Abstract: A training method for similarity measurement and a measuring apparatus for similarity measurement and operating method thereof are provided. A method, performed by a computing device, includes: based on a first training parameter, embedding vectors of first processes included in a first process-sequence and embedding vectors of second processes included in a second process-sequence, respectively; based on a second training parameter, mapping first embedding vectors respectively corresponding to the first processes to second embedding vectors respectively corresponding to the second processes; and based on a result of the mapping, determining a similarity score indicating a similarity between the first process-sequence and the second process-sequence.

Abstract: A method of quantifying sodium concentration can include extracting one or more bi-T2 sodium signals from one or more echo time acquisitions. The method can include separating, via a matrix equation including at least one of T2 decays or T2* decays of mono-T2 sodium and bi-T2 sodium, an intensity of the one or more bi-T2 sodium signals from an intensity of one or more mono-T2 sodium signals. The method can include quantifying bi-T2 sodium concentration, mono-T2 sodium concentration, and total sodium concentration based on the one or more echo time acquisitions. The one or more echo time acquisitions can be performed with single-quantum sodium excitations.

Abstract: Provided are peptoid-peptide macrocycles. The peptoid-peptide macrocycles may have inhibitory activity towards the Wnt signaling pathway. The Wnt signaling pathway is associated with cancer and other diseases and conditions. Such diseases include, for example, pulmonary fibrosis. Also described are methods of making the peptoid-peptide macrocycles, compositions containing the peptoid-peptide macrocycles, and methods of using the peptoid-peptide macrocycles.

Abstract: Exemplary systems, methods and computer-accessible medium according to the exemplary embodiments of the present disclosure are provided for determining bias in at least one large language model (LLMs). Thus, exemplary systems, methods, and computer-accessible medium can receive a plurality of baseline resumes, create or generate a plurality of flagged resumes from the plurality of baseline resumes, create or generate a resume corpus from the plurality of baseline resumes and the plurality of flagged resumes, input the resume corpus into the LLM, receive an LLM classification output for the resume corpus, and measure a LLM bias based on the classification output.

Abstract: A system includes an eye tracker having a camera, the eye tracker being configured and arranged to track an eye movement of a subject, and a processor in communication with the eye tracker, the processor being configured and arranged to create a dataset of the eye movement, generate a plot of the dataset, the plot reflecting a timecourse of eye position versus time, and identify one or more streaking vertical lines in the plot to indicate a deficit in a cranial nerve function.

Abstract: Embodiments of recombinant HIV-1 gp120 proteins that contain a V1 deletion are disclosed. Also provided are gp140, gp145, and gp160 proteins containing the V1 deletion, as well as HIV-1 Env ectodomain trimers containing protomers containing the V1 deletion. Nucleic acid molecules encoding these proteins are also provided. In several embodiments, the disclosed recombinant HIV-1 proteins and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

Abstract: A processing technique for creating nanowires and hierarchically porous micro/nano structures of ceramic materials is provided. The process includes evaporation of micron-sized water droplets containing dissolved organic salts on heated substrates followed by thermal decomposition of the deposited material. The micron-sized droplets may be generated by supercritical CO2 assisted nebulization, in which high-pressure streams of aqueous solution and supercritical CO2 are mixed, followed by controlled depressurization through a fine capillary. Rapid evaporation takes place on the heated substrates and structures are generated due to CO2 effervescence from the droplets and evaporation of water, along with the pinning of the three phase contact line. Depending on the mass deposited, a mesh of nano-wires or membrane-like structures may result. Sintering of the membrane-like scaffolds above the decomposition temperature of the organic salt creates nanopores within the structures, creating a dual hierarchy of pores.

Abstract: A method of treating a patient includes tracking eye pupil movement of at least one of a first eye and a second eye of the patient using a device suitable for tracking eye pupil movement, analyzing eye pupil movement of the at least one of the first eye and the second eye of the patient using a computer in electronic communication with the device suitable for tracking eye pupil movement, generating a plot that reflects a trajectory traveled of each of the at least one of the first eye and the second eye in response to a visual stimuli, comparing eye pupil movement of the at least one of the first eye and the second eye of the patient to a normal or mean eye pupil movement, and calculating a plurality of velocities.

Abstract: Systems and methods for continuously estimating interoceptive awareness. An eye tracker device collects eye-tracking data comprising pupillometry measurements and gaze measurements. A computer system processes the eye-tracking data, with an extraction module and an interoceptive awareness state estimator to produce an estimated interoceptive awareness state shown on a display of the computer system.

Abstract: This application relates to methods for overcoming or preventing resistance of a KRAS mutant cancer cell to a growth inhibition and/or cell death induction by a KRAS inhibitor or a SHP2 inhibitor, as well as to methods for enhancing sensitivity of a KRAS mutant cancer cell to a KRAS inhibitor or a SHP2 inhibitor. The application further relates to methods of treating a KRAS mutant cancer in a subject, the method comprising administering to the subject an effective amount of a KRAS inhibitor or a SHP2 inhibitor and an inhibitor of expression or function or a degrader or a binding partner of one or more of various proteins described herein. Related pharmaceutical compositions and kits are also disclosed.

