Patents Assigned to Niigata University
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Patent number: 8105840Abstract: Described are a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The urine pretreatment agent for urinary protein quantitation, includes a buffer, a chelating agent, and a surfactant; the urine pretreatment method includes a step of mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and the urinary protein quantitation method includes steps of: mixing 10 to 1000 parts by mass of the urine pretreatment agent with 100 parts by mass of urine; and then measuring the protein concentration.Type: GrantFiled: September 26, 2008Date of Patent: January 31, 2012Assignees: Niigata University, Denka Seiken Co., Ltd.Inventors: Masanori Hara, Akihiko Saito, Shinya Ogasawara, Yoshiaki Hirayama, Hiroyuki Kurosawa
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Patent number: 8037761Abstract: There is provided a quantitative evaluation device or the like of atomic vacancy existing in a silicon wafer in which the atomic vacancy concentration in the silicon wafer can be quantitatively evaluated by forming a rationalized thin-film transducer on a surface of a silicon sample without conducting an acceleration treatment for enhancing the concentration.Type: GrantFiled: March 2, 2007Date of Patent: October 18, 2011Assignees: Niigata University, Sumco CorporationInventors: Terutaka Goto, Yuichi Nemoto, Hiroshi Kaneta, Masataka Hourai
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Patent number: 8017039Abstract: Provided is a fluorescent body for use in a near-ultraviolet excitation light-emitting element, comprising the compound given by formula (1), having part of element M1 and/or M2 therein replaced by an activation element (M3). M1aM2bPcO15(1) (Here, M1 represents one or more elements chosen from the group comprising Ca, Sr, and Ba; M2 represents one or more elements chosen from the group comprising Mg and Zn; a is a number between 1.5 and 2.5, inclusive; b is a number between 2.5 and 3.5, inclusive; and c is a number between 3.5 and 4.5, inclusive.) A fluorescent body in which M1 is Sr and M2 is Mg, and a fluorescent body in which M3 is Eu are preferable. Also provided are a fluorescent paste having the fluorescent body, and a near-ultraviolet excitation light-emitting element having the fluorescent body and having a high luminescent intensity.Type: GrantFiled: March 18, 2009Date of Patent: September 13, 2011Assignees: Niigata University, Sumitomo Chemical Company, LimitedInventors: Kenji Toda, Kazuyoshi Uematsu, Mineo Sato, Tetsu Umeda, Yutaka Ito
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MICROCAPSULES, METHOD OF PRODUCING THE MICROCAPSULES AND FOOD AND DRINK CONTAINING THE MICROCAPSULES
Publication number: 20110159152Abstract: A method of producing microcapsules that comprises an emulsification step in which a fat-soluble substance and a sodium alginate aqueous solution are mixed to obtain an emulsified liquid in which there are dispersed emulsified particles composed of the fat-soluble substance and having a mean particle size of not greater than 800 nm, and a spraying step in which the emulsified liquid is sprayed into a calcium ion-containing solution to obtain microcapsules in which the emulsified particles are encapsulated.Type: ApplicationFiled: May 26, 2009Publication date: June 30, 2011Applicants: NIIGATA UNIVERSITY, SAPPORO BREWERIES LIMITEDInventors: Masato Tanaka, Norihiko Tsuchimoto -
Patent number: 7959139Abstract: Provided is a noncontact apparatus for performing rotating process to a subject to be processed, without contaminating environment in an airtight container. A spin head (1) is held on a holder (7) in an airtight container, a pinning force is generated between the spin head (1) and a Type-II superconductor (11), and the spin head 1 is floated by lifting the Type-II superconductor (11) by a lifting means (22). Then, rotating force generated by a noncontact rotating power transmitting body (18) arranged in the internal center of the Type-II superconductor (11) is subsequently generated on the side of the spin head (1) and the spin head (1) is rotated in conjunction with a driving motor (19).Type: GrantFiled: November 21, 2006Date of Patent: June 14, 2011Assignees: Niigata University, MTC Co., Ltd.Inventors: Satoshi Fukui, Jun Ogawa, Mitsugi Yamaguchi, Tetsuo Oka, Tomoe Sasahara, Shinsuke Miyazaki
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Patent number: 7955809Abstract: This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed.Type: GrantFiled: March 28, 2007Date of Patent: June 7, 2011Assignees: Niigata University, Denka Seiken Co., Ltd.Inventors: Shinya Ogasawara, Shuhei Miura, Akihiko Saito, Tetsuro Takeda
