Patents Assigned to National Taiwan University
  • Publication number: 20230030753
    Abstract: The present disclosure provides a method for detecting short-chain fatty acids in biological samples, including a derivatizing step, a loading step and a detecting step. The derivatizing step includes treating the short-chain fatty acids in the biological sample with 2-nitrophenylhydrazine for derivatizing the short-chain fatty acids into a sample to be detected. The loading step includes loading the sample onto a paper carrier. The detecting step includes analyzing the sample loaded onto the paper carrier by direct analysis in real time mass spectrometry for obtaining a detection result. The method provided by the present disclosure may complete the analysis of the biological sample within a short period of time and achieve a quantitative result comparable to that obtained by conventional chromatographic approaches.
    Type: Application
    Filed: January 21, 2022
    Publication date: February 2, 2023
    Applicant: National Taiwan University
    Inventors: Cheng-Chih HSU, Ting-Hao KUO, Cheng-Yu WENG, Laura Min Xuan CHAI, Hsin-Bai ZOU
  • Publication number: 20230028090
    Abstract: Provided is a method of using an aptamer for detecting a glycated hemoglobin in a whole blood, the method includes that the aptamer is provided, the aptamer includes a DNA sequence selected from the group consisting of derived sequences of SEQ ID NOs: 1, 2, 3, and 4, in which the derived sequences refer to that 3? end and/or 5? end of the derived sequences are modified, and the derived sequences have 90% identity to the SEQ ID NOs: 1, 2, 3, and 4. The aptamer and the whole blood are contacted. A concentration of a conjugate of the aptamer and the glycated hemoglobin is estimated. Provided also is a nanoelectronic aptasensor including the above aptamer.
    Type: Application
    Filed: July 21, 2021
    Publication date: January 26, 2023
    Applicant: National Taiwan University
    Inventor: Yit-Tsong Chen
  • Publication number: 20230010001
    Abstract: The present invention discloses a partially crosslinked hydrogels blended composition with enhanced viscosity and yield stress, which is formed by the polymerization of one or more colloid monomers through crosslinking. The polymerization is initiated by a photoinitiator under irradiation of the light of a specific wavelength, which promotes crosslinking of the one or more colloid monomers. The hydrogels blended composition can be further crosslinked with one or more other colloid monomers through repeated excitation of the photoinitiator. The hydrogels blended composition can be polymerized into a gel upon re-irradiation, and can also be used as a biomaterial for wound repair, three-dimensional cell culture, personal nursing care, health care, medical and pharmaceutical applications.
    Type: Application
    Filed: June 14, 2022
    Publication date: January 12, 2023
    Applicant: National Taiwan University
    Inventors: Po-Ling Kuo, Shih-Hao Fu
  • Patent number: 11552574
    Abstract: An interleaved three-phase Y-Delta connected power converter is provided. The interleaved three-phase Y-Delta connected power converter includes an input voltage source, an input capacitor, a first converter module, a second converter module, an output circuit, and a control circuit. The control circuit calculates a phase shift amount and an operating frequency through voltage and current feedbacks to generate a plurality of switch signal groups for controlling the first converter module and the second converter module, respectively.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: January 10, 2023
    Assignee: National Taiwan University of Science and Technology
    Inventors: Jing-Yuan Lin, Guan-Lin Chen, Kuan-Hung Chen, Yi-Feng Lin
  • Patent number: 11552716
    Abstract: An antenna measurement system includes an array of antennas, an array of reflectors, and a measurement surface. The array of antennas includes a plurality of antenna elements arranged in a straight line; any two adjacent antenna elements in the above antenna elements are separated by a predetermined distance, and each of the antenna elements in the above antenna elements has a radiator and a feed point. The array of reflectors includes at least one reflector and is arranged in a width direction or a height direction, and the array of reflectors is configured to generate a reflection signal according to a signal sent by the array of antennas. An antenna to be measured is configured to perform a measurement operation on the reflection signal on the measurement surface.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: January 10, 2023
    Assignee: National Taiwan University
    Inventors: Zhao He Lin, Hsi Tseng Chou, Chih Wei Chiu
  • Patent number: 11541551
    Abstract: A robotic arm comprising an operation end, a base, a sensor unit and a control unit is provided. The operation end is connected to the base, and the operation end is configured to reach an operational area. The sensor unit provides a sensor signal according to the force applied by or the motion of an operator. When the operation end reaches the operational area, the control unit sets a fixed position on the robotic arm between the base and the operation end. When the sensor signal from the operator fulfills a default condition, the control unit moves the robotic arm away from the operator, without moving the fixed position on the robotic arm.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: January 3, 2023
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Jia-Yush Yen, You-Ting Liao, Ching-Yuan Chen, Yen-Han Wang, Yung-Yaw Chen, Ming-Chih Ho
  • Patent number: 11546571
    Abstract: A method and a system for generating a multiview stereoscopic image are provided. The method includes the following steps. An image capturing apparatus captures a real calibration panel to obtain multiple images, and a processor obtains a datum image and multiple images to be calibrated by analyzing the images including the real calibration panel. The processor respectively calculates a homography matrix of each of the images to be calibrated corresponding to the datum image according to the datum image and the images to be calibrated. The processor obtains a calibration matrix of the homography matrix by performing a matrix disassembly calculation on each of the homography matrices. The processor multiplies the images to be calibrated by the corresponding calibration matrix to obtain multiple calibrated images. The processor outputs the multiview stereoscopic image including the datum image and the calibrated images.
