Patents Assigned to Ohio State Innovation Foundation
  • Patent number: 10465170
    Abstract: Described herein are mutant pneumoviruses comprising a nucleotide sequence which encodes a mutated zinc binding motif in an M2-1 protein of the pneumovirus, wherein the zinc binding motif is mutated relative to wild-type pneumovirus. The mutant pneumoviruses described herein grow to high titer in cell culture, are genetically stable, are attenuated in vitro and in vivo, and are highly immunogenic. Also described herein are vaccines and vaccine compositions comprising the live attenuated mutant pneumoviruses. Vaccine compositions can further comprise a pharmaceutically acceptable carrier, vehicle, excipient, and/or adjuvant. Methods for inducing a protective immune response in a subject against a pneumovirus infection are also described and disclosed.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: November 5, 2019
    Assignees: Ohio State Innovation Foundation, Research Institute at Nationwide Children's Hospital
    Inventors: Mark E. Peeples, Jianrong Li, Hui Cai, Rongzhang Wang
  • Patent number: 10456443
    Abstract: Improved calcineurin inhibitors and methods of using these improved calcineurin inhibitors to inhibit calcineurin-NFAT signaling in cells and in subjects are disclosed.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: October 29, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Dehua Pei, Ziqing Qian, John W Christman, Manjula Karpurapu
  • Patent number: 10458501
    Abstract: A hyperdamping inclusion under constraint with large, broadband frequency damping properties is disclosed. The inclusion includes materials under near-buckling constraint such that fundamental eigenfrequency vanishes at near-buckling.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: October 29, 2019
    Assignee: Ohio State Innovation Foundation
    Inventor: Ryan L. Harne
  • Patent number: 10457631
    Abstract: The present disclosure relates to a series of biodegradable amino-ester lipid-like nanoparticles. In some embodiments, the biodegradable amino-ester lipid-like nanoparticles are used in methods for the delivery of nucleic acids.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 29, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Yizhou Dong, Xinfu Zhang, Xiao Luo
  • Patent number: 10451751
    Abstract: Provided herein are charge generating devices and methods of making and use thereof. The charge generating devices comprise a substrate having a top surface; a plurality of spaced-apart three-dimensional elements disposed on the top surface of the substrate; and a plurality of cavities formed by the plurality of spaced-apart three-dimensional elements, the plurality of cavities being the area between the plurality of spaced-apart three-dimensional elements. The charge generating devices can further comprise a radioactive layer disposed on at least a portion of the plurality of spaced-apart three-dimensional elements and the top surface such that the plurality of cavities and the top surface are substantially coated by the radioactive layer. In some examples, the charge generating devices can comprise a radiation material and/or a scintillating material disposed within at least a portion of the plurality of cavities.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: October 22, 2019
    Assignee: Ohio State Innovation Foundation
    Inventor: Lei Cao
  • Patent number: 10444311
    Abstract: Techniques for optimizing a magnetic resonance imaging (MRI) protocols are described herein. An example method can include receiving one or more MRI scanner settings for an imaging sequence; selecting at least one objective function from a plurality of objective functions; selecting an acquisition train length; selecting a k-space strategy; selecting one or more imaging parameters; and acquiring a magnetic resonance (MR) image using at least one of an optimized k-space strategy, an optimized acquisition train length, or optimized imaging parameters.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: October 15, 2019
    Assignees: Ohio State Innovation Foundation, Research Institute at Nationwide Children's Hospital
    Inventors: Jinghua Wang, Zhong-lin Lu, Nehal Parikh, Lili He
  • Patent number: 10433554
    Abstract: The present disclosure relates to deodorizing compounds and compositions for use in methods of repelling insects and methods of reducing or preventing the transmission of mosquito-borne pathogens.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 8, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Peter Marc Piermarini, William L. Marr
  • Patent number: 10439851
    Abstract: Example systems and methods described herein relate to radio communication architectures and techniques for beamforming and down-conversion without a priori knowledge of the source location or frequency. An example radio receiver includes a plurality of antenna elements that include a first element, a second element, and a third element. The radio receiver also includes a plurality of mixers coupled to the plurality of antenna elements and a combiner coupled to the plurality of antenna elements. A signal incident on the first element is mixed with itself via a first mixer of the plurality of mixers. An output of the first mixer is mixed with a signal incident on the second element via a second mixer of the plurality of mixers, and an output of the second mixer is combined via the combiner with a signal incident on the third element.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: October 8, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Markus H. Novak, Satheesh Bojja Venkatakrishnan, John L. Volakis
  • Patent number: 10436978
    Abstract: Provided is a cladded single crystal sapphire optical fiber. In one embodiment, the innovation provides a method for forming a cladding in a single crystal sapphire optical fiber by reactor irradiation. The reactor irradiation creates ions external to the fiber that enter the fiber, displace atoms in the fiber, and are implanted in the fiber, thus modifying the index of refraction of the fiber near the surface of the fiber and creating a cladding in the sapphire fiber.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: October 8, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Thomas Elder Blue, Brandon Augustus Wilson
  • Publication number: 20190298450
    Abstract: Systems and methods are described herein for predictive heart valve simulation. The systems and methods described herein can include segmenting anatomical region of a heart of a patient from image data characterizing the heart of the patient. Anatomical model data that can include three-dimensional shapes of the anatomical regions of the heart can be generated based on the image data. The anatomical model data can be used to generate anatomical model data. The analytical model data can include a three-dimensional mesh of the anatomical regions of the heart. A deformed analytical model that can be indicative of a deformed position of the anatomical regions of the heart and a deformed position of the surgical object can be generated based on the analytical model data.
