Patents Assigned to National Research Council of Canada
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Patent number: 10301659Abstract: The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-?-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-?-D-glucopyranose. Methods for producing the sugars are also provided.Type: GrantFiled: November 17, 2016Date of Patent: May 28, 2019Assignee: National Research Council of CanadaInventors: Dennis M. Whitfield, Susan M. Logan, Ian C. Schoenhofen, Christopher N. Boddy, Benjamin R. Lundgren
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Patent number: 10259864Abstract: Campylobacter jejuni is a leading cause of bacterial food-borne diseases in humans, ranging from acute diarrheal disease to neurological disorders. An isolated or purified antibody or fragment thereof specific to C. jejuni is described. The antibody or fragment thereof binds to a flagellar protein and reduces motility of C. jejuni. The antibody or fragment thereof is derived from a heavy chain IgG variable domain fragment (VHH) of a camelid animal immunized with C. jejuni flagellar protein. A multivalent form, as well as a phage format, of the antibody or fragment thereof is described. Methods of reducing presence of C. jejuni in an animal or an animal environment, methods and formulations for treating C. jejuni infection, and method of detecting C. jejuni are also described.Type: GrantFiled: December 20, 2017Date of Patent: April 16, 2019Assignee: National Research Council of CanadaInventors: Mehdi Arbabi Ghahroudi, Ali Riazi, Christine M. Szymanski, Greg Hussack, Jamshid Tanha, Roger MacKenzie
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Publication number: 20190092840Abstract: Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human VHs and VLs, are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human VHs and VLs are identified, which may be useful for immunotherapy or as diagnostic agents. Multimer complexes of human VHs and VLs are also identified. The VHs and VLs identified may be used to create further libraries for identifying additional polypeptides. Further, the VHs and VLs may be subjected to DNA shuffling to select for improved biophysical properties.Type: ApplicationFiled: December 5, 2018Publication date: March 28, 2019Applicant: National Research Council of CanadaInventor: Jamshid Tanha
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Patent number: 10228356Abstract: A liquid chromatography method for identifying an analyte of interest utilizing as retention index standards a homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge. The method is especially useful for liquid chromatography-mass spectrometry (LC-MS) methods, more especially for LC-MS methods employing electrospray (ESI) or atmospheric pressure chemical ionization (APCI) ionization systems.Type: GrantFiled: December 22, 2016Date of Patent: March 12, 2019Assignee: National Research Council of CanadaInventor: Michael Arthur Quilliam
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Patent number: 10227575Abstract: An isolated chimeric recombinant protein has cutinase activity. The protein includes a cutinase catalytic domain and a polymer binding domain operably linked by a proline/threonine-rich linker domain. The proline/threonine-rich linker domain includes at least 50% proline or threonine residues over a stretch of 15 to 55 consecutive amino acids.Type: GrantFiled: August 9, 2017Date of Patent: March 12, 2019Assignees: Ozymes, National Research Council of CanadaInventors: Kofi Abokitse, Peter C. K. Lau, Stephan Grosse
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Patent number: 10222346Abstract: A process for purifying semiconducting single-walled carbon nanotubes (sc-SWCNTs) extracted with a conjugated polymer, the process comprising exchanging the conjugated polymer with an s-tetrazine based polymer in a processed sc-SWCNT dispersion that comprises the conjugated polymer associated with the sc-SWCNTs. The process can be used for production of thin film transistors and chemical sensors. In addition, disclosed herein is use of an s-tetrazine based polymer for purification of semiconducting single-walled carbon nanotubes (sc-SWCNTs).Type: GrantFiled: September 19, 2017Date of Patent: March 5, 2019Assignee: National Research Council of CanadaInventors: Zhao Li, Jianfu Ding, Patrick Roland Lucien Malenfant
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Patent number: 10208129Abstract: An erbB2 antibody is provided that binds preferentially to disease cells having an erbB2 density greater than a normal erbB2 density. The erbB2 antibody comprises a heavy chain and a light chain. Each chain has a constant region and a variable region. Each variable region comprises framework regions and complementarity determining regions (CDRs), wherein the CDRs have an amino acid sequence set forth below: For the heavy chain: CDR1 GFNIKDTYIH (SEQ ID No. 1) CDR2 RIYPTNGY57TR59 YADSVKG (SEQ ID No. 2) CDR3 WGGDGFYAMDY (SEQ ID No. 3) For the light chain: CDR1 RASQDVN30TAVA (SEQ ID No. 4) CDR2 SASF53LYS (SEQ ID No. 5) CDR3 QQHY92TTPPT (SEQ ID No. 6). At least one of Y57, R59, N30, F53, and Y92 is substituted by an amino acid that confers on said antibody a reduced erbB2 binding affinity (Kd) that is in the range from 0.1 nM to 100 nM. The substitution is other than N30A, F53N, Y92A and Y92F when there is a single substitution in the antibody light chain.Type: GrantFiled: December 2, 2011Date of Patent: February 19, 2019Assignee: National Research Council of CanadaInventors: Ilia Alexandre Tikhomirov, Maria L. Jaramillo, Maureen D. O'Connor-McCourt, Traian Sulea, Renald Gilbert, Bruno Gaillet, Jason Baardsnes
