Patents Assigned to Ohio State Innovation Foundation
  • Patent number: 11607135
    Abstract: Signal processing techniques that can include an embedded software low-noise response pulse detection, which can help provide an enhanced signal-to-noise characteristic, such as can help permit highly specific fast IR spectroscopic tissue analysis. Using a difference between (1) response signal values during a first time period duration of a response pulse from a tissue sample illuminated by illumination pulse, and (2) response signal values for a similar first time period duration between response pulses, for a low duty cycle (e.g., less than 50%, 10% or even at about 5% duty cycle) illumination pulse, accumulation of noise in the response signal between electromagnetic illumination pulses can be limited. In particular, the described signal pre-processing techniques can help extract meaningful information for performing spectroscopic analysis and characterization of the tissue sample despite amplitude and temporal variations that can be encountered when using the system.
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: March 21, 2023
    Assignees: IR MEMTEK LLC, OHIO STATE INNOVATION FOUNDATION
    Inventors: James V. Coe, Jr., Rebecca C. Bradley
  • Patent number: 11590182
    Abstract: Disclosed herein are methods and compositions related to probiotic formulas. These formulas comprise the bacterial strain Lactobacillus crispatus WZ-12 or a derivative thereof. Other strains which can be included in the composition include, but are not limited to, Lactobacillus salivarius 1-14, or Lactobacillus reuteri 2-2, and derivatives thereof. These compositions can be used in a variety of methods to treat and/or ameliorate diseases, such as colonization of antibiotic-resistant bacteria in the host organism. Also disclosed herein are methods of treating those subjects in need thereof by administering the compositions disclosed herein.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: February 28, 2023
    Assignee: Ohio State Innovation Foundation
    Inventors: Hua Wang, Lu Zhang, Yang Zhou, Zihua Wang
  • Patent number: 11583564
    Abstract: Methods and materials for intrathecal delivery of recombinant Adeno-associated virus 9 (rAAV9) encoding Methyl-CpG binding protein 2 (MECP2) are provided. Use of the methods and materials is contemplated, for example, for the treatment of Rett syndrome.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: February 21, 2023
    Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., OHIO STATE INNOVATION FOUNDATION
    Inventors: Brian K. Kaspar, Kevin Foust
  • Patent number: 11578107
    Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: February 14, 2023
    Assignee: Ohio State Innovation Foundation
    Inventors: Daniel Gallego-Perez, Ly James Lee, Durba Pal, Subhadip Ghatak, Chandan Sen
  • Patent number: 11576946
    Abstract: Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU1, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: February 14, 2023
    Assignee: Ohio State Innovation Foundation
    Inventors: Dehua Pei, John W. Christman, Manjula Karpurapu, Patrick G. Dougherty
  • Publication number: 20230039456
    Abstract: Disclosed herein are modified Leishmania species and compositions thereof, such as live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions. Further disclosed are methods related to the modified Leishmania species, such as methods of production and methods of use.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 9, 2023
    Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Ohio State Innovation Foundation
    Inventors: Hira L. Nakhasi, Ranadhir Dey, Sreenivas Gannavaram, Subir Karmakar, Gregory Matlashewski, Abhay Satoskar, Wen-Wei Zhang, Patrick Lypaczewski
  • Patent number: 11564598
    Abstract: A system and method are provided for monitoring body kinematics. A wearable coil configuration of the system comprises at least first and second electrically-conductive coils adapted to be secured to a subject in a predetermined spatial relationship and orientation relative to one another. The first coil acts as a first transmitter and generates a first magnetic flux when a first electrical current is passed through it. The second coil acts as a receiver. The first magnetic flux induces a first electrical current or voltage in the second coil. A measurement instrument of the system is configured to measure the first electrical current or voltage and to output a first measurement signal. A processor, which may be part of, or external to, the system is configured to execute a motion monitoring algorithm that processes at least the measurement signal to determine at least a first motion made by the subject.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 31, 2023
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Asimina Kiourti, Vigyanshu Mishra
  • Publication number: 20230022235
    Abstract: The present invention provides benzamide compounds, compositions containing the benzamides, and use of the benzamides for inhibiting androgen receptor (AR) and/or aldo-keto reductase family 1 member C3 (AKR1C3). Also described herein methods for the treatment of hormone-mediated diseases and conditions, including hormone-related cancers such as castration resistant prostate cancer.
