Abstract: The paths that alternating electric fields take through a body part can be controlled by providing at least eight electrically isolated signal generators, each of which is configured to apply electrical signals between a respective electrode element on one side of the target region and a respective electrode element on the opposite side of the target region. This replaces the prior art's single wide-cross-section electric field with eight independently controllable electric fields, each of which has a relatively narrow cross-section. Using these relatively narrow cross-section fields, either alone or in combination, can improve aiming of the electric field, which can in turn increase the field strength in the target region. Optionally, activation of these relatively narrow cross-section fields can be shifted in time to achieve steering of the overall electric field.

Abstract: Viral infections in a target region can be inhibited by imposing an alternating electric field in the target region for a duration of time. The alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus. Optionally, the inhibition of viral infections using the alternating electric field approach can be combined with delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the alternating electric fields are imposed.

Abstract: Disclosed herein are methods of increasing sensitivity of a cancer cell to alternating electric fields comprising exposing the cancer cell to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, and exposing the cancer cell to an IGFR1 inhibitor, JNK inhibitor, RPS6 inhibitor or ERK inhibitor. Disclosed are methods of increasing treatment efficacy comprising applying an alternating electric field to a target site of the subject for a period of time, the alternating electric field having a frequency and field strength, wherein the target site comprises one or more cancer cells, and administering a therapeutically effective amount of one or more of an IGF1R inhibitor, JNK inhibitor, RPS6 inhibitor, and/or ERK inhibitor to the subject.

Abstract: A computer-implemented method to generate a three-dimensional model, wherein the computer comprises one or more processors and memory accessible by the one or more processors, and the memory stores instructions that when executed by the one or more processors cause the computer to perform the computer-implemented method, includes: receiving first image data of a first portion of the patient's body in a first image modality, receiving second image data of a second portion of the patient's body in a second image modality, modifying the second image data from the second image modality to the first image modality, and generating, based on the first image data in the first image modality and the modified second image data in the second image modality, a three-dimensional model of the first portion and the second portion of the patient's body.

Abstract: A composition and method of use is herein disclosed. The composition comprises a semi-solid conductive gel for application to a patient's skin and for placement between the patient's skin and at least one insulated electrode; and at least one bulk electron transport agent disposed upon at least a portion of a surface of the semi-solid conductive gel and/or disposed within at least a portion of the semi-solid conductive gel, wherein the bulk electron transport agent is selected from the group consisting of an ionic compound, a metal, a non-metal, and combinations thereof.

Abstract: To plan tumor treating fields (TTFields) therapy, a model of a patient's head is often used to determine where to position the transducer arrays during treatment, and the accuracy of this model depends in large part on an accurate segmentation of MRI images. The quality of a segmentation can be improved by presenting the segmentation to a previously-trained machine learning system. The machine learning system generates a quality score for the segmentation. Revisions to the segmentation are accepted, and the machine learning system scores the revised segmentation. The quality scores are used to determine which segmentation provides better results, optionally by running simulations for models that correspond to each segmentation for a plurality of different transducer array layouts.

Abstract: A system for generating a TTField is herein described. The system comprises a generator configured to generate an electrical signal; a first lead coupled to the generator and a first conductive pad and configured to carry the electrical signal; the first conductive pad having a first electrode element electrically coupled to a first conductive gel element to supply electrical current to the first conductive gel element; a second lead coupled to the generator and a second conductive pad and configured to carry the electrical signal; and the second conductive pad having the second electrode element electrically coupled to a second conductive gel element to supply electrical current to the second conductive gel element, wherein the first conductive gel element and the second conductive gel element are each configured to be in contact with a patient's skin and each supporting a shaping member adjacent to one or more air channel.

Abstract: Autoinflammatory and mitochondrial disorders can be treated by positioning a plurality of electrodes in or on a subject's body, and applying an AC voltage between the plurality of electrodes so as to impose an alternating electric field through the tissue that is being affected by the autoinflammatory or mitochondrial disease. The frequency and field strength of the alternating electric field are selected such that the alternating electric field inhibits inflammation or mitochondrial disorders in the tissue.

Abstract: A pad having a topcoat layer, an electrode element and a conductive gel element are described. The electrode element is connected to the topcoat layer, and configured to receive an electrical signal from a generator producing an electric signal as a TTField. The electrode element includes an electrode layer and a non-conductive flexible polymer layer. The non-conductive flexible polymer layer is positioned between the electrode layer and the conductive gel element to electrically isolate the electrode layer from the conductive gel element.

Abstract: A conductive pad is described. The conductive pad includes a topcoat layer, an electrode element, and a conductive gel element. The topcoat layer is constructed of a non-conductive material. The electrode element has a first side and a second side, the second side connected to the topcoat layer, and configured to receive an electrical signal from a generator producing an electric signal as a TTField. The conductive gel element is connected to the first side of the electrode element and electrically coupled to the electrode element so as to receive an electrical current from the electrode element, the conductive gel element being in the form of at least one line and operable to be in contact with a patient's skin at specific locations and operable to flex with movement of the patient without substantially moving from the specific location.

