Patents Assigned to Northwestern University
  • SINGLE-CELL LEVEL CONNECTOMICS USING A DNA-SYNTHESIS BASED BARCODING SYSTEM AND METHODS OF USING THE SAME
    Publication number: 20220282295
    Abstract: The present disclosure provides a DNA-synthesis based recording system that, in combination with CRISPR-Cas9 or other CRISPR systems, can establish single-cell level connectivity for densely packed cells, for example in the brain.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 8, 2022
    Applicant: Northwestern University
    Inventor: Keith E.J. Tyo
  • BRUSH POLYMERS FOR THERAPEUTIC APPLICATIONS
    Publication number: 20220280625
    Abstract: In an aspect, the invention provides therapeutic agents comprising brush polymers that address challenges associated with conventional administration of free therapeutic peptides. In an embodiment, for example, the invention provides brush polymers incorporating one or more therapeutic peptides as side chain moieties. Therapeutic agents of the invention comprising brush polymers include high-density brush polymers including cross-linked brush polymers and brush block copolymers. In an embodiment, brush polymers of the invention exhibit proteolysis-resistant characteristics and maintain their biological function during formulation and administration. The invention also includes methods of making and using therapeutic agents comprising brush polymers.
    Type: Application
    Filed: August 11, 2020
    Publication date: September 8, 2022
    Applicant: Northwestern University
    Inventors: Nathan C. GIANNESCHI, Jeremy A. LAVINE, Bin ZHANG, Or BERGER, Wonmin CHOI, Max Mu WANG, Claudia BATTISTELLA, Hao SUN
  • Adoptive cell therapy using spherical nucleic acids (SNAs)
    Patent number: 11433131
    Abstract: The disclosure is related to compositions comprising a cell and a spherical nucleic acid (SNA) comprising a nanoparticle, an oligonucleotide on the surface of the nanoparticle, and an antigen; and to methods for production of such compositions and their applications, including but not limited to adoptive cell therapy.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: September 6, 2022
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Andrew Lee, Bin Zhang, Donye Dominguez
  • PRODUCTION OF VANILLIN-GLUCOSIDE FROM LIGNIN-DERIVED CARBON
    Publication number: 20220275405
    Abstract: The present disclosure provides engineered bacteria for producing vanillin.
    Type: Application
    Filed: February 25, 2022
    Publication date: September 1, 2022
    Applicant: Northwestern University
    Inventors: Bradley W. Biggs, Keith E.J. Tyo
  • METHODS OF USING MODIFIED CYTOTOXINS TO TREAT CANCER
    Publication number: 20220273607
    Abstract: The present disclosure provides methods of using prodrugs of small-molecule cytotoxins for the treatment of cancer. In some embodiments, the cancer is a tumor comprising cells that overexpress fatty acid uptake proteins, such as cells that overexpress fatty acid translocase CD36. In some other aspects, the disclosure provides compositions suitable for use in such methods. In some further aspects, the disclosure provides combination therapies that may be suitable used in combination with the use of small-molecule prodrugs disclosed herein.
    Type: Application
    Filed: July 8, 2020
    Publication date: September 1, 2022
    Applicant: NORTHWESTERN UNIVERSITY
    Inventor: Nathan C. GIANNESCHI
  • Methods for treatment of erectile dysfunction with sonic hedgehog compounds
    Patent number: 11426448
    Abstract: Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: August 30, 2022
    Assignees: NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Carol Podlasek, Samuel I. Stupp, Kevin McVary, Dan Harrington
  • Tunable current-mirror qubit system
    Patent number: 11429887
    Abstract: One example includes a tunable current-mirror qubit. The qubit includes a plurality of flux tunable elements disposed in a circuit loop. A first portion of the flux tunable elements can be configured to receive a first input flux and a remaining portion of the flux tunable elements can be configured to receive a second input flux to control a mode of the tunable current-mirror qubit between a microwave excitation mode to facilitate excitation or quantum state manipulation of the tunable current-mirror qubit via a microwave input signal and a noise-protected mode to facilitate storage of the quantum state of the tunable current-mirror qubit. The qubit also includes at least one capacitor interconnecting nodes between respective pairs of the flux tunable elements to facilitate formation of Cooper-pair excitons in each of the microwave excitation mode and the noise-protected mode.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: August 30, 2022
    Assignees: NORTHROP GRUMMAN SYSTEMS CORPORATION, NORTHWESTERN UNIVERSITY
    Inventors: David George Ferguson, Cheong Yiu Li, Jens Koch, Moe Shwan Khalil
  • Substituted heterocycles as c-MYC targeting agents
    Patent number: 11420957
    Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: August 23, 2022
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Gary E. Schiltz, Atul Jain, Huiying Han, Sarki A. Abdulkadir
  • ENANTIOSELECTIVE CROSS DEHYDROGENATIVE COUPLING REACTIONS AND COMPOUNDS SYNTHESIZED BY THE REACTIONS
    Publication number: 20220259171
    Abstract: Disclosed are enantioselective cross dehydrogenative coupling reactions for synthesizing tetrahydropyran compounds. Novel tetrahydropyran compounds may be synthesized by the disclosed methods as well as tetrahydropyran precursor compounds for synthesizing various naturally occurring compounds. The enantioselective cross dehydrogenative coupling reactions utilize in situ Lewis Acid activation in combination with oxidative formation of an oxocarbenium ion to provide a highly efficient and selective coupling reaction for synthesizing tetrahydropyran compounds.
