Patents Assigned to New York University
  • Patent number: 11124479
    Abstract: The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and/or fibrillation of amyloidogenic peptides such as islet amyloid polypeptide (IAPP).
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: September 21, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Andrew D. Hamilton, Sunil Kumar
  • Publication number: 20210285835
    Abstract: A sensor having a layer and one or more sensing elements which sense shear force and compressive force on the layer. The sensor having a computer in communication with the one or more sensing elements which causes prompting signals to be sent to the one or more sensing elements and reconstructs shear force and compressive force on the layer from data signals received from the one or more sensing elements. A method for sensing forces. A method for producing a sensor.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 16, 2021
    Applicants: New York University, Tactonic Technologies, LLC
    Inventors: Kenneth Perlin, Charles Hendee
  • Patent number: 11119169
    Abstract: System and methods that reconstruct absolute temperature using a multi-nuclear approach. Specifically, the methods and systems utilize independent NMR/MRI information provided by the precession frequency of two different nuclei to reconstruct a map of the absolute temperature.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: September 14, 2021
    Assignee: New York University
    Inventors: Leeor Alon, Guillaume Madelin, Emilia Silletta, Alexej Jerschow
  • Patent number: 11110122
    Abstract: The present invention is directed to methods of inducing a phenotypic change in a population of monocytes and/or macrophages. The method includes administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein the carrier molecule facilitates macropinocytic uptake of the agent by monocytes and macrophages in the population and is defective in neonatal Fc receptor binding, wherein the administering induces a phenotypic change in the monocytes and macrophages in the population.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 7, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Dafna Bar-Sagi, Jane Cullis, Craig Ramirez
  • Patent number: 11110171
    Abstract: Provided are compositions and methods for identifying individuals with cancer who will benefit from PD-1 inhibitor therapy. The method comprises determining levels of signaling lymphocyte activation molecule-associated protein (SAP) in an individual and based on the SAP levels, determining if the individual is suitable for PD-1 inhibitor therapy. Also provided is a method of treatment of X-linked lymphoproliferative disease comprising administering to an individual PD-1 inhibitory therapy, with or without SHP2 inhibitors.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: September 7, 2021
    Assignee: New York University
    Inventors: Adam Mor, Ben Neel
  • Patent number: 11103168
    Abstract: Systems and methods for measuring electrophysiological and electrochemical signals in a portion of a body of a subject are provided. The structure includes an array of electrochemical sensors made of miniaturized multi-layer graphene, an array of electrophysiological electrodes, an integrated front-end readout circuit, and narrow silicon shafts with metal spines. The sensor arrays offer significantly higher sensitivity than conventional methods and enable simultaneous, multi-site measurement of chemical and electrophysiological. The front-end circuit contains features that allow significant improvement in detection of the resulting electrochemical current produced by the electrochemical sensing electrodes. The silicone probes allow measurements deep in the body.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: August 31, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Roozbeh Kiani, Davood Shahrjerdi, Bayan Nasri
  • Patent number: 11108840
    Abstract: Aspects of the subject disclosure may include, for example, a virtual processing system initiating a first streaming session with a content streaming server to receive content data, creating a first transport connection with a viewer streaming the content data in a second streaming session with the content streaming server by imitating a transport connection of the content streaming server with the viewer, creating a second transport connection with the content streaming server by imitating a transport connection of the viewer with the content streaming server, splitting the first streaming session between the content streaming server and the viewer, and streaming the content data to the viewer. Other embodiments are disclosed.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: August 31, 2021
    Assignees: AT&T Intellectual Property I, L.P., New York University
    Inventors: Shu Shi, Rittwik Jana, Hung-Hsiang Jonathan Chao, Yang Xu, Bo Yan
  • Patent number: 11104724
    Abstract: The disclosure is directed to antibodies that bind to Staphylococcus aureus bi-component leukotoxins and/or gamma-hemolysins. Other aspects of the disclosure are directed to pharmaceutical compositions and diagnostic kits containing the leukotoxin and hemolysin antibodies, and therapeutic and diagnostic methods utilizing the leukotoxin and hemolysin antibodies.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: August 31, 2021
    Assignees: NEW YORK UNIVERSITY, JANSSEN BIOTECH, INC.
    Inventors: Victor J. Torres, Anthony S. Lynch, Peter T. Buckley, Nathan Majewski
  • Publication number: 20210260092
    Abstract: The application relates to methods based on modulating pancreatic and/or gastrointestinal microbiota and related antifungal compositions. Specifically, the application relates to the use of microbiome for prevention, treatment and diagnosis of pancreatic cancers or tumors, such as pancreatic ductal adenocarcinoma.
    Type: Application
    Filed: September 30, 2020
    Publication date: August 26, 2021
    Applicant: New York University
    Inventors: George MILLER, Berk AYKUT, Deepak SAXENA, Smruti PUSHALKAR
  • Patent number: 11093853
    Abstract: A system combines inputs from human processing and machine processing, and employs machine learning to improve processing of individual tasks based on comparison of human processing results. Once performance of a particular task by machine processing reaches a threshold, the level of human processing used on that task is reduced.