Abstract: The present disclosure provides methods of treating an inflammatory skin disease (e.g., psoriasis) in a subject by administering an inhibitor of Hypoxia Inducible Factor 1? (HIF1?) or an inhibitor of glucose transporter 1 (Glut1). The present disclosure also provides topical formulations comprising an inhibitor of HIF1? or an inhibitor of Glut1.

Abstract: A method of manufacturing a microfluidic analytical device comprising providing a top lamination layer and a bottom lamination layer, wherein each of the top lamination layer and bottom lamination layer comprises an outer layer and an inner layer, cutting out one or more channel spaces from the at least one of the top lamination layer and the bottom lamination layer, wherein the one or more channel spaces form a microfluidic path, positioning at least one middle layer between the top lamination layer and the bottom lamination layer, such that each of the two inner layers face the at least one middle layer, and subjecting the top lamination layer and the bottom lamination layer to a process, wherein the process allows both the inner layers to permeate substantially through the at least one middle layer.

Abstract: The invention relates to methods for simultaneously measuring transcription, chromatin accessibility, surface markers, and immune receptor sequence of a biological sample at the single-cell level, comprising one or more cells.

Abstract: Exemplary apparatus can be provided that can comprise a plurality of antennas; a plurality of conversion systems, each capable of accepting and/or producing one or more digital signals; a circuit (e.g., radio circuit) configured to couple the antennas to the conversion systems; and computer arrangement configurable to selectively control operation of the conversion systems according to one or more predetermined criteria. In some embodiments, the conversion systems can be configured to utilize different sampling rates and/or quantization resolutions and/or to accept and/or produce different numbers of digital signals. Exemplary conversion systems can be enabled/disabled such that one or more can operate simultaneously based on, e.g., subframe timing of received signal, predetermined schedule, power or energy of s, availability of reference signals, channel coherence time, and apparatus energy consumption.

Abstract: The present disclosure is related to systems and methods to be used as aids in the diagnosis of risk for oral cancer, potentially malignant oral lesion (PMOL), and/or oral epithelial dysplasia (OED) by identifying cellular phenotype characteristics of cell samples, including percentage of mature squamous cells, presence or absence of nuclear actin in mature squamous cells, percentage of non-mature squamous cells, percentage of small round cells, percentage of white blood cells, and percentage of lone nuclei.

Abstract: A method for detecting, diagnosing or screening for cognitive impairment in a subject includes a) positioning the subject in front of a screen, b) displaying a video to the subject on the screen, the video including a target that moves around a predefined closed perimeter of the screen, the target forming at least one revolution on the screen around the closed perimeter, c) tracking eye movement of at least one eye of the subject as the subject watches the video, d) analyzing eye movement of at least one eye of the subject, e) calculating a statistical test for eye movement of at least one eye of the subject as compared to a normal or mean eye movement, f) detecting, diagnosing or screening for an impairment based on the calculated statistical test, and g) providing a suitable clinical intervention based on the calculated statistical test.

Abstract: Disclosed herein are modified soluble ?-Klotho proteins and isolated fragments of wildtype soluble ?-Klotho protein. Also disclosed are pharmaceutical compositions including the modified soluble ?-Klotho proteins and/or isolated fragments of soluble ?-Klotho protein and methods of their use in treating a subject.

Abstract: This application relates to isolated antibodies, or antigen-binding fragments thereof, that bind to at least one isoform of cluster of differentiation 97 (CD97), also known as adhesion G protein-coupled receptor E5 (ADGRE5), antibody-drug conjugates comprising such antibodies or antigen-binding fragments, as well as polynucleotides and vectors that encode for such antibodies or antigen-binding fragments. This application further relates to methods of producing the antibodies or antigen-binding fragments and using the antibodies or antigen-binding fragments for treatment of diseases.

Abstract: Described is a system including an air pressure supply arrangement, a sensor and a titration device. The air pressure supply arrangement provides air pressure to a patient's airways. The sensor detects input data corresponding to a patient's breathing patterns of a plurality of breaths. The titration device receives and analyzes the input data to determine existence of breathing disorder and corresponding characteristics. The titration device generates output data for adjusting the air pressure supplied to the patient as a function of an index of abnormal respiratory events included in the input data.

Abstract: Provided are compositions and methods for making a diploid yeast having heterozygosity for at least one chromosome. The method includes mating haploid yeast having at least a first modified chromosome comprising a synthetic chromosome suitable for recombination-site-mediated evolution (as a SCRaMbLE-ready modification). The SCRaMbLE-ready modification includes introduced site-specific recombinase recognition sites that can be recognized by a recombinase. Yeast that have at least one SCRaMbLE-ready modification of a chromosome are mated with a haploid yeast devoid of the SCRaMbLE-ready modification to obtain diploid SCRaMbLE-ready yeast. Subsequent to mating the haploid SCRaMbLE-ready yeast to yeast devoid of the SCRaMbLE-ready modification the method includes using the recombinase to recombine the first modified chromosome to obtain heterozygous diploid yeast comprising at least one recombined (SCRaMbLEd) chromosome and a homologous non-SCRaMbLEd chromosome.