Abstract: It is an object to provide a combination therapy effective in cancer immunotherapy. The object is achieved by providing an anti-tumor agent, including a transformed Bifidobacterium containing DNA encoding a WT1 protein and DNA encoding a GNB/LNB substrate-binding membrane protein derived from a Bifidobacterium, the transformed Bifidobacterium being designed to display the WT1 protein as an antigen on a surface of the transformed Bifidobacterium, the anti-tumor agent being for use in combination with an immunosuppression inhibitor. The transformed Bifidobacterium can be used as an oral tumor vaccine.

Abstract: In the design of a mechanical component for a mechanical device driven by a feedback controlled electric motor, the user is enabled to easily know how the properties of mechanical component affect the generation of abnormal vibrations of the mechanical device. In a design assist apparatus (1), the processor (11) is configured to set a plurality of parameters of a mathematical model of an analysis target component selected from one or more mechanical components (24, 56, 58) forming the mechanical device, compute a pole of a transfer function of the mechanical device associated with one or more vibration modes of the mechanical device according to the parameters, and create a stability determination diagram including an isoline of a real part of the pole of the transfer function.

Abstract: The present invention provides an organelle transformant screening method. More specifically, the present invention provides an organelle transformant screening method utilizing inhibition of a lipid synthetic pathway.

Abstract: A method for producing a hollow fine particulate containing a fluorine-containing resin and having a large average particle size. The method includes dispersing a solution containing a fluorine-containing monomer, a phase separation promoter, and a non-polymerizable solvent into water to provide a dispersion, and polymerizing the fluorine-containing monomer to provide a hollow fine particulate containing a fluorine-containing resin.

Abstract: The present invention addresses the problem of providing a novel method which is for preparing a DNA fragment for microbial cell transformation, and by which the combinatorial library of a long-chain DNA can be efficiently constructed and confirmation of the genotype of the obtained clone is facilitated.

Abstract: A draw solute for forward osmosis membrane process, comprising an addition polymer obtained by addition polymerization of an alkylene oxide having 2 to 10 carbon atoms to an amine compound.

Abstract: An embodiment of the present invention is to provide a bioabsorbable medical material having adhesiveness to a biological tissue and improved degradability. A bioabsorbable medical material according to an embodiment of the present invention contains a crosslinked polymer material forming a specific shape, and a disintegration delaying material retained by the crosslinked polymer material. The crosslinked polymer material has degradability in water, the degradability being suppressed in the presence of an acid. The disintegration delaying material releases 0.5 mol%/day or greater of an acid until the seventh day upon contact with water at 37° C.

Abstract: An organic fine particle comprising a core polymer and a shell polymer. The core polymer has a Tg or a melting point of 15° C. or more, the core polymer has a water contact angle of 100° or more, all monofunctional monomers constituting the core polymer are a hydrophobic core monomer of which homopolymer has a water contact angle of 100° or more, the shell polymer has a Tg or a melting point lower than Tg or the melting point of the core polymer, the shell polymer has a water contact angle of less than 100°, and all monofunctional monomers constituting the shell polymer are a water-insoluble shell monomer of which homopolymer is water-insoluble. Also disclosed is a surface coating structure including the organic fine particle and a water-repellant composition including a dispersion of the organic fine particle.

Abstract: The balloon catheter of the present invention is provided with a balloon base at a front end of a tubular catheter body having a predetermined length. The balloon base includes a cylindrical base having a larger diameter than an outer diameter of the catheter body, and a lumen having substantially the same diameter as the outer diameter of the catheter body is formed on the base over an entire length with both ends opened. A central axis of the lumen is inclined at a predetermined angle with respect to a central axis of the base concentric with a central axis of the catheter body, and an outer peripheral surface is formed in parallel with the central axis of the base. The balloon is provided on the outer peripheral surface of the parallel base to obliquely inflate with respect to the central axis of the catheter body during inflation.

Abstract: The objective of the present invention is to provide a composite separation membrane which is excellent in not only a liquid permeable performance and a separation performance relatively but also a durability and which is particularly useful as a membrane for liquid treatment, and a method for treating a liquid by using the composite separation membrane. The composite separation membrane according to the present invention is characterized in comprising a supporting base material and a complex layer, wherein the complex layer is placed on the supporting base material, the complex layer comprises oxidized metal nanosheets, graphene oxide and an alkanolamine, and at least one of the alkanolamine is present between the oxidized metal nanosheets.