    Type: Grant
    Filed: November 6, 2016
    Date of Patent: August 17, 2021
    Assignees: Tagasauris, Inc., New York University
    Inventors: Joshua M. Attenberg, Panagiotis G. Ipeirotis
  • Patent number: 11085864
    Abstract: Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: August 10, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: David G. Grier, David B. Ruffner, Aaron Yevick, Mark Hannel
  • Publication number: 20210240942
    Abstract: A method of obtaining, by an electronic device, a sentence corresponding to context information, including obtaining first output information including at least one word output by decoding the context information based on at least one data; based on detecting that a first token is not included in the first output information, determining whether a number of words included in the first output information is greater than or equal to a reference value; based on a result of the determining, replacing the at least one data with other data; and obtaining the sentence corresponding to the context information based on at least one output information obtained by decoding the context information based on the other data.
    Type: Application
    Filed: October 22, 2020
    Publication date: August 5, 2021
    Applicants: SAMSUNG ELECTRONICS CO., LTD., NEW YORK UNIVERSITY
    Inventors: Yoonjung CHOI, Jaedeok KIM, Ilia KULIKOV, Sean WELLECK, Yuanzhe PANG, Kyunghyun CHO
  • Patent number: 11078258
    Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: August 3, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Victor J. Torres, Francis Alonzo, III
  • Patent number: 11071631
    Abstract: A total knee replacement prosthesis is presented whose bearing surfaces are derived from an anatomically representative femur and a modified baseline tibial surface. The contacting femoral and tibial bearing surfaces include the inter-condylar as well as condylar regions. A knee replacement implant includes a femoral component and a tibial component. The femoral component includes an outer femoral bearing surface shaped to match an outer bearing surface of an anatomic femur. The tibial component includes a proximal tibial bearing surface based on a proximal baseline tibial bearing surface that is shaped to conform to an envelope of a composite of sequence of positions and orientations of the femoral component throughout a full range of flexure angles and axial rotation angles of the femur relative to the tibia.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 27, 2021
    Assignee: New York University
    Inventor: Peter Stanley Walker
  • Patent number: 11063879
    Abstract: Due to massive available spectrum in the millimeter wave (mmWave) bands, cellular systems in these frequencies may provide orders of magnitude greater capacity than networks in conventional lower frequency bands. However, due to high susceptibility to blocking, mmWave links can be extremely intermittent in quality. This combination of high peak throughputs and intermittency can cause significant challenges in end-to-end transport-layer mechanisms such as TCP, such as the challenging problem of bufferbloat. Specifically, with current buffering and congestion control mechanisms, high throughput-high variable links can lead to excessive buffers incurring long latency. A dynamic receive window approach addresses the problem of bufferbloat.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: July 13, 2021
    Assignee: New York University
    Inventors: Menglei Zhang, Marco Mezzavilla, Sundeep Rangan, Shivendra S. Panwar
  • Patent number: 11051711
    Abstract: A plurality of stimulations is transmitted to tissue or other material using one or more transmitters. The plurality of signals associated with the excited tissue and the transmitted stimulations are measured. The measured signals are processed to generate field-related quantities, such as B1+ and/or MR signal maps. Field-related quantities are generated also from simulation, by calculating the one or more incident fields from a simulator model of the one or more transmitters and assuming a given distribution of electrical properties in the tissue or other material. Field-related quantities generated from simulation and experimental procedures are compared to each other. The assumed electrical properties distribution is updated and the procedure is repeated iteratively until the difference between simulated and experimental field-related quantities is smaller than a threshold.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: July 6, 2021
    Assignee: New York University
    Inventors: Riccardo Lattanzi, Daniel K. Sodickson, José E. Cruz Serralles, Athanasios Polymeridis, Luca Daniel, Jacob K. White
  • Patent number: 11053289
    Abstract: Yeast having modified chromosomes are provided. The chromosomes are modified such that at least one of yeast histones H3, H4, H2A or H2B are fully or partially replaced by their human histone counterparts H3, H4, H2A or H2B, respectively. Histone amino acid substitutions are included. Cell fusions with the yeast having the modified chromosomes and non-yeast cells are provided. Methods for screening test agents using the yeast are also provided. Yeast with a mutated yeast DAD1 gene, the mutated DAD1 gene encoding an E50D mutation in yeast DAD1 protein, are provided, and provide a useful genetic background for making the yeast with partially or fully replaced histone(s).
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: July 6, 2021
    Assignee: New York University
    Inventors: David M. Truong, Jef D. Boeke
  • Publication number: 20210198349
    Abstract: The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.
    Type: Application
    Filed: February 16, 2021
    Publication date: July 1, 2021
    Applicant: New York University
    Inventor: Einar Sigurdsson
  • Patent number: 11045521
    Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: June 29, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Leslie I. Gold, Marek Michalak
  • Patent number: 11046009
    Abstract: A system for detecting corruption in a three-dimensional model for use in additive manufacturing comprises a non-transitory computer-readable medium with instructions stored thereon, that when executed by a processor, perform the steps of obtaining a set of tool-control language instructions that define an additive manufactured part, obtaining a first mechanical specification for the additive manufactured part, constructing a virtual three dimensional model from the set of tool-control language instructions, performing at least one analysis step on the virtual three dimensional model to determine whether the virtual three dimensional model meets the first mechanical, electrical, thermal, and/or magnetic specification, and indicating that the set of tool-control language instructions is corrupt when the virtual three dimensional model fails to meet the first mechanical, electrical, thermal, and/or magnetic specification. A method of producing an additive manufactured part is also described.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: June 29, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Nektarios Georgios Tsoutsos, Nikhil Gupta, Michail Maniatakos