Patents Assigned to Novocure GmbH
  • SYSTEMS AND METHODS FOR INCREASING INTESTINAL ABSORPTION OF THERAPEUTIC AGENTS
    Publication number: 20230398367
    Abstract: Systems and methods for increasing absorption of ingested substances into a subject's bloodstream are disclosed. The systems and methods involve application of an alternating field to the subject's abdomen, and may further include oral administration of at least one substance to the subject. Also disclosed are methods of treating or reducing the occurrence of a malabsorption condition in a subject via application of the alternating electric field to the subject's abdomen.
    Type: Application
    Filed: June 13, 2023
    Publication date: December 14, 2023
    Applicant: Novocure GmbH
    Inventors: Moshe Giladi, Tali Voloshin-Sela, Lilach Avigdor, Gadi Cohen
  • Fabricating organic light emitting diodes (OLEDs) using tubulin
    Patent number: 11818943
    Abstract: Organic light-emitting diodes are disclosed comprising an electron transport layer and a hole transport layer. At least one of the transport layers is formed by (a) dissolving tubulin or microtubules in a mixture of water and a solvent that changes the surface charge of tubulin, wherein the percentage of solvent in the mixture is selected so that the tubulin acquires a desired surface charge, and (b) using the tubulin with the desired surface charge to fabricate the at least one of the transport layers. Advantageously, the solvent may be DMSO. Methods of fabricating such organic light emitting diodes are also disclosed.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: November 14, 2023
    Assignee: Novocure GmbH
    Inventors: Aarat Pratyaksh Kalra, Jack Adam Tuszynski, Sahil Deepak Patel, Karthik Shankar
  • ALTERNATING ELECTRIC FIELD WAVEFORM FOR ELECTROSENSATION REDUCTION
    Publication number: 20230310854
    Abstract: A method to treat a target region of a subject's body with an alternating electric field, the method including: applying the alternating electric field to the target region of the subject's body at a first frequency while increasing an intensity of the alternating electric field from zero to a target intensity; and changing the frequency of the alternating electric field from the first frequency to a target frequency while maintaining the alternating electric field at the target intensity, wherein the target frequency and the target intensity have a known efficacy for treating the target region of the subject's body with the alternating electric field; and wherein the first frequency is greater than the target frequency.
    Type: Application
    Filed: March 30, 2023
    Publication date: October 5, 2023
    Applicant: Novocure GmbH
    Inventors: Moshe GILADI, Lilach AVIGDOR
  • Delivering Tumor Treating Fields (TTFields) Using Implanted Sheets of Graphite
    Publication number: 20230310849
    Abstract: Alternating electric fields (e.g., tumor treating fields, a.k.a. TTFields) may be applied to a target region in a subject's body via sheets of graphite that are implanted in the subject's body. One or more ports configured for affixation to the subject's body include or connect to one or more mating electrical connectors. Electrical conductors are positioned to route electrical signals between the electrical connector(s) and the sheets of graphite. The alternating electric fields are applied to the target region by applying (via the ports) an alternating voltage between two sheets of graphite that are positioned on opposite sides of the target region.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 5, 2023
    Applicant: Novocure GmbH
    Inventors: Yoram WASSERMAN, Stas OBUCHOVSKY, Nataliya KUPLENNIK, David SHAPIRO
  • Using Interleaved Cooling Periods to Increase the Peak Intensity of Tumor Treating Fields
    Publication number: 20230310848
    Abstract: Alternating electric fields (e.g., TTFields) may be induced in a target region in a subject's body by applying, during each of a plurality of first time intervals, a series of pulses of alternating current between electrode elements positioned on or in the subject's body. Immediately following each first interval of time, the electrode elements are allowed to cool. Although the pulses of alternating current within any given first time interval have amplitudes at a level that would cause overheating if the series of pulses was allowed to continue for one hour, each series of pulses does not, in fact, continue for one hour. To the contrary, each series of pulses is short enough to avoid overheating. Interleaving the cooling periods between the pulsing periods enables higher-current pulses to be used, and the use of those higher-current pulses can advantageously improve the efficacy of treatment.
