Abstract: A method for producing a medical immobilization device, including: obtaining medical image data of a site of a body of a patient; extracting an outer shape of the site from the obtained medical image data; preparing a block made of a material that allows radiation to pass through; obtaining basic shape data of the block; subtracting the extracted outer shape of the site from the basic shape data of the block, to thereby obtain data of a holder portion having such a shape to allow at least a region from a lower surface to both sides of the site of the body of the patient to be fitted therein with an entire surface of the region being in contact; and processing the block to thereby form the holder portion. The block includes multiple parts, and the data of the holder portion has multiple pieces each for a part thereof.

Abstract: Provided is a novel technique for providing a substrate advantageous when producing a sensor for analysis. The substrate for producing a sensor for analysis provided in the present disclosure has specific characteristics (for example, monodispersion, a single layer, or a specific density), such that it is possible to produce a sensor for analysis that is stable and enables highly accurate analysis. In the present disclosure, it is not required to remove excess fine particles after arranging the fine particles on the substrate, reproducibility of the density of the fine particles immobilized on the substrate is improved, and monodispersibility and single-layer properties are also improved.

Abstract: Provided is a thermoelectric generation module including a plurality of p-type thermoelectric elements 24a and a plurality of n-type thermoelectric elements 24b alternately connected in series and mounted with sandwiched by first and second flexible printed circuit boards 32, 33. The p-type thermoelectric elements and the n-type thermoelectric elements have a chip size of 1 mm or less and 0.2 mm or greater and a height of 0.8 mm or greater and 3 mm or less.

Abstract: A cap attaching/detaching device 20 is a device for attaching or detaching a cap 141 in which a screw portion is formed to or from a test tube 14 by rotating the cap 141. A cap grip portion 21 grips the cap 141. A rotation mechanism 22 attaches or detaches the cap 141 to or from the test tube 14 by rotating the cap 141 by rotating the cap grip portion 21. The rotation mechanism 22 has an axial portion 221, and a nut portion 222. The axial portion 221 has an outer peripheral surface on which a screw thread 223 is formed. The nut portion 222 has an inner peripheral surface on which a screw groove 224 to be screwed into the screw thread 223 of the axial portion 221 is formed, and rotatably holds the axial portion 221 in a fixed state. A pitch of the screw thread 223 is the same as a pitch of the screw portion formed in the cap 141.

Abstract: The object of the present invention is to provide a Ras/Raf binding inhibitory compound exhibiting a Ras/Raf signaling inhibitory action even against cancer cells bearing proved drug resistance and those with a variety of Ras mutations. The Ras/Raf binding inhibitory compound of the present invention is represented by the following formula (I) (wherein A, B, X, and R1 to R4 are as defined in the present description).

Abstract: The object is to provide a method for inducing pili formation in bacterium of genus Bifidobacterium and a method for promoting intestinal colonization of the bacterium. 3-Phenylpropionic acid and/or 3-(4-hydroxyphenyl)propionic acid are an active ingredient of a composition for inducing the pili formation in the bacterium of genus Bifidobacterium and a composition for promoting the intestinal colonization of the bacterium.

Abstract: The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently. A method for producing a polycarbonate is characterized in comprising the step of irradiating a light to a composition comprising a C1-4 halogenated hydrocarbon, the specific diol compound and the specific base in the presence of oxygen.

Abstract: The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently. A method for producing a polycarbonate is characterized in comprising the step of irradiating a light to a composition comprising a C1-4 halogenated hydrocarbon, the specific diol compound and the specific base in the presence of oxygen.

Abstract: Provided is an artificial biological membrane containing a membrane protein retaining lateral diffusivity. Also provided is a method of producing an artificial biological membrane containing a membrane protein retaining lateral diffusivity. The artificial biological membrane is obtained by a method of producing an artificial biological membrane, the method including a step of partially laminating a polymer lipid membrane (b) on the surface of a substrate (a), followed by the lamination of a fluid lipid membrane (c) on the surface of the substrate (a), on which the polymer lipid membrane (b) is not laminated, together with a peptide nanodisc and a membrane protein (d). The membrane protein (d) is reconstituted in the produced artificial biological membrane at a high probability, and retains lateral diffusivity.

