Patents Assigned to Ohio University
  • Phosphaplatins and their use in the treatment of cancers resistant to cisplatin and carboplatin
    Patent number: 8445710
    Abstract: The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: May 21, 2013
    Assignee: Ohio University
    Inventor: Rathindra N. Bose
  • Multi-Modal Vehicle
    Publication number: 20130112804
    Abstract: A multi-modal vehicle (“MMV”) 20a-20d. The MMV 20a-20d includes a fuselage 22 and a chassis 26 supporting at least three wheels 44 having deployed and stowed states. Extending away from the fuselage 22 is a canard wing system 28 and a main wing system 30. The main wing system 30 includes an inboard portion 134 and an outboard portion 132. The inboard portion 134 is pivotally connected to the fuselage 22; the outboard portion 132 is pivotally connected to the inboard portion 134. The MMV 20a-20d further includes a vertical thrust system 32 comprising a pair of ducted fans 100 that are incorporated into the fuselage 22, and a dual-use thrust system 34 that is configured to transition between a first position for supplying vertical thrust and a second position for supplying a horizontal thrust. A controller 42 is configured to control the MMV operations, reconfigurations, or transitions.
    Type: Application
    Filed: May 9, 2011
    Publication date: May 9, 2013
    Applicant: OHIO UNIVERSITY
    Inventor: Jianchao Zhu
  • IMMERSIVE VIDEO INTELLIGENCE NETWORK
    Publication number: 20130104073
    Abstract: A method of providing a navigable environment of an indoor space. The indoor space includes a plurality of rooms 18-30, which are optionally mapped to a floor plan 12. The method includes acquiring a plurality of images 60, 62 that are associated with the plurality of rooms 18-30 of the indoor space. At least a portion of the plurality of images 60, 62 are combined into at least two panoramic views 74 for each room 18-30 and rendered into a model of the indoor space. A three-dimensional model is defined from the rendered model and graphically illustrated as a three-dimensional navigable representation with a graphics engine so that a first user may navigate the indoor space.
    Type: Application
    Filed: June 22, 2011
    Publication date: April 25, 2013
    Applicant: OHIO UNIVERSITY
    Inventors: John R. Bowditch, Stephen D. Mokris, John E. Gibson, Roger Good
  • Pretreatment method for the synthesis of carbon nanotubes and carbon nanostructures from coal and carbon chars
    Patent number: 8409305
    Abstract: Carbon nanostructures such as multiwalled carbon nanotubes are formed from electrolyzed coal char. The electrolyzed coal char is formed by forming a slurry of coal particles, metal catalyst and water and subjecting this to electrolysis, which generates carbon dioxide and hydrogen. This forms a coating on the particles which includes metal catalysts. These particles can be used as is for formation of multi-walled carbon nanotubes using a pyrolysis method or other method without the addition of any catalyst. The gelatinous coating can be separated from the char and used as a fuel or as a carbon source to form carbon nanostructures.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: April 2, 2013
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • PHOSPHAPLATINS AND THEIR USE FOR TREATMENT OF CANCERS
    Publication number: 20130064902
    Abstract: Stable monomeric phosphaplatins, namely, (pyrophosphato)platinum(II) or platinum(IV) complexes containing a cis-cyclohexanediamine ligand or enantiomerically enriched or enantiopure trans-cyclohexanediamine ligands, and synthesis of these complexes, are provided. Efficacies and toxicities of the phosphaplatin compounds are determined toward a variety of cancers, including sensitive and resistant ovarian cancers, head and neck, and colon cancers. Compositions comprising the platinum complexes, and methods for treatment of proliferative diseases or disorders by means of the complexes or the compositions comprising them are disclosed.
    Type: Application
    Filed: June 2, 2011
    Publication date: March 14, 2013
    Applicant: OHIO UNIVERSITY
    Inventor: Rathindra N. Bose
  • Method for sequencing peptides and proteins using metastable-activated dissociation mass spectrometry
    Patent number: 8389931
    Abstract: Methods for fragmentation of large molecular ions, including proteins, nucleic acids, dendromers, and nanomaterials, compatible with several mass spectrometric techniques. The methods involve providing a gas-phase ion and allowing the gas phase ion to undergo collisions with metastable states of noble gases or nitrogen gas.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: March 5, 2013
    Assignee: Ohio University
    Inventors: Glen P. Jackson, Olivier Collin
  • Selective catalytic reduction via electrolysis of urea
    Patent number: 8388920
    Abstract: A method and apparatus for producing ammonia suitable for use as a reductant in a selective catalytic reduction (SCR), a selective non-catalytic reduction (SNCR), or a flue gas conditioning system is provided. A method for treating combustion exhaust gas with ammonia is provided that includes the electrolytic hydrolysis of urea under mild conditions. The electrolysis apparatus includes an electrolytic cell, which may be operatively coupled to an exhaust gas treatment system to provide an apparatus for reducing nitrogen oxides (NOx) and/or particulate in exhaust gases.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: March 5, 2013
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • ELECTROLYTIC CELLS AND METHODS FOR THE PRODUCTION OF AMMONIA AND HYDROGEN
    Publication number: 20130037424
    Abstract: A method using an electrolytic cell to electrolyze urea to produce at least one of H2 and NH3 is described. An electrolytic cell having a cathode with a first conducting component, an anode with a second conducting component, urea and an alkaline electrolyte composition in electrical communication with the anode and the cathode is used to electrolyze urea. The alkaline electrolyte composition has a hydroxide concentration of at least 0.01 M.
    Type: Application
    Filed: October 12, 2012
    Publication date: February 14, 2013
    Applicant: OHIO UNIVERSITY
    Inventor: Ohio University
  • Engineering of an Ultra-Thin Molecular Superconductor by Charge Transfer
    Publication number: 20130040822
    Abstract: A method of forming a superconductive device of a single layer of (BETS)2GaCl4 molecules on a substrate surface which displays a superconducting gap that increases exponentially with the length of the molecular chain is provided.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 14, 2013
    Applicant: Ohio University
    Inventors: Saw Wai Hla, Abdelrahim Hassanien, Kendal Clark