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Publication number: 20190049272Abstract: Provided is an optical waveguide with an inscribed Bragg grating, where the Bragg grating is stable at high temperature, has low scattering loss and high reflectivity. Also provided is a method for inscribing a Bragg grating in an optical waveguide, the method comprising irradiating the optical waveguide with electromagnetic radiation from an ultrashort pulse duration laser of sufficient intensity to cause a permanent change in an index of refraction within a core of the optical waveguide, where the irradiating step is terminated prior to erasure of a Bragg resonance, and heating the optical waveguide to a temperature and for a duration sufficient to substantially remove a non-permanent grating formed in the optical waveguide by the irradiating step.Type: ApplicationFiled: February 16, 2017Publication date: February 14, 2019Applicant: National Research Council of CanadaInventors: Dan Grobnic, Stephen Mihailov, Robert Walker, Ping Lu, Huimin Ding, David Coulas, Cyril Hnatovsky
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Patent number: 10201634Abstract: The present invention is directed to implants and the modification of the surface of implants using amino acid or polypeptide functionalized rosette nanotubes.Type: GrantFiled: June 23, 2014Date of Patent: February 12, 2019Assignees: Brown University, National Research Council of Canada, The Governors of the University of AlbertaInventors: Thomas J. Webster, Hicham Fenniri, Usha Devi Hemraz
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Publication number: 20190036305Abstract: A technique for narrowing a linewidth of a plurality of lines of a coherent comb laser (CCL) concurrently comprises providing a mode-locked semiconductor coherent comb laser (CCL) adapted to output of at least 4 mode-locked lines; tapping a fraction of a power from the CCL from the laser cavity to form a tapped beam; propagating the tapped beam to an attenuator to produce an attenuated beam; and reinserting the attenuated beam into the laser cavity, where the reinserted beam has a power less than 10% of a power of the tapped beam. The reinsertion allows the CCL to be operated to output the mode-locked lines, each with a linewidth of less than 80% of the original linewidth. By propagating the tapped and attenuated beams on a solid waveguide, and ensuring that the secondary cavity is polarization maintaining, improved stability of the linewidth narrowing is ensured.Type: ApplicationFiled: July 31, 2018Publication date: January 31, 2019Applicant: National Research Council of CanadaInventors: Zhenguo Lu, Jiaren Liu, Philip Poole, Chunying Song, Shoude Chang
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Publication number: 20190032074Abstract: Methods are provided for modulating an abiotic stress response to drought in a plant, for example by introducing a heritable change to the plant, which alters the expression in the plant of an endogenous or exogenous protein that is a member of a particular gene family, the Kanghan genes. Similarly, plants and plants cells having such heritable changes are provided.Type: ApplicationFiled: September 14, 2018Publication date: January 31, 2019Applicant: NATIONAL RESEARCH COUNCIL OF CANADAInventors: Jitao Zou, Wenyun Shen, Peng Gao
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Publication number: 20190036304Abstract: A technique for narrowing a linewidth of a plurality of lines of a coherent comb laser (CCL) concurrently comprises providing a mode-locked semiconductor coherent comb laser (CCL) adapted to output of at least 4 mode-locked lines; tapping a fraction of a power from the CCL from the laser cavity to form a tapped beam; propagating the tapped beam to an attenuator to produce an attenuated beam; and reinserting the attenuated beam into the laser cavity, where the reinserted beam has a power less than 10% of a power of the tapped beam. The reinsertion allows the CCL to be operated to output the mode-locked lines, each with a linewidth of less than 80% of the original linewidth. By propagating the tapped and attenuated beams on a solid waveguide, and ensuring that the secondary cavity is polarization maintaining, improved stability of the linewidth narrowing is ensured.Type: ApplicationFiled: July 31, 2018Publication date: January 31, 2019Applicant: National Research Council of CanadaInventors: Zhenguo Lu, Jiaren Liu, Philip Poole, Chunying Song, Shoude Chang
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Publication number: 20190001360Abstract: Provided is an apparatus for aerosol deposition of nanoparticles on a substrate. The apparatus includes: an aerosol generator for generating an aerosol of micron-sized droplets, each droplet having a limited number of nanoparticles; and a deposition chamber for receiving the aerosol from the aerosol generator. The deposition chamber having an electrostatic field for attracting droplets in the aerosol to the substrate. The electrostatic field being substantially perpendicular to the substrate. The apparatus allows for films/networks of nanoparticles to be patterned on the substrate to sub-millimeter feature sizes, which allows the fabrication of transistor devices for printable electronics applications. Also provided are methods for depositing nanoparticles on a substrate and materials having networks of such nanoparticles.Type: ApplicationFiled: June 14, 2016Publication date: January 3, 2019Applicant: National Research Council of CanadaInventors: Jacques LEFEBVRE, Patrick MALENFANT