Abstract: Provided is a novel cancer gene therapeutic means. More specifically, provided is a nucleic acid having a structure in which (A) a nucleic acid encoding a protein having a CD44 extracellular function, (B) a nucleic acid encoding a protein having a Notch core region function, and (C) a nucleic acid encoding a protein having an HIF-3?4 function are linked in the order of (A)-(B)-(C).

Abstract: The present disclosure addresses the problem of providing at least a composition for suppressing obesity and the problem is solved by a composition for suppressing obesity comprising a prenylflavonoid represented by general formula (1), as an active ingredient, below.

Abstract: An object of the present invention is to provide a phosphorus adsorbent that is inexpensive and can exert high phosphorus adsorption performance. The present invention relates to a phosphorus adsorbent comprising incinerator ash, cement, and lanthanum.

Abstract: One or more embodiments of the present invention are to provide a new means of improving the productivity of a target protein. The present inventors have identified a novel protein consisting of the amino acid sequence set forth in SEQ ID NO: 2 through an exhaustive analysis of the nucleotide sequence of chromosomal DNA of a yeast belonging to the genus Komagataella. Activation of a gene encoding the novel protein provides a cell having an improved productivity of a target protein.

Abstract: The purpose of the present invention is to provide a spinal fusion implant capable of preserving turning properties of vertebral bodies, and in addition, capable of preventing false screwing (false insertion) of screws. Connection plates 3 constituting a spinal fusion implant 101 each have, on a ventral-side surface 3b, a convex-shaped portion 8 that is fitted into a concave-shaped portion of an intervertebral joint 53. In addition, a center hole 3d through which a center rod 4 is slidably inserted is formed on a side surface of the connection plate 3, such that the center of the hole is positioned closer to the back side than a virtual line L1 connecting midpoints on arc-shaped contour lines C of the concave-shaped portions of the adjacent intervertebral joints 53 when viewed from the head side of a human body.

Abstract: One objective of the present invention is to provide a novel simple and efficient transformation method for gram-positive bacteria, the transformation method being capable of introducing a large-sized DNA into a host DNA of the gram-positive bacteria without damage. In addition, another objective of the present invention is to provide a method in which desired DNA segments are accumulated in a chromosome of a recipient (recipient bacteria) to enable an artificially designed huge DNA to be constructed, and in which a transformed cell does not cause any problems in terms of controlling the natural environment. The present invention relates to a transformation method for gram-positive bacteria by conjugative transfer, characterized to use a helper plasmid having an origin of DNA transfer (oriT) region is inactivated. Preferably, the helper plasmid is a plasmid in which an oriT region is inactivated from pLS20cat.

Abstract: A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.

Abstract: The objective of the present invention is to provide a method for producing a halogenated carbonyl safely and efficiently. The method for producing a halogenated carbonyl according to the present invention is characterized in comprising the step of applying ultrasound to a composition containing a C1-4 halogenated hydrocarbon having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen to decompose the C1-4 halogenated hydrocarbon.

Abstract: Provided is a measurement device including an application unit, a detection unit, and a calculation unit. The application unit applies a first magnetic field, which is generated by applying a pulse current to a coil or applying currents with a plurality of frequencies to the coil in order, to an object. The detection unit detects a second magnetic field which is generated by applying the first magnetic field to the object. The calculation unit calculates a distribution of a magnetic field source m in the second magnetic field. The calculation unit may further generate an imaging signal for displaying the calculated distribution of the magnetic field source m, as an image. The display unit displays the image indicating the distribution of the magnetic field source m by using the imaging signal.

Abstract: The present invention provides an odorant composition having good palatability allowing peoples to feel comfortable using a small number of chemical compounds. An odorant composition according to an embodiment of the present invention consists of: when the total mass of ingredients contained in the odorant composition is 100.0% by mass, 40.0% by mass or more and 97.5% by mass or less of an ingredient (A) composed of aldehydes; 1.0% by mass or more and 20.0% by mass or less of an ingredient (B) composed of a ketone(s); and the balance being an ingredient (C) composed of a chemical compound(s) other than the ingredient (A) and the ingredient (B). The aldehydes of the ingredient (A) are: an essential ingredient (A1) composed of nonanal; and an optional ingredient (A2) selected from the group consisting of decanal, heptanal, octanal, benzaldehyde, undecanal, hexanal, and combinations thereof.