Patents Assigned to Nissho Corporation
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Patent number: 5891102Abstract: A self-administration device includes a cylindrical casing opened at one end but closed at the opposite end. The closed opposite end is provided with a drug inflow port and a drug outflow port. An easily deformable and restorable reservoir is housed in the casing and is held by the closed end of the casing. The inflow port and outflow port are opened to the interior of the reservoir while a pushing device is provided at the open end of the casing and is movable along an inner wall of the casing to exert a pressure on the reservoir. A control device is provided for adjusting a moving distance of the pushing device to control a dosage of a liquid drug.Type: GrantFiled: April 9, 1997Date of Patent: April 6, 1999Assignee: Nissho CorporationInventors: Katsuhiro Hiejima, Takeshi Mori
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Patent number: 5891109Abstract: A medical device having good surface lubricity in the wet condition, high frictional durability and surface lubricity stability comprises a body and a smoothing or lubricating coating on a surface of the body. The coating is produced by applying a solution of a mixture of maleic anhydride high polymer and polyurethane having allophanate bond on a surface of the body, insolubilizing the resultant coating by heating, and then hydrophilizing the coating with a hydrophilizing agent such as ammonia, amine or alcohol.Type: GrantFiled: August 8, 1997Date of Patent: April 6, 1999Assignee: Nissho CorporationInventors: Hiroyuki Inoue, Takeshi Nizuka
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Patent number: 5866061Abstract: Method of manufacturing containers for dispensing solutions, includes the steps of: (a) extruding a parison from a die while injecting supporting air into the parison, and sealing a forward part of the extruded parison; (b) forming a middle portion of the parison constituting a barrel portion of a container to be produced, during extrusion of the parison, so as to have a wall thickness thinner than the forward part of the parison; (c) injecting air into the parison, after being inserted into a mold with a vacuum mechanism, to blow it out while keeping a pressure in the interior of the mold to a value lower than an internal pressure of the parison, and cutting off the parison from the die to form a container, (d) inserting a mandrel into the molded container through a cut opening of the container after transferring the mold retaining the molded container to a solution-charging station and charging a medical solution into the molded container; and (e) pulling the mandrel out of the container after charging a meType: GrantFiled: July 17, 1997Date of Patent: February 2, 1999Assignee: Nissho CorporationInventors: Tetsuji Miyamoto, Mitsuhiro Tadano
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Patent number: 5865309Abstract: A dual-chambered container includes a chamber which contains, for example, a dry drug and a chamber which contains, for example, a medical liquid. The chambers are defined in first and second bags, with each bag having a weak seal formed in a side thereof. The bags are formed separately and then joined to one another so that the weak seals therein are positioned so that a passageway is formed between the bags when the weak seals are forcibly broken. The chambers can be sterilized independently of each other and, consequently, the container can be manufactured in a manner which minimizes the amount of labor required.Type: GrantFiled: October 24, 1997Date of Patent: February 2, 1999Assignee: Nissho CorporationInventors: Hitoshi Futagawa, Noriyoshi Yamamoto
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Patent number: 5839470Abstract: A three-way stopcock and a flow rate control device having a flow rate control unit for controlling the flow rate by flow resistances of flow rate control tubes. The three-way stopcock includes a plug portion in a cylindrical shape having a liquid path in a T-like shape, a cylindrical portion having two flow inlet ports and one flow outlet port, into which the plug portion can be inserted rotatably and in a liquid tight fit, and a switch lever capable of attachably and detachably engaging with the plug portion, wherein when the liquid path of the plug portion communicates with the flow outlet portion of the cylindrical portion by rotation of the plug portion by the switching lever, the liquid path of the plug portion communicates with at least one of the two flow inlet ports of the cylindrical portion.Type: GrantFiled: April 3, 1997Date of Patent: November 24, 1998Assignee: Nissho CorporationInventors: Katsuhiro Hiejima, Yosuke Naoki
