Patents Assigned to Ohio State University
  • Materials and Methods Related to MicroRNA-21, Mismatch Repair, and Colorectal Cancer
    Publication number: 20150126585
    Abstract: Described herein is the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense miR-21 is therefore proven as therapeutic herein. Therefore, compositions, kits, therapies and other methods, including methods of treatment/amelioration of symptoms, are disclosed herein.
    Type: Application
    Filed: December 31, 2014
    Publication date: May 7, 2015
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Nicola Valeri
  • Methods for diagnosing pancreatic cancer using miR-103-1, miR-103-2, miR-24-2 and miR-107
    Patent number: 9023598
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: May 5, 2015
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Materials and methods related to modulation of mismatch repair and genomic stability by miR-155
    Patent number: 9023825
    Abstract: The present invention provides materials and methods related to modulation of mismatch repair and genomic stability by miR-155.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: May 5, 2015
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Nicola Valeri
  • Methods for diagnosing colon cancer using MicroRNA signatures
    Patent number: 9017940
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: April 28, 2015
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Methods for diagnosing breast, colon, lung, pancreatic and prostate cancer using miR-21 and miR-17-5p
    Patent number: 9017939
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of solid cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: April 28, 2015
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, George A. Calin, Stefano Volinia
  • Polymorphisms in genes affecting ace-related disorders and uses thereof
    Patent number: 9012143
    Abstract: A method for predicting a subject's risk factors for ACE-related disorders includes detecting the allelic status of one or more polymorphisms in a nucleic acid sample of the subject.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: April 21, 2015
    Assignee: The Ohio State University Research Foundation
    Inventors: Wolfgang Sadee, Andrew D. Johnson, Danxin Wang, Audrey C. Papp
  • COMPOSITIONS AND METHODS RELATED TO VIRAL VACCINES
    Publication number: 20150104475
    Abstract: Provided herein are methods and compositions relating to Infectious Bursal Disease Virus (IBDV), and vaccines for treatment and prevention thereof.
    Type: Application
    Filed: July 5, 2013
    Publication date: April 16, 2015
    Applicant: The Ohio State University
    Inventor: Daral John Jackwood
  • Materials and Methods Useful for Affecting Tumor Cell Growth, Migration and Invasion
    Publication number: 20150104412
    Abstract: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Applicant: THE OHIO STATE UNIVERSITY
    Inventor: Carlo M. Croce
  • Nanochanneled device and related methods
    Patent number: 9005185
    Abstract: A capsule configured for in vivo refilling of a therapeutic agent. In certain embodiments, the capsule may contain methotrexate.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 14, 2015
    Assignees: The Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Randy Goodall, Lee Hudson
  • Methods for Differentiating Pancreatic Cancer from Normal Pancreatic Function and/or Chronic Pancreatitis
    Publication number: 20150094357
    Abstract: There is provided herein methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer, along with methods of identifying anti-pancreatic cancer agents.
    Type: Application
    Filed: December 9, 2014
    Publication date: April 2, 2015
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventor: Carlo M. Croce
  • Artificial compound eye with adaptive microlenses
    Patent number: 8964019
    Abstract: An artificial compound eye formed of three layers of membrane bonded to one another in a stacked relationship. A field chamber is located intermediate the two bottommost membranes. A plurality of focus chambers is located intermediate the two topmost membranes, and an image sensor is located below each focus chamber. The field chamber and each focus chamber contain a pressurized fluid medium. The ceilings of the focus chambers function as lenses though which light must pass to reach the sensors. The fluid pressure in the field chamber can be varied to expand or contract the eye between a planer and a domed configuration, thereby allowing the field of view of the eye to be varied. The fluid pressure in each focus chamber can be varied to expand or contract each lens between a planar and a domed configuration for independently varying the focal length of each lens.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: February 24, 2015
    Assignee: The Ohio State University
    Inventors: Yi Zhao, Hansong Zeng
  • GLUCOSE TRANSPORTER INHIBITORS
    Publication number: 20150051255
    Abstract: Thiazolidinedione compounds and pharmaceutically acceptable salts thereof are described. The compounds can be used in methods of treating cancer in a subject by administering to the subject a therapeutically effective amount of the compound. The compounds can also be used in methods of inhibiting glucose uptake in a cell by contacting the cell with the compound.
    Type: Application
    Filed: March 28, 2013
    Publication date: February 19, 2015
    Applicant: The Ohio State University Research Foundation
    Inventors: Ching-Shih Chen, Dasheng Wang, Samuel K. Kulp
  • Transcription Factor Inhibitors and Related Compositions, Formulations and Methods
    Publication number: 20150038443
    Abstract: The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL12, are disclosed. The STAT3 inhibitors are useful to treat breast cancer in general and breast cancer initiating cells in particular.