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Publication number: 20110123680Abstract: The method of producing microcapsules 100 comprises a primary dispersion step in which a water-soluble substance and a fat-soluble substance are mixed to obtain a primary dispersion liquid having primary dispersion particles 10 composed of the water-soluble substance dispersed in the fat-soluble substance, a secondary dispersion step in which the primary dispersion liquid and a sodium alginate aqueous solution are mixed to obtain a secondary dispersion liquid having secondary dispersion particles 20 composed of the primary dispersion liquid dispersed in the sodium alginate aqueous solution, and a spraying step in which the secondary dispersion liquid is sprayed for contact with a calcium ion-containing solution 9 to form a calcium alginate gel 30 and to obtain microcapsules 100 having the secondary dispersion particles 20 dispersed in the calcium alginate gel 30.Type: ApplicationFiled: July 22, 2009Publication date: May 26, 2011Applicants: NIIGATA UNIVERSITY, SAPPORO BREWERIES LIMITEDInventors: Masato Tanaka, Norihiko Tsuchimoto
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Publication number: 20110064844Abstract: The present invention aims to provide a poultry diet that can soften the flesh quality of poultry meat and improve the texture, a method of producing a large amount of meat with improved texture by using the diet, and a breeding method of poultry having flesh quality with good texture, and a flesh quality softening agent for poultry to be used by addition to feed. Astaxanthin is contained in a diet to give a poultry diet for improving texture. The present invention can improve texture by decreasing the shear force of poultry meat by breeding the poultry on the diet.Type: ApplicationFiled: September 9, 2010Publication date: March 17, 2011Applicants: ASKA PHARMACEUTICAL CO., LTD., NIIGATA UNIVERSITYInventors: Shinobu FUJIMURA, Motoni KADOWAKI, Hitomi TOJO, Toru OKADA
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Publication number: 20110045588Abstract: The present invention provides a method for forcingly culturing a piece of human periosteum tissue in a shorter culture period, the method including the steps of: (1) placing a periosteum piece dissected from a patient on a culture dish containing no culture solution; (2) dropping platelet-rich plasma collected from the patient onto the surface of the periosteum piece on the culture dish and coagulating the platelet-rich plasma so as to cover the surface of the periosteum piece; (3) adding a first culture medium to the culture dish and growing the culture; and (4) growing the culture in a second culture medium containing a basic fibroblast growth factor and no platelet-rich plasma, after the step (3).Type: ApplicationFiled: August 22, 2008Publication date: February 24, 2011Applicant: Niigata UniversityInventors: Tomoyuki Kawase, Kazuhiro Okuda
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Publication number: 20110038891Abstract: An object aims to develop a lactic acid bacterium having an anti-allergic activity, which can be grown by using rice, particularly polished white rice, and can be collected, cooked and ingested together with rice in such a state that the lactic acid bacterium is attached to the surface of the rice. Another object aims to develop a food composition and a pharmaceutical composition, each of which comprises rice containing the lactic acid bacterium as a material. Thus, disclosed are: a lactic acid bacterium Lactobacillus paracasei K71 strain which has been internationally deposited in National Institute of Advanced Industrial Science and Technology, International Patent Organism Depositary under Accession No.Type: ApplicationFiled: April 24, 2009Publication date: February 17, 2011Applicants: KAMEDA SEIKA CO., LTD., NIIGATA UNIVERSITYInventors: Takashi Hara, Toshio Joh, Takehisa Kumagai, Mariko Saito, Kimiko Uchiyama
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Publication number: 20110012060Abstract: Provided is a fluorescent body for use in a near-ultraviolet excitation light-emitting element, comprising the compound given by formula (1), having part of element M1 and/or M2 therein replaced by an activation element (M3). M1aM2bPcO15(1) (Here, M1 represents one or more elements chosen from the group comprising Ca, Sr, and Ba; M2 represents one or more elements chosen from the group comprising Mg and Zn; a is a number between 1.5 and 2.5, inclusive; b is a number between 2.5 and 3.5, inclusive; and c is a number between 3.5 and 4.5, inclusive.) A fluorescent body in which M1 is Sr and M2 is Mg, and a fluorescent body in which M3 is Eu are preferable. Also provided are a fluorescent paste having the fluorescent body, and a near-ultraviolet excitation light-emitting element having the fluorescent body and having a high luminescent intensity.Type: ApplicationFiled: March 18, 2009Publication date: January 20, 2011Applicants: NIIGATA UNIVERSITY, SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Kenji Toda, Kazuyoshi Uematsu, Mineo Sato, Tetsu Umeda, Yutaka Ito
