Patents Assigned to Novozymes A/S
  • Modified filamentous fungal host cell for encoding a secreted polypetide of interest
    Patent number: 11434475
    Abstract: The present invention relates to filamentous fungal cells secreting a polypeptide of interest, wherein the expression of a citT gene is altered, reduced or eliminated compared to a non-mutated otherwise isogenic or parent cell, and methods of producing a secreted polypeptide of interest in said cells as well as methods of producing said cells.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: September 6, 2022
    Assignee: Novozymes A/S
    Inventor: Hiroaki Udagawa
  • TEMPERATURE-SENSITIVE RNA- Guided Endonuclease
    Publication number: 20220275354
    Abstract: The present invention relates to temperature-sensitive variants of an RNA-guided endonuclease, polynucleotides encoding said variants, nucleic acid constructs and expression vectors comprising polynucleotides encoding said variants, host cells expressing said variant, methods of transient repression and expression of one or more DNA target sequence using said variants, and use of said variants, polynucleotides, nucleic acid constructs, expression vectors, host cells, and methods.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 1, 2022
    Applicant: Novozymes A/S
    Inventors: Brian Koebmann, Michael Dolberg Rasmussen, Carsten Andersen
  • Polypeptides having pullulanase activity suitable for use in liquefaction
    Patent number: 11427811
    Abstract: The present invention relates to a variant pullulanase, wherein the pullulanase comprises at least the following combination of substitutions: N368G+N393A+Q431E+L432F+A492A,S+N610R+G624S+T631S+S632C, and optionally further comprises N222P+Q252A+Q256R; wherein the variant has pullulanase activity, and wherein the variants have at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, but less than 100% sequence identity to the polypeptide of SEQ ID NO: 3. Further aspect the present invention relates to a process for liquefying starch-containing material at a temperature above the initial gelatinization temperature using an alpha-amylase and a thermo-stable pullulanase of the invention.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: August 30, 2022
    Assignee: Novozymes A/S
    Inventors: Tomoko Matsui, Suzanne Clark, Aki Tomiki
  • FILAMENTOUS FUNGAL EXPRESSION SYSTEM
    Publication number: 20220267783
    Abstract: The present invention provides recombinant filamentous fungal host cells producing one or more secreted polypeptide of interest, said cells comprising in their genome at least one nucleic acid construct comprising a first polynucleotide encoding a signal peptide operably linked in translational fusion to a second polynucleotide encoding the polypeptide of interest, wherein the first polynucleotide is heterologous to the second polynucleotide, wherein the first polynucleotide is a polynucleotide having at least 70% sequence identity with SEQ ID NO:1 or a polynucleotide encoding a signal peptide having at least 70% sequence identity with SEQ ID NO:2, as well as methods of producing one or more secreted polypeptide of interest.
    Type: Application
    Filed: June 25, 2020
    Publication date: August 25, 2022
    Applicant: Novozymes A/S
    Inventor: Dominique Aubert Skovlund
  • PROCESSES FOR REDUCING LACTIC ACID IN A BIOFUEL FERMENTATION SYSTEM
    Publication number: 20220267811
    Abstract: The present invention relates to a process for reducing and/or preventing an increase in lactic acid levels in a fermentation product production process, such as especially ethanol production, wherein a lytic polysaccharide monooxygenase (LPMO) or an enzyme composition comprising an LPMO is added before or during saccharification and/or fermentation, or before or during propagation, to reduce and/or prevent an increase in lactic acid levels.
