Patents Assigned to Ohio State Innovation Foundation
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Patent number: 11607135Abstract: Signal processing techniques that can include an embedded software low-noise response pulse detection, which can help provide an enhanced signal-to-noise characteristic, such as can help permit highly specific fast IR spectroscopic tissue analysis. Using a difference between (1) response signal values during a first time period duration of a response pulse from a tissue sample illuminated by illumination pulse, and (2) response signal values for a similar first time period duration between response pulses, for a low duty cycle (e.g., less than 50%, 10% or even at about 5% duty cycle) illumination pulse, accumulation of noise in the response signal between electromagnetic illumination pulses can be limited. In particular, the described signal pre-processing techniques can help extract meaningful information for performing spectroscopic analysis and characterization of the tissue sample despite amplitude and temporal variations that can be encountered when using the system.Type: GrantFiled: July 6, 2022Date of Patent: March 21, 2023Assignees: IR MEMTEK LLC, OHIO STATE INNOVATION FOUNDATIONInventors: James V. Coe, Jr., Rebecca C. Bradley
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Patent number: 11590182Abstract: Disclosed herein are methods and compositions related to probiotic formulas. These formulas comprise the bacterial strain Lactobacillus crispatus WZ-12 or a derivative thereof. Other strains which can be included in the composition include, but are not limited to, Lactobacillus salivarius 1-14, or Lactobacillus reuteri 2-2, and derivatives thereof. These compositions can be used in a variety of methods to treat and/or ameliorate diseases, such as colonization of antibiotic-resistant bacteria in the host organism. Also disclosed herein are methods of treating those subjects in need thereof by administering the compositions disclosed herein.Type: GrantFiled: September 10, 2019Date of Patent: February 28, 2023Assignee: Ohio State Innovation FoundationInventors: Hua Wang, Lu Zhang, Yang Zhou, Zihua Wang
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Patent number: 11583564Abstract: Methods and materials for intrathecal delivery of recombinant Adeno-associated virus 9 (rAAV9) encoding Methyl-CpG binding protein 2 (MECP2) are provided. Use of the methods and materials is contemplated, for example, for the treatment of Rett syndrome.Type: GrantFiled: November 17, 2017Date of Patent: February 21, 2023Assignees: NATIONWIDE CHILDREN'S HOSPITAL, INC., OHIO STATE INNOVATION FOUNDATIONInventors: Brian K. Kaspar, Kevin Foust
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Patent number: 11578107Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.Type: GrantFiled: December 20, 2017Date of Patent: February 14, 2023Assignee: Ohio State Innovation FoundationInventors: Daniel Gallego-Perez, Ly James Lee, Durba Pal, Subhadip Ghatak, Chandan Sen
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Patent number: 11576946Abstract: Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU1, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH.Type: GrantFiled: January 29, 2019Date of Patent: February 14, 2023Assignee: Ohio State Innovation FoundationInventors: Dehua Pei, John W. Christman, Manjula Karpurapu, Patrick G. Dougherty
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Publication number: 20230039456Abstract: Disclosed herein are modified Leishmania species and compositions thereof, such as live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions. Further disclosed are methods related to the modified Leishmania species, such as methods of production and methods of use.Type: ApplicationFiled: December 17, 2020Publication date: February 9, 2023Applicants: The U.S.A., as represented by the Secretary, Department of Health and Human Services, Ohio State Innovation FoundationInventors: Hira L. Nakhasi, Ranadhir Dey, Sreenivas Gannavaram, Subir Karmakar, Gregory Matlashewski, Abhay Satoskar, Wen-Wei Zhang, Patrick Lypaczewski
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Patent number: 11564598Abstract: A system and method are provided for monitoring body kinematics. A wearable coil configuration of the system comprises at least first and second electrically-conductive coils adapted to be secured to a subject in a predetermined spatial relationship and orientation relative to one another. The first coil acts as a first transmitter and generates a first magnetic flux when a first electrical current is passed through it. The second coil acts as a receiver. The first magnetic flux induces a first electrical current or voltage in the second coil. A measurement instrument of the system is configured to measure the first electrical current or voltage and to output a first measurement signal. A processor, which may be part of, or external to, the system is configured to execute a motion monitoring algorithm that processes at least the measurement signal to determine at least a first motion made by the subject.Type: GrantFiled: July 25, 2019Date of Patent: January 31, 2023Assignee: OHIO STATE INNOVATION FOUNDATIONInventors: Asimina Kiourti, Vigyanshu Mishra
