Patents Assigned to Nicox S.A.
  • Steroidal pharmaceutical compounds
    Patent number: 6909007
    Abstract: Steroidal compounds or their salts having general formulas (I) and (II) wherein: s is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A?R—, wherein R is the steroidal drug radical, C and C1 are two bivalent radials. The precursors of the radicals B and B1 are such as to the pharmacological tests repotted in the description.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: June 21, 2005
    Assignee: Nicox S.A.
    Inventor: Piero del Soldato
  • Pharmaceutical compounds
    Patent number: 6869974
    Abstract: Compounds or their salts having general formulas (I) and (II): wherein s is an integer equal to 1 or 2, A is the radical of a drug that satisfies certain pharmacological tests, C and C1 are bivalent radicals, and precursors of the radicals B and B1 satisfy certain pharmacological tests.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: March 22, 2005
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Nitric esters and nitrate salts of specific drugs
    Patent number: 6828342
    Abstract: The present invention relates to nitric acid salts with medicines active in the respiratory system pathology treatment.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 7, 2004
    Assignee: Nicox, S.A.
    Inventor: Piero Del Soldato
  • Nitric oxide donors capable of reducing toxicity from drugs
    Publication number: 20040242651
    Abstract: Use of organic compounds containing the —ONO2 function, or inorganic compound containing the —NO group or compositions comprising said compounds to reduce the toxicity caused by drugs to the gastrointestinal and/or renal apparatus, said compounds being characterized in that they are nitric oxide NO donors i.e., when they are put into contact in vitro with cells of the vasal endothelium or platelets.
    Type: Application
    Filed: July 7, 2004
    Publication date: December 2, 2004
    Applicant: NICOX S.A.
    Inventor: Piero Del Soldato
  • Nitrate salts of antimicrobial agents
    Patent number: 6794372
    Abstract: Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: September 21, 2004
    Assignee: Nicox S.A.
    Inventors: Piero Del Soldato, F{overscore (r)}ancesca Benedini, Patrizia Antognazza
  • Nitrate salts of antihypertensive medicines
    Publication number: 20040147575
    Abstract: Nitric acid salts with medicines having an antihypertensive activity.
    Type: Application
    Filed: September 29, 2003
    Publication date: July 29, 2004
    Applicant: Nicox S.A.
    Inventor: Piero Del Soldato
  • Nitric esters and nitrate salts of specific drugs
    Publication number: 20040132744
    Abstract: Nitric acid salts with medicines active in the respiratory system pathology treatment.
    Type: Application
    Filed: December 17, 2003
    Publication date: July 8, 2004
    Applicant: Nicox S.A.
    Inventor: Piero Del Soldato
  • Amorphous nitric esters and their pharmaceutical compositions
    Patent number: 6753442
    Abstract: Compounds of formula A—X1—ONO2 (I) in a partially or completely amorphous form and pharmaceutical compositions thereof.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: June 22, 2004
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Patrizia Antognazza
  • Nitric ester derivatives and their use in treating gastrointestinal tumors
    Publication number: 20040082652
    Abstract: Use of the following groups of compounds or their compositions for the preparation of medicaments for the treatment of gastrointestinal tumors, such compounds having general formula: A-X1—NO2 or their salts, where A=R(COX)t and where t is an integer 0 or 1; X═O, NH, NR1c, where R1c is a linear or branched alkyl having from 1 to 10 C atoms; R is (IA) where t=1 and X1 is equal to —YO— where Y is a C1-C20 alkylene, C5-C7 cycloalkyl or oxyalkyl derivatives.
    Type: Application
    Filed: October 17, 2003
    Publication date: April 29, 2004
    Applicant: Nicox S.A.
    Inventors: Piero Del Soldato, Francesco Sannicolo
  • Process for the preparation of naproxene nitroxyalkylesters
    Patent number: 6700011
    Abstract: A process for obtaining nitroxyalkylesters of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid of formula A-Hal, wherein A is the acid acyl residue, is reacted in an inert organic solvent with an aliphatic nitroxyalkanol HO—Y—ONO2, wherein Y is a C2-C20 alkylene or a cycloalkylene from 3 to 8 carbon atoms, or an alkylene as defined containing a cycloalkylene as defined, in the presence of an inorganic base.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: March 2, 2004
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Erminio Oldani, Graziano Castaldi, Antonio Tarquini
  • Methods of making 21-[4?-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
    Patent number: 6696592
    Abstract: The present invention provides methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives according to the following general reaction scheme: The invention also provides intermediates useful in making such 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives as well as methods for making such intermediates.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: February 24, 2004
    Assignee: NicOx-S.A.
