Patents Assigned to Niigata University
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Patent number: 8564781Abstract: Provided is an SPR sensor which can achieve compaction and multichannel detection by simple configuration at a low cost. The SPR sensor comprises an optical path, and detection areas on the side surface thereof formed by laminating metal layers formed to cause surface plasmon resonance phenomenon. The SPR sensor is characterized in that two or more detection areas are formed for one optical path, a dielectric constant regulation layer is further laminated in at least one of the two or more detection areas, dielectric constant is regulated to have a different surface plasmon resonance in each detection area, and a dielectric constant regulation layer laminated in the at least one of the two or more detection areas functions as a layer exhibiting sensitivity to an object to be detected.Type: GrantFiled: August 21, 2009Date of Patent: October 22, 2013Assignees: Hitachi Chemical Company, Ltd., Niigata UniversityInventors: Nobuo Miyadera, Kenta Mizusawa, Kazunari Shinbo, Yasuo Ohdaira, Akira Baba, Keizo Kato, Futao Kaneko, Takahiro Kawakami
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Patent number: 8540962Abstract: The disclosed method for producing hydrogen by means of thermochemical water-splitting can efficiently use solar energy obtained by means of a beam-down typed light collecting system. Further disclosed is a device for producing hydrogen. While circulating within a reactor (1) a fluidized bed (2) made of metal oxide particles, two reactions are simultaneously caused to proceed: a thermal reduction reaction, which is an oxygen evolution reaction wherein a portion of the fluidized bed (2) is heated by solar light (S) in a nitrogen atmosphere, which is a low oxygen partial pressure gas, releasing oxygen from the metal oxide; and a thermochemical water-splitting reaction, which is a hydrogen evolution reaction wherein water vapor is brought into contact with the metal oxide after oxygen has been released, generating hydrogen.Type: GrantFiled: December 1, 2010Date of Patent: September 24, 2013Assignee: Niigata UniversityInventors: Tatsuya Kodama, Nobuyuki Gokon
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Patent number: 8541624Abstract: Disclosed are: a novel palladium catalyst which does not undergo leakage, can be recycled, does not require the use of any phosphorus-containing ligand, and has a high catalytic activity; and a process for producing a novel bisaryl compound using the palladium catalyst. In the production of a bisaryl compound by reacting an aromatic halide with an aromatic boronic acid in the presence of a palladium catalyst and a base, the palladium catalyst comprises a dendrimer containing a silica particle as a core and a palladium compound dissolved in an ionic liquid and supported on the dendrimer.Type: GrantFiled: November 11, 2010Date of Patent: September 24, 2013Assignee: Niigata UniversityInventors: Hisahiro Hagiwara, Norio Tsubokawa
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Publication number: 20130224252Abstract: The purpose of the present invention is to provide a better intestine immunomodulator. The intestine immunomodulator of the present invention comprises bacterial cells or a bacterial component of a Lactobacillus paracasei K71 strain having an international deposit No.: FERM BP-11098 as an active ingredient. Preferably, the intestine immunomodulator is used to facilitate production of secretory immunoglobulin A or to activate natural killer cells.Type: ApplicationFiled: May 26, 2011Publication date: August 29, 2013Applicant: NIIGATA UNIVERSITYInventors: Takashi Hara, Yuki Higuchi, Mikio Fujii
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Patent number: 8420392Abstract: The present invention provides a method for forcingly culturing a piece of human periosteum tissue in a shorter culture period, the method including the steps of: (1) placing a periosteum piece dissected from a patient on a culture dish containing no culture solution; (2) dropping platelet-rich plasma collected from the patient onto the surface of the periosteum piece on the culture dish and coagulating the platelet-rich plasma so as to cover the surface of the periosteum piece; (3) adding a first culture medium to the culture dish and growing the culture; and (4) growing the culture in a second culture medium containing a basic fibroblast growth factor and no platelet-rich plasma, after the step (3).Type: GrantFiled: August 22, 2008Date of Patent: April 16, 2013Assignee: Niigata UniversityInventors: Tomoyuki Kawase, Kazuhiro Okuda