    Type: Application
    Filed: March 30, 2023
    Publication date: October 5, 2023
    Applicant: Novocure GmbH
    Inventors: Tali VOLOSHIN-SELA, Lilach AVIGDOR, Reuven SHAMIR
  • Reducing Electrosensation Whilst Treating a Subject Using Alternating Electric Fields by Pairing Transducer Arrays Together
    Publication number: 20230310877
    Abstract: When treating a subject using alternating electric fields (e.g., using TTFields to treat a tumor, or using alternating electric fields to increase the permeability of the blood brain barrier), some subjects experience an unpleasant electrosensation effect. This electrosensation can be reduced or eliminated by increasing the area of the transducer arrays that is active during certain times in the treatment. In some embodiments, this is accomplished by applying an AC signal between two pairs of transducer arrays at certain times (as opposed to the prior art approach of applying an AC signal between two individual transducer arrays).
    Type: Application
    Filed: March 30, 2023
    Publication date: October 5, 2023
    Applicant: Novocure GmbH
    Inventor: Moshe GILADI
  • GEOMETRICALLY FITTED TRANSDUCERS FOR TUMOR TREATING FIELDS
    Publication number: 20230302289
    Abstract: A transducer apparatus for delivering tumor treating fields to a subject’s body, the transducer apparatus including: an array of electrode elements, the array configured to be positioned over the subject’s body with a face of the array facing the subject’s body; wherein, when viewed from a direction perpendicular to the face of the array, an outer perimeter of the array substantially tracing the electrode elements has a shape including: at least one convex edge portion protruding away from a centroid of the array; and at least one concave edge portion recessed toward the centroid of the array.
    Type: Application
    Filed: March 21, 2023
    Publication date: September 28, 2023
    Applicant: Novocure GmbH
    Inventors: Noa HALAVEE, Shalom STRAUSS
  • Applying Tumor Treating Fields (TTFields) Via Electrodes Embedded into Skull Implants
    Publication number: 20230248969
    Abstract: Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates.
    Type: Application
    Filed: April 13, 2023
    Publication date: August 10, 2023
    Applicant: Novocure GmbH
    Inventors: Yoram WASSERMAN, Uri WEINBERG, Zeev BOMZON
  • Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
    Publication number: 20230248826
    Abstract: Cancer cells can be synchronized to the G2/M phase by delivering an anti-microtubule agent (e.g., paclitaxel or another taxane) to the cancer cells, and applying an alternating electric field with a frequency between 100 and 500 kHz to the cancer cells, wherein at least a portion of the applying step is performed simultaneously with at least a portion of the delivering step. This synchronization can be taken advantage of by treating the cancer cells with radiation therapy after the combined action of the delivering step and the applying step has increased a proportion of cancer cells that are in the G2/M phase. The optimal frequency and field strength will depend on the particular type of cancer cell being treated. For certain cancers, this frequency will be between 125 and 250 kHz (e.g., 200 kHz) and the field strength will be at least 1 V/cm.
    Type: Application
    Filed: April 14, 2023
    Publication date: August 10, 2023
    Applicant: Novocure GmbH
    Inventors: Moshe GILADI, Tali VOLOSHIN-SELA
  • Electrode Assembly with a Skin Contact Layer Comprising a Conductive Adhesive Composite, and Systems and Methods of Applying Tumor Treating Fields Using Same
    Publication number: 20230241374
    Abstract: Alternating electric fields (e.g., TTFields) may be applied to a subject's body using an electrode assembly that includes a skin contact layer formed at least partially of a conductive adhesive. An electrode element is electrically coupled to the conductive adhesive. Optionally, the electrode assembly can include a layer (e.g., sheet) of anisotropic material between the electrode element and the skin contact layer. Optionally, the skin contact layer may comprise an outer adhesive layer comprising conductive adhesive composite, an inner adhesive layer comprising conductive adhesive composite, and a substrate positioned between the inner and outer adhesive layers.
