Abstract: A drug vessel suitable for aseptic mixing of a drug with a solvent or diluent and for parenteral administration of the resultant solution, which includes a cylindrical vessel body reduced in diameter at both sides thereof to form a narrow mouth portion at each end, and a seal member to be attached to each mouth portion of the vessel body for sealing the same.

Abstract: A drug vessel includes a vessel body with a narrow neck extending to an open end of a mouth portion thereof, and a stopper fitted in the open end. The stopper includes a stopper body of an elastomeric material with a through-hole passing through a central portion thereof along its center axis, and a closing body fitted into the through-hole of stopper body to block the through-hole.

Abstract: A fluid container comprises a drug container, a deformable solvent container, a double-pointed hollow needle having a sharp piercing edge at each end and being arranged between the drug container and the solvent container, a guide capsule with a cap rotatably mounted thereon, and a means for converting rotary motion of the cap to a linear motion of the drug container to push the drug container toward the solvent container in cooperation with the cap and the guide capsule so that a fluid communication is made between two containers through the needle.

Abstract: A drug container is sealed by an annular packing arranged on an open end of a container body, a spherical closing member held on the annular packing, and a cap-like holder fitted on the mouth portion of the container body. In use, the drug container is screwed to a solvent container assembly having a partition wall with a pushing rod. The spherical closing member is pushed out from the packing by the pushing rod and then the partition wall is broken out by the holder of the drug container to communicate the container body with the solvent container.

Abstract: A connector assembly including an injection needle for providing fluid communication through a closed injection site at one end of an infusion line for infusing fluid therapy to a patient which includes an injection needle, a hub at one end of the needle, a tube connected to the hub, and a connector mounted to the hub. The connector includes a thread or other device for securing the connector to a complimentary connector provided the end of the infusion line. A second end of the needle extends beyond the thread or other device to permit the needle to pierce the injection site prior to engagement of the thread or other device with the complimentary connector and at least one of the two connectors is mounted for rotary movement relative to the needle and the injection site to permit the connectors to be secured together by rotary movement subsequent to piercing the needle through the injection site without rotating the needle.

Abstract: An apparatus for the self-dosing of a liquid medicine. The apparatus includes a chamber formed in a casing for receiving a liquid medicine to be self-dosed by a patient, with an inlet and outlet port formed to communicate with the chamber free from leakage of the medicine. The apparatus further includes a piston fitted liquid-tightly in the chamber, a push button attached to and adapted to actuate the piston and which is capable of being pressed by the patient a desired number of times corresponding to an amount of liquid medicine to be dosed, and a spring urging the piston towards its home position. After the patient presses the button and removes his hand from the button, the spring forces the piston backwards to its home position and the resulting negative pressure causes a subsequent smooth refilling of the chamber. The apparatus, which is a simple structure and can be manufactured at a low cost, can be employed in an integrated system for the self-dosing of the liquid medicine.

Abstract: A blood separation composition for use in blood collection tubes. The composition comprises a fatty acid amide(s) blended with a gel-like material which is the main ingredient of said composition. The amide(s) render(s) stable and less flowable the blood separation composition during storage, allowing it to form a stable partition barrier in each collection tube when centrifuged, with the blood cells above the barrier being prevented from remaining within the serum. The blood separation composition containing the fatty acid amide(s) does not release any harmful oily substance.

Abstract: A device for forming an inserting hole comprising at least two tubes having different outer diameters, and at least one of a guide wire and a sticking needle. A largest diameter tube has at its thick-walled end at least one longitudinal and approximately linear tearing line. The largest diameter tube, after being inserted into the body, can be torn using the tearing line and fixed to the skin of a patient by sewing a folded portion of the tube on the skin. The tube is not moved by the breathing or pressure since it is fixed to the skin. When the tearing line is formed by an ultrasonic cutter, width of the tearing line can be made narrow thereby preventing adhesion of bacteria to a cut portion and unexpected opening of the tearing line in the body.

Abstract: A viscosity of liquids is measured by inserting one end of a fine tube into one end of a tubular vessel sealed and maintained at a reduced pressure, while dipping the other end of the fine tube in a liquid to be measured, to cause the liquid to flow into the the vessel through the fine tube under the influence of a difference in pressure between both ends of the fine tube, detecting an internal pressure of the tubular vessel with a pressure sensor connected to the vessel to measure a change of an internal pressure of the vessel with passage of time and a change of a flow rate of the liquid passing through the fine tube with passage of time, and determining a viscosity of the liquid from the change of the internal pressure of the vessel and the change of the flow rate of the liquid. The pressure sensor is connected to the vessel by a device for piercing the other stopper and its output signals are fed to a computer through an A/D converter to calculate the viscosity of the liquid.

Abstract: A blood collecting tube includes a bottom-closed tubular member closed at one end and open at the other end, a stopper having an upper flange portion and a lower annular skirt portion extending therefrom and fitted in the open end of the tubular member, and a cap member placed on the tubular member. The tubular member has an annular flange so designed that its diameter increases in the direction toward the closed bottom to form a groove between its flange and the flange of the stopper whereas the cap member is provided with at least two inward projections of which one projection is adapted to engage with the flange of the tubular member, the other projection being engaged with the flange of the stopper and held in the groove.

Abstract: An artificial tubular organ composed of a tubular supporting frame made of a plastic material which is provided on at least one surface therefore with a medical prosthetic material. The supporting frame is composed of a plurality of ring portions arranged on an axis, and a plurality of pairs of connecting portions extending between adjacent two ring portions so as to connect them to each other, every other pair of the connecting portions being diametrically arranged on the ring portions, the remaining pairs of the connecting portions being arranged such that a plane containing their center lines is perpendicular to a plane containing the center lines of pairs of diametrically arranged connecting portions. The medical prosthetic material may be a woven fabric, a knitted fabric, a nonwoven fabric, or a combination thereof. Preferred fabric includes absorbable macromolecular yarns and nonabsorbable macromolecular yarns.