    Type: Application
    Filed: October 16, 2014
    Publication date: February 5, 2015
    Applicants: NATIONWIDE CHILDREN'S HOSPITAL, INC., THE OHIO STATE UNIVERSITY
    Inventors: Pui-Kai Li, Chenglong Li, Jiayuh Lin
  • Fast-cycling, conduction-cooled, quasi-isothermal, superconducting fault current limiter
    Patent number: 8948830
    Abstract: Fault Current Limiters (FCL) provide protection for upstream and/or downstream devices in electric power grids. Conventional FCL require the use of expensive conductors and liquid or gas cryogen handling. Disclosed embodiments describe FCL systems and devices that use lower cost superconductors, require no liquid cryogen, and are fast cycling. These improved FCL can sustain many sequential faults and require less time to clear faults while avoiding the use of liquid cryogen. Disclosed embodiments describe a FCL with a superconductor and cladding cooled to cryogenic temperatures; these are connected in parallel with a second resistor across two nodes in a circuit. According to disclosed embodiments, the resistance of the superconducting components and its sheath in the fault mode are sufficiently high to minimize energy deposition within the cryogenic system, minimizing recovery time.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: February 3, 2015
    Assignee: The Ohio State University
    Inventors: Michael Sumption, Edward Collings, Milan Majoros
  • Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
    Patent number: 8946187
    Abstract: The present invention discloses the discovery that miR-21 targets and down-regulates the core mismatch repair (MMR) recognition protein complex hMSH2 and hMSH6. Anti-sense miR-21 is therefore proven as therapeutic herein. Therefore, compositions, kits, therapies and other methods, including methods of treatment/amelioration of symptoms, are disclosed in the present invention.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: February 3, 2015
    Assignee: The Ohio State University
    Inventors: Carlo M. Croce, Nicola Valeri
  • microRNA Signatures in Human Ovarian Cancer
    Publication number: 20150024963
    Abstract: Described herein are methods and compositions for the diagnosis, prognosis and treatment of ovarian cancer. Also described are methods of identifying anti-cancer agents.
    Type: Application
    Filed: September 15, 2014
    Publication date: January 22, 2015
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventor: Carlo M. Croce
  • CBP AND p300-MEDIATED TRANSCRIPTION MODULATORS AND RELATED METHODS
    Publication number: 20150025045
    Abstract: The present invention relates to gene regulation. In particular, the present invention provides small compounds capable of modulating p300 and/or CBP-mediated transcription and related methods of therapeutic and research use. In addition, the present invention provides methods for treating conditions associated with aberrant p300 and/or CBP-mediated transcription with p300 and/or CBP-mediated transcription modulators (e.g., p300 and/or CBP-mediated transcription inhibitors).
    Type: Application
    Filed: September 14, 2012
    Publication date: January 22, 2015
    Applicants: THE OHIO STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Anna Mapp, Quintin Pan
  • System for expression of genes in plants from a virus-based expression vector
    Patent number: 8936937
    Abstract: Modified expression vectors, including Tobacco Mosaic Virus (TMV) expression vectors, methods for modifying such vectors, and uses of the same are disclosed.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: January 20, 2015
    Assignee: The Ohio State University Research Foundation
    Inventor: John A. Lindbo
  • ESX-MEDIATED TRANSCRIPTION MODULATORS AND RELATED METHODS
    Publication number: 20150017156
    Abstract: The present invention relates to gene regulation. In particular, the present invention provides small compounds capable of modulating ESX-mediated transcription and related methods of therapeutic and research use. In addition, the present invention provides methods for treating conditions associated with aberrant EGFR expression with ESX-mediated transcription modulators (e.g., ESX-mediated transcription inhibitors).
    Type: Application
    Filed: September 14, 2012
    Publication date: January 15, 2015
    Applicants: THE OHIO STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Anna Mapp, Quintin Pan
  • Methods for Identifying Fragile Histidine Triad (FHIT) Interaction and Uses Thereof
    Publication number: 20150010647
    Abstract: Provided herein are methods and compositions for the diagnosis, prognosis and treatment of a cancer associated disorders using the Fhit gene.
    Type: Application
    Filed: September 11, 2014
    Publication date: January 8, 2015
    Applicant: THE OHIO STATE UNIVERSITY
    Inventors: Carlo M. Croce, Francesco Trapasso