Patents Assigned to National University Corporation Kobe University
  • Patent number: 12258251
    Abstract: A cap attaching/detaching device 20 is a device for attaching or detaching a cap 141 in which a screw portion is formed to or from a test tube 14 by rotating the cap 141. A cap grip portion 21 grips the cap 141. A rotation mechanism 22 attaches or detaches the cap 141 to or from the test tube 14 by rotating the cap 141 by rotating the cap grip portion 21. The rotation mechanism 22 has an axial portion 221, and a nut portion 222. The axial portion 221 has an outer peripheral surface on which a screw thread 223 is formed. The nut portion 222 has an inner peripheral surface on which a screw groove 224 to be screwed into the screw thread 223 of the axial portion 221 is formed, and rotatably holds the axial portion 221 in a fixed state. A pitch of the screw thread 223 is the same as a pitch of the screw portion formed in the cap 141.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: March 25, 2025
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, SHIMADZU CORPORATION
    Inventors: Tsutomu Watanabe, Akari Oda, Tomohisa Hasunuma
  • Publication number: 20250091994
    Abstract: The object of the present invention is to provide a Ras/Raf binding inhibitory compound exhibiting a Ras/Raf signaling inhibitory action even against cancer cells bearing proved drug resistance and those with a variety of Ras mutations. The Ras/Raf binding inhibitory compound of the present invention is represented by the following formula (I) (wherein A, B, X, and R1 to R4 are as defined in the present description).
    Type: Application
    Filed: July 29, 2022
    Publication date: March 20, 2025
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Fumi SHIMA, Yoko YOSHIKAWA, Shigeyuki MATSUMOTO, Yoshiteru MAKINO, Hirokazu KUBOTA, Hitomi YUKI, Takashi KUMASAKA, Takashi KAWAMURA, Ko KIKUZATO
  • Patent number: 12239619
    Abstract: The object is to provide a method for inducing pili formation in bacterium of genus Bifidobacterium and a method for promoting intestinal colonization of the bacterium. 3-Phenylpropionic acid and/or 3-(4-hydroxyphenyl)propionic acid are an active ingredient of a composition for inducing the pili formation in the bacterium of genus Bifidobacterium and a composition for promoting the intestinal colonization of the bacterium.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: March 4, 2025
    Assignees: Morinaga Milk Industry Co., Ltd., National University Corporation Kobe University, The Kitasato Institute
    Inventors: Kanetada Shimizu, Ro Osawa, Keita Nishiyama, Nobuhiko Okada, Nobuhiro Koyama, Takao Mukai, Hiroshi Tomoda
  • Patent number: 12234321
    Abstract: The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently. A method for producing a polycarbonate is characterized in comprising the step of irradiating a light to a composition comprising a C1-4 halogenated hydrocarbon, the specific diol compound and the specific base in the presence of oxygen.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: February 25, 2025
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventor: Akihiko Tsuda
  • Patent number: 12202936
    Abstract: The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently. A method for producing a polycarbonate is characterized in comprising the step of irradiating a light to a composition comprising a C1-4 halogenated hydrocarbon, the specific diol compound and the specific base in the presence of oxygen.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: January 21, 2025
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventor: Akihiko Tsuda
  • Publication number: 20240410894
    Abstract: Provided is an artificial biological membrane containing a membrane protein retaining lateral diffusivity. Also provided is a method of producing an artificial biological membrane containing a membrane protein retaining lateral diffusivity. The artificial biological membrane is obtained by a method of producing an artificial biological membrane, the method including a step of partially laminating a polymer lipid membrane (b) on the surface of a substrate (a), followed by the lamination of a fluid lipid membrane (c) on the surface of the substrate (a), on which the polymer lipid membrane (b) is not laminated, together with a peptide nanodisc and a membrane protein (d). The membrane protein (d) is reconstituted in the produced artificial biological membrane at a high probability, and retains lateral diffusivity.
