Patents Assigned to Nicox S.A.
  • Patent number: 6436975
    Abstract: Pharmaceutical compositions for the therapy and the prevention of ulcer and dyspepsia relapses comprising as essential components the following components a) and b): component a): one or more components selected from the conventional anti-ulcer products; component b): organic compounds containing the —ONO2 function, or inorganic compounds containing the —NO group, characterized in that they are NO nitric oxide donors.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: August 20, 2002
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Patent number: 6410791
    Abstract: A nitrate salt of a compound selected from the group consisting of: salbutamol having the formula (I)
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: June 25, 2002
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Patent number: 6242432
    Abstract: Compounds or compositions containing compounds of the formula A-(X1—NO2)to or salts thereof, for the preparation of antithrombotic medications wherein “to” is the integer 1 or 2X1 is an alkylene connecting bridge and “A” is the residue of timolol or analapril.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: June 5, 2001
    Assignee: Nicox S.A.
    Inventor: Piero del Soldato
  • Patent number: 6218417
    Abstract: Compounds having platelet anti-aggregating activity and antihypertension activity having reduced branchial side effects.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: April 17, 2001
    Assignee: Nicox, S.A.
    Inventor: Piero Del Soldato
  • Patent number: 6211233
    Abstract: Compounds of the general formula A—X1—NO2, or their pharmaceutical compositions, wherein A contains a prostaglandin residue, X1 is a bivalent connecting bridge.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: April 3, 2001
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Patent number: 6040341
    Abstract: Compounds and their compositions, of general formula: A--X.sub.1 --NO.sub.2 are used as medicaments wherein: A=R(COX).sub.t t=0 or 1; X=O and the remaining substituents are defined in the specification.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: March 21, 2000
    Assignee: Nicox S.A.
    Inventors: Piero Del Soldato, Francesco Sannicolo'
  • Patent number: 5861426
    Abstract: New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A--X.sub.1 --NO.sub.2 or their salts, wherein: A is R(COX.sub.u).sub.t, wherein t is zero or 1 and u is zero or 1; and X is O, NH or NR.sub.1C wherein R.sub.1C is C.sub.1 -C.sub.10 alkyl; and R is(Ia) wherein R.sub.1 is acetoxoy, preferably n ortho-position with respect to --CO-- and R.sub.2 is hydrogen; or derivatives of acetylsalylsalicyclic acid; and X.sub.1 is --YO-- wherein Y is C.sub.1 -C.sub.20 alkylene, C.sub.5 -C.sub.7 cycloalkylene, oxy-alkyl derivatives and oxy-methyl benzyl derivatives.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: January 19, 1999
    Assignee: Nicox S.A.
    Inventors: Piero Del Soldato, Francesco Sannicolo
  • Patent number: 5780495
    Abstract: This invention is directed to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihidro-3H-pyrrolo ?1,2-a!pyrrole-1-carboxylic acid, 6-methoxy-2-napthylacetic acid, characterized in that they have the following general formula: ##STR1## These nitric ester derivatives may be formulated into pharmaceutical compositions and administered for their anti-inflammatory and/or analgesic activity.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 14, 1998
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Patent number: 5700947
    Abstract: This invention is directed to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihydro-3H-pyrrolo?1,2-a!pyrrole-1-carboxylic acid, 6-methoxy-2-napthylacetic acid, characterized in that they have the following general formula: ##STR1## These nitric ester derivatives may be formulated into pharmaceutical compositions and administered for their anti-inflammatory and/or analgesic activity.
    Type: Grant
    Filed: April 5, 1996
    Date of Patent: December 23, 1997
    Assignee: NICOX S.A.
    Inventor: Piero Del Soldato
  • Patent number: 5621000
    Abstract: Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: April 15, 1997
    Assignee: Nicox S.A.
    Inventors: Barbara Arena, Piero Del Soldato