Patents Assigned to Northwestern University
  • Method and apparatus for double-sided incremental flanging
    Patent number: 11338348
    Abstract: Flanges formed on sheet metal parts to increase the part stiffness or create mating surface for further assembly are created in an incremental sheet forming process using forming tool and supporting tool that move along a specified tool path so as to gradually deform a peripherally-clamped sheet metal work piece into the desired geometry. With two universal tools moving along the designed toolpath on the both sides of the part, the process is very flexible. Process time is can also be reduced by utilizing an accumulative double-sided incremental hole-flanging strategy, in which the flange is formed in only one step.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: May 24, 2022
    Assignees: NORTHWESTERN UNIVERSITY, SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Huan Zhang, Jian Cao, Kornel Ehmann, Jun Chen
  • Non-neuroinvasive viruses and uses thereof
    Patent number: 11339378
    Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: May 24, 2022
    Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College
    Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
  • HIGH DENSITY LIPOPROTEIN MIMETIC NANOPARTICLES USING LIPID CONJUGATED CORE SCAFFOLDS
    Publication number: 20220151928
    Abstract: Disclosed herein are spherical high-density lipoprotein-like nanoparticles (HDL-NP) having a soft material core (e.g., a lipid-conjugated inorganic core). Also disclosed herein are methods for synthesizing the spherical HDL-NPs. Also disclosed herein are methods for treating disorders such as cardiovascular disease, cancer, inflammatory disorders or reducing NF-kB activity with the spherical HDL-NPs.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 19, 2022
    Applicant: Northwestern University
    Inventors: Stephen E. Henrich, C. Shad Thaxton, Sonbinh T. Nguyen, Bong Jin Hong
  • IDENTIFICATION AND OPTIMIZATION OF CARBON RADICALS ON HYDRATED GRAPHENE OXIDE FOR UBIQUITOUS ANTIBACTERIAL COATINGS
    Publication number: 20220153589
    Abstract: In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (.C) density.
    Type: Application
    Filed: November 19, 2021
    Publication date: May 19, 2022
    Applicants: The Regents of the University of California, Northwestern University
    Inventors: Andre E. Nel, Tian Xia, Ruibin Li, Mark C. Hersam, Nikhita D. Mansukhani, Linda Guiney
  • Method and system for activity detection with obfuscation
    Patent number: 11336823
    Abstract: A camera system includes a camera configured to capture first video of a scene in the form of first image frames. The camera system also includes an infrared sensor configured to capture second video of the scene in the form of second image frames. The system also includes a processor in communication with the camera and the infrared sensor. The processor is configured to obfuscate one or more portions of the scene.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: May 17, 2022
    Assignee: Northwestern University
    Inventors: Nabil I. Alshurafa, Josiah D. Hester
  • Method and system for three-dimensional surface measurement with a mobile device
    Patent number: 11336883
    Abstract: A three-dimensional (3D) imaging system includes a mobile device that has a display screen configured to display a series of patterns onto an object that is to be imaged. The mobile device also includes a front-facing camera configured to capture reflections of the series of patterns off of the object. The system also includes a controller that is configured to control a timing of the series of patterns that appear on the display screen and activation of the front-facing camera in relation to the appearance of the series of patterns.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: May 17, 2022
    Assignee: Northwestern University
    Inventors: Florian Willomitzer, Oliver Strider Cossairt, Marc Walton, Chia-Kai Yeh, Vikas Gupta, William Spies, Florian Schiffers
  • INSULIN LIKE GROWTH FACTOR BINDING PROTEIN BIOACTIVE PEPTIDE FRAGMENTS
    Publication number: 20220144896
    Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Applicant: Northwestern University
    Inventors: Joseph R. Moskal, Jeffrey S. Burgdorf
  • MODIFIED BACTERIA FOR ENHANCED BIOPRODUCTION AND METHODS OF USING THE SAME
    Publication number: 20220144899
    Abstract: The present disclosure relates generally to modified bacteria, such as E. coli, with modification in the expression of at least one gene encoding a type I and/or type II toxin-antitoxin (TA) system protein and/or at least one gene encoding a structural protein that modulates ribosomes and methods of using the disclosed bacteria for producing a biological compound of interest. The modifications of the bacteria result in enhanced bioproduction.