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Patent number: 7843570Abstract: A substance adsorption detection method and a sensor utilizing amounts of change in the optical characteristic of a sensitive thin film with respect to the adsorbed amount of a substance to be detected. A clad 4, a core 5, and a thin film 7 for detecting an adsorbed substance are sequentially stacked on a crystal oscillator 10 to constitute an optical waveguide layer 12 and a gas adsorption member 11. An incoming light prism 8 and an outgoing light prism 9 are provided on the surface of the core 5. Changes in the adsorbed mass of the target substance and in the optical characteristic involved can be detected accurately and simultaneously by utilizing a change in outgoing light originating from a change in propagation loss and a change in the oscillation characteristic of the oscillator 10, both caused by adsorption of the target substance on the core surface.Type: GrantFiled: July 28, 2005Date of Patent: November 30, 2010Assignee: Niigata UniversityInventors: Kazunari Shinbo, Futao Kaneko, Keizo Kato, Yasuo Ohdaira, Takahiro Kawakami
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Publication number: 20100287133Abstract: There are provided an identification device, an identification method and an identification processing program, which are capable of significantly reducing a processing burden. An identification device 1 can judge the magnitude relation between an occurrence probability value of a class 0 and an occurrence probability value of a class 1 from the magnitude relation between gkupper and gklower. Hence, it can be identified which one of the classes 0 and 1 is applicable to observed data D1 with a simple arithmetic processing. Accordingly, a complicated and heavy-burden arithmetic processing of an exponential function can be avoided for obtaining the occurrence probability values of the classes 0 and 1, enabling the processing burden to be significantly reduced.Type: ApplicationFiled: January 16, 2009Publication date: November 11, 2010Applicant: Niigata UniversityInventors: Shogo Muramatsu, Hidenori Watanabe
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Publication number: 20100233738Abstract: The present invention is intended to develop a urine pretreatment agent, a urine pretreatment method, and a urinary protein quantitation method which reduce or cancel the influences of urine pH variations, cancel the influences of precipitates of urinary inorganic salts, and solubilize membrane proteins. The present invention provides: a urine pretreatment agent for urinary protein quantitation, comprising a buffer, a chelating agent, and a surfactant; a urine pretreatment method comprising a step of mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and a urinary protein quantitation method comprising steps of: mixing 10 to 1000 parts by mass of the urine pretreatment agent of the present invention with 100 parts by mass of urine; and then measuring the protein concentration.Type: ApplicationFiled: September 26, 2008Publication date: September 16, 2010Applicants: Niigata University, Masanori HARA, Denka Seiken Co., Ltd.Inventors: Masanori Hara, Akihiko Saito, Shinya Ogasawara, Yoshiaki Hirayama, Hiroyuki Kurosawa
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Publication number: 20100217789Abstract: There is provided a physical random number generation method and a physical random number generator by which safe random numbers can be obtained at high speed. The physical random number generator comprises a laser equipment which irradiates laser light, a frequency discrimination filter which discriminates frequencies of the laser light, an photodetector which converts intensity of laser light into electric signals, an on-off detector or an A/D converter which converts analogue signals output from the photodetector as a detected result into digital data. First, the laser light irradiated from the laser equipment is allowed to pass through the frequency discrimination filter. Transmitted light changes in intensity depending on frequency fluctuations of the laser light. Then, this intensity of the transmitted light is converted into electric signals by the photodetector to be converted into binary random numbers using the on-off detector or the A/D converter.Type: ApplicationFiled: October 4, 2006Publication date: August 26, 2010Applicant: NIIGATA UNIVERSITYInventors: Yoshiaki Saitoh, Takashi Satoh