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Patent number: 10164595Abstract: A clipping circuit for an amplifier, the clipping circuit using a tunneling junction. A molecular or other tunneling electronic-based component within a hybrid analog-tunneling circuit is used to produce soft or hard clipping capability with enhanced control over the output. The circuit may be used as a distortion circuit for an electric guitar signal or other electronic signals.Type: GrantFiled: August 14, 2014Date of Patent: December 25, 2018Assignees: The Governors of the University of Alberta, National Research Council of CanadaInventors: Adam Johan Bergren, Richard McCreery
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Patent number: 10156680Abstract: An apparatus for use with a pulsed laser source for forming an optical grating in a target includes an adjustable telescope having an element with a negative optical power, for generation of a diverging optical beam, so that the optical beam has adjustable divergence upon exiting the telescope while focusing of light inside the telescope is avoided. A transmission diffraction grating is disposed in the optical beam exiting the telescope, for forming an optical interference pattern on the target. Optical gratings with different grating periods may be formed by adjusting the divergence of the optical beam exiting the telescope. Lack of tight focal spots inside the telescope enables use of ultrashort pulse duration, high peak intensity laser sources.Type: GrantFiled: July 10, 2015Date of Patent: December 18, 2018Assignee: National Research Council of CanadaInventors: Dan Grobnic, Stephen J. Mihailov, Robert B. Walker, Ping Lu, Huimin Ding, David Coulas
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Patent number: 10155802Abstract: A locally-activatable bivalent thrombin binding agent is provided having two thrombin binding moieties for non-overlapping sites on a surface of thrombin linked together by a linker. The linker is a polypeptide having 5 to 30 amino acid residues existing in a folded state under an environmental condition where the binding agent is inactive. The linker changes conformation from the folded state to an unfolded state in response to a change in bulk temperature and/or to the presence of hyper-mobile water thereby activating the binding agent. Such locally-activatable thrombin binding agents can be administered systemically while only targeting specific sites of coagulation or inflammation since the thrombin binding agent will only activate at the site where the existence of atherosclerotic plaques has changed the local bulk temperature and/or created hyper-mobile water sufficiently to unfold the linker and activate the binding agent.Type: GrantFiled: April 13, 2012Date of Patent: December 18, 2018Assignee: National Research Council of CanadaInventors: Feng Ni, Ping Xu, Sazzard Hossain, Dmitri Tolkatchev, Kenji Tonan
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Patent number: 10150807Abstract: Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation, including monomeric human VHs and VLs, are identified using a high throughput method for screening polypeptides, comprising the steps of obtaining a phage display library, allowing infection of a bacterial lawn by the library phage, and identifying phage which form larger than average plaques on the bacterial lawn. Sequences of monomeric human VHs and VLs are identified, which may be useful for immunotherapy or as diagnostic agents. Multimer complexes of human VHs and VLs are also identified. The VHs and VLs identified may be used to create further libraries for identifying additional polypeptides. Further, the VHs and VLs may be subjected to DNA shuffling to select for improved biophysical properties.Type: GrantFiled: September 11, 2015Date of Patent: December 11, 2018Assignee: National Research Council of CanadaInventor: Jamshid Tanha
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Patent number: 10125285Abstract: Disclosed is a method of printing ultranarrow-gap lines of a functional material, such as an electrically conductive silver ink. The method entails providing a substrate having an interlayer coated on the substrate and printing the ultranarrow-gap lines by depositing ink on the interlayer of the substrate, the ink comprising the functional material and a solvent that swells the interlayer to cause the interlayer to bulge at edges of the ink to thereby define embankments that confine the ink.Type: GrantFiled: June 30, 2016Date of Patent: November 13, 2018Assignee: National Research Council of CanadaInventors: Ta-Ya Chu, Christophe Py, Ye Tao, Zhiyi Zhang, Afshin Dadvand
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Patent number: 10121968Abstract: A process for purifying semiconducting single-walled carbon nanotubes (sc-SWCNTs) extracted with a conjugated polymer, the process comprising exchanging the conjugated polymer with an s-tetrazine based polymer in a processed sc-SWCNT dispersion that comprises the conjugated polymer associated with the sc-SWCNTs. The process can be used for production of thin film transistors. In addition, disclosed herein is use of an s-tetrazine based polymer for purification of semiconducting single-walled carbon nanotubes (sc-SWCNTs).Type: GrantFiled: January 9, 2017Date of Patent: November 6, 2018Assignee: National Research Council of CanadaInventors: Zhao Li, Jianfu Ding, Patrick Roland Lucien Malenfant
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Patent number: 10112998Abstract: The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF 1R)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF 1R polypeptide. Humanized forms of the camelid VHH are also generated.Type: GrantFiled: December 4, 2014Date of Patent: October 30, 2018Assignee: National Research Council of CanadaInventors: Danica Stanimirovic, Kristin Kemmerich, Arsalan S. Haqqani, Traian Sulea, Mehdi Arbabi-Ghahroudi, Bernard Massie, Rénald Gilbert