    Type: Application
    Filed: November 15, 2021
    Publication date: August 18, 2022
    Applicant: Northwestern University
    Inventors: Karl A. Scheidt, Ansoo Lee, Richard C. Betori
  • Liquid masks for microfabrication processes
    Patent number: 11415877
    Abstract: Disclosed herein are methods of using a fluoro oil mask to prepare a beam pen lithography pen array.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 16, 2022
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, David A. Walker, James L. Hedrick, III
  • Flexible woven thermoelectric fabrics for thermal management
    Patent number: 11417817
    Abstract: Woven flexible thermoelectric fabrics are provided. The fabric is a woven material that includes a series of longitudinal threads interwoven with a series of transverse threads. Within the longitudinal series, the threads have a repeating thread pattern of an n-type thermoelectric thread, a p-type thermoelectric thread, and an insulating thread. Within the transverse series, the threads have a repeating thread pattern of a first double-sided thread with conducting side down and insulating side up, a second double-sided thread with conducting side down and insulating side up, and a third double-sided thread with conducting side up and insulating side down.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: August 16, 2022
    Assignee: Northwestern University
    Inventors: Matthew Grayson, Ramille Shah, Jun Peng, Adam Jakus, Nicholas Geisendorfer
  • Amphoteric p-type and n-type doping of group III-VI semiconductors with group-IV atoms
    Patent number: 11417523
    Abstract: Methods of forming a p-type IV-doped III-VI semiconductor are provided which comprise exposing a substrate to a vapor composition comprising a group III precursor comprising a group III element, a group VI precursor comprising a group VI element, and a group IV precursor comprising a group IV element, under conditions to form a p-type IV-doped III-VI semiconductor via metalorganic chemical vapor deposition (MOCVD) on the substrate. Embodiments make use of a flow ratio defined as a flow rate of the group VI precursor to a flow rate of the group III precursor wherein the flow ratio is below an inversion flow ratio value for the IV-doped III-VI semiconductor.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 16, 2022
    Assignee: Northwestern University
    Inventor: Manijeh Razeghi
  • Surface hardening of substrates by a particle-containing cavitating waterjet
    Patent number: 11414717
    Abstract: In an embodiment, a method of hardening a surface of a substrate comprises directing a waterjet having a transition flow region, the waterjet comprising water and particles, at a surface of a substrate such that the waterjet impacts the surface within the transition flow region to provide a layer of embedded particles underneath the surface of the substrate, thereby forming a hardened substrate. The hardened substrates are also provided.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: August 16, 2022
    Assignee: Northwestern University
    Inventors: Qian Wang, Yip-Wah Chung, Kornel F. Ehmann, Xingliang He, Yi Shi, Zhong Liu
  • Peptide conjugated particles for the treatment of inflammation
    Patent number: 11413337
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: August 16, 2022
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick Mccarthy
  • Lewis Acid Polymerization Catalyst
    Publication number: 20220251283
    Abstract: A method of producing a polyether alcohol that includes feeding an initiator into a reactor, feeding one or more monomers into the reactor, feeding a polymerization catalyst into the reactor, the polymerization catalyst being a Lewis acid catalyst having a general formula M(R1)1(R2)1(R3)1(R4)0 or 1, separate from feeding the initiator into the reactor, feeding a hydrogen bond acceptor additive into the reactor, the hydrogen bond acceptor additive being a C2 to C20 organic molecule having at least two hydroxyl groups, of which two hydroxyl groups are situated in 1,2-, 1,3-, or 1,4- positions on the organic molecule, and allowing the initiator to react with the one or more monomers in the presence of the polymerization catalyst and the hydrogen bond acceptor additive to form a polyether alcohol having a number average molecular weight greater than a number average molecular weight of the initiator.
