Abstract: Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. In another aspect, provided is an antibody-drug-conjugate comprising an antibody conjugated with a compound described herein. In still another aspect, provided is a pharmaceutical composition comprising a compound or antibody-drug-conjugate described herein. In a further aspect, provided is method of treating a cancer comprising administering a therapeutically effective amount of a compound or antibody-drug-conjugate described herein to a patient in need thereof.

Abstract: Systems and methods can include a transponder configured to communicate wirelessly with a receiver and sensor module (RSM), wirelessly communicate with a high-speed network, and radio-frequency (RF) powering of RSM. The high-speed network can include a wired network such as USB or Ethernet, or wireless network such as a Wi-Fi or cellular network. Additionally or alternatively, an antenna module can be configured to transmit radio-frequency (RF) power to a receiver configured to monitor a condition of a machine. A harmonic harvesting circuit design for harvesting unrectified AC power contained in the fundamental and harmonic at RF frequencies at the output of conventional rectifying circuits for storage and for powering of the entire RSM.

Abstract: Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.

Abstract: Disclosed are zeolitic materials that include a microporous crystalline framework substituted with one or more paired Lewis acid sites. Each of the one or more paired Lewis acid sites within the zeolitic material can comprise a first Lewis acid metal center and a second Lewis acid metal center. The first Lewis acid metal center and the second Lewis acid metal center can be separated by three or fewer atoms within the crystalline framework. Also provided herein are methods of making these zeolitic materials as well as methods of using these zeolitic materials as catalysts.

Abstract: The embodiments described herein relate to systems, methods, and devices for capturing arm motion. The arm motion can be transformed into a rendered object that can interact with a three dimensional scene that allows a user to intuitively grab, move, manipulate and hit objects within the scene.

Abstract: Disclosed herein is a Chlamydia-activated B cell (CAB) platform. Also disclosed is a method of enhancing a population of B cells, comprising exposing said B cells to Chlamydia spp. under conditions suitable to enhance the population of B cells, such that expansion and differentiation of said B cells takes place, and said B cells are exposed or crosslinked to an antigen. Also disclosed are methods of producing said CABs, and treating a subject in need thereof with said CABs.

Abstract: Surrogates for roadside objects, such as metal guardrails, can be used for vehicle testing. A surrogate for a metal guardrail can have substantially the same size and/or shape as the metal guardrail that the surrogate is mimicking. The surrogate can be configured to exhibit substantially the same characteristics as their actual counterpart metal guardrail when sensed by one or more vehicle sensors (e.g., cameras, radar sensors, and/or LIDAR sensors). Such surrogates can be used to test autonomous vehicles, one or more vehicle sensors, a vehicle sensor system, and/or one or more vehicle system (e.g., a road departure mitigation system). The surrogates can be configured to withstand being crashed into by a test vehicle without being damaged and without damaging the test vehicle.

Abstract: Disclosed herein are methods and compositions for treating or preventing swine influenza in a subject.

Abstract: Described are arylnaphthalene lactone derivatives. Also disclosed herein are methods of use of the arylnaphthalene lactone derivatives as anticancer agents.

Abstract: Compositions for and methods of treating corneal injury, among other tissue of or around the eye, are provided. Said compositions comprise MG53 or express MG53. Said compositions can be used for treating chronic or acute injured tissue of the eye or orbit of the eye and can be administered systemically, locally, or both.

Abstract: Disclosed herein are methods and compositions for treating multiple myeloma, and for enhancing antibody-dependent cellular toxicity (ADCC). Specifically, disclosed herein are methods of using antagonists of the aryl hydrocarbon receptor (AHR) to treat multiple myeloma and enhance ADCC. Also specifically disclosed is liposomal CH233191.

Abstract: Disclosed herein are topical compositions for the administration of active agents. The compositions can comprise zeolite nanoparticles dispersed in a topically acceptable carrier. The zeolite nanoparticles can further comprise an effective amount of an active agent adsorbed on the zeolite nanoparticles, encapsulated within the zeolite nanoparticles, or a combination thereof. Also provided sunscreen agents and antimicrobial agents, as well as compositions comprising sunscreen agents and antimicrobial agents.

Abstract: According to the embodiments provided herein, a trajectory determination device for geo-localization can include one or more relative position sensors, one or more processors, and memory. The one or more processors can execute machine readable instructions to receive the relative position signals from the one or more relative position sensors. The relative position signals can be transformed into a sequence of relative trajectories. Each of the relative trajectories can include a distance and directional information indicative of a change in orientation of the trajectory determination device. A progressive topology can be created based upon the sequence of relative trajectories; this progressive topology can be compared to map data. A geolocation of the trajectory determination device can be determined.

Abstract: A system for optimizing the use of network bandwidth by a mobile device including a mobile application client, which resides on the mobile device, and is connected to a cloud server, wherein the system analyzes user content consumption, provides a prefetching schedule to the mobile device, and the mobile device prefetches content partially in accordance with the schedule. A method of optimizing the use of network bandwidth using the system is also provided.

Abstract: Medical radiation attenuation thin films, methods of making the same, and articles such as gloves made therefrom, are disclosed. The thin films utilize guayule natural rubber, sulfur and an attenuation filler such as Bi2O3. The films mix the guayule natural rubber, sulfur and attenuation filler and cure the mixture at about 80 to about 105° C. for about 40 to about 90 minutes.

Abstract: Methods and systems for predicting prognosis of a patient are provided. An example method can comprise determining a target set, wherein the target set comprises patient data from a target patient, determining a reference set, wherein the reference set comprises patient data from a plurality of patients, and the plurality of patients have one or more features in common with the target patient, determining common comparison features, normalizing common comparison feature data by a normalization method, weighting the normalized common comparison feature data, and determining one or more best matches by applying a classification method to the weighted normalized common comparison feature data. Finally, the prognosis of the patient in the target set is predicted.

Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.

Abstract: A medical testing apparatus and method of use for for penetrating a patient's tissue with an agent, the apparatus comprises an arcuate rail having spaced first and second sides supported by upper and lower arcuate surfaces and an arcuate handle having first and second ends extending from the upper surface of the arcuate rail. A plurality of tips extend substantially from and normally outward as the lower arcuate surface. The plurality of tips comprises alternating blunt tips and reed tips.

Abstract: A system for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.

Abstract: A cantilever system for use in an atomic force microscope (AFM) is disclosed. The cantilever system comprises a base cantilever portion and a paddle connected to the base cantilever portion with one end free to move relative to the base cantilever portion. The base cantilever portion has an effective bending stiffness, k1, and the paddle has an effective bending stiffness, k2. The ratio of the effective bending stiffness, k1, to the bending stiffness, k2, is at least greater than 4. Such a cantilever system provides a stable, i.e., invariant contact resonant frequency, independent of the changes in the local contact stiffness.