Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
Type:
Grant
Filed:
October 5, 2007
Date of Patent:
July 21, 2009
Assignee:
Nicox S.A.
Inventors:
Francesca Benedini, Ennio Ongini, Piero Del Soldato
Abstract: Compounds or their salts of general formula (I): A-B—N(O)s wherein: s is an integer equal to 1 or 2; A=R-T1-, wherein R is the drug radical and T1=(CO)t or (X)t?, wherein X=O, S, NR1c, R1c is H or a linear or branched alkyl or a free valence, t and t? are integers and equal to zero or 1, with the proviso that t=1 when t?=0; t=0 when t?=1; B=-TB-X2—O— wherein TB=(CO) when t=0, TB=X when t?=0, X being as above defined; X2 is equal to R1B—X—R2B radical wherein X is as above defined, R1B and R2B, equal to or different from each other, are linear or branched C1-C6 alkylenes, or X2 is a radical wherein two alkylene chains C1-C4 are linked to nonadjacent positions of a central ring having 4 or 6 atoms, said ring being an unsaturated cycloaliphatic ring, or a saturated or aromatic heterocylic ring, containing one or two heteroatoms, equal or different, selected from O, S, N; wherein the unsaturated cycloaliphatic ring does not have aromatic character according to Huckel's rule.
Abstract: The present invention relates to the use of the following compounds, their compositions, and their salts for the preparation of medicaments for the treatment of urinary incontinence and other diseases, the compounds having the general formula: A-X1—NO2 wherein: A=RCO(X)t, wherein t is the integer 0 or 1; X?O, NH, NR1C, wherein R1C is a linear or branched C1 to C10 alkyl group; when t=1, R= and X1=—YO—, wherein Y is a C1 to C20 alkylene, C5 to C7 cycloalkyl or oxyalkyl derivative.
Type:
Grant
Filed:
December 22, 2004
Date of Patent:
June 9, 2009
Assignee:
Nicox S.A.
Inventors:
Piero Del Soldato, Francesco Sannicolo'
Abstract: Steroidal compounds or their salts having general formulas (I) and (II) wherein: s is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A=R—, wherein R is the steroidal drug radical, C and C1 are two bivalent radicals. The precursors of the radicals B and B1 are such as to meet the pharmacological tests reported in the description.
Abstract: Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X1-L-(W)p-NO2 wherein A contains the radical of a drug, X1 and W are bivalent radicals, L is a covalent bond or oxygen, sulphur, NR1c wherein R1c is H or a C1-C5 linear or branched alkyl.
Type:
Application
Filed:
November 14, 2008
Publication date:
March 19, 2009
Applicant:
NICOX S.A.
Inventors:
Piero DEL SOLDATO, Francesca BENEDINI, Patrizia ANTOGNAZZA
Abstract: Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, having the following general formula (I): A-X1-L-(W)p—NO2 wherein A contains the radical of a drug, X1 and W are bivalent radicals, p is an integer equal to 1 or 0, and L is a covalent bond, CO, oxygen, sulphur, or NR1C where R1C is H or a C1-C5 linear or branched alkyl.
Type:
Grant
Filed:
October 9, 2001
Date of Patent:
December 16, 2008
Assignee:
Nicox S.A.
Inventors:
Piero Del Soldato, Francesca Benedini, Patrizia Antognazza
Abstract: Stating nitro derivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
Type:
Grant
Filed:
October 5, 2007
Date of Patent:
December 9, 2008
Assignee:
Nicox S.A.
Inventors:
Francesca Benedini, Ennio Ongini, Piero Del Soldato
Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
Type:
Grant
Filed:
August 20, 2007
Date of Patent:
November 11, 2008
Assignee:
Nicox S.A.
Inventors:
Ennio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
Abstract: The present invention relates to the use of 4-(Nitrooxy)-butyl-(S)-2-(6-methoxy-2-naphthyl)-propanoate (naproxcinod) for treating pain and inflammation, in particular musculo-skeletal disorders, in patients with congestive heart failure, liver disease, cirrhosis, pre-existing renal disease, volume depletion, elderly with renal impairment, chronic renal failure or essential hypertension.
Type:
Application
Filed:
April 23, 2008
Publication date:
October 30, 2008
Applicant:
NICOX S.A.
Inventors:
Pottumarthi V. PRASAD, Manlio Bolla, Marianna Armogida
Abstract: Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C1 are two bivalent radicals. The precursors of the radicals B and B1 are such as to meet the pharmacological test reported in the description.
Abstract: Compounds or their salts of general formula (I): A-B-N(O)s wherein: s is an integer equal to 1 or 2; A=R-T1-, wherein R is the drug radical and T1=(CO)t or (X)t?, wherein X=O, S, NR1c, R1c is H or a linear or branched alkyl or a free valence, t and t? are integers and equal to zero or 1, with the proviso that t=1 when t?=0; t=0 when t?=1; B=-TB-X2—O— wherein TB=(CO) when t=0, TB=X when t?=0, X being as above defined; X2 is equal to R1B-X-R2B radical wherein X is as above defined, R1B and R2B, equal to or different from each other, are linear or branched C1-C6 alkylenes, or X2 is a radical wherein two alkylene chains C1-C4 are linked to nonadjacent positions of a central ring having 4 or 6 atoms, said ring being an unsaturated cycloaliphatic ring, or a saturated or aromatic heterocylic ring, containing one or two heteroatoms, equal or different, selected from O, S, N; wherein the unsaturated cycloaliphatic ring does not have aromatic character according to Huckel's rule.
Abstract: Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B)b0—(C)c0—NO2 wherein A contains the radical of a drug having an antiinflammatory or analgesic activity, B is a bivalent linking group wherein the precursor must meet the tests described in the application, C is a a bivalent linking group as defined in the invention.
Abstract: Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
Type:
Grant
Filed:
November 1, 2006
Date of Patent:
November 20, 2007
Assignee:
Nicox S.A.
Inventors:
Francesca Benedini, Ennio Ongini, Piero Del Soldato
Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
Type:
Grant
Filed:
January 5, 2005
Date of Patent:
September 25, 2007
Assignee:
Nicox S.A.
Inventors:
Eninnio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
Abstract: A process for obtaining nitroxyalklesters of the 2(S)(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6 methoxy-2-naphthyl)propanoic acid of formula A-Hal, wherein A is the acid acyl residue, is reacted in an inert organic solvent with an aliphatic nitroxyalkanol HO—Y—ONO2, wherein Y is a C2-C20 alkylene or a cycloalkylene from 3 to 8 carbon atoms, or an alkylene as defined containing a cycloalkylene as defined, in the presence of an inorganic base.
Type:
Grant
Filed:
July 24, 2003
Date of Patent:
July 3, 2007
Assignee:
Nicox S.A.
Inventors:
Francesca Benedini, Erminio Oldani, Graziano Castaldi, Antonio Tarquini
Abstract: ACE inhibitor nitroderivatives of formula (I): A—(X1—ONO2)s ??(I) having wider pharmacological activity and enhanced tolerability. They can be employed for treating cardiovascular and renal diseases and inflammatory processes.
Type:
Grant
Filed:
June 17, 2004
Date of Patent:
May 15, 2007
Assignee:
Nicox, S.A.
Inventors:
Nicoletta Almirante, Ennio Ongini, Piero Del Soldato