    Inventor: Donald G. McIntyre
  • Process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives
    Patent number: 6696591
    Abstract: A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R1 is the OCOR3 group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid derivative with hydroxybenzylacohol in the presence of a base: b) nutration of the obtained product in anhydrous conditions by a mixture of nitric acid with a different inorganic acid, or an organic acid, or an anhydride of one or two organic acids: c) recovery of the final product.
    Type: Grant
    Filed: January 9, 2002
    Date of Patent: February 24, 2004
    Assignee: Nicox S.A.
    Inventors: Graziano Castaldi, Erminio Oldani, Gabriele Razzetti, Francesca Benedini
  • Nitrate salts of antihypertensive medicines
    Patent number: 6645965
    Abstract: Nitric acid salts with medicines having an antihypertensive activity.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: November 11, 2003
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Nitroxyderivatives having antinflammatory, analgesic and antithrombotic activity
    Patent number: 6613784
    Abstract: Organic or inorganic salts of compounds of general formula: A—X1—N(O)z for use as medicaments having anti-inflammatory, analgesic and antithrombotic activity, wherein A is R(COXu)t wherein t is 0 or 1; u is 0 or 1 and X is O, NH, NR1c wherein R1c us a C1-C10 alkyl and R is, for example, (Ia) wherein R1 is acetoxy, preferably in ortho position with respect to —CO— and R2 is hydrogen or acetylsalicylsalicylic acid derivatives; and X1 is the formula (B), Y being a ring containing at least one salified nitrogen atom.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: September 2, 2003
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Piero Del Soldato
  • Nitrate esters of corticoid compounds and pharmaceutical applications thereof
    Patent number: 6610676
    Abstract: Compounds of the formula and use of the compounds as medicaments.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: August 26, 2003
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato
  • Medicine nitrate salts
    Patent number: 6573252
    Abstract: The present invention relates to nitrate salts of compounds having therapeutic activity in bony disorders, such compounds being characterized in that they contain at least a reactive group capable of being salified with nitric acid.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: June 3, 2003
    Assignee: Nicox, S.A.
    Inventor: Piero Del Soldato
  • Nitric esters and nitrate salts of specific drugs
    Publication number: 20030028026
    Abstract: The present invention relates to nitric acid salts with medicines active in the respiratory system pathology treatment.
    Type: Application
    Filed: May 22, 2002
    Publication date: February 6, 2003
    Applicant: Nicox S.A.
    Inventor: Piero Del Soldato
  • Pharmaceutical compositions for ulcer
    Publication number: 20030027844
    Abstract: Pharmaceutical compositions for the therapy and the prevention of ulcer and dyspepsia relapses comprising as essential components the following components a) and b): component a): one or more components selected from the conventional anti-ulcer products; component b): organic compounds containing the —ONO2 function, or inorganic compounds containing the —NO group, characterized in that they are NO nitric oxide donors.
    Type: Application
    Filed: July 8, 2002
    Publication date: February 6, 2003
    Applicant: Nicox S.A.
    Inventor: Piero Del Soldato
  • Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
    Patent number: 6512137
    Abstract: The invention describes a method for the synthesis of nitroxymethylphenyl esters of aspirin derivatives.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: January 28, 2003
    Assignee: Nicox S.A.
    Inventors: Piero Del Soldato, Michele Garufi
  • Nitrate salt of anti-ulcer medicine
    Patent number: 6503929
    Abstract: Nitrate salt compositions with anti-ulcer medicines having formula (A) and (B) wherein the (A) class compounds: R=H, OCH3, OCHF2; R1=CH3, OCH3; R2=H, CH3; R3=CH3, CH2—CF3, (CH2)3—OCH3; wherein the (B) class compounds: RI3, RI4 equal to or different from each other, are respectively free valence hydrogen, (1), —CH2—N(CH3)2; Y=S, N—RI6, CRI7RI8; X=O, S, N—RI1; RI2=H, CH3; n=0, 1; Z=N—CN, N—SO2NH2, CH—NO2 or formula (VIIA) RI5=H, —NH—CH3, NH2; RI6, RI7, RI8, RI1, equal to or different from each other, are hydrogen, free valence. The invention also comprises the methods for the preparation of above salts.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: January 7, 2003
    Assignee: Nicox S.A.
    Inventor: Piero Del Soldato