    Type: Application
    Filed: February 28, 2023
    Publication date: August 3, 2023
    Applicants: Novocure GmbH, Novocure GmbH
    Inventors: Rosa S. SHNAIDERMAN, Yoram WASSERMAN, Stas OBUCHOVSKY, Nataliya KUPLENNIK, David SHAPIRO
  • Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
    Patent number: 11701161
    Abstract: Tumors can be treated with an alternating electric field. The size of cells in the tumor is determined prior to the start of treatment by, for example, biopsy or by inverse electric impedance tomography. A treatment frequency is chosen based on the determined cell size. The cell size can be determined during the course of treatment and the treatment frequency is adjusted to reflect changes in the cell size. A suitable apparatus for this purpose includes a device for measuring the tumor impedance, an AC signal generator with a controllable output frequency, a processor for estimating the size of tumor cells and setting the frequency of the AC signal generator based thereon, and at least one pair of electrodes operatively connected to the AC signal generator such that an alternating electric field is applied to the tumor.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: July 18, 2023
    Assignee: Novocure GmbH
    Inventors: Yoram Palti, Matan Dishon
  • Selecting Values of Parameters for Treatment Using Tumor Treating Fields (TTFields)
    Publication number: 20230218912
    Abstract: Characteristics of alternating electric fields that will be applied to a target region in a subject’s body can be selected by applying different sets of pulses between electrode elements positioned on opposite sides of the target region. Thermal responses to the different sets of pulses are determined. Based on these thermal responses, the system selects a set of characteristics for output pulses of alternating current that will (a) maximize peak current amplitude and (b) keep temperatures at the electrode elements below a threshold value.
    Type: Application
    Filed: December 28, 2022
    Publication date: July 13, 2023
    Applicant: Novocure GmbH
    Inventors: Moshe GILADI, Reuven R. SHAMIR, Kirill STEPOVOY
  • METHODS, SYSTEMS, AND APPARATUSES FOR MANAGING TRANSDUCER ARRAY PLACEMENT
    Publication number: 20230206548
    Abstract: Methods, systems, and apparatuses are described for managing placement of transducer arrays on a subject/patient.
    Type: Application
    Filed: March 2, 2023
    Publication date: June 29, 2023
    Applicant: Novocure GmbH
    Inventors: Hadas Sara HERSHKOVICH, Zeev BOMZON, Gil ZIGELMAN, Shira LUK-ZILBERMAN, Ori Kook, Oren Ben Zion BAKALO
  • Delivering Tumor Treating Fields (TTFields) Using Implantable Transducer Arrays
    Publication number: 20230191123
    Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person’s body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person’s body.
    Type: Application
    Filed: February 14, 2023
    Publication date: June 22, 2023
    Applicant: Novocure GmbH
    Inventors: Yoram WASSERMAN, Zeev BOMZON, Hadas Sara HERSHKOVICH, Ariel NAVEH, Moshe GILADI, Eilon KIRSON, Golan BAR-TAL, Tali VOLOSHIN-SELA
  • High Voltage, High Efficiency Sine Wave Generator that Prevents Spikes During Amplitude Adjustments and Switching of Channels
    Publication number: 20230188055
    Abstract: This application describes a variety of approaches for generating high voltage sinusoidal signals whose output voltage can be adjusted rapidly, without introducing high-frequency artifacts on the output. When these approaches are used, stronger electric fields can be applied to the tumor for a higher percentage of time, which can increase the efficacy of TTFields therapy. In some embodiments, this is accomplished by preventing adjustments to a DC power source during times when the output of that DC power source is powering the output signal. In some embodiments, this is accomplished by synchronizing the operation of an AC voltage generator and an electronic switch that is connected to the output of the AC voltage generator.