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Publication number: 20230022235Abstract: The present invention provides benzamide compounds, compositions containing the benzamides, and use of the benzamides for inhibiting androgen receptor (AR) and/or aldo-keto reductase family 1 member C3 (AKR1C3). Also described herein methods for the treatment of hormone-mediated diseases and conditions, including hormone-related cancers such as castration resistant prostate cancer.Type: ApplicationFiled: May 16, 2022Publication date: January 26, 2023Applicants: The Regents of the University of California, Ohio State Innovation Foundation, The United States Government as represented by the Department of Veterans AffairsInventors: Allen C. Gao, Pui-Kai Li, Enming Xing, Xiaolin Cheng, Xiaotian Kong, Wei Lou
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Patent number: 11563499Abstract: Systems, methods, and computer program products for delivering information to an individual, group, or device. The information is carried by audio signals beyond the audible frequency range of human hearing, but within the frequency range of an audio system. The information is modulated onto an ultrasonic frequency and embedded into an audio signal transmitted by the audio system. Each individual, group member, or device may have or be coupled to a receiver configured to receive an acoustic signal transmitted by the audio system that includes the modulated ultrasonic frequency. The receiver extracts the information from the modulated ultrasonic frequency and provides the information to the individual, group member, or device.Type: GrantFiled: November 10, 2021Date of Patent: January 24, 2023Assignee: Ohio State Innovation FoundationInventors: Can Emre Koksal, Harihara Varma Indukuri
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Patent number: 11562006Abstract: Apparatus and method for receiving, processing and interactively displaying real-time air traffic data representative of the movement of aircraft throughout an airspace. The apparatus is an interactive data visualization framework which provides an immediately visualized aviation-oriented insights, with a focus on evaluating the deviations among flights by route, type, airport, and aircraft performance. The apparatus includes utilities for such as capacity planning, flight route prediction, and fuel consumption analysis.Type: GrantFiled: October 2, 2018Date of Patent: January 24, 2023Assignee: OHIO STATE INNOVATION FOUNDATIONInventors: Seth Young, Arnab Nandi, Behrooz Omidvar Tehrani
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Patent number: 11552204Abstract: An apparatus for light detection includes a light, or photon, detector assembly and a dielectric resonator layer coupled to the detector assembly. The dielectric resonator layer is configured to receive transmission of incident light that is directed into the detector assembly by the dielectric resonator layer. The dielectric resonator layer resonates with a range of wavelengths of the incident light.Type: GrantFiled: February 3, 2020Date of Patent: January 10, 2023Assignees: Ohio State Innovation Foundation, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Sanjay Krishna, Anthony Grbic, Christopher Ball, Theodore Ronningen, Alireza Kazemi, Mohammadamin Ranjbaraskari, Qingyuan Shu
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Patent number: 11540722Abstract: An etalon-based mid-infrared probe can be configured for spectroscopic tissue discrimination, such as between non-normal (e.g., cancerous) and normal (e.g., healthy) tissue. A broadband light source can be applied to the etalon to generate fringes at spectroscopic wavelengths of interest, which can be delivered to a tissue specimen via a fiber loop probe. A response signal can be spectral dispersed across a parallel array of detector pixels, such as using a diffraction grating, and signal processed for performing the tissue classification. A learning model can be trained, using full IR spectral data, for applying a reduced set of wavelengths for performing the spectroscopic tissue analysis and classification.Type: GrantFiled: April 8, 2022Date of Patent: January 3, 2023Assignee: Ohio State Innovation FoundationInventor: James Coe
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Patent number: 11542542Abstract: The present disclosure relates to improved methods for detecting nucleic acids using DNA fingerloop stem loop structures, wherein the DNA fingerloop stem loop structures diminish base pairing of a detection probe to a mismatched target nucleic acid. The present disclosure also relates to improved methods for amplifying nucleic acids. Further disclosed are chimeric fingerloop DNAs for use in methods for modulating protein expression levels and/or RNA stability.Type: GrantFiled: July 18, 2018Date of Patent: January 3, 2023Assignee: Ohio State Innovation FoundationInventor: Richard A. Lease