    Type: Grant
    Filed: November 25, 2021
    Date of Patent: January 3, 2023
    Assignee: National Taiwan University of Science and Technology
    Inventor: Tzung-Han Lin
  • Patent number: 11545593
    Abstract: The subject disclosure provides a simple, fast, and high-yield method for encapsulating solar cells. This method can produce an encapsulation of solar cell(s) that is flat, bubble-free, lightweight, and flexible. In addition, it can also reduce equipment and material costs.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: January 3, 2023
    Assignee: National Taiwan University
    Inventor: Ching-Fuh Lin
  • Patent number: 11539620
    Abstract: An anomaly flow detection device and an anomaly flow detection method thereof are provided.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: December 27, 2022
    Assignee: National Taiwan University
    Inventors: Phone Lin, Xin-Xue Lin, En-Hau Yeh, Chia-Peng Lee, Char-Dir Chung
  • Publication number: 20220401623
    Abstract: An intervertebral fusion device includes a structural ceramic body. The structural ceramic body has a bottom surface, a top surface, a peripheral surface connected between the bottom surface and the top surface, and at least one pore channel penetrating the bottom surface and the top surface. The inner surface of the pore channel is either a convex curved surface or a funnel-shaped surface. For the pore channel having the convex curved surface, the pore diameter of the pore channel gradually expands from the center of the pore channel to the top surface and the bottom surface. The pore diameter can also gradually expand from the bottom surface to the top surface. The peripheral surface of the structural ceramic body is wavy or zigzag.
    Type: Application
    Filed: July 26, 2021
    Publication date: December 22, 2022
    Applicant: National Taiwan University
    Inventor: Wei-Hsing Tuan
  • Patent number: 11532924
    Abstract: A distributed feedback (DFB) laser array includes a substrate, a semiconductor stacked structure, a first electrode layer, and a second electrode layer. The semiconductor stacked structure is formed above a surface of the substrate and includes two light-emitting modules and a tunnel junction. Each light-emitting module of the two light-emitting modules includes an active layer, a first cladding layer, and a second cladding layer. The active layer is installed between the first cladding layer and the second cladding layer, and the active layer has multiple lasing spots along a first direction, wherein the multiple lasing spots are used for generating multiple lasers. The tunnel junction is installed between the two light-emitting modules. The first electrode layer is formed above the semiconductor stacked structure. The second electrode layer is formed above another surface of the substrate.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: December 20, 2022
    Assignee: National Taiwan University
    Inventors: Chao-Hsin Wu, Chieh Lo
  • Patent number: 11532923
    Abstract: A vertical-cavity surface emitting laser includes a substrate, a first reflector, an active region, an oxide layer, a second reflector, and a circular metal electrode. The first reflector is formed above the substrate. The active region is formed above the first reflector, and includes at least one quantum well. The at least one quantum well generates a laser beam with a plurality of modes. The oxide layer is formed above the active region and includes an oxide aperture. The second reflector is formed above the oxide layer. The circular metal electrode is formed in a circular concave in the second reflector. The circular metal electrode reflects other modes of the laser beam with the plurality of modes except for a fundamental mode and receive an operational voltage. A window exists between the circular concave and lets the laser beam with the fundamental mode pass.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: December 20, 2022
    Assignee: National Taiwan University
    Inventors: Chao-Hsin Wu, Szu-Yu Min, Hao-Tien Cheng
  • Patent number: 11524472
    Abstract: A method of manufacturing an optical component having micro-structures is described. The method detects a crystallization temperature within a crystallization temperature interval for fully filling the molding material into a mold cavity to rapidly produce the optical element having a micro-structure with a large area.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: December 13, 2022
    Assignee: NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chao-Chang Chen, Cheng-Fan Yu, Chang-Shun Lai, Chien-Yu Hou
  • Patent number: 11520104
    Abstract: A robust conjugate symmetric optical apparatus is disclosed. The robust conjugate symmetric optical apparatus comprises a first optical cell set and a second optical cell set. The first optical cell set includes a first plurality of cells, each of which includes a first left half cell and a first right half cell, and the respective first right half cell and the corresponding first left half cells form a first symmetric structure therebetween.