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Publication number: 20100186512Abstract: A quantitative evaluation device and method of an atomic vacancy, which are capable of efficiently and quantitatively evaluating an atomic vacancy existing in a silicon wafer. A quantitative evaluation device 1 is equipped with a detector 5 including an ultrasonic generator 27 and an ultrasonic receiver 28, a silicon sample 6 formed with the ultrasonic generator 27 and the ultrasonic receiver 28 on a silicon wafer 26 comprising perfect crystal silicon, a magnetic force generator 4 for applying an external magnetic field to the silicon sample 6, and a cooler 3 capable of cooling and controlling the silicon sample 6 to a range of temperatures lower than or equal to 50K.Type: ApplicationFiled: July 2, 2008Publication date: July 29, 2010Applicant: Niigata UniversityInventors: Terutaka Goto, Hiroshi Kaneta, Yuichi Nemoto
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Patent number: 7760963Abstract: A method employing a statistic means to test whether or not luminance signals around a point of interest are distributed according to the same probability distribution with respect to luminance signals of respective pixels constituting the image; determining a range where the same probability distribution can be regarded as being satisfied, estimating the true luminance value of the point of interest by using the luminance data of the range. Especially when the image signals are faint to such an extent that the intensity of the luminance signal is based on the Poisson distribution, it is effective to perform a smoothing processing for each of the probability distributions of the signals and the noises by a test of a uniformity of the Poisson distribution, enabling a clear and denoised image to be obtained.Type: GrantFiled: December 7, 2005Date of Patent: July 20, 2010Assignee: Niigata UniversityInventors: Takayuki Matsuto, Kohei Akazawa, Shin-ichi Toyabe, Tatsuo Ushiki
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Publication number: 20100145346Abstract: A jig and a system for supporting artificial hip joint with which an artificial shelf can be arranged at an ideal arranging position more easily at reduced facility cost. Since existing arthroscope (3) and a medical drill generally used in an operating room are fixed to and held on a small jig (4) for supporting artificial hip joint replacement of simple arrangement which can be fixed to the shell of a patient, correct profile of the shell HC of the patient at current moment in time can be recognized easily and surely with an arthroscope (3). Furthermore, since drilling position and direction of the medical drill can be determined using a first two-dimensional coordinates and a second two-dimensional coordinates, the shell HC of the patient can be shaped into ideal profile accurately without using an expensive special device for exclusive use and thereby the artificial shell can be arranged at an ideal position more easily.Type: ApplicationFiled: June 15, 2006Publication date: June 10, 2010Applicant: Niigata UniversityInventors: Yoshio Koga, Koichi Kobayashi
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Publication number: 20100129914Abstract: An object is to provide a Tol1 element transposase and a use thereof. Provided is a Tol1 element transposase containing (a) a protein having the amino acid sequence of SEQ ID No: 1 or (b) a protein having an amino acid sequence homologous to the amino acid sequence of SEQ ID NO: 1 and having an enzymatic activity for transferring Tol1 element. Further, provided are a polynucleotide encoding the transposase and an expression construct containing the polynucleotide therein. The present invention also provides a DNA introduction system including (a) a donor factor having such a structure that a desired DNA is inserted in a transposase gene-defected Tol1 element and (b) a helper factor containing the transposase or the polynucleotide.Type: ApplicationFiled: December 6, 2007Publication date: May 27, 2010Applicants: National University Corporation Nagoya University, NIIGATA UNIVERSITYInventors: Akihiko Koga, Satoshi Hamaguchi
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Publication number: 20100068709Abstract: An object is to provide: a method for determining a tongue cancer in which the malignancy of tongue cancer can be objectively and accurately determined; a method for analyzing a tongue cancer tissue specimen; and a kit for analyzing a tongue cancer tissue specimen. There is provided: a method for determining a tongue cancer, comprising measuring mRNA quantity of an integrin family gene and a reference gene in the tongue cancer tissue specimen, and determining the malignancy of the tongue cancer based on a ratio of the mRNA quantity of the integrin family gene/the mRNA quantity of the reference gene; a method for analyzing a tongue cancer tissue specimen, comprising the steps of measuring mRNA quantity of an integrin family gene and a reference gene in the tongue cancer tissue specimen, and correlating a ratio of the mRNA quantity of the integrin family gene/the mRNA quantity of the reference gene with clinical data; and a kit for analyzing a tongue cancer tissue specimen.Type: ApplicationFiled: September 28, 2007Publication date: March 18, 2010Applicant: NIIGATA UNIVERSITYInventors: Masaki Nagata, Akira Kurokawa