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Patent number: 11536343Abstract: A hyperdamping inclusion under constraint with large, broadband frequency damping properties is disclosed. The inclusion includes materials under near-buckling constraint such that fundamental eigenfrequency vanishes at near-buckling.Type: GrantFiled: September 30, 2019Date of Patent: December 27, 2022Assignee: Ohio State Innovation FoundationInventor: Ryan L. Harne
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Patent number: 11529323Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.Type: GrantFiled: September 13, 2018Date of Patent: December 20, 2022Assignee: Ohio State Innovation FoundationInventors: Ching-Shih Chen, Christopher C. Coss, Samuel Kulp, Yu-Chou Tseng, Tanios Bekaii-Saab
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Patent number: 11527810Abstract: A multiband antenna comprises a dielectric substrate with a first surface defining an annular ledge and a central recess with a plurality of pockets. A MIMO radiator body is disposed in the central recess having a first surface defining a plurality of lobes which are disposed in respective ones of the plurality of pockets and having a second surface defining an outer rim and a central shelf. A radiator ring is disposed at the annular ledge so that the radiator ring and the outer rim converge along an annular gap therebetween. A plurality of MIMO feed lines provide external connection to respective lobes. The MIMO radiator body and the radiator ring provide a substantially horizontally-directed radiation pattern (e.g., for terrestrial signals). At least one low-profile radiator on the central shelf provides a substantially circularly polarized or vertically-directed radiation pattern for receiving signals radiated from a satellite.Type: GrantFiled: November 16, 2020Date of Patent: December 13, 2022Assignees: FORD GLOBAL TECHNOLOGIES, LLC, OHIO STATE INNOVATION FOUNDATIONInventors: John F. Locke, Chi-Chih Chen, Jiukun Che
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Patent number: 11518790Abstract: Disclosed herein are compositions and methods that involve using compositions containing one or more of ETV2, FOXC2, FLI1 and a miR-200b inhibitor for directly reprogramming somatic cells into induced vasculogenic cells both in vitro and in vivo. These compositions and methods are useful for a variety of purposes, including the development of pro-angiogenic therapies.Type: GrantFiled: December 20, 2017Date of Patent: December 6, 2022Assignee: Ohio State Innovation FoundationInventors: Daniel Gallego-Perez, Ly James Lee, Durba Pal, Subhadip Ghatak, Chandan Sen
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Patent number: 11521994Abstract: An open circuit voltage photodetector comprises a photovoltaic device including a photovoltaic junction, and a transistor. The photovoltaic device is connected to the gate terminal of the transistor to input an open circuit voltage of the photovoltaic device to the gate terminal. An array of such photodetectors and a readout integrated circuit forms an image sensor. In a photodetection method, an open circuit voltage is generated in a photovoltaic device in response to illumination by incident radiation, and the open circuit voltage is applied to a gate terminal of a transistor to modulate a channel current flowing in a channel of the transistor. A readout electronic circuit may be fabricated with an extra transistor, and a photovoltaic device disposed on the readout electronic circuit and electrically connected to apply an open circuit voltage of the photovoltaic device to a gate of the extra transistor.Type: GrantFiled: December 5, 2018Date of Patent: December 6, 2022Assignee: Ohio State Innovation FoundationInventors: Sanjay Krishna, Earl Fuller, Waleed Khalil, Theodore Ronningen, Alireza Kazemi, Dale Shane Smith, Teressa Specht, Ramy Tantawy
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Patent number: 11510991Abstract: The present disclosure provides novel polypeptide conjugates. The polypeptide conjugates disclosed herein comprise a stapled peptide comprising a peptide and at least one staple which holds the peptide in an ?-helical conformation, and a cyclic cell-penetrating peptide (cCPP) conjugated, directly or indirectly, to the stapled peptide. The present disclosure demonstrates that cCPPs can be used to confer consistent cell-permeability to stapled peptides.Type: GrantFiled: October 28, 2018Date of Patent: November 29, 2022Assignee: Ohio State Innovation FoundationInventor: Dehua Pei
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Patent number: D972152Type: GrantFiled: June 7, 2021Date of Patent: December 6, 2022Assignee: Ohio State Innovation FoundationInventors: Jordan Thomas, Samantha Warren