    Type: Application
    Filed: February 14, 2020
    Publication date: August 11, 2022
    Applicants: Dow Global Technologies LLC, Northwestern University, Northwestern University
    Inventors: Mihir Bhagat, Charmaine Bennett, Youlong Zhu, SonBinh T. Nguyen, Linda Broadbelt, Justin M. Notestein, Matthew E. Belowich, Arjun Raghuraman, William H. Heath, Sukrit Mukhopadhyay, Heather A. Spinney, David R. Wilson
  • Annuloplasty Ring For Receiving A Replacement Valve
    Publication number: 20220249231
    Abstract: An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “Valve In Ring Procedure.” The elastic features provide a squeezing force on the native valve annulus that both ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently-placed prosthetic valve.
    Type: Application
    Filed: April 26, 2022
    Publication date: August 11, 2022
    Applicant: Northwestern University
    Inventor: Patrick M. McCarthy
  • High temperature, creep-resistant aluminum alloy microalloyed with manganese, molybdenum and tungsten
    Patent number: 11408061
    Abstract: A high temperature creep-resistant aluminum alloy microalloyed with manganese and molybdenum and/or tungsten is provided. The aluminum alloy includes scandium, zirconium, erbium, silicon, at least one of molybdenum and tungsten, manganese and the balance aluminum and incidental impurities. The concentration of the alloying elements, in atom %, is greater than 0.0 and less than or equal to 0.15 scandium, greater than 0.0 and less than or equal to 0.35 zirconium, greater than 0.0 and less than or equal to 0.15 erbium, greater than 0.0 and less than or equal to 0.2 silicon, greater than 0.0 and less or equal to 0.75 molybdenum when included, greater than 0.0 and less than or equal to 0.35 tungsten when included, and greater than 0.0 and less than or equal to 1.5 manganese. And the total concentration of Zr+Er+Sc is greater than or equal to 0.1.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: August 9, 2022
    Assignees: Ford Global Technologies, LLC, Northwestern University
    Inventors: Anthony De Luca, David N. Seidman, David C. Dunand, James M. Boileau, Bita Ghaffari
  • TREATMENT OF CANCER
    Publication number: 20220241424
    Abstract: Described herein are compounds of Formula I, or their pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of using such compounds or compositions in inducing Cdc20 degradation in a cell, blocking mitotic progression, inhibiting tumor proliferation, treating cancer, and/or re-sensitizing a subject to cancer treatment with tamoxifen.
    Type: Application
    Filed: April 14, 2020
    Publication date: August 4, 2022
    Applicant: Northwestern University
    Inventors: Yong WAN, Zhaun ZHOU, Junlong Chi, Gary SCHLITZ
  • Photocontrolled dynamic covalent linkers for polymer networks
    Patent number: 11401387
    Abstract: Reversibly crosslinkable polymeric networks, including reversibly crosslinkable hydrogel networks are provided. Also provided are methods of making the polymeric networks and methods of using the hydrogel networks in tissue engineering applications. The reversibly crosslinkable polymeric networks are composed of polymer chains that are covalently crosslinked by azobenzene boronic ester bonds that can be reversibly formed and broken by exposing the polymeric networks to different wavelengths of light.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: August 2, 2022
    Assignee: Northwestern University
    Inventors: Julia A. Kalow, Joseph V. Accardo, Boyeong Kang
  • Protective anode coatings for high energy batteries
    Patent number: 11404719
    Abstract: Materials for coating a metal anode in a high energy battery, anodes coated with the materials, and batteries incorporating the coated anodes are provided. Also provided are batteries that utilize the materials as electrolytes. The coatings, which are composed of binary, ternary, and higher order metal and/or metalloid oxides, nitrides, fluorides, chlorides, bromides, sulfides, and carbides limit the reactions between the electrolyte and the metal anode in a battery, thereby improving the performance of the battery, relative to a battery that employs a bare anode.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: August 2, 2022
    Assignee: Northwestern University
    Inventors: Vinay Ishwar Hegde, David H. Snydacker, Christopher M. Wolverton