    Type: Application
    Filed: April 5, 2022
    Publication date: August 25, 2022
    Applicant: Novozymes A/S
    Inventors: Armindo Ribeiro Gaspar, Victor Gabriel Guadalupe Medina, Xin Li, Kelly Cristina Leite Mulder, Angela Shows
  • Enzymatic treatment of cellulosic textile
    Patent number: 11421379
    Abstract: A process for treatment of cellulosic material, for example, knitted or woven cotton fabric or yarn, comprises treating cellulosic material with a pectinase and a surfactant.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: August 23, 2022
    Assignee: Novozymes A/S
    Inventors: Shuang Xie, Lijuan Cao, Yucheng Zhou
  • Process for Preparing an Acidified Milk Product
    Publication number: 20220256871
    Abstract: The present invention relates to preparation of an acidified milk product using a transglutaminase and a trypsin-like or lysine-specific endopeptidase.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 18, 2022
    Applicant: Novozymes A/S
    Inventors: Hanna Maria Lilbaek, Hans Peter Heldt-Hansen, Jens Magnus Eklof
  • Methods for treating inflammatory conditions of the lungs
    Patent number: 11413328
    Abstract: The present invention relates to methods for treatment or prevention of asthma, mild intermittent asthma, mild persistent asthma, moderate persistent asthma, severe persistent asthma, eosinophilic asthma, neutrophilic asthma, steroid refractory asthma, status asthmaticus, pneumonia, bronchiectasis, COPD, sarcoidosis, and lung cancer based on reducing airway hyper responsiveness, increasing pulmonary compliance, reducing lung inflammation, reducing inflammatory cell count in bronchoalveolar fluid and reducing cytokine production by administration of a mammalian ?- and/or ?-defensin.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: August 16, 2022
    Assignee: NOVOZYMES A/S
    Inventors: Peter Nordkild, Søren Kjærulff
  • Cleaning compositions comprising enzymes
    Patent number: 11414652
    Abstract: The present invention relates to compositions, methods and use of a mixture of enzymes having DNase activity and an enzyme having hexosaminidase activity.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: August 16, 2022
    Assignee: NOVOZYMES A/S
    Inventors: Rebecca Munk Vejborg, Klaus Gori, Lilian Eva Tang Baltsen
  • Polypeptides
    Patent number: 11414814
    Abstract: The present invention relates to novel polypeptides having nuclease activity and the use and methods for preventing or reducing creases of a fabric; a composition comprising such polypeptide. The invention further related to polynucleotide encoding polypeptides having nuclease activity.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: August 16, 2022
    Assignee: Novozymes A/S
    Inventors: Morten Gjermansen, Lone Baunsgaard, Fabian Barrientos Garcia
  • MODIFIED FILAMENTOUS FUNGAL HOST CELL
    Publication number: 20220251581
    Abstract: The present invention relates to phospholipase D-inactivated filamentous fungal cells secreting a polypeptide of interest and methods of producing a secreted polypeptide of interest in said cells as well as methods of producing said cells.
    Type: Application
    Filed: July 24, 2020
    Publication date: August 11, 2022
    Applicant: Novozymes A/S
    Inventor: Hiroaki Udagawa
  • CROSS-LINKED MILK PROTEIN CO-PRECIPITATE
    Publication number: 20220248710
    Abstract: The present invention relates to preparation of cross-linked milk protein co-precipitate, which includes treatment with a transglutaminase, and use of the cross-linked milk protein co-precipitate in production of acidified milk products.
    Type: Application
    Filed: June 19, 2020
    Publication date: August 11, 2022
    Applicant: Novozymes A/S
    Inventor: Per Munk Nielsen
  • MICROORGANISMS WITH IMPROVED NITROGEN TRANSPORT FOR ETHANOL PRODUCTION
    Publication number: 20220251609
    Abstract: Described herein are fermention organisms, such as yeasts, comprising a genetic modification that increases or decreases expression of a transporter or regulator thereof, such as yeasts that express an Amino Acid/Auxin Permease (AAAP). Also described are processes for producing a fermentation product, such as ethanol, from starch or cellulosic-containing material with the fermenting organisms.