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Patent number: 5826713Abstract: A fluid vessel including a drug vessel with a mouth portion sealed with a penetrable plug, a vial guide which holds the drug vessel and a flexible solvent vessel. The flexible solvent vessel has a drug solution outlet port and a communication port to the drug vessel, and an integrally molded tubular guide portion concentrically surrounding the communication port. Also included is a slidable communication mechanism housed in the tubular guide portion for communicating an inside of the solvent vessel and an inside of the drug vessel. Furthermore, also included is a cap for housing the vial guide and for rotatably sealing an opening of the guide portion, and a drug vessel push-down mechanism for moving the drug vessel down towards the communication port of the solvent vessel.Type: GrantFiled: April 30, 1997Date of Patent: October 27, 1998Assignees: Fujisawa Pharmaceutical Co., Ltd., Nissho CorporationInventors: Seizo Sunago, Osamu Takahata, Akira Kagayama, Hitoshi Futagawa, Tetsuji Miyamoto, Mitsuo Murakami
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Patent number: 5814068Abstract: A suture thread for intracardiac suture operation, comprises a thread guide element (1) and a thread (2) joined to a rear end thereof, the thread guide element (1) being composed of a slender straight member (11) of a super-elastic alloy wire and a looped member (12) of a super-elastic alloy wire provided at a front end of the straight member (11). The thread guide element (1) may be further provided at its rear end with a looped member (13) of a super-elastic alloy wire. The super-elastic alloy may be an alloy selected from the group consisting of Ti-Ni, Cu-Zn-AI and Cu-AI-Ni alloys. The looped member (12) of the suture thread is captured by suture-hooking means (42) of a catheter assembly (C) including a hooking catheter (4).Type: GrantFiled: June 13, 1997Date of Patent: September 29, 1998Assignee: Nissho CorporationInventors: Kazuyuki Koike, Yoshikazu Kishigami, Katsuya Miyagawa, Syu Kurashima
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Patent number: 5810167Abstract: An infectious waste container for blood collection needles comprises a container body (1) for containing blood collection needles, a lid body (2) attached to the container body (1), and needle-removing means (3) attached to the lid body (1) for removing a blood collection needle from a blood collection needle holder, the needle-removing means having a holder insertion section (31) and a holder suspension section (32) and being axisymmetrially provided with first and second notched portions (33, 34) extending from the holder insertion section to the holder suspension section. The first notched portion is stretched to a downwardly slanted portion protruded inwardly from a bottom of the first notched portion, the second notched portion is extended to a position deeper than a level of the slanted portion by a certain distance and terminated within the holder suspension section.Type: GrantFiled: July 28, 1997Date of Patent: September 22, 1998Assignee: Nissho CorporationInventor: Tsuguo Fujii
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Patent number: 5802814Abstract: A fiber bundle is wrapped with a tape by helically and entirely winding the tape around the bundle, while applying a constant longitudinal tension to the bundle; and thereafter unwinding and removing the tape from its last turn to gradually expose the bundle towards its basal end, while inserting the exposed portion of the bundle gradually into a cylindrical protector. The method keeps constant the outer diameter of the bundle by adjusting the tape tension, even if the bundles are composed of varied numbers of fibers in one protector, so that a wider use of the protector is realized. In the method, the wrapping operation does not produce any damaged fibers from which a fluid such as blood leaks in a hollow fiber apparatus, and no later adjustment is necessary for the wrapped bundles, thus improving the production efficiency.Type: GrantFiled: August 10, 1995Date of Patent: September 8, 1998Assignee: Nissho CorporationInventor: Kazuhiko Sano
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Patent number: 5797490Abstract: A holder for a blood collection needle includes a cylinder and a needle fixing mechanism disposed at a distal end wall of the cylinder. The needle fixing mechanism includes a first slider, a second slider, a retainer, and a frame. The first slider and the retainer have half female members integrally formed thereon. The first slider is movable toward the second slider such that the mechanism is in a closed state in which the first slider engages the frame such that the half female members come together to define a complete female member. The second slider is movable toward the first slider such that the mechanism is in an open state in which the first slider is disengaged from the frame. The frame is affixed to the cylinder so as to hold the first slider, the second slider, and the retainer on the end wall thereof.Type: GrantFiled: October 9, 1996Date of Patent: August 25, 1998Assignee: Nissho CorporationInventors: Tsuguo Fujii, Keizo Matsumura, Toshihiro Kikuchi