Abstract: A hollow needle for use in measurement of viscosity of liquids, includes at least one small and slender straight tube and a hub fixed thereto and provided with a connector member. The tube includes a piercing portion and a suction portion extending therefrom to form an opening for suction of a liquid to be measured. The piercing portion has a sharp edge at its one end and is fixed to the hub at the other end, the inside diameter (D) of a bore of the tube including the edge of the piercing portion being made uniform over a specified length (L) of the tube defined by equation: L/D=50 to 500.

Abstract: A method for producing a rubber stopper for a vial, a leg portion side of which is covered with a synthetic resin film. The producing method comprises (i) a primary forming step of piling a synthetic resin film 1 resistant to medicines or medical chemicals onto an unvulcanized rubber sheet 2, and forming by pressing and heating them between the molds (A, B), (ii) a secondary forming step of covering the primary formed article from the leg side of the primary formed article with a half-vulcanized rubber sheet having a hole 10 of which diameter is the same as that of a root portion of the leg portion 4 of the primary formed article and forming by pressing and heating it by means of a pair of molds, and (iii) a step of cutting and removing a flash around the resulting secondary formed article. A rubber stopper and a synthetic resin sheet being laminated can be formed at one time.

Abstract: Apparatus for manufacturing an injection needle having a hub and a cannula whose back end terminates within the hub. The apparatus includes a first subassembly jig for mounting the hub, inserting a cannula into a center hole of the hub, and securing the hub and cannula together with an adhesive. A silicone-containing-liquid is applied to the back end of the hub-cannula assembly. A second subassembly jig is provided for mounting the hub-cannula assembly to remove excess silicone-containing-liquid within the cannula, covering the front end with a cap, and housing the hub-cannula-cap assembly with a container. An opening of the container is sealed after the hub-cannula-cap assembly is removed from the second subassembly jig.

Abstract: A method for applying silicone oil to a back end of an injection needle having a hub with a center hole and a cannula inserting in the center hole, in which the cannula has a front end with a sharp bevel and a back end with another sharp bevel and the back end terminates within the hub. The method comprises allowing silicone-containing-liquid to continue to overflow at a constant rate of flow from a top end of a rising pipe having an inner diameter larger than an outer diameter of the cannula and an outer diameter smaller than an inner diameter of the hub, and concurrently dipping the back end into silicone-containing-liquid at the top end of the rising pipe. Silicone with no foreign matter can be applied to the injection needle while preventing adhesion of silicone containing liquid to the hub. The apparatus used for carrying out the method is also disclosed.

Abstract: A method of manufacturing an injection needle having a hub and a cannula whose back end terminates within the hub. The method comprises the step of mounting the hub on a first subassembly jig, inserting the cannula into a center hole of the hub, applying an adhesive to a bonding area of the hub and cannula, curing the adhesive, dismounting the hub-cannula assembly from the first subassembly jig, applying silicone-containing-liquid to the back end, mounting the hub-cannula assembly on a second subassembly jig removing excess amount of silicone-containing-liquid within the cannula, covering the front end with a cap, housing the hub-cannula-cap assembly with a container, dismounting the hub-cannula-cap-container assembly from the second subassembly jig, and sealing an opening of the container. The apparatus used for carrying out the method is also disclosed.

Abstract: A closing appliance used in a flexible tube comprising a communicating tube, a column-like portion, and a thin-walled portion formed between the communicating tube and column-like portion. The column-like portion has two wings facing to each other at an end opposite to the thin-walled portion. The wings have rounded surface on the side of the inner surface of the flexible tube, and a total lateral sectional area of the two wings is from 25 to 50% of a sectional area of a hollow portion of the flexible tube. Thanks to wings, damage of the flexible tube on centrifugal separation process can be avoided.

Abstract: A liquid infusion device comprising a bladder assembly, an approximately tubular housing, and a liquid-drug-dispensing portion. The bladder assembly comprises a rod-like inner shaft, a tubular outer shaft slidably encasing the inner shaft, an inner shaft supporter, and a bladder made of elastic material and placed outside two shafts. The housing contains the bladder assembly and has an inlet/outlet portion at an end of the housing. The inner shaft supporter has at least one port for liquid drug communicating with the inlet/outlet portion. An amount of liquid drug remaining in the bladder can be greatly reduced, since a clearance between the inner shaft and outer shaft can be made very small.

Abstract: A pharmaceutical composition for treating inflammatory diseases, comprising (A) an effective amount of hyaluronic acid or its salt, and (B) an effective amount of an anti-inflammatory agent. The composition exhibits a synergistic therapeutic effect on inflammations and is useful for treating inflammatory diseases, particularly diseases of joint with inflammation.

Abstract: A fluid-communicating device with valve function comprising a tubular body having an inlet and an outlet, and a blocking body inserted in the tubular body is disclosed. The blocking body comprises a plug portion, and a supporting portion on which a diameter-enlarging portion for enlarging an inner wall of the tubular body is provided. The plug portion of the blocking body is placed in a seal portion of the tubular body to close the tubular body and to prevent the passage of fluid. In use, a tip of a syringe and the like is inserted into the tubular body, so that there is formed a clearance between the outer wall of the plug portion and the inner wall of the seal portion. Fluid passes through the clearance and a fluid passage formed longitudinally on the supporting portion or on an inner wall of the tubular body.