    Type: Application
    Filed: February 2, 2023
    Publication date: June 15, 2023
    Applicant: Novocure GmbH
    Inventor: Yoram WASSERMAN
  • TRANSDUCER ARRAY WITH ADHESIVE LAYER SHAPED TO REDUCE SKIN IRRITATION
    Publication number: 20230181918
    Abstract: A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus including: an array of electrodes configured to be positioned over the subject's body with a face of the array facing the subject's body; a substrate including an adhesive layer, wherein the array of electrodes is disposed entirely on a first side of the substrate, the face of the array faces away from the substrate, the adhesive layer is on the first side of the substrate facing the same direction as the face of the array; and, when viewed from a direction perpendicular to the face of the array, a non-adhesive region is located between a pair of adjacent electrodes of the array, the non-adhesive region spanning at least 25% of a total distance between the pair of adjacent electrodes for at least one measurement measured along a straight line between the pair of adjacent electrodes.
    Type: Application
    Filed: December 13, 2022
    Publication date: June 15, 2023
    Applicant: Novocure GmbH
    Inventors: Boaz MARSAULT, Elie YAACOBI
  • SHIFTING OF TRANSDUCER ARRAY TO REDUCE SKIN IRRITATION
    Publication number: 20230181899
    Abstract: A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus including: an array of electrodes, the array configured to be positioned over the subject's body with a face of the array facing the subject's body, the array including electrode elements positioned in existing electrode positions arranged around a centroid of the array; and at least one void space in the array capable of enclosing an areal footprint equivalent to at least 40% of an areal footprint of at least one existing electrode position, and superimposable on at least 40% of at least one existing electrode position by rotation of the array around the centroid.
    Type: Application
    Filed: December 13, 2022
    Publication date: June 15, 2023
    Applicant: Novocure GmbH
    Inventors: Noa Halavee, Boaz Marsault, Elie Yaacobi, Golan Bar-Tal, Nitzan Shany
  • TRANSDUCER ARRAY WITH SHAPE THAT CONTOURS TO A SUBJECT'S BODY AND METHOD OF DETERMINING SHAPE AND PLACEMENT OF TRANSDUCER ARRAYS
    Publication number: 20230181919
    Abstract: A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus including: a substrate and an array of electrodes disposed on the substrate, the array configured to be positioned over the subject's body with a face of the array facing the subject's body; wherein, when viewed from a direction perpendicular to the face of the array, the substrate has at least one concave edge forming at least a portion of a boundary of the array, the at least one concave edge defines an opening between two opposing sides of the substrate, no electrodes are present in the opening, and the substrate has a substantially C-shaped, U-shaped, rounded V-shaped, or annular shaped surface.
    Type: Application
    Filed: December 13, 2022
    Publication date: June 15, 2023
    Applicant: Novocure GmbH
    Inventors: Darja WENDEL, Woonghee HAN
  • Methods of Reducing Ciliogenesis with Alternating Electric Fields
    Publication number: 20230168242
    Abstract: A method of determining susceptibility of cancer cells to treatment with alternating electric fields, or of reducing the viability of cancer cells by applying alternating electric fields, by measuring percentage of ciliated cancer cells or by measuring average length of a primary cilia of cancer cells. A method of treating Huntington's disease by applying alternating electric fields to a brain of a subject.
    Type: Application
    Filed: November 29, 2022
    Publication date: June 1, 2023
    Applicant: Novocure GmbH
    Inventors: Matthew R. SARKISIAN, Lilach AVIGDOR, Preshita DESAI
  • Applying tumor treating fields (TTFields) via electrodes embedded into skull implants
    Patent number: 11654279
    Abstract: Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: May 23, 2023
    Assignee: Novocure GmbH
    Inventors: Yoram Wasserman, Uri Weinberg, Zeev Bomzon