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Patent number: 5774996Abstract: A biaxial inclination sensor including, in the inner bottom of a circular liquid chamber 11 formed in a sensor holder 1 made of an insulating material and having a bottom surface 28 made horizontal, one common electrode 2 made of 18K gold having a low ionization tendency in a central position and vertical with respect to the bottom surface 28 and four outer electrodes 3 made of the same material as the common electrode 2 and passing vertically through the bottom surface 28 at points of intersection of two horizontal orthogonal lines passing through the center and a circle of a predetermined radius about the center and all having the same surface area. An opening in the liquid chamber 11 of the sensor holder 1 is closed off in a liquidproof manner by a glass window plate 4 having a spherical concave portion 9 of a surface roughness less than JIS Rmax 0.25 in its inner surface.Type: GrantFiled: February 8, 1996Date of Patent: July 7, 1998Assignee: Nissho CorporationInventors: Hideo Ogawa, Norihisa Teraji, Isshu Terauchi
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Patent number: 5755707Abstract: A vascular dilating catheter comprising an outer tube, an inner tube and a connector, wherein said connector comprises an inlet for injecting a balloon distending solution and an inlet for insertion of a guidewire into the inner tube; the inner tube is inserted into the outer tube; and the outer tube having flexibility at a distal end side and rigidity at a proximal end side is provided with a balloon at the distal end portion thereof, the outer tube being adhered to the inner tube at the position enclosed by the balloon, and the outer tube having, between the proximal end of the balloon and the site of adhesion to the inner tube, a through-hole which connects the inner cavity of the balloon and a circular lumen formed as a gap between the outer tube and the inner tube. According to the catheter of the present invention, various forces applied to the proximal end of the catheter can be directly and positively transmitted to the distal end portion of the catheter.Type: GrantFiled: July 30, 1996Date of Patent: May 26, 1998Assignee: Nissho CorporationInventors: Katsuya Miyagawa, Shu Kurashima, Nozomu Fujita
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Patent number: 5720731Abstract: Prefilled syringe for injection of two liquids includes a syringe body with an injection port at a closed end thereof, first and second gaskets fluid-tightly fitted into the syringe body to separate two medical solutions filled therein, and a closing member for closing the injection port. The syringe body is provided with bypassing grooves extending in the longitudinal direction of the syringe from a position adjacent to the closed end thereof. Liquid communication means is provided between the closed end and the first gasket. By pushing a plunger, the first and second gaskets are forced to move forward so that two medical solutions are injected one after another.Type: GrantFiled: April 12, 1996Date of Patent: February 24, 1998Assignee: Nissho CorporationInventors: Masafumi Aramata, Hitoshi Futagawa, Hideki Yagi
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Patent number: 5716367Abstract: A catheter assembly for intracardiac suture comprises a hooking catheter (4) provided at a distal end with a suture-hooking member (42) and at the proximal end with a manipulating element (41) at a proximal end thereof; a first sheath (3) for movably holding the hooking catheter therein; a piercing catheter (2) for movably holding the first sheath, provided at a distal end with a piercing needle and at the proximal end with a hemostatic valve 29; and a second sheath (1) for movably holding the piercing catheter, provided at the proximal end with a hemostatic valve 19. The piercing catheter (2) and second sheath (1) are provided at each distal portion with a side hole (21, 11) so that the side hole (21) of the piercing catheter (2) is laid to lie the side hole (11) of the second sheath (1) when the tip of the piercing catheter (2) is reached to the tip of the second sheath to allow the first sheath (3) to protrude through the overlapped side holes (21, 11).Type: GrantFiled: October 18, 1996Date of Patent: February 10, 1998Assignee: Nissho CorporationInventors: Kazuyuki Koike, Yoshikazu Kishigami, Katsuya Miyagawa, Nozomu Fujita
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Patent number: 5706937Abstract: A flexible and dual-chambered container includes a first frontal sheet fusion bonded to a first rear sheet to define a first chamber for containing, for example, a medical liquid. The first frontal sheet is a flexible and transparent sheet for intercepting water, moisture, and oxygen gas. The first rear sheet is a flexible composite sheet composed of aluminum foil and a water-absorbing stratum. A second frontal sheet is fusion bonded to a second rear sheet to define a second chamber for containing, for example, a medical liquid. The second frontal and rear sheets are joined to the first frontal and rear sheets so that the first and second chambers are isolated by a breakable or weak seal. An opaque and flexible cover sheet composed of aluminum foil is removably disposed on the first frontal sheet. When the weak seal is broken by manually compressing the second chamber, the first and second chambers are brought into liquid communication.Type: GrantFiled: March 18, 1996Date of Patent: January 13, 1998Assignee: Nissho CorporationInventors: Hitoshi Futagawa, Noriyoshi Yamamoto, Masanobu Iwasa
