Council of Canada, University of Saskatchewan
    Inventors: Jonathan E. Page, Steve Gagne
  • Publication number: 20180238677
    Abstract: A technique for acquiring target's coordinates for industrial dimensional metrology involves a target that serves both as a 2D contrast target and a 3D contact target, and a metrology tool. The target has proximal and distal surfaces, at least some of which being primarily flat and facing a common normal direction. At least 3 mm separate the proximal and distal surfaces in the normal direction. Reflectivity factors of the distal and proximal surfaces differ by at least 20%. Risers connecting pairs of the proximal and distal surfaces are sufficiently undercut so that none of the risers are in view at nominal viewing angles. At least two reference edges are defined where risers meet proximal surfaces. The tool has meeting features for registration with the edges and primarily flat surfaces, in at least two registered positions, to permit a retroreflector of the tool to acquire coordinates the target centre.
    Type: Application
    Filed: August 16, 2017
    Publication date: August 23, 2018
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Luc COURNOYER, Michel PICARD
  • Patent number: 10046893
    Abstract: A patterned thermoplastic elastomer (TPE) film for fabricating a liquid-filled blister, has a blister-sized cavity in fluid communication with a microfluidic channel via a gating region.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: August 14, 2018
    Assignee: National Research Council of Canada
    Inventors: Mojra Janta, Xuyen Dai Hoa, Matthias Geissler, Teodor Veres
  • Publication number: 20180221985
    Abstract: A technique for joining parts of incompatible metals involves cold spraying a 150-900 micron thick layer of a metal compatible with the second part onto the first part, and friction stir joining the parts by lap welding while keeping a tool of the FSJ tool at least 300 microns away from the first part (less layer) throughout the joining, to avoid damaging the cold spray to first part interface, and formation of intermetallics. Improved fatigue resistance is shown. A sealant can advantageously further improve fatigue resistance.
    Type: Application
    Filed: October 28, 2016
    Publication date: August 9, 2018
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Sofiene AMIRA, Patrick GOUGEON, Jean-Gabriel LEGOUX, Francois NADEAU
  • Patent number: 10044055
    Abstract: A fuel cell comprises an anode having an inner face and an outer face fluidly communicable with a fuel; a cathode having an inner face ionically communicable with and physically separated from the anode inner face, and having an outer face fluidly communicable with an oxidant; and at least one movable guard movable over at least one of the anode outer face, cathode outer face, anode inner face, and cathode inner face. The guard has a structure sufficient to block at least part of one or more of the anode's communication with the fuel, the cathode's communication with the oxidant, and the ionic communication between the anode and cathode thereby reducing a maximum potential active area of the fuel cell to an effective active area of the fuel cell.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: August 7, 2018
    Assignees: THE UNIVERSITY OF BRITISH COLUMBIA, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: David P. Wilkinson, Alfred Lam
  • Patent number: 10030209
    Abstract: A particulate composite lubricant for powder metallurgy comprises: first discrete particles comprising at least about 90 wt % of a fatty primary monoamide wax, being substantially free of fatty bisamide wax, and being at least partially coated with metal oxide nanoparticles and second metal-stearate free discrete particles comprising a fatty bisamide wax. A particulate composite lubricant for powder metallurgy can comprise: a Montan acid ester wax and at least one fatty amide wax comprising at least one of a fatty monoamide wax and a fatty bisamide wax.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: July 24, 2018
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Yannig Thomas, Vincent Paris, Sylvain St-Laurent
  • Patent number: 10033160
    Abstract: An interband cascade (IC) light emitting device comprising a plurality of interband cascade stages, wherein at least one of the IC stages is constructed to have an electron injector made of one or more QWs, a type-I quantum well (QW) active region, a barrier layer positioned between the active region and the electron injector, a hole injector made of one or more QWs, and a barrier layer positioned between the active region and the hole injector. In at least one embodiment, a type II heterointerface layer is between the electron injector and an adjacent hole injector. The well layer of the type-I QW active region has compressive strain, while the barrier layers which flank the type-I QW active region comprise tensile strain layers. In certain embodiments, the electron injector and the hole injector comprise tensile strained layers.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: July 24, 2018
    Assignees: The Board of Regents of the University of Oklahoma, National Research Council of Canada
    Inventors: Rui Q. Yang, James A. Gupta
  • Patent number: 10024802
    Abstract: A method for laser induced breakdown spectroscopy (LIBS) calibration or LIBS assay comprises providing a plurality of reference samples, each having a respective, known concentration of an analyte, assaying each reference sample to obtain a respective LIBS spectrum, and for each reference LIBS spectrum, measuring an intensity of at least one spectral analyte line that varies with concentration of the analyte, and measuring a peak amplitude of at least one saturating line of a reference element. The ratio and known concentrations define a calibration curve for the analyte.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: July 17, 2018
    Assignee: National Research Council of Canada
    Inventors: Mohamad Sabsabi, Jean-Pierre Monchalin, René Héon, Paul Bouchard
  • Publication number: 20180186893
    Abstract: The present invention relates to isolated or purified antibodies or fragments thereof specific for Carbohydrate Anhydrase IX (CA-IX) and their use as therapeutic tools. Specifically, the present invention is directed to high-affinity Carbohydrate Anhydrase IX-specific antibodies and fragments thereof and their use as antibody-drug conjugates. Compositions for use in therapy as well as therapeutic methods are also described.