    Type: Application
    Filed: October 4, 2017
    Publication date: October 3, 2019
    Applicant: Ohio State Innovation Foundation
    Inventors: Lakshmi Dasi, Amirsepehr Azimian
  • Patent number: 10420825
    Abstract: Disclosed are vaccines containing one or more immunogenic polypeptides derived from an EtpE protein from an Ehrlichia sp. or nucleic acid encoding these polypeptides. Also disclosed is a method for vaccinating a subject against Ehrlichia sp. that involves administering to the subject a composition comprising any of the disclosed vaccines. Also disclosed is a method for diagnosing and/or monitoring the treatment of Ehrlichiosis in a subject that comprising assaying a biological sample (e.g., blood, serum, or plasma sample) from the subject for the presence of an antibody that specifically binds an EtpE polypeptide. Also disclosed are methods for delivering a therapeutic or diagnostic agent to a cell in a subject that involves conjugating the agent, or a delivery vehicle comprising the agent, to polypeptide containing the C-terminal domain of an EtpE protein.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: September 24, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Yasuko Rikihisa, Dipu Mohan-Kumar
  • Patent number: 10418238
    Abstract: Amorphous silicon devices, systems, and related methods are described herein. An example method for fabricating a thin film with light-emitting or light-detecting capability can include depositing a thin film of amorphous silicon on a wafer such that crystalline defects are distributed throughout the thin film. Additionally, an example photonic device can include a p-doped region and an n-doped region formed on a wafer, and a resonator structure formed on the wafer. The resonator structure can be formed from amorphous silicon and can be arranged between the p-doped and n-doped regions to form a PIN junction. Optionally, the photonic device can be incorporated into a monolithic integrated optical system.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: September 17, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Ronald M. Reano, Michael Wood, Ryan Patton
  • Patent number: 10407726
    Abstract: Disclosed herein are miRNA biomarkers and methods for measuring exposure of a mammalian subject to ionizing radiation using a cell-free biological sample. Also disclosed are dosimeters and methods for triaging and treating a subject exposed to ionizing radiation.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 10, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Naduparambil Jacob, Arnab Chakravarti
  • Publication number: 20190269315
    Abstract: A system can include a non-transitory memory to store machine readable instructions and data, and a processor to access the non-transitory memory and execute the machine-readable instructions. The machine-readable instruction can include a global module that can be programmed to generate a visual field map (VFM) model that can include a set of visual function map parameters for an entire visual field for a subject. The global module can be programmed to update the set of visual function map parameters corresponding to updating a shape of the VFM based on subject response data generated during each administration of a vision test to a subject.
    Type: Application
    Filed: March 1, 2019
    Publication date: September 5, 2019
    Applicant: Ohio State Innovation Foundation
    Inventors: Zhong-Lin Lu, Pengjing Xu, Luis Lesmes, Deyue Yu
  • Patent number: 10393741
    Abstract: Described herein are improved diagnostic tools for veterinary and human use which can be used for serodiagnosing A. platys in mammals, particularly in members of the Canidae family and in humans. The diagnostic tools are a group of outer membrane proteins of A. platys and variants thereof, referred to hereinafter as the “OMP proteins”, a group of outer membrane proteins of A. platys and variants thereof referred to hereinafter as the “P44 proteins”, and antibodies to the OMP proteins and the P44 proteins.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: August 27, 2019
    Assignee: Ohio State Innovation Foundation
    Inventor: Yasuko Rikihisa
  • Patent number: 10387746
    Abstract: A shade selection program is disclosed that predicts the shade choice with the smallest CIEDE2000 color difference for dental composite resin restorations when given a backing and target shade. By utilizing generated regression models, a database of spectral reflectance information, and principles of Kubelka-Munk layering, a highly accurate shade selection program was designed. Additionally, a blending model for quantification of color adjustment potential was developed. Systems and methods for correlating RGB data from the VITA Linearguide 3D Master and VITA Bleached Guide 3D Master shade guides with their spectroradiometric correlates through a regression model while indicating a methodology for validation of accuracy of digital imaging systems are disclosed.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: August 20, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Melody Noelle Carney, William Michael Johnston
  • Patent number: 10383654
    Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: August 20, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Alper Yilmaz, Edward W. Martin, Stephen P. Povoski, Charles L. Hitchcock, Enver Ozer, Ronald Xu
  • Patent number: 10380788
    Abstract: The innovation describes and discloses systems and methods related to deep neural networks employing machine learning to detect item 2D landmark points from a single image, such as those of an image of a face, and to estimate their 3D coordinates and shape rapidly and accurately. The system also provides for mapping by a feed-forward neural network that defines two criteria, one to learn to detect important shape landmark points on the image and another to recover their depth information. An aspect of the innovation may utilize camera models in a data augmentation approach that aids machine learning of a complex, non-linear mapping function. Other augmentation approaches are also considered.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: August 13, 2019
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventor: Aleix Martinez
  • Patent number: 10369122
    Abstract: The present invention relates to compounds, compositions, lipid-like nanoparticles, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a polynucleotide).
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: August 6, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Yizhou Dong, Bin Li
  • Patent number: 10369176
    Abstract: Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: August 6, 2019
    Assignees: Research Institute at Nationwide Children's Hospital, Ohio State Innovation Foundation
    Inventors: Steven D. Goodman, Lauren O. Bakaletz, Gail Besner, Michael Bailey