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Patent number: 8384284Abstract: Provided are phosphors that can exhibit higher emission luminance. Phosphors in which the activator is included in a compound represented by Formula xM1O.M2O.yM3O2 (wherein M1 represents one or more of a group comprising Ca, Sr and Ba, M2 represents Mg and/or Zn, M3 represents Si and/or Ge, x is a value in the range 4 to 6 and y is a value in the range 2 to 4). Phosphors represented by Formula M15(1?z)EuzM2M33O12 (wherein M1, M2 and M3 have the same meanings as above, and z is a value in the range 0.0001 to 0.3). The above phosphors have the same crystal structure as bredigite.Type: GrantFiled: March 18, 2009Date of Patent: February 26, 2013Assignees: Niigata University, Sumitomo Chemical Company, LimitedInventors: Kenji Toda, Kazuyoshi Uematsu, Mineo Sato, Tetsu Umeda, Yutaka Ito
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Publication number: 20120329968Abstract: The present invention aims at solving the problems of conventional methods for producing an 18F-labeled compound, that is, the problem of purification of a compound in a liquid phase synthesis method and the problem of an insufficient yield due to the reduction of reactivity in a solid phase synthesis method. There is provided a method for producing an 18F-labeled compound including: allowing a high molecular compound containing a residue of a precursor compound to be labeled and a residue of a phase transfer catalyst in the molecule thereof to react with 18F?; and removing the 18F-labeled compound from the high molecular compound.Type: ApplicationFiled: February 8, 2011Publication date: December 27, 2012Applicants: NIIGATA UNIVERSITY, TOKYO INSTITUTE OF TECHNOLOGYInventors: Takashi Takahashi, Hiroshi Tanaka, Tsutomu Nakada
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Patent number: 8321368Abstract: There are provided an identification device, an identification method and an identification processing program, which are capable of significantly reducing a processing burden. An identification device 1 can judge the magnitude relation between an occurrence probability value of a class 0 and an occurrence probability value of a class 1 from the magnitude relation between gkupper and gklower. Hence, it can be identified which one of the classes 0 and 1 is applicable to observed data D1 with a simple arithmetic processing. Accordingly, a complicated and heavy-burden arithmetic processing of an exponential function can be avoided for obtaining the occurrence probability values of the classes 0 and 1, enabling the processing burden to be significantly reduced.Type: GrantFiled: January 16, 2009Date of Patent: November 27, 2012Assignee: Niigata UniversityInventors: Shogo Muramatsu, Hidenori Watanabe
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Publication number: 20120237440Abstract: The disclosed method for producing hydrogen by means of thermochemical water-splitting can efficiently use solar energy obtained by means of a beam-down typed light collecting system. Further disclosed is a device for producing hydrogen. While circulating within a reactor (1) a fluidized bed (2) made of metal oxide particles, two reactions are simultaneously caused to proceed: a thermal reduction reaction, which is an oxygen evolution reaction wherein a portion of the fluidized bed (2) is heated by solar light (S) in a nitrogen atmosphere, which is a low oxygen partial pressure gas, releasing oxygen from the metal oxide; and a thermochemical water-splitting reaction, which is a hydrogen evolution reaction wherein water vapor is brought into contact with the metal oxide after oxygen has been released, generating hydrogen.Type: ApplicationFiled: December 1, 2010Publication date: September 20, 2012Applicant: Niigata UniversityInventors: Tatsuya Kodama, Nobuyuki Gokon
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Publication number: 20120232310Abstract: Disclosed are: a novel palladium catalyst which does not undergo leakage, can be recycled, does not require the use of any phosphorus-containing ligand, and has a high catalytic activity; and a process for producing a novel bisaryl compound using the palladium catalyst. In the production of a bisaryl compound by reacting an aromatic halide with an aromatic boronic acid in the presence of a palladium catalyst and a base, the palladium catalyst comprises a dendrimer containing a silica particle as a core and a palladium compound dissolved in an ionic liquid and supported on the dendrimer.Type: ApplicationFiled: November 11, 2010Publication date: September 13, 2012Applicant: Niigata UniversityInventors: Hisahiro Hagiwara, Norio Tsubokawa
