Patents Assigned to National Taiwan University
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Publication number: 20230030753Abstract: The present disclosure provides a method for detecting short-chain fatty acids in biological samples, including a derivatizing step, a loading step and a detecting step. The derivatizing step includes treating the short-chain fatty acids in the biological sample with 2-nitrophenylhydrazine for derivatizing the short-chain fatty acids into a sample to be detected. The loading step includes loading the sample onto a paper carrier. The detecting step includes analyzing the sample loaded onto the paper carrier by direct analysis in real time mass spectrometry for obtaining a detection result. The method provided by the present disclosure may complete the analysis of the biological sample within a short period of time and achieve a quantitative result comparable to that obtained by conventional chromatographic approaches.Type: ApplicationFiled: January 21, 2022Publication date: February 2, 2023Applicant: National Taiwan UniversityInventors: Cheng-Chih HSU, Ting-Hao KUO, Cheng-Yu WENG, Laura Min Xuan CHAI, Hsin-Bai ZOU
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Publication number: 20230028090Abstract: Provided is a method of using an aptamer for detecting a glycated hemoglobin in a whole blood, the method includes that the aptamer is provided, the aptamer includes a DNA sequence selected from the group consisting of derived sequences of SEQ ID NOs: 1, 2, 3, and 4, in which the derived sequences refer to that 3? end and/or 5? end of the derived sequences are modified, and the derived sequences have 90% identity to the SEQ ID NOs: 1, 2, 3, and 4. The aptamer and the whole blood are contacted. A concentration of a conjugate of the aptamer and the glycated hemoglobin is estimated. Provided also is a nanoelectronic aptasensor including the above aptamer.Type: ApplicationFiled: July 21, 2021Publication date: January 26, 2023Applicant: National Taiwan UniversityInventor: Yit-Tsong Chen
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Publication number: 20230010001Abstract: The present invention discloses a partially crosslinked hydrogels blended composition with enhanced viscosity and yield stress, which is formed by the polymerization of one or more colloid monomers through crosslinking. The polymerization is initiated by a photoinitiator under irradiation of the light of a specific wavelength, which promotes crosslinking of the one or more colloid monomers. The hydrogels blended composition can be further crosslinked with one or more other colloid monomers through repeated excitation of the photoinitiator. The hydrogels blended composition can be polymerized into a gel upon re-irradiation, and can also be used as a biomaterial for wound repair, three-dimensional cell culture, personal nursing care, health care, medical and pharmaceutical applications.Type: ApplicationFiled: June 14, 2022Publication date: January 12, 2023Applicant: National Taiwan UniversityInventors: Po-Ling Kuo, Shih-Hao Fu
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Patent number: 11552574Abstract: An interleaved three-phase Y-Delta connected power converter is provided. The interleaved three-phase Y-Delta connected power converter includes an input voltage source, an input capacitor, a first converter module, a second converter module, an output circuit, and a control circuit. The control circuit calculates a phase shift amount and an operating frequency through voltage and current feedbacks to generate a plurality of switch signal groups for controlling the first converter module and the second converter module, respectively.Type: GrantFiled: May 6, 2021Date of Patent: January 10, 2023Assignee: National Taiwan University of Science and TechnologyInventors: Jing-Yuan Lin, Guan-Lin Chen, Kuan-Hung Chen, Yi-Feng Lin
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Patent number: 11552716Abstract: An antenna measurement system includes an array of antennas, an array of reflectors, and a measurement surface. The array of antennas includes a plurality of antenna elements arranged in a straight line; any two adjacent antenna elements in the above antenna elements are separated by a predetermined distance, and each of the antenna elements in the above antenna elements has a radiator and a feed point. The array of reflectors includes at least one reflector and is arranged in a width direction or a height direction, and the array of reflectors is configured to generate a reflection signal according to a signal sent by the array of antennas. An antenna to be measured is configured to perform a measurement operation on the reflection signal on the measurement surface.Type: GrantFiled: May 4, 2021Date of Patent: January 10, 2023Assignee: National Taiwan UniversityInventors: Zhao He Lin, Hsi Tseng Chou, Chih Wei Chiu
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Patent number: 11541551Abstract: A robotic arm comprising an operation end, a base, a sensor unit and a control unit is provided. The operation end is connected to the base, and the operation end is configured to reach an operational area. The sensor unit provides a sensor signal according to the force applied by or the motion of an operator. When the operation end reaches the operational area, the control unit sets a fixed position on the robotic arm between the base and the operation end. When the sensor signal from the operator fulfills a default condition, the control unit moves the robotic arm away from the operator, without moving the fixed position on the robotic arm.Type: GrantFiled: July 31, 2019Date of Patent: January 3, 2023Assignee: NATIONAL TAIWAN UNIVERSITYInventors: Jia-Yush Yen, You-Ting Liao, Ching-Yuan Chen, Yen-Han Wang, Yung-Yaw Chen, Ming-Chih Ho