    Type: Application
    Filed: June 10, 2016
    Publication date: July 5, 2018
    Applicant: National Research Council of Canada
    Inventors: Anne E.G. Lenferink, Maureen D. O'Connor, Anne Marcil, Yves Durocher
  • Patent number: 9999354
    Abstract: A method and system for inspecting biological tissue that has no applied coatings or treatments to improve reflectivity comprises an optical detection system with an exposed surface for inspection by an optical detection system; and a laser for exciting an ultrasonic wave within the tissue, which wave propagates within the tissue at least near the surface.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: June 19, 2018
    Assignee: National Research Council of Canada
    Inventors: Guy Rousseau, Alain Blouin, Jean-Pierre Monchalin
  • Publication number: 20180156306
    Abstract: A vibration reduction (VR) human support has exactly two paths to ground in each degree of VR: one provided by respective displacement actuators (DAs) for active VR, the other by one or more elastomeric damping bodies (EDBs). These paths extend from a frame for carrying a support structure for a live human, to a grounding for fixing the VR system in a vibrating environment. Each EDB is composed of a material having a dynamic Young's Modulus of 0.1-2.5 MPa, and a resilience test rebound height less than 40, and is positioned between the grounding and frame to provide elastic restorative forces and damping in each of the respective directions. The use of EDBs simplifies construction, and allows for a more compact arrangement, without reducing VR efficiency.
    Type: Application
    Filed: December 1, 2017
    Publication date: June 7, 2018
    Applicant: National Research Council of Canada
    Inventors: Amin FEREIDOONI, Viresh WICKRAMASINGHE, Yong Eric CHEN
  • Publication number: 20180147879
    Abstract: A security device comprising a microstructure and one or more curable fluids, in which the microstructure is configured to direct the one or more curable fluids from a local application zone of the microstructure to one or more regions of the microstructure prior to curing each curable fluid. Alternatively, the security device may comprise a microstructure; and one or more cured fluids; in which each cured fluid is derived from a corresponding curable fluid that is directed by the microstructure from a local application zone of the microstructure to one or more regions of the microstructure prior to curing each curable fluid. The microstructure can have a depth of at least 100 nm, and a spacing aspect ratio (depth to height) greater than 1:10. A process for fabricating a security device is also described.
    Type: Application
    Filed: May 11, 2016
    Publication date: May 31, 2018
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Keith MORTON, Teodor VERES, Liviu CLIME
  • Patent number: 9982088
    Abstract: The present disclosure describes a polyester that contains plural pendant adjacent carboxylic acid or acid salt side groups for use in making a toner for use in imaging devices.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 29, 2018
    Assignees: XEROX CORPORATION, NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Karen A. Moffat, Dragan Nikolic, Valerie M. Farrugia, Jordan H. Wosnick, Andriy Kovalenko, Alexander Kobryn, Sergey Gusarov
  • Publication number: 20180142000
    Abstract: Campylobacter jejuni is a leading cause of bacterial food-borne diseases in humans, ranging from acute diarrheal disease to neurological disorders. An isolated or purified antibody or fragment thereof specific to C. jejuni is described. The antibody or fragment thereof binds to a flagellar protein and reduces motility of C. jejuni. The antibody or fragment thereof is derived from a heavy chain IgG variable domain fragment (VHH) of a camelid animal immunized with C. jejuni flagellar protein. A multivalent form, as well as a phage format, of the antibody or fragment thereof is described. Methods of reducing presence of C. jejuni in an animal or an animal environment, methods and formulations for treating C. jejuni infection, and method of detecting C. jejuni are also described.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 24, 2018
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Mehdi ARBABI GHAHROUDI, Ali RIAZI, Christine M. SZYMANSKI, Greg HUSSACK, Jamshid TANHA, Roger MACKENZIE