    Type: Application
    Filed: July 16, 2020
    Publication date: August 11, 2022
    Applicant: Novozymes A/S
    Inventors: Hamid Rismani Yazdi, Sarah Schultheis Elliott, Paul Vincent Harris, Michael Glenn Catlett
  • Alpha-Amylase Variants
    Publication number: 20220251528
    Abstract: The present invention relates to variants of a parent alpha-amylase having an improved wash performance when compared to the parent alpha-amylase. The present invention also relates to polynucleotides encoding the variants, nucleic acid constructs, vectors, and host cells comprising the polynucleotides, and method of producing the variants of the present invention.
    Type: Application
    Filed: June 23, 2020
    Publication date: August 11, 2022
    Applicant: Novozymes A/S
    Inventors: Carsten Andersen, Chakshusmathi Ghadiyaram, Madhupriya Mahankali, Rajendra Kulothungan Sainathan
  • Enzyme variants and polynucleotides encoding same
    Patent number: 11407986
    Abstract: The present invention relates to polypeptide having alpha-amylase activity. The present invention also relates to polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the polypeptides.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: August 9, 2022
    Assignee: Novozymes A/S
    Inventors: Torsten Bak Regueira, Bitten Plesner, Thomas Holberg Blicher, Anne Dorte Houg, Sofia Arnehed, Lars Lehmann Hylling Christensen, Carsten Andersen
  • Cleaning compositions and uses thereof
    Patent number: 11407964
    Abstract: The present invention relates to compositions such as cleaning compositions comprising a mix of enzymes. The invention further relates, use of compositions comprising such enzymes in cleaning processes and/or for deep cleaning of organic soiling, methods for removal or reduction of components of organic matter.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 9, 2022
    Assignee: Novozymes A/S
    Inventors: Christian Berg Oehlenschlaeger, Dorotea Raventos Segura, Jesper Salomon, Rebecca Munk Vejborg
  • Protease variants and polynucleotides encoding same
    Patent number: 11407989
    Abstract: The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: August 9, 2022
    Assignee: Novozymes A/S
    Inventors: Annette H. Johansen, Rolf T. Lenhard, Peter Esben Friis
  • Lipolytic Polymer Particles For Esterification And Interesterification
    Publication number: 20220243232
    Abstract: The invention provides enzyme particles comprising an immobilized lipolytic enzyme, a hydrophobic polymer, an organic filter aid, and a water-soluble polyol selected from carbohydrates and sugar alcohols. The particles are suitable for enzymatic interesterification of triglycerides, and subsequent separation of the enzyme and triglycerides by filtration.
    Type: Application
    Filed: May 29, 2020
    Publication date: August 4, 2022
    Applicant: Novozymes A/S
    Inventors: Pavle Andric, Per Munk Nielsen, Hans Christian Holm
  • METHOD OF DOUGH RELAXATION INVOLVING ENDOPEPTIDASES
    Publication number: 20220240521
    Abstract: A method for increasing the softness and the relaxation of a dough comprising a) adding at least one endopeptidase having at least 60% identity to SEQ ID NO:1 or SEQ ID NO:2 to flour or to a dough comprising a flour, wherein no L-cystein and/or sodium metabisulfite is added to the dough; b) kneading the dough; and c) making the dough into an edible product.
    Type: Application
    Filed: August 5, 2020
    Publication date: August 4, 2022
    Applicant: Novozymes A/S
    Inventors: Irina Victorovna Matveeva, Katja Puder, Sajid Akbar
  • ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
    Publication number: 20220235341
    Abstract: The present invention relates to alpha-amylase variants of a parent alpha-amylase wherein said alpha-amylase variants have an improved wash performance as compared to said parent alpha-amylase. The invention also relates to compositions comprising the variants of the invention, uses of said variants and methods of producing said variants.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 28, 2022
    Applicant: Novozymes A/S
    Inventors: Carsten Andersen, Sofia Arnehed, Lars Lehmann Hylling Christensen, Ali Fallah-Araghi, Markus Klinger, Anders Gunnar Sandstrom