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Patent number: 5704368Abstract: An apparatus for measuring an electrogastrogram and an intestinal electrogram including at least an electrode fixed to a body surface, an amplifier for amplifying a potential detected by said electrode, a low-pass filter for removing frequency signals other than the potentials of the stomach and the bowel amplified by said amplifier and a recorder.The relationship between the frequency of the input signal of said low-pass filter and the phase of the output signal is made linear.Type: GrantFiled: June 12, 1995Date of Patent: January 6, 1998Assignees: Gram Corporation, Nissho CorporationInventors: Fumitaka Asano, Yoshio Yamada
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Patent number: 5700251Abstract: A catheter body includes a main lumen and an auxiliary lumen. The main lumen has an outlet opening located at a distal end of the body and an inlet opening at a proximal end. The auxiliary lumen has an outlet opening located behind and spaced from the distal end a distance of 5-10 cm and an inlet lateral opening located toward the proximal end. An adapter for providing inlet ports communicating with the inlet openings of the main lumen and auxiliary lumen is provided on the catheter body. The adapter includes three members detachably connected to one another. The forward and middle members have threaded portions which engage one another and the middle and rearward members also have threaded portions which engage with one another. Annular seals are provided between the forward and middle members and the middle and rearward members. The adapter can be readily attached to the catheter body and an external device for dosing a liquid medicine can be attached to the adapter.Type: GrantFiled: December 1, 1995Date of Patent: December 23, 1997Assignee: Nissho CorporationInventors: Hidekazu Miyauchi, Katsuhiro Hiejima
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Patent number: 5666966Abstract: A suction-type blood sampler has a housing (1), a lancet unit (2) having a rod (4) extending backward from the lancet unit, and a plunger (3) connected to the rod in the housing and having a seal (7) attached to a forward end of the plunger. The seal is in sliding airtight contact with an inner periphery of the housing. The lancet unit consists of a lancet body (11) having a forwardly extending needle (12) and held by a lancet retainer (18) which is in sliding contact with the inner periphery. The blood sampler further has first, second and third springs (8, 9, 10) placed between the lancet unit and the plunger. The second spring urges the lancet unit to project the needle forwards, and the third spring tends to retract it. The first spring acts to reduce air pressure in the housing when the plunger is released.Type: GrantFiled: June 2, 1995Date of Patent: September 16, 1997Assignee: Nissho CorporationInventors: Masao Horie, Yoshikazu Kishigami, Hiroyuki Nakagami, Masayuki Takatera
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Patent number: 5656153Abstract: A water-removal control system for dialysis device includes a volume-setting device for setting a planned volume of water to be removed; a rate-setting device for setting a water-removing rate; and a time-display for calculating from the planned volume of water to be removed, set by said volume-setting device, and the water-removing rate set by said rate-setting device, and for displaying the resultant finish time of dialysis treatment. The control system is so designed as to allow the water-removing rate to be changed step by step by operating the rate-setting device during dialysis, and allow the time-display to calculate the finish time of dialysis treatment synchronously with a stepped change of the water-removing rate as well as to display the resultant finish time of dialysis treatment.Type: GrantFiled: June 6, 1995Date of Patent: August 12, 1997Assignee: Nissho CorporationInventors: Masahiro Kameno, Junichi Kawashita
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Patent number: 5624405Abstract: A prefilled syringe comprising a syringe body of glass; a sealing member with a through-hole extending in the axial direction of said syringe body; a tip member including a top wall, a skirt portion extending therefrom and a tubular projection passing through said top wall, said tubular projection including an outwardly extending projection and an inwardly extending projection; a covering means for closing the outwardly extending projection of said tip member; and a holding member for holding said covering member along with said tip member in place on the mouth portion of said syringe body, said tip member being liquid-tightly fixed to the mouth portion of the syringe body by said holding member.Type: GrantFiled: May 24, 1995Date of Patent: April 29, 1997Assignee: Nissho CorporationInventors: Hitoshi Futagawa, Masafumi Aramata, Yoji Arifuku, Kenji Himeshima