    Type: Application
    Filed: October 14, 2022
    Publication date: December 12, 2024
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Kenichi MORIGAKI, Fumio HAYASHI
  • Patent number: 12165744
    Abstract: A method for making a recombinant gene includes searching a database using a nucleotide sequence of a coding region, a nucleotide sequence that encodes an amino acid sequence, or an amino acid sequence, of a gene, for one or more nucleotide sequences having homology; selecting one or more nucleotide sequences other than nucleotide sequences only derived from a genome from the selected nucleotide sequences; for ones of the selected one or more nucleotide sequences comprising an upstream or downstream nucleotide sequence, analyzing whether the upstream or downstream nucleotide sequence is a functional sequence to select one or more first functional sequences; for ones of the selected one or more nucleotide sequences comprising no upstream or downstream nucleotide sequence, analyzing whether a gene information has any description indicating a functional sequence to select one or more second functional sequences; scoring the selected functional sequences; and selecting one or more functional sequences.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: December 10, 2024
    Assignees: Hitachi, Ltd., National University Corporation Kobe University, Kyoto University
    Inventors: Maiko Tanabe, Shizu Takeda, Kiyoto Ito, Osamu Imaichi, Kenji Tsuge, Michihiro Araki
  • Patent number: 12139730
    Abstract: The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal wherein at least a part of the amino acid residues is substituted by serine.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 12, 2024
    Assignee: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventor: Keiji Nishida
  • Publication number: 20240344075
    Abstract: The present invention provides a method for selecting a promoter that functions in an organelle, the method comprising: (1) the step of preparing sequence information obtained by RNA sequencing analysis; (2) the step of mapping the sequence information prepared in the step (1) onto a sequence of organellar DNA; (3) the step of calculating the amount of change in RNA expression in each region based on the mapping information obtained in the step (2); (4) the step of selecting regions in which the amount of change obtained in the step (3) is within a range of preset reference values; and (5) the step of identifying a region, among the regions selected, as a promoter functioning in an organelle.
    Type: Application
    Filed: June 12, 2024
    Publication date: October 17, 2024
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Kenta KATAYAMA, Keiji NISHIDA
  • Patent number: 12105159
    Abstract: An external field response distribution visualization device includes: an induction circuit that induces a first field component from each of induction positions; a sensor that senses a field strength at sensing positions for each of the induction positions; and an information processing circuit that generates an image showing an external field response distribution. The information processing circuit: calculates, using the sensing result as a boundary condition, an induction position dependent field function that takes an induction and sensing positions as inputs and outputs the field strength; calculates an imaging function that takes an imaging target position as an input and outputs an image intensity, and is defined based on the strength output from the induction position dependent field function in response to inputting the imaging target position; and generates the image based on the imaging function.
    Type: Grant
    Filed: November 27, 2020
    Date of Patent: October 1, 2024
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, Integral Geometry Science Inc.
    Inventors: Kenjiro Kimura, Yuki Mima, Shogo Suzuki, Noriaki Kimura
  • Patent number: 12105085
    Abstract: Provided is a convenient measurement system by which a target to be detected can be quickly recognized with high specificity. This base material for manufacturing a sensor for analyzing a detection target has: a base material; and a polymer film provided on the surface of the base material, wherein the polymer film has a concave that receives the detection target, and the concave has an antibody material bonding group and a signal material bonding group. A sensor for analyzing a detection target has: the base material for manufacturing a sensor for analyzing a detection target; an antibody material specific to the detection target and bonded to the antibody material bonding group; and a signal material that is bonded to the signal material bonding group.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: October 1, 2024
    Assignee: National University Corporation Kobe University
    Inventors: Toshifumi Takeuchi, Yukiya Kitayama, Hirobumi Sunayama
  • Publication number: 20240294660
    Abstract: An anti-SIRP? antibody that can be used as a tumor agent and an anti-tumor agent comprising the antibody as an active ingredient. An antibody that binds specifically to human SIRP? to inhibit binding of human SIRP? to CD47.
    Type: Application
    Filed: May 10, 2024
    Publication date: September 5, 2024
    Applicants: National University Corporation Kobe University, Daiichi Sankyo Company, Limited
    Inventors: Takashi Matozaki, Mayumi Sue, Kensuke Nakamura, Chigusa Yoshimura
  • Publication number: 20240285547
    Abstract: In one embodiment, the object of the present invention is to provide a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, and a method for reducing nephrotoxicity of the pharmaceutical composition. In one embodiment, the present invention relates to a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, wherein the nephrotoxicity reducing agent comprises a sugar alcohol and is used in an amount such that the concentration of the sugar alcohol in the pharmaceutical composition is 1 mg/ml to 400 mg/mL.
