Abstract: Disclosed are titanium alloys for use in additive manufacturing that comprise a titanium material and a beta eutectoid stabilizer. The beta eutectoid stabilizer can be present in an effective amount to produce an equiaxed grain structure when the titanium alloy is melted or sintered during an additive manufacturing process. Also provided are methods of forming objects via additive manufacturing processes as well as methods of forming titanium alloys for use in additive manufacturing.

Abstract: An air conditioning system and method of air conditioning is provided. The air conditioning system includes an intake mechanism configured to draw into the air conditioner a first amount of air and an amount of moisture from an exterior of the air conditioner. The system further includes metal organic frameworks in fluid communication with the intake mechanism, the metal organic frameworks configured to adsorb the amount of moisture from the first amount of air. The system further includes an indirect evaporative cooler configured to cool the first amount of air. The system further includes a solar heater configured to heat a second amount of air. The system further includes a heat exchanger configured to contact the second amount of air with the metal organic frameworks to regenerate the metal organic frameworks.

Abstract: The present disclosure provides a large combinatorial library of cell-permeable bicyclic peptides. The bicyclic peptides described herein include the first ring consisted of randomized peptide sequences for potential binding to a target of interest while the second ring featured a family of different cell-penetrating motifs, for both cell penetration and target binding. The library was screened against the I?B kinase ?/? (IKK?/?)-binding domain of NF-?B essential modulator (NEMO), resulting in the discovery of several cell-permeable bicyclic peptides which inhibited the NEMO-IKK? interaction, thereby selectively inhibiting canonical NF-?B signaling in mammalian cells and the proliferation of cisplatin-resistant ovarian cancer cells.

Abstract: Bluetooth Address Tracking (BAT) is an allowlist-based side channel attack to track Bluetooth devices, by either passively sniffing the Bluetooth packets, or actively replaying the sniffed ones. Securing addresses of Bluetooth Low Energy (BLE) is described, which uses an interval unpredictable, central and peripheral synchronized random media access control (MAC) address generation scheme to defend against passive BAT attacks, and uses a current timestamp to derive random MAC addresses to defeat active BAT attacks, such that attackers can no longer be able to replay them.

Abstract: The present disclosure generally relates to systems, methods and compositions for use in Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cpf1 genome editing systems.

Abstract: A prosthetic heart valve includes a first upper frame portion and a stent frame connected to the first upper frame portion via at least two stent frame extensions. The stent frame includes a base and at least two stent posts extending upwardly from the base towards the first upper frame portion. The first upper frame portion, the base, and the at least two stent posts each has an inner surface and an outer surface. The prosthetic heart valve also includes at least one sheet of leaflet material configured to encircle the stent frame and weave through the stent frame between the first upper frame portion and the base.

Abstract: Disclosed herein is a method of “reprogramming” highly motile cells found in tumors, such as these highly motile GSC and/or MDSC clones, into “auto-destructive” cell “missiles” (referred to herein as therapeutic stealth cells) that can seek and destroy new foci of recurrence within the body, such as the brain. Cells with enhanced motility can be sorted out from heterogeneous populations and then be rendered “auto-destructive” by deterministic delivery of an anti-cancer agent, such as an oncolytic virus plasmid cocktail.

Abstract: Disclosed are systems and methods utilizing an infrared probe and discriminating software to rapidly discriminate abnormal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g.

Abstract: Electrically controlled solid-state thermal switches and methods of controlling heat flow. An electrostrictive material is electromagnetically coupled to first and second electrodes that provide an electric field to the electrostrictive material. Different portions of the electrostrictive material are thermally coupled to each of a heat sink and a thermal load so that heat flowing from one into the other passes through the electrostrictive material. A control voltage is applied to the electrodes to selectively generate the electric field, thereby selectively altering the thermal conductivity of the electrostrictive material. The heat sink and thermal load are thereby selectively thermally coupled to each other in dependence on the control voltage.

Abstract: Systems, methods, and computer program products for delivering information to an individual, group, or device. The information is carried by audio signals beyond the audible frequency range of human hearing, but within the frequency range of an audio system. The information is modulated onto an ultrasonic frequency and embedded into an audio signal transmitted by the audio system. Each individual, group member, or device may have or be coupled to a receiver configured to receive an acoustic signal transmitted by the audio system that includes the modulated ultrasonic frequency. The receiver extracts the information from the modulated ultrasonic frequency and provides the information to the individual, group member, or device.