    Type: Application
    Filed: November 9, 2021
    Publication date: May 12, 2022
    Applicant: Northwestern University
    Inventors: William H. Bothfeld, Keith E.J. Tyo
  • Biomarkers of endogenous biological time
    Patent number: 11328790
    Abstract: Provided herein are biomarkers of endogenous biological time (e.g. circadian time). In particular compositions and methods are provided for assessing the biological time of a subject, and diagnosis of diseases/conditions and/or providing treatments based thereon.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: May 10, 2022
    Assignee: Northwestern University
    Inventors: Rosemary Braun, Ravi Aliada, Phyllis Zee
  • Self-assembled particles for targeted delivery of immunomodulators to treat autoimmunity and cancer
    Patent number: 11311485
    Abstract: The present invention provides for delivery of therapeutic drug in a polymeric delivery system comprising a PEG-bl-PPS di-block polymer formed in a micelle, filomicelle, or polymersome structure, wherein the structure effectively binds and/or interacts through shape-based targeting with a targeted cell type.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: April 26, 2022
    Assignees: University of Maryland, Baltimore County, University of Maryland, Baltimore, Northwestern University
    Inventors: Marilyn Allen, Evan Scott, Amit Golding, Gregory Szeto, Nicholas B. Karabin
  • Agility trainer
    Patent number: 11311447
    Abstract: An agility trainer apparatus that provides a robotic system that applies forces laterally to a harness worn by a person during walking so as to provide highly controllable interventions targeting locomotor stability.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: April 26, 2022
    Assignees: Northwestern University, U.S. Department of Veterans Affairs
    Inventors: Keith E. Gordon, Geoffrey L. Brown, Mengnan Wu, Felix C. Huang
  • Components and methods for producing toxic RNAs in eukaryotic cells
    Patent number: 11312958
    Abstract: Disclosed are components and methods for producing toxic RNAs and/or extracellular vesicles comprising the toxic RNAs in cells that are resistant to the toxic RNAs, which toxic RNAs may include toxic shRNA/siRNA and/or toxic pre-miRNA/miRNA. The disclosed components may include engineered cells that can be utilized to express the toxic RNAs, in which the engineered cells do not express one or more genes that are required for processing the toxic RNAs for RNA interference (RNAi) and/or one or more genes that are required for executing RNAi. The toxic RNAs and/or extracellular vesicles comprising the toxic RNAs may be utilized in methods for treating diseases and disorders through RNAi.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 26, 2022
    Assignee: Northwestern University
    Inventors: Marcus E. Peter, Andrea E. Murmann
  • Inhibiting tumor cell migration by inhibition of kinesin light chain 1, variant 1 (KLC1C)
    Patent number: 11304988
    Abstract: Provided herein are compositions and methods for inhibiting tumor cell transendothelial migration by inhibition of kinesin light chain 1, variant 1 (KLC1C) expression and/or activity, and treatment or prevention of cancer and/or metastasis therewith.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: April 19, 2022
    Assignee: Northwestern University
    Inventor: William A. Muller
  • Method and system for joining robotic components
    Patent number: 11305421
    Abstract: A robot includes a power bus assembly configured to receive a voltage and a continuous dock. The robot also includes a microcontroller in communication with the power bus assembly and the continuous dock. The microcontroller is configured to determine that the continuous dock is in contact with a surface that results in a voltage differential between the continuous dock and the surface. The microcontroller is also configured to activate a motor to apply a force that presses the continuous dock against the surface. The voltage causes a current to flow from the continuous dock to the surface such that a portion of the continuous dock melts and forms a bond to the surface.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: April 19, 2022
    Assignee: Northwestern University
    Inventors: Petras J. Swissler, Michael S. Rubenstein
  • High-efficiency two-phase heusler thermoelectric materials
    Patent number: 11302855