    Type: Application
    Filed: July 8, 2022
    Publication date: August 29, 2024
    Applicants: Nippon Shinyaku Co., Ltd., National University Corporation Kobe University
    Inventors: Satoru SONOKE, Kae FUJIWARA, Youhei SATOU, Tatsushi WAKAYAMA, Hirofumi MASUDA, Ryosuke SEKI, Takuma MATSUBARA, Yuki NUMAKURA, Kentaro OKAMOTO, Tatsushi TODA, Mariko IKEDA, Kazuhiro KOBAYASHI
  • Patent number: 12071624
    Abstract: The purpose of the present invention is to provide an antisense oligonucleotide that targets an ARL4C molecule and exerts an antitumor effect in vivo, and a nucleic acid drug using the antisense oligonucleotide. An antisense oligonucleotide that has a base sequence consisting of at least 10 consecutive bases contained in the base sequence represented by SEQ ID NO: 1. This antisense oligonucleotide targets an ARL4C molecule and thus can inhibit the expression of ARL4C in a tumor cell in vitro and suppress the migration and proliferation thereof. When systemically administered, moreover, the antisense oligonucleotide can exert an excellent antitumor effect in vivo too.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: August 27, 2024
    Assignees: Osaka University, National Institutes of Biomedical Innovation, Health and Nutrition, National University Corporation Kobe University
    Inventors: Akira Kikuchi, Shinji Matsumoto, Satoshi Obika, Yuya Kasahara, Takumi Fukumoto
  • Patent number: 12060312
    Abstract: The objective of the present invention is to provide a method for producing an isocyanate compound safely and efficiently. The method for producing an isocyanate compound according to the present invention is characterized in comprising the steps of irradiating a high energy light to a halogenated methane at a temperature of 15° C. or lower in the presence of oxygen, and further adding a primary amine compound to be reacted without irradiating a high energy light.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: August 13, 2024
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, AGC INC.
    Inventors: Akihiko Tsuda, Takashi Okazoe
  • Publication number: 20240254516
    Abstract: The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal wherein at least a part of the amino acid residues is substituted by serine
    Type: Application
    Filed: April 12, 2024
    Publication date: August 1, 2024
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventor: Keiji NISHIDA
  • Patent number: 12048548
    Abstract: A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: July 30, 2024
    Assignees: NIHON KOHDEN CORPORATION, NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE
    Inventors: Kunihiko Kiuchi, Takashi Ashihara, Kaori Uchiyama, Akio Ota, Naoki Koura, Koji Takizawa
  • Patent number: 12037430
    Abstract: The present invention provides a polymer replica of a target molecule, the polymer replica being capable of accurately inheriting surface information possessed by the target molecule in a molecular imprinting technique.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: July 16, 2024
    Assignees: National University Corporation Kobe University, Murata Manufacturing Co., Ltd.
    Inventors: Toshifumi Takeuchi, Hirobumi Sunayama, Eri Takano
  • Publication number: 20240229050
    Abstract: The invention provides a method for producing a plant cell modified at a targeted site of a double-stranded DNA, including (i) a step of providing a plant cell comprising the double-stranded DNA of interest, (ii) a step of providing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in the double-stranded DNA and a DNA glycosylase with sufficiently low reactivity with the double-stranded DNA are bound, (iii) a step of placing the complex in a condition under which the plant cell is transfected, (iv) a step of placing the transfected plant cell in a condition that induces modification of the targeted site, without cleaving at least one strand of the double-stranded DNA in the targeted site, and (v) a step of selecting a cell into which the complex has been introduced and/or a cell into which the modification has been introduced.
    Type: Application
    Filed: February 25, 2022
    Publication date: July 11, 2024
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Keiji NISHIDA, Zenpei SHIMATANI, Ushio FUJIKURA
  • Patent number: 12024566
    Abstract: An anti-SIRP? antibody that can be used as a tumor agent and an anti-tumor agent comprising the antibody as an active ingredient. An antibody that binds specifically to human SIRP? to inhibit binding of human SIRP? to CD47.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: July 2, 2024
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Takashi Matozaki, Mayumi Sue, Kensuke Nakamura, Chigusa Yoshimura