Abstract: An optical fiber-based gamma-ray calorimeter (OFBGC) sensor array which uses a thermal mass with a low thermal conductivity is provided. Advantages of the OFBGC sensor array include: 1) the number of sensors in the OFBGC sensor array is adjustable and limited only by the spatial resolution of the OFBGC sensors, within the OFBGC sensor array, and 2) the OFBGC sensor design is simpler to build than a conventional optical fiber-based gamma thermometer (OFBGT) sensor array. One purpose of the OFBGC is to determine the power distribution in nuclear reactors.

Abstract: The present disclosure describes additive manufacturing methods, in particular methods for optimizing the manufacture of objects by three-dimensional printing processes. Also provided are bioreactors as well as methods of using thereof.

Abstract: An ultrasonic resistance welding apparatus 10 contains a resistance spot welding apparatus 15, a first electrode 16 and a vibrable second electrode 18, the vibrable second electrode 18 in operable communication with an ultrasonic transducer 12, whereby the ultrasonic transducer 12 selectively imparts vibratory energy to the vibrable second electrode 18 based on signals from a controller 32. The vibrable second electrode 18 may be tuned or designed to resonate within 2.5% of an operating frequency of the ultrasonic transducer 12. During operation of the welding apparatus 10, a tip 19 of the second vibrable electrode 18 may be positioned at an anti-nodal point 38 of the vibratory energy and the vibrable second electrode 18 may be attached to the resistance spot welding apparatus 15 at a nodal plane 36 of the vibratory energy. A process for employing the apparatus 10 is also presented.

Abstract: Disclosed are methods of measuring the quantity of active organic matter in a soil sample, as well as kits for performing such measurements.

Abstract: Disclosed herein is a process for isolating phospholipids from milk by-products, such as acid whey, the process comprising: a) exposing milk by-products to filtration, thereby enriching for phospholipids; and b) solubilizing and removing whey proteins and caseins; thereby isolating phospholipids from the milk by-product. Also disclosed are products produced by this method.

Abstract: Described herein are Notch-modulating peptides (including monomers and multimers) capable of increasing or decreasing an immune response in a subject, compositions comprising the peptides, and methods of use thereof.

Abstract: Example systems and methods for lesion detection are described herein. An example system includes at least one processor and a memory operably coupled to the at least one processor. The system also includes a candidate selection module configured to receive an image, determine a plurality of candidate points in the image, and select a respective volumetric region centered by each of the candidate points. A portion of a lesion has a high probability of being determined as a candidate point. The system further includes a deep learning network configured to receive the respective volumetric regions selected by the candidate selection module, and determine a respective probability of each respective volumetric region to contain the lesion. Additionally, example methods for training a deep learning network to detect lesions are described herein.

Abstract: A spinal fixation device includes an outer housing and an end plate assembly coupled with the outer housing. The outer housing defines an aperture and a longitudinal axis. At least a portion of the end plate assembly is slidably received within the outer housing. The end plate assembly includes a first end plate configured to engage a vertebral body, wherein the end plate assembly is selectively movable between a first position in which the first end plate is spaced apart from the outer housing and a second position in which the first end plate is adjacent the outer housing. Further, the first end plate is selectively adjustable to an angular orientation of a plurality of angular orientations with respect to the longitudinal axis of the outer housing.

Abstract: Disclosed are lung-targeted extracellular vesicles (EVs) loaded with an anti-inflammatory cargo, as well as compositions, systems, and methods for making same. The disclosed EVs can contain a lung targeted ligand, such as a fusion protein containing a lung targeting moiety. Also disclosed is a composition comprising an EV containing the disclosed fusion protein. In some embodiments, the EV is loaded with an anti-inflammatory cargo. Also disclosed is an EV-producing cell engineered to produce the disclosed EVs. Also disclosed is a method for making the disclosed EVs that involves culturing the disclosed EV-producing cells under conditions suitable to produce EVs.

Abstract: The present technology is directed to a potassium metal battery, particularly a potassium metal secondary battery, that includes a cathode; an anode that includes potassium metal; and a non-aqueous electrolyte that includes a potassium salt as well as a solvent. The solvent may include dimethoxyethane, digylme, triglyme, tetraglyme, or a mixture of any two or more thereof.