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Publication number: 20120214949Abstract: A polymer having a repeating unit represented by formula (1). [R1 represents a hydrogen atom, a halogeno group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, a trialkylsilyl group, or a trialkylgermyl group, each R2 is independently represented by the following formula (2), m is an integer of from 1 to 5, and when a plurality of R2s are present, the R2s may be the same as or different from each other.] [Each X is independently a monovalent group, and the plurality of Xs may be the same as or different from each other, at least one X is a monovalent group containing a halogen atom, and p is an integer of from 0 to 10.Type: ApplicationFiled: August 12, 2010Publication date: August 23, 2012Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, NIIGATA UNIVERSITYInventors: Toshiki Aoki, Masahiro Teraguchi, Takashi Sato, Taketsugu Yamamoto
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Publication number: 20120189631Abstract: Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention including thrombolytic agents and an inhibitor of vascular endothelial growth factor (VEGF) receptor-mediated signal transduction are disclosed.Type: ApplicationFiled: January 26, 2012Publication date: July 26, 2012Applicant: Niigata UniversityInventors: Takayoshi SHIMOHATA, Lawrence M. KAUVAR
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Patent number: 8215175Abstract: A quantitative evaluation device and method of an atomic vacancy, which are capable of efficiently and quantitatively evaluating an atomic vacancy existing in a silicon wafer. A quantitative evaluation device 1 is equipped with a detector 5 including an ultrasonic generator 27 and an ultrasonic receiver 28, a silicon sample 6 formed with the ultrasonic generator 27 and the ultrasonic receiver 28 on a silicon wafer 26 comprising perfect crystal silicon, a magnetic force generator 4 for applying an external magnetic field to the silicon sample 6, and a cooler 3 capable of cooling and controlling the silicon sample 6 to a range of temperatures lower than or equal to 50K.Type: GrantFiled: July 2, 2008Date of Patent: July 10, 2012Assignee: Niigata UniversityInventors: Terutaka Goto, Hiroshi Kaneta, Yuichi Nemoto
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Publication number: 20120168912Abstract: A quantitative evaluation method, a method for manufacturing a silicon wafer, and a silicon wafer manufactured by the method, enabling more efficient evaluation of the concentration of atomic vacancies existing in a silicon wafer. The quantitative evaluation method includes steps of: oscillating, in a state in which an external magnetic field is applied to a silicon wafer (26) while keeping the silicon wafer (26) at a constant temperature, an ultrasonic wave pulse and receiving a measurement wave pulse obtained after the ultrasonic wave pulse is propagated through the silicon wafer (26) for detecting a phase difference between the ultrasonic wave pulse and the measurement wave pulse; and calculating an elastic constant from the phase difference. The external magnetic field is changed to calculate the elastic constant corresponding to a change in the external magnetic field for evaluating a concentration of atomic vacancies in the silicon wafer (26).Type: ApplicationFiled: August 19, 2010Publication date: July 5, 2012Applicant: Niigata UniversityInventors: Terutaka Goto, Hiroshi Kaneta, Yuichi Nemoto, Mitsuhiro Akatsu
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Patent number: 8212141Abstract: There is provided a high-sensitivity organic semiconductor radiation/light sensor and a radiation/light detector which can detect rays in real time. In the high-sensitivity organic semiconductor radiation/light sensor, a signal amplification wire 2 is embedded in an organic semiconductor 1. Carriers created by passage of radiation or light are avalanche-amplified by a high electric field generated near the signal amplification wire 2 by means of applying a high voltage to the signal amplification wire 2, thus dramatically improving detection efficiency of rays. Hence, even rays exhibiting low energy loss capability can be detected in real time with high sensitivity.Type: GrantFiled: October 20, 2006Date of Patent: July 3, 2012Assignees: Niigata University, Japan Carlit Co., Ltd.Inventors: Hitoshi Miyata, Yoshimasa Fujigaki, Yoji Yamaguchi, Yoshinori Muto, Masaaki Tamura