    Type: Application
    Filed: May 16, 2022
    Publication date: January 26, 2023
    Applicants: The Regents of the University of California, Ohio State Innovation Foundation, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Allen C. Gao, Pui-Kai Li, Enming Xing, Xiaolin Cheng, Xiaotian Kong, Wei Lou
  • Patent number: 11563499
    Abstract: Systems, methods, and computer program products for delivering information to an individual, group, or device. The information is carried by audio signals beyond the audible frequency range of human hearing, but within the frequency range of an audio system. The information is modulated onto an ultrasonic frequency and embedded into an audio signal transmitted by the audio system. Each individual, group member, or device may have or be coupled to a receiver configured to receive an acoustic signal transmitted by the audio system that includes the modulated ultrasonic frequency. The receiver extracts the information from the modulated ultrasonic frequency and provides the information to the individual, group member, or device.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: January 24, 2023
    Assignee: Ohio State Innovation Foundation
    Inventors: Can Emre Koksal, Harihara Varma Indukuri
  • Patent number: 11562006
    Abstract: Apparatus and method for receiving, processing and interactively displaying real-time air traffic data representative of the movement of aircraft throughout an airspace. The apparatus is an interactive data visualization framework which provides an immediately visualized aviation-oriented insights, with a focus on evaluating the deviations among flights by route, type, airport, and aircraft performance. The apparatus includes utilities for such as capacity planning, flight route prediction, and fuel consumption analysis.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: January 24, 2023
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Seth Young, Arnab Nandi, Behrooz Omidvar Tehrani
  • Patent number: 11552204
    Abstract: An apparatus for light detection includes a light, or photon, detector assembly and a dielectric resonator layer coupled to the detector assembly. The dielectric resonator layer is configured to receive transmission of incident light that is directed into the detector assembly by the dielectric resonator layer. The dielectric resonator layer resonates with a range of wavelengths of the incident light.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: January 10, 2023
    Assignees: Ohio State Innovation Foundation, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Sanjay Krishna, Anthony Grbic, Christopher Ball, Theodore Ronningen, Alireza Kazemi, Mohammadamin Ranjbaraskari, Qingyuan Shu
  • Patent number: 11540722
    Abstract: An etalon-based mid-infrared probe can be configured for spectroscopic tissue discrimination, such as between non-normal (e.g., cancerous) and normal (e.g., healthy) tissue. A broadband light source can be applied to the etalon to generate fringes at spectroscopic wavelengths of interest, which can be delivered to a tissue specimen via a fiber loop probe. A response signal can be spectral dispersed across a parallel array of detector pixels, such as using a diffraction grating, and signal processed for performing the tissue classification. A learning model can be trained, using full IR spectral data, for applying a reduced set of wavelengths for performing the spectroscopic tissue analysis and classification.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: January 3, 2023
    Assignee: Ohio State Innovation Foundation
    Inventor: James Coe
  • Patent number: 11542542
    Abstract: The present disclosure relates to improved methods for detecting nucleic acids using DNA fingerloop stem loop structures, wherein the DNA fingerloop stem loop structures diminish base pairing of a detection probe to a mismatched target nucleic acid. The present disclosure also relates to improved methods for amplifying nucleic acids. Further disclosed are chimeric fingerloop DNAs for use in methods for modulating protein expression levels and/or RNA stability.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: January 3, 2023
    Assignee: Ohio State Innovation Foundation
    Inventor: Richard A. Lease
  • Patent number: 11536343
    Abstract: A hyperdamping inclusion under constraint with large, broadband frequency damping properties is disclosed. The inclusion includes materials under near-buckling constraint such that fundamental eigenfrequency vanishes at near-buckling.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: December 27, 2022
    Assignee: Ohio State Innovation Foundation
    Inventor: Ryan L. Harne
  • Patent number: 11529323
    Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: December 20, 2022
    Assignee: Ohio State Innovation Foundation
    Inventors: Ching-Shih Chen, Christopher C. Coss, Samuel Kulp, Yu-Chou Tseng, Tanios Bekaii-Saab
  • Patent number: 11527810
    Abstract: A multiband antenna comprises a dielectric substrate with a first surface defining an annular ledge and a central recess with a plurality of pockets. A MIMO radiator body is disposed in the central recess having a first surface defining a plurality of lobes which are disposed in respective ones of the plurality of pockets and having a second surface defining an outer rim and a central shelf. A radiator ring is disposed at the annular ledge so that the radiator ring and the outer rim converge along an annular gap therebetween. A plurality of MIMO feed lines provide external connection to respective lobes. The MIMO radiator body and the radiator ring provide a substantially horizontally-directed radiation pattern (e.g., for terrestrial signals). At least one low-profile radiator on the central shelf provides a substantially circularly polarized or vertically-directed radiation pattern for receiving signals radiated from a satellite.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: December 13, 2022
    Assignees: FORD GLOBAL TECHNOLOGIES, LLC, OHIO STATE INNOVATION FOUNDATION
    Inventors: John F. Locke, Chi-Chih Chen, Jiukun Che
  • Patent number: 11518790
    Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: December 6, 2022
    Assignee: Ohio State Innovation Foundation
    Inventors: Daniel Gallego-Perez, Ly James Lee, Durba Pal, Subhadip Ghatak, Chandan Sen
  • Patent number: 11521994
    Abstract: An open circuit voltage photodetector comprises a photovoltaic device including a photovoltaic junction, and a transistor. The photovoltaic device is connected to the gate terminal of the transistor to input an open circuit voltage of the photovoltaic device to the gate terminal. An array of such photodetectors and a readout integrated circuit forms an image sensor. In a photodetection method, an open circuit voltage is generated in a photovoltaic device in response to illumination by incident radiation, and the open circuit voltage is applied to a gate terminal of a transistor to modulate a channel current flowing in a channel of the transistor. A readout electronic circuit may be fabricated with an extra transistor, and a photovoltaic device disposed on the readout electronic circuit and electrically connected to apply an open circuit voltage of the photovoltaic device to a gate of the extra transistor.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: December 6, 2022
    Assignee: Ohio State Innovation Foundation
    Inventors: Sanjay Krishna, Earl Fuller, Waleed Khalil, Theodore Ronningen, Alireza Kazemi, Dale Shane Smith, Teressa Specht, Ramy Tantawy
  • Patent number: 11510991
    Abstract: The present disclosure provides novel polypeptide conjugates. The polypeptide conjugates disclosed herein comprise a stapled peptide comprising a peptide and at least one staple which holds the peptide in an ?-helical conformation, and a cyclic cell-penetrating peptide (cCPP) conjugated, directly or indirectly, to the stapled peptide. The present disclosure demonstrates that cCPPs can be used to confer consistent cell-permeability to stapled peptides.
    Type: Grant
    Filed: October 28, 2018
    Date of Patent: November 29, 2022
    Assignee: Ohio State Innovation Foundation
    Inventor: Dehua Pei
  • Patent number: D972152
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: December 6, 2022
    Assignee: Ohio State Innovation Foundation
    Inventors: Jordan Thomas, Samantha Warren