Abstract: The invention is directed to the use of carbonic anhydrase inhibitors for treatment of neurological and psychiatric disorders.

Abstract: The goal of detecting modifications, such as unauthorized modifications for example, of the code and/or behavior of an embedded device (e.g., unexpected/unauthorized remote reprogramming, re-flashing), changes to code at run-time (e.g.

Abstract: The present disclosure is directed to staphylococcal leukotoxin and hemolysin binding molecules and fusion constructs. The present disclosure is further directed to methods of treating, preventing, and diagnosing staphylococcal infection in a subject using the binding molecules and fusion constructs described herein.

Abstract: Aspects of the subject disclosure may include, for example, a wireless framework for delivering TV services. The wireless framework can include a mix of wireless access technologies (e.g. Satellite, WiFi and/or LTE overlay links). One or more aspects of the subject disclosure include injecting TV content into the network at a few locations (e.g., residential locations) using satellite antennas (e.g., satellite dishes). The content is then further distributed to other homes using a house-to-house WiFi network and/or via an overlay LTE network. Other embodiments are disclosed.

Abstract: A generative adversarial network including a generator portion and a discriminator portion is constructed. The network is configured such that the network operates to enhance intensity images, wherein an intensity image is obtained by illuminating an object with an energy pulse and measuring the return strength of the energy pulse, and wherein a pixel of the intensity image corresponds to the return strength. As a part of the configuring, a loss function of the generative adversarial network is minimized, the loss function comprising a mean square error loss measurement of a noisy intensity image relative to a mean square error loss measurement of a corresponding clean intensity image. An enhanced intensity image is generated by applying the minimized loss function of the network to an original intensity image, the applying improving an image quality measurement of the enhanced intensity image relative to the original intensity image.

Abstract: Provided are approaches to improving CRISPR-based DNA editing by performing the editing in cells in which pol ? (“POLQ”) enzyme and/or its function is reduced. Approaches are provided that are applicable to Cas9 nuclease and Cas9 nickase CRISPR editing. Also provided are kits that can contain a polynucleotide encoding a Cas9 and an agent for use in inhibiting POLQ, and/or or an expression vector configured for expressing a mutation template for use in CRISPR chromosome editing and an agent for use in inhibiting POLQ.

Abstract: The present invention relates to devices and methods for balancing joints, including knee joints. The devices convert unequal forces at a joint to a rotation or displacement of a pointer or gauge. The devices are able to display the relative difference in force between the lateral and medial sides of a joint from flexion to extension. In certain aspects, the devices are useful for balancing the knee during total knee surgery. The devices can be inserted between the trial femoral and tibial components of the knee and measures whether one condyle experiences more force than the other.

Abstract: A method of preventing or inhibiting L-cystine crystallization is disclosed, using the compounds of formula I: R1a—[O]v-(-A-L-)m-A-[O]v—R1b?? I wherein A, L, R1a, R1b, m, and v are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to L-cystine crystallization, such as comprising (but not limited to) kidney stones.

Abstract: The present invention relates to a polymeric nanoparticle conjugate of formula (I). The present invention also relates to pharmaceutical compositions including these polymeric nanoparticle conjugates, and methods of preparation and use thereof.

Abstract: The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample. The present invention further relates to methods of preventing and treating relapse leukemia in a subject based on the determined prognosis of the subject.

Abstract: Amino, amido, and heterocyclic compounds are disclosed. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

Abstract: Disclosed herein are internal standard compositions, a plurality of calibration standards, and one or more kits for use with mass spectrometry, particularly for use with an inductively coupled plasma mass spectrometer capable of simultaneous detection of a large number of ionization products over a large range of masses. Methods of using these reagent materials for the simultaneously detection of absolute concentrations of a plurality of elements in a liquid sample.

Abstract: An exemplary system, method and computer-accessible medium for determining a starting point of a header field(s) in a network packet(s) can be provided, which can include, for example receiving the network(s) packet, determining a header location of the header field(s) in the network packet(s), determining a delimiter location of a delimiter(s) in the network packet(s), and determining the starting point of the header field(s) based on the header and delimiter locations. The header location can be determined using a header finder module. The delimiter location can be determined using a delimiter finder module. The header and delimiter locations can be determined using a plurality of comparators arranged into a plurality of sets.

Abstract: A mixed reality headset for a participant of a synchronized shared mixed reality for co-located participants. A system for a synchronized shared mixed reality for co-located participants of an audience in an auditorium. The system includes a plurality of mixed reality headsets. Each headset has a display screen on which a display image is displayed in synchronization with all display screens of the plurality of headsets, and a sensor which receives a location signal to determine a position and orientation of the participant which is used to generate the display image is displayed and a receiver. The system includes a synchronizer which produces the synchronization signal that is received by the receiver of each headset.

Abstract: The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and/or fibrillation of amyloidogenic peptides such as amyloid beta peptide (Abeta or A?).

Abstract: The present invention provides a facile method for separation (fractionation) of HA in a sample over a broad M range, including low M HA, by ion exchange (IEX) chromatography. The present invention also provides an assay method for quantifying in a sample the presence of low M HA in total HA isolated from a biological source. The method involves HA fractionation according to M by use of IEX separation, followed by HA-specific assay of HA size range fractions.

Abstract: In a magnetic resonance (MR) apparatus, and model-based method, for identifying a nuclear spin-dependent attribute of a subject, MR signals are acquired in multiple repetitions of an MR data acquisition sequence that is changed from repetition-to-repetition so as to deliberately encode effects of magnetization transfer between nuclear spins into the acquired MR signals. A model is generated, composed of at least two molecule pools, in which a single magnetization transfer parameter is used that is derived from the MR signals in which the magnetization transfer is encoded. A nuclear spin-dependent attribute of the subject is then identified, by comparing at least one MR signal evolution from the subject to at least one signal evolution produced by the model.

Abstract: The present invention relates to the use of NS1/2 region of murine norovirus MNV or a corresponding region from a member of the Caliciviridae family or a protein encoded by any one of those regions, for treating dysbiosis, immune system dysregulation and various disorders, as well as for enhancing mucosal integrity and stimulating IFN-induced genes.

Abstract: A method of probing the layers above, at, and below the surface of a conducting region includes exciting nuclear or electronic spins within the conducting region using a first frequency, receiving a second frequency from the conducting region, determining the length scales by the conductivity of the conducting region, the first frequency, and the second frequency, obtaining a depth profile of the conducting region, and indirectly measuring the presence of the surface by characterizing signal distortions above the surface.

Abstract: An apparatus for creating movement in a virtual reality for a user includes a computer includes a virtual reality headset in communication with the computer that is worn on the head of the user so the user sees the virtual reality shown by the headset and produced by the computer in the headset. The apparatus includes a foot controller in communication with the computer against which the user moves at least one of his feet to create control signals with the foot to cause movement in the virtual reality. A method for creating movement in a virtual reality for a user having the steps of the user seeing the virtual reality shown by a virtual headset and produced by a computer in the headset, a virtual reality headset in communication with the computer that is worn on the head of the user.