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Patent number: 11546571Abstract: A method and a system for generating a multiview stereoscopic image are provided. The method includes the following steps. An image capturing apparatus captures a real calibration panel to obtain multiple images, and a processor obtains a datum image and multiple images to be calibrated by analyzing the images including the real calibration panel. The processor respectively calculates a homography matrix of each of the images to be calibrated corresponding to the datum image according to the datum image and the images to be calibrated. The processor obtains a calibration matrix of the homography matrix by performing a matrix disassembly calculation on each of the homography matrices. The processor multiplies the images to be calibrated by the corresponding calibration matrix to obtain multiple calibrated images. The processor outputs the multiview stereoscopic image including the datum image and the calibrated images.Type: GrantFiled: November 25, 2021Date of Patent: January 3, 2023Assignee: National Taiwan University of Science and TechnologyInventor: Tzung-Han Lin
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Patent number: 11545593Abstract: The subject disclosure provides a simple, fast, and high-yield method for encapsulating solar cells. This method can produce an encapsulation of solar cell(s) that is flat, bubble-free, lightweight, and flexible. In addition, it can also reduce equipment and material costs.Type: GrantFiled: June 2, 2021Date of Patent: January 3, 2023Assignee: National Taiwan UniversityInventor: Ching-Fuh Lin
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Patent number: 11539620Abstract: An anomaly flow detection device and an anomaly flow detection method thereof are provided.Type: GrantFiled: December 21, 2020Date of Patent: December 27, 2022Assignee: National Taiwan UniversityInventors: Phone Lin, Xin-Xue Lin, En-Hau Yeh, Chia-Peng Lee, Char-Dir Chung
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Publication number: 20220401623Abstract: An intervertebral fusion device includes a structural ceramic body. The structural ceramic body has a bottom surface, a top surface, a peripheral surface connected between the bottom surface and the top surface, and at least one pore channel penetrating the bottom surface and the top surface. The inner surface of the pore channel is either a convex curved surface or a funnel-shaped surface. For the pore channel having the convex curved surface, the pore diameter of the pore channel gradually expands from the center of the pore channel to the top surface and the bottom surface. The pore diameter can also gradually expand from the bottom surface to the top surface. The peripheral surface of the structural ceramic body is wavy or zigzag.Type: ApplicationFiled: July 26, 2021Publication date: December 22, 2022Applicant: National Taiwan UniversityInventor: Wei-Hsing Tuan
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Patent number: 11532924Abstract: A distributed feedback (DFB) laser array includes a substrate, a semiconductor stacked structure, a first electrode layer, and a second electrode layer. The semiconductor stacked structure is formed above a surface of the substrate and includes two light-emitting modules and a tunnel junction. Each light-emitting module of the two light-emitting modules includes an active layer, a first cladding layer, and a second cladding layer. The active layer is installed between the first cladding layer and the second cladding layer, and the active layer has multiple lasing spots along a first direction, wherein the multiple lasing spots are used for generating multiple lasers. The tunnel junction is installed between the two light-emitting modules. The first electrode layer is formed above the semiconductor stacked structure. The second electrode layer is formed above another surface of the substrate.Type: GrantFiled: July 27, 2020Date of Patent: December 20, 2022Assignee: National Taiwan UniversityInventors: Chao-Hsin Wu, Chieh Lo
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Patent number: 11532923Abstract: A vertical-cavity surface emitting laser includes a substrate, a first reflector, an active region, an oxide layer, a second reflector, and a circular metal electrode. The first reflector is formed above the substrate. The active region is formed above the first reflector, and includes at least one quantum well. The at least one quantum well generates a laser beam with a plurality of modes. The oxide layer is formed above the active region and includes an oxide aperture. The second reflector is formed above the oxide layer. The circular metal electrode is formed in a circular concave in the second reflector. The circular metal electrode reflects other modes of the laser beam with the plurality of modes except for a fundamental mode and receive an operational voltage. A window exists between the circular concave and lets the laser beam with the fundamental mode pass.Type: GrantFiled: July 20, 2020Date of Patent: December 20, 2022Assignee: National Taiwan UniversityInventors: Chao-Hsin Wu, Szu-Yu Min, Hao-Tien Cheng