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Publication number: 20120164662Abstract: Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination, and a test reagent for use in the test method and a test reagent kit for use in the test method. The present invention allows the discrimination of a poor prognosis group even for poor prognosis cases with no overt findings in a conventional test method, and thus allows the assessment of a renal disease, the assessment of the necessity of renal biopsy, prognostic prediction, and the like to be performed exactly.Type: ApplicationFiled: June 9, 2010Publication date: June 28, 2012Applicants: DENKA SEIKEN CO., LTD, JUNTENDO EDUCATIONAL FOUNDATION, NIIGATA UNIVERSITYInventors: Masanori Hara, Akihiko Saito, Yasuhiko Tomino, Katsuhiko Asanuma, Hiroyuki Kurosawa, Shinya Ogasawara, Yoshiaki Hirayama
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Publication number: 20120164667Abstract: Provided is a test method for the detection of diabetic nephropathy at an early stage as compared to a conventional method. Specifically provided are: a test method for diabetic nephropathy, including detecting urinary podocalyxin; the test method, further including assessing diabetic nephropathy at least Stage I; a test reagent for use in the test method; and a test reagent kit for use in the test method. The present invention is based on a finding that urinary podocalyxin reflects the development and condition of diabetic nephropathy with high sensitivity at an early stage as compared to urinary albumin.Type: ApplicationFiled: June 9, 2010Publication date: June 28, 2012Applicants: DENKA SEIKEN CO., LTD., JUNTENDO EDUCATIONAL FOUNDATION, NIIGATA UNIVERSITYInventors: Masanori Hara, Akihiko Saito, Yasuhiko Tomino, Katsuhiko Asanuma, Hiroyuki Kurosawa, Shinya Ogasawara, Yoshiaki Hirayama
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Publication number: 20120125770Abstract: A hydrogen gas sensor comprising a detection electrode, a reference electrode, and an electrolyte contacting with these electrodes, in which the reference electrode and the detection electrode are composed of a material having a property that hydrogen molecule doesn't voluntarily dissociate into atomic hydrogen on a surface of the electrode in Standard State such as nickel, titanium, copper, tungsten and the like, in which hydrogen gas is detected by an electromotive force generated between the reference electrode and the detection electrode while at least the detection electrode is maintained at a temperature not less than a temperature that hydrogen molecule begins to dissociate into atomic hydrogen voluntarily on the surface of the detection electrode.Type: ApplicationFiled: May 21, 2010Publication date: May 24, 2012Applicant: NATIONAL UNIVERSITY CORPORATION NIIGATA UNIVERSITYInventors: Shuji Harada, Tatsuya Ishiduka, Tsuneo Nakamura
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Publication number: 20120055658Abstract: A device for recovering heat of molten slag, having a simple structure and high heat recovery efficiency. The device includes: a fluidized bed (3) formed of a fluidized bed material (32) composed of a crushed solidified slag; a slag pool (4) for feeding a molten slag to the fluidized bed; heat transfer tubes (7) for recovering heat from the fluidized bed; and a solidified slag withdrawing device (21) for recovering a solidified slag (34), such solidified slag (34) being formed in the fluidized bed as the molten slag is solidified therein. Molten slag droplets (31) are dripped into the fluidized bed (3) from the slag pool (4) and solidified in the corresponding fluidized bed. The heat released at that time is transferred to the heat transfer tubes (7) through the bed material (32).Type: ApplicationFiled: May 11, 2010Publication date: March 8, 2012Applicant: Niigata UniversityInventor: Tadaaki Shimizu
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Patent number: 8110362Abstract: An object is to provide: a method for determining a tongue cancer in which the malignancy of tongue cancer can be objectively and accurately determined; a method for analyzing a tongue cancer tissue specimen; and a kit for analyzing a tongue cancer tissue specimen. There is provided: a method for determining a tongue cancer, comprising measuring mRNA quantity of an integrin family gene and a reference gene in the tongue cancer tissue specimen, and determining the malignancy of the tongue cancer based on a ratio of the mRNA quantity of the integrin family gene/the mRNA quantity of the reference gene; a method for analyzing a tongue cancer tissue specimen, comprising the steps of measuring mRNA quantity of an integrin family gene and a reference gene in the tongue cancer tissue specimen, and correlating a ratio of the mRNA quantity of the integrin family gene/the mRNA quantity of the reference gene with clinical data; and a kit for analyzing a tongue cancer tissue specimen.Type: GrantFiled: September 28, 2007Date of Patent: February 7, 2012Assignee: Niigata UniversityInventors: Masaki Nagata, Akira Kurokawa