Abstract: A pad having a topcoat layer, an electrode element and a conductive gel element are described. The electrode element is connected to the topcoat layer, and configured to receive an electrical signal from a generator producing an electric signal as a TTField. The conductive gel element is directly connected to the electrode element so as to receive an electrical current from the electrode element. The conductive gel element is configured to be in contact with a patient's skin. The electrode element and the conductive gel element define at least one perforation extending through the electrode element and the conductive gel element.

Abstract: A pad having a topcoat layer, an electrode element and a conductive gel element are described. The electrode element is connected to the topcoat layer, and configured to receive an electrical signal from a generator producing an electric signal as a TTField. The conductive gel element is directly connected to the electrode element so as to receive an electrical current from the electrode element. The conductive gel element is configured to be in contact with a patient's skin. The electrode element and the conductive gel element define kirigami-like cuts, the kirigrami-like cuts being a predetermined pattern of cuts resulting in the electrode element, the flexible polymer layer, and the conductive gel element forming a three-dimensional shape conforming to a predetermined portion of a patient's body.

Abstract: A system for generating a TTField utilizing at least one conductive pad is herein described. The system comprises a generator configured to generate an electrical signal; a first lead coupled to the generator and a first conductive pad and configured to carry the electrical signal; the first conductive pad having a first electrode element electrically coupled to a first conductive gel element to supply electrical current to the first conductive gel element; a second lead coupled to the generator and a second conductive pad and configured to carry the electrical signal; and the second conductive pad having the second electrode element electrically coupled to a second conductive gel element to supply electrical current to the second conductive gel element, wherein the first conductive gel element and the second conductive gel element are each configured to be in contact with a patient's skin and each have one or more air channel.

Abstract: A transducer array for use in tumor-treating fields (TTFields) therapy is particularly suited for use in treating abdominal or thoracic cancers. The transducer array has features that increase its flexibility and adhesion to the patient's skin, including a branching configuration and a correspondingly branching top covering adhesive-backed layer. Additionally, a skin-level adhesive layer is provided beneath the flex circuit to which the electrode elements are attached, to help ensure thorough, lasting adhesion of the transducer array to the patient's skin over the course of treatment.

Abstract: Tumor treating fields (TTFields) can be delivered to a subject's body at higher field strengths by switching off one or more electrode elements in a transducer array that are overheating. This may be accomplished by using thermistors that sense the temperature of each electrode element. Portions of the wiring of each transducer array is shared between the electrode elements and the thermistors by using a plurality of conductors, each of which electrically connects (a) a pin of a connector, (b) a respective electrode element, and (c) a respective thermistor. In some embodiments, all of the thermistors are wired in series. In other embodiments, all the thermistors share a common connection.

Abstract: Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

Abstract: A computer-implemented method to determine locations of transducers to apply tumor treating fields to a target tissue of a subject's body, the computer-implemented method comprises: obtaining a three-dimensional model of at least a portion of the subject's body, wherein the portion of the subject's body includes the target tissue, wherein a single lung of the subject's body includes the target tissue; determining a first location on the three-dimensional model to place a first transducer, wherein the first location is a front of a thorax of the subject's body; determining a second location on the three-dimensional model to place a second transducer, wherein the second location is a back of the thorax of the subject's body, wherein the single lung of the subject is located between the first transducer and the second transducer; determining a third location on the three-dimensional model to place a third transducer, wherein the third location is on a torso of the subject's body; determining a fourth location on

Abstract: When arrays of electrode elements are used to apply alternating electric fields to a subject's body, the subject may experience electrosensation. This electrosensation can be ameliorated by selectively deactivating different electrode elements (or reducing the current that flows through different electrode elements) during respective different periods of time, and accepting feedback that indicates whether the electrosensation is occurring during each of those respective different periods of time. If deactivating a given one of the electrode elements (or reducing the current) ameliorates the electrosensation, the subject can be treated with alternating electric fields while the given electrode element is deactivated (or being driven with less current).

Abstract: Compositions, systems, and methods for reducing electrosensation and/or skin irritation in response to the application of alternating electric fields to a skin of a subject are disclosed. The compositions, systems, and methods involve administration of at least one composition comprising at least one localized numbing agent to the subject followed by application of an alternating electric field to the subject.

Abstract: A computer-implemented method to background noise from a medical image comprising voxels, each voxel having a voxel intensity, the method comprising: generating a mask based on the medical image, wherein the mask comprises a foreground portion designating foreground voxels, a background portion designating background voxels, and a perimeter separating the foreground portion from the background portion; designating a perimeter portion of the mask, the perimeter portion enclosing the perimeter, a subset of the foreground portion, and a subset of the background portion; designating a threshold for the perimeter portion to separate voxels based on voxel intensity; filtering the medical image with the mask and the threshold to obtain a filtered image; and displaying the filtered image on a display.