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: December 6, 2022
    Assignee: National Taiwan University
    Inventors: Wen-Jeng Hsueh, Yu-Chuan Lin, Shih-Han Chou
  • Patent number: 11515334
    Abstract: A MOSFET structure including stacked vertically isolated MOSFETs and a method for forming the same are disclosed.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: November 29, 2022
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventors: Yu-Shiang Huang, Hung-Yu Yeh, Wen Hung Huang, Chee-Wee Liu
  • Publication number: 20220370824
    Abstract: A light supply method and a light supply system for phototherapy are provided. The light supply method includes the following. A plurality of light emitting modules of a light source device are driven so that a light source device outputs a first light. The first light is sensed by a light sensing module. A light parameter corresponding to best physiology of a user is received. A light output ratio of the light emitting modules is adjusted based on the light parameter, thereby adjusting the first light to a second light. The light emitting modules respectively have different central wavelengths. A half-height width of a plurality of spectra of the light emitting modules is less than 30 nanometers.
    Type: Application
    Filed: November 11, 2021
    Publication date: November 24, 2022
    Applicant: National Taiwan University of Science and Technology
    Inventors: Chien-Yu Chen, Hung-Wei Chen
  • Patent number: 11505529
    Abstract: A series of 8-phenyl-isoquinoline derivatives (I) exhibit high binding affinity to 5-HT7 receptor (5-HT7R) and demonstrate potent antinociceptive activity in two animal models for Irritable Bowel Syndrome (IBS) by intraperitoneal injection (i.p.) or by oral administration (p.o.). These 5-HT7 receptor antagonists are a new class of therapeutic agents for the treatment of IBS.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: November 22, 2022
    Assignee: NATIONAL TAIWAN UNIVERSITY
    Inventor: Linda Chia-Hui Yu
  • Patent number: 11508566
    Abstract: A use of an anthranilic acid derivative as a matrix for a MALDI Mass spectrometry, comprising: preparing a matrix compound represented by the following formula: wherein X is selected from hydrogen and a hydroxyl group, and Y is selected from hydrogen, a methyl group or an acetyl group, provided that when X is hydrogen, Y is hydrogen or an acetyl group, and when X is a hydroxyl group, Y is a methyl group; applying the matrix compound and an analyte onto a sample holder; and analyzing the analyte by the MALDI mass spectrometer.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: November 22, 2022
    Assignee: National Taiwan University
    Inventors: Cheng-Chih Hsu, Pi-Tai Chou, Chuping Lee, Peng-Hsuan Huang, Li-En Lin, Chun-Ying Huang, Ta-Chun Lin
  • Patent number: 11496677
    Abstract: A signal control module integrated to a low coherence interferometry including a one-dimensional (1D) array image sensor is provided. The signal control module includes an image acquisition controller and a signal controller. The image acquisition controller sends a 1D image acquisition control signal. The signal controller sends a two-dimensional (2D) image acquisition control signal, wherein the 1D and 2D image acquisition control signals are synchronized with each other. The 1D array image sensor captures 1D image information of an object-to-be-tested at different positions along a direction according to the 1D and 2D image acquisition control signals. The 1D image information constitutes 2D image information. Furthermore, a low coherence interferometry is provided.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: November 8, 2022
    Assignee: National Taiwan University
    Inventors: Hsiang-Chieh Lee, Ting-Hao Chen, Ting-Yen Tsai, Chuan-Bor Chueh, Yu-Wei Chang, Ching-Yu Wang
  • Patent number: RE49340
    Abstract: The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: December 20, 2022
    Assignees: National Taiwan University, National Yang Ming Chiao Tung University, National Health Research Institutes
    Inventors: Yufeng Jane Tseng, Yu-Li Liu, Chung-Ming Sun, Hai-Gwo Hwu, Chih-Min Liu, Wen-Sung Lai