    Abstract: A thermoelectric material may be composed of an isostructural pair of Heusler compounds, either a pair of full Heusler (FH) X2YZ compounds or a pair of half Heusler (HH) XYZ compounds. In the FH pair, a first compound of the pair may the formula (X1)2Y1Z1, wherein X1 is selected from Fe and Co; Y1 is selected from Ti, V, Nb, Hf, and Ta; and Z1 is selected from Al, Ga, Si, and Sn and a second compound of the pair has the formula (X2)2Y2Z2, wherein X2 is selected from Mn, Fe, Co, Ru, and Rh; Y2 is selected from Ti, V, Mn, Zr, Nb, Hf, and Ta; and Z2 is selected from Be, Al, Ga, Si, Ge and Sn. The first and second compounds of the pair may share two elements in common and have third elements which are different and are either isovalent or have a valency which differs by ±1.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: April 12, 2022
    Assignee: Northwestern University
    Inventors: Vancho Kocevski, Christopher M. Wolverton
  • System and method for high-resolution, high-speed, and noise-robust imaging
    Patent number: 11303793
    Abstract: An imaging system includes an event camera configured to capture a first image of a scene. The system also includes a shutter camera collocated with the event camera, where the shutter camera is configured to capture a second image of the scene. The system also includes a processor operatively coupled to the event camera and the shutter camera. The processor is configured to apply guided event filtering (GEF) on the first image and the second image. The processor is also configured to generate a third image based on filtering of the first image and the second image.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: April 12, 2022
    Assignees: Northwestern University, Peking University
    Inventors: Oliver Strider Cossairt, Boxin Shi, Zihao Wang, Peiqi Duan, Aggelos K. Katsaggelos, Tiejun Huang
  • Lithiated cyclodextrin metal organic frameworks and methods of making and using the same
    Patent number: 11298677
    Abstract: Disclosed herein are lithiated cyclodextrin metal organic frameworks and method of making and using the same. A metal organic framework comprising a coordinated network of repeating units extending in three dimensions, wherein the repeating unit comprises a cyclodextrin, a first coordinating metal cation, and a second coordinating metal cation.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: April 12, 2022
    Assignees: Northwestern University, King Abdulaziz City for Science and Technology
    Inventors: James Fraser Stoddart, Hasmukh A. Patel, Zhichang Liu, Siva Krishna Mohan Nalluri
  • Magnetic nanocomposite compositions
    Patent number: 11298430
    Abstract: Superparamagnetic nanocomposites are provided. In an embodiment, a superparamagnetic nanocomposite comprises a superparamagnetic core comprising a first, soft superparamagnetic ferrite and a superparamagnetic shell comprising a second, soft superparamagnetic ferrite, the shell formed over the core, wherein the first and second soft superparamagnetic ferrites are different compounds and have different magnetocrystalline anisotropies.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: April 12, 2022
    Assignee: Northwestern University
    Inventors: Vikas Nandwana, Vinayak P. Dravid
  • Core-shell heterostructures composed of metal nanoparticle core and transition metal dichalcogenide shell
    Patent number: 11293869
    Abstract: Provided herein are core-shell heterostructures design comprising a metal (e.g., noble metal) nanoparticle core and a transition metal dichalcogenide (TMD) shell, and methods of preparation and use thereof. In particular embodiments, the core-shell heterostructures described herein are synthesized by direct growth of a monolayer or multilayer fullerene-like TMD shell on a metal (e.g., noble metal) nanoparticle core, exhibit unique Raman scattering and photoluminescence characteristics, and are useful, for example, in plasmonic hot electron enhanced optics and optoelectronics.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: April 5, 2022
    Assignee: Northwestern University
    Inventors: Yuan Li, Xinqi Chen, Vinayak P. Dravid
  • Method for the fabrication of three-dimensional objects and apparatus for same
    Patent number: 11292187
    Abstract: Methods and apparatus comprising a dewetting phase and a polymerization liquid that are immiscible, and can be used for the formation of three-dimensional objects, wherein the method does not require a dead zone. Additionally, methods and apparatus that employ an optically transparent cooling apparatus to mitigate heat generated during the fabrication process, and the use of a mobile phase to provide a shearing interface to reduce interfacial adhesive forces.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: April 5, 2022
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, David A. Walker, James L. Hedrick, III