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Patent number: 11524472Abstract: A method of manufacturing an optical component having micro-structures is described. The method detects a crystallization temperature within a crystallization temperature interval for fully filling the molding material into a mold cavity to rapidly produce the optical element having a micro-structure with a large area.Type: GrantFiled: January 28, 2021Date of Patent: December 13, 2022Assignee: NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Chao-Chang Chen, Cheng-Fan Yu, Chang-Shun Lai, Chien-Yu Hou
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Patent number: 11520104Abstract: A robust conjugate symmetric optical apparatus is disclosed. The robust conjugate symmetric optical apparatus comprises a first optical cell set and a second optical cell set. The first optical cell set includes a first plurality of cells, each of which includes a first left half cell and a first right half cell, and the respective first right half cell and the corresponding first left half cells form a first symmetric structure therebetween.Type: GrantFiled: January 14, 2021Date of Patent: December 6, 2022Assignee: National Taiwan UniversityInventors: Wen-Jeng Hsueh, Yu-Chuan Lin, Shih-Han Chou
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Patent number: 11515334Abstract: A MOSFET structure including stacked vertically isolated MOSFETs and a method for forming the same are disclosed.Type: GrantFiled: August 14, 2020Date of Patent: November 29, 2022Assignee: NATIONAL TAIWAN UNIVERSITYInventors: Yu-Shiang Huang, Hung-Yu Yeh, Wen Hung Huang, Chee-Wee Liu
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Publication number: 20220370824Abstract: A light supply method and a light supply system for phototherapy are provided. The light supply method includes the following. A plurality of light emitting modules of a light source device are driven so that a light source device outputs a first light. The first light is sensed by a light sensing module. A light parameter corresponding to best physiology of a user is received. A light output ratio of the light emitting modules is adjusted based on the light parameter, thereby adjusting the first light to a second light. The light emitting modules respectively have different central wavelengths. A half-height width of a plurality of spectra of the light emitting modules is less than 30 nanometers.Type: ApplicationFiled: November 11, 2021Publication date: November 24, 2022Applicant: National Taiwan University of Science and TechnologyInventors: Chien-Yu Chen, Hung-Wei Chen
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Patent number: 11505529Abstract: A series of 8-phenyl-isoquinoline derivatives (I) exhibit high binding affinity to 5-HT7 receptor (5-HT7R) and demonstrate potent antinociceptive activity in two animal models for Irritable Bowel Syndrome (IBS) by intraperitoneal injection (i.p.) or by oral administration (p.o.). These 5-HT7 receptor antagonists are a new class of therapeutic agents for the treatment of IBS.Type: GrantFiled: March 2, 2018Date of Patent: November 22, 2022Assignee: NATIONAL TAIWAN UNIVERSITYInventor: Linda Chia-Hui Yu
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Patent number: 11508566Abstract: A use of an anthranilic acid derivative as a matrix for a MALDI Mass spectrometry, comprising: preparing a matrix compound represented by the following formula: wherein X is selected from hydrogen and a hydroxyl group, and Y is selected from hydrogen, a methyl group or an acetyl group, provided that when X is hydrogen, Y is hydrogen or an acetyl group, and when X is a hydroxyl group, Y is a methyl group; applying the matrix compound and an analyte onto a sample holder; and analyzing the analyte by the MALDI mass spectrometer.Type: GrantFiled: September 3, 2020Date of Patent: November 22, 2022Assignee: National Taiwan UniversityInventors: Cheng-Chih Hsu, Pi-Tai Chou, Chuping Lee, Peng-Hsuan Huang, Li-En Lin, Chun-Ying Huang, Ta-Chun Lin
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Patent number: 11496677Abstract: A signal control module integrated to a low coherence interferometry including a one-dimensional (1D) array image sensor is provided. The signal control module includes an image acquisition controller and a signal controller. The image acquisition controller sends a 1D image acquisition control signal. The signal controller sends a two-dimensional (2D) image acquisition control signal, wherein the 1D and 2D image acquisition control signals are synchronized with each other. The 1D array image sensor captures 1D image information of an object-to-be-tested at different positions along a direction according to the 1D and 2D image acquisition control signals. The 1D image information constitutes 2D image information. Furthermore, a low coherence interferometry is provided.Type: GrantFiled: September 15, 2020Date of Patent: November 8, 2022Assignee: National Taiwan UniversityInventors: Hsiang-Chieh Lee, Ting-Hao Chen, Ting-Yen Tsai, Chuan-Bor Chueh, Yu-Wei Chang, Ching-Yu Wang
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Patent number: RE49340Abstract: The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.Type: GrantFiled: May 2, 2019Date of Patent: December 20, 2022Assignees: National Taiwan University, National Yang Ming Chiao Tung University, National Health Research InstitutesInventors: Yufeng Jane Tseng, Yu-Li Liu, Chung-Ming Sun, Hai-Gwo Hwu, Chih-Min Liu, Wen-Sung Lai