Abstract: A method for making a recombinant gene includes searching a database using a nucleotide sequence of a coding region, a nucleotide sequence that encodes an amino acid sequence, or an amino acid sequence, of a gene, for one or more nucleotide sequences having homology; selecting one or more nucleotide sequences other than nucleotide sequences only derived from a genome from the selected nucleotide sequences; for ones of the selected one or more nucleotide sequences comprising an upstream or downstream nucleotide sequence, analyzing whether the upstream or downstream nucleotide sequence is a functional sequence to select one or more first functional sequences; for ones of the selected one or more nucleotide sequences comprising no upstream or downstream nucleotide sequence, analyzing whether a gene information has any description indicating a functional sequence to select one or more second functional sequences; scoring the selected functional sequences; and selecting one or more functional sequences.

Abstract: The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal wherein at least a part of the amino acid residues is substituted by serine.

Abstract: The present invention provides a method for selecting a promoter that functions in an organelle, the method comprising: (1) the step of preparing sequence information obtained by RNA sequencing analysis; (2) the step of mapping the sequence information prepared in the step (1) onto a sequence of organellar DNA; (3) the step of calculating the amount of change in RNA expression in each region based on the mapping information obtained in the step (2); (4) the step of selecting regions in which the amount of change obtained in the step (3) is within a range of preset reference values; and (5) the step of identifying a region, among the regions selected, as a promoter functioning in an organelle.

Abstract: An external field response distribution visualization device includes: an induction circuit that induces a first field component from each of induction positions; a sensor that senses a field strength at sensing positions for each of the induction positions; and an information processing circuit that generates an image showing an external field response distribution. The information processing circuit: calculates, using the sensing result as a boundary condition, an induction position dependent field function that takes an induction and sensing positions as inputs and outputs the field strength; calculates an imaging function that takes an imaging target position as an input and outputs an image intensity, and is defined based on the strength output from the induction position dependent field function in response to inputting the imaging target position; and generates the image based on the imaging function.

Abstract: Provided is a convenient measurement system by which a target to be detected can be quickly recognized with high specificity. This base material for manufacturing a sensor for analyzing a detection target has: a base material; and a polymer film provided on the surface of the base material, wherein the polymer film has a concave that receives the detection target, and the concave has an antibody material bonding group and a signal material bonding group. A sensor for analyzing a detection target has: the base material for manufacturing a sensor for analyzing a detection target; an antibody material specific to the detection target and bonded to the antibody material bonding group; and a signal material that is bonded to the signal material bonding group.

Abstract: An anti-SIRP? antibody that can be used as a tumor agent and an anti-tumor agent comprising the antibody as an active ingredient. An antibody that binds specifically to human SIRP? to inhibit binding of human SIRP? to CD47.

Abstract: In one embodiment, the object of the present invention is to provide a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, and a method for reducing nephrotoxicity of the pharmaceutical composition. In one embodiment, the present invention relates to a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, wherein the nephrotoxicity reducing agent comprises a sugar alcohol and is used in an amount such that the concentration of the sugar alcohol in the pharmaceutical composition is 1 mg/ml to 400 mg/mL.

Abstract: The purpose of the present invention is to provide an antisense oligonucleotide that targets an ARL4C molecule and exerts an antitumor effect in vivo, and a nucleic acid drug using the antisense oligonucleotide. An antisense oligonucleotide that has a base sequence consisting of at least 10 consecutive bases contained in the base sequence represented by SEQ ID NO: 1. This antisense oligonucleotide targets an ARL4C molecule and thus can inhibit the expression of ARL4C in a tumor cell in vitro and suppress the migration and proliferation thereof. When systemically administered, moreover, the antisense oligonucleotide can exert an excellent antitumor effect in vivo too.

Abstract: The objective of the present invention is to provide a method for producing an isocyanate compound safely and efficiently. The method for producing an isocyanate compound according to the present invention is characterized in comprising the steps of irradiating a high energy light to a halogenated methane at a temperature of 15° C. or lower in the presence of oxygen, and further adding a primary amine compound to be reacted without irradiating a high energy light.

Abstract: The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal wherein at least a part of the amino acid residues is substituted by serine

Abstract: A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.