Abstract: The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and/or fibrillation of amyloidogenic peptides such as islet amyloid polypeptide (IAPP).

Abstract: A sensor having a layer and one or more sensing elements which sense shear force and compressive force on the layer. The sensor having a computer in communication with the one or more sensing elements which causes prompting signals to be sent to the one or more sensing elements and reconstructs shear force and compressive force on the layer from data signals received from the one or more sensing elements. A method for sensing forces. A method for producing a sensor.

Abstract: System and methods that reconstruct absolute temperature using a multi-nuclear approach. Specifically, the methods and systems utilize independent NMR/MRI information provided by the precession frequency of two different nuclei to reconstruct a map of the absolute temperature.

Abstract: The present invention is directed to methods of inducing a phenotypic change in a population of monocytes and/or macrophages. The method includes administering to the population of monocytes and/or macrophages, a macrophage stimulating agent coupled to a carrier molecule, wherein the carrier molecule facilitates macropinocytic uptake of the agent by monocytes and macrophages in the population and is defective in neonatal Fc receptor binding, wherein the administering induces a phenotypic change in the monocytes and macrophages in the population.

Abstract: Provided are compositions and methods for identifying individuals with cancer who will benefit from PD-1 inhibitor therapy. The method comprises determining levels of signaling lymphocyte activation molecule-associated protein (SAP) in an individual and based on the SAP levels, determining if the individual is suitable for PD-1 inhibitor therapy. Also provided is a method of treatment of X-linked lymphoproliferative disease comprising administering to an individual PD-1 inhibitory therapy, with or without SHP2 inhibitors.

Abstract: Systems and methods for measuring electrophysiological and electrochemical signals in a portion of a body of a subject are provided. The structure includes an array of electrochemical sensors made of miniaturized multi-layer graphene, an array of electrophysiological electrodes, an integrated front-end readout circuit, and narrow silicon shafts with metal spines. The sensor arrays offer significantly higher sensitivity than conventional methods and enable simultaneous, multi-site measurement of chemical and electrophysiological. The front-end circuit contains features that allow significant improvement in detection of the resulting electrochemical current produced by the electrochemical sensing electrodes. The silicone probes allow measurements deep in the body.

Abstract: Aspects of the subject disclosure may include, for example, a virtual processing system initiating a first streaming session with a content streaming server to receive content data, creating a first transport connection with a viewer streaming the content data in a second streaming session with the content streaming server by imitating a transport connection of the content streaming server with the viewer, creating a second transport connection with the content streaming server by imitating a transport connection of the viewer with the content streaming server, splitting the first streaming session between the content streaming server and the viewer, and streaming the content data to the viewer. Other embodiments are disclosed.

Abstract: The disclosure is directed to antibodies that bind to Staphylococcus aureus bi-component leukotoxins and/or gamma-hemolysins. Other aspects of the disclosure are directed to pharmaceutical compositions and diagnostic kits containing the leukotoxin and hemolysin antibodies, and therapeutic and diagnostic methods utilizing the leukotoxin and hemolysin antibodies.

Abstract: The application relates to methods based on modulating pancreatic and/or gastrointestinal microbiota and related antifungal compositions. Specifically, the application relates to the use of microbiome for prevention, treatment and diagnosis of pancreatic cancers or tumors, such as pancreatic ductal adenocarcinoma.

Abstract: A system combines inputs from human processing and machine processing, and employs machine learning to improve processing of individual tasks based on comparison of human processing results. Once performance of a particular task by machine processing reaches a threshold, the level of human processing used on that task is reduced.

Abstract: Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.

Abstract: A method of obtaining, by an electronic device, a sentence corresponding to context information, including obtaining first output information including at least one word output by decoding the context information based on at least one data; based on detecting that a first token is not included in the first output information, determining whether a number of words included in the first output information is greater than or equal to a reference value; based on a result of the determining, replacing the at least one data with other data; and obtaining the sentence corresponding to the context information based on at least one output information obtained by decoding the context information based on the other data.

Abstract: The present invention relates to methods and compositions for preventing and treating Staphylococcus aureus in a subject. Therapeutic compositions of the present invention comprise leukocidin E and/or D proteins or polypeptides and anti-leukocidin E and/or D antibodies. The invention further relates to methods of identifying inhibitors of LukE/D cytotoxicity and inhibitors of LukE/D-leukocyte binding.

Abstract: A total knee replacement prosthesis is presented whose bearing surfaces are derived from an anatomically representative femur and a modified baseline tibial surface. The contacting femoral and tibial bearing surfaces include the inter-condylar as well as condylar regions. A knee replacement implant includes a femoral component and a tibial component. The femoral component includes an outer femoral bearing surface shaped to match an outer bearing surface of an anatomic femur. The tibial component includes a proximal tibial bearing surface based on a proximal baseline tibial bearing surface that is shaped to conform to an envelope of a composite of sequence of positions and orientations of the femoral component throughout a full range of flexure angles and axial rotation angles of the femur relative to the tibia.

Abstract: Due to massive available spectrum in the millimeter wave (mmWave) bands, cellular systems in these frequencies may provide orders of magnitude greater capacity than networks in conventional lower frequency bands. However, due to high susceptibility to blocking, mmWave links can be extremely intermittent in quality. This combination of high peak throughputs and intermittency can cause significant challenges in end-to-end transport-layer mechanisms such as TCP, such as the challenging problem of bufferbloat. Specifically, with current buffering and congestion control mechanisms, high throughput-high variable links can lead to excessive buffers incurring long latency. A dynamic receive window approach addresses the problem of bufferbloat.

Abstract: A plurality of stimulations is transmitted to tissue or other material using one or more transmitters. The plurality of signals associated with the excited tissue and the transmitted stimulations are measured. The measured signals are processed to generate field-related quantities, such as B1+ and/or MR signal maps. Field-related quantities are generated also from simulation, by calculating the one or more incident fields from a simulator model of the one or more transmitters and assuming a given distribution of electrical properties in the tissue or other material. Field-related quantities generated from simulation and experimental procedures are compared to each other. The assumed electrical properties distribution is updated and the procedure is repeated iteratively until the difference between simulated and experimental field-related quantities is smaller than a threshold.

Abstract: Yeast having modified chromosomes are provided. The chromosomes are modified such that at least one of yeast histones H3, H4, H2A or H2B are fully or partially replaced by their human histone counterparts H3, H4, H2A or H2B, respectively. Histone amino acid substitutions are included. Cell fusions with the yeast having the modified chromosomes and non-yeast cells are provided. Methods for screening test agents using the yeast are also provided. Yeast with a mutated yeast DAD1 gene, the mutated DAD1 gene encoding an E50D mutation in yeast DAD1 protein, are provided, and provide a useful genetic background for making the yeast with partially or fully replaced histone(s).

Abstract: The present invention relates to antibody-based molecules (including single domain antibody fragment, scFv molecules, antibodies, antibody fragments, diabodies, and the epitope-binding domains thereof) that are capable of immunospecifically and selectively binding to the truncated Asp421 epitope of Tau. Such antibody-based molecules are useful to detect pathological Tau protein conformer if present in a biological sample, especially in conjunction with the diagnosis and/or treatment of Alzheimer's disease or other tauopathy, and thus provide a diagnostic for Alzheimer's disease and other Tau pathologies. The antibody-based molecules of the present invention have particular utility as diagnostic markers for, Alzheimer's disease and related tauopathies and as pharmaceutical compositions for the treatment of such conditions.

Abstract: The invention relates to therapeutic and cosmetic uses of calreticulin including reducing eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.

Abstract: A system for detecting corruption in a three-dimensional model for use in additive manufacturing comprises a non-transitory computer-readable medium with instructions stored thereon, that when executed by a processor, perform the steps of obtaining a set of tool-control language instructions that define an additive manufactured part, obtaining a first mechanical specification for the additive manufactured part, constructing a virtual three dimensional model from the set of tool-control language instructions, performing at least one analysis step on the virtual three dimensional model to determine whether the virtual three dimensional model meets the first mechanical, electrical, thermal, and/or magnetic specification, and indicating that the set of tool-control language instructions is corrupt when the virtual three dimensional model fails to meet the first mechanical, electrical, thermal, and/or magnetic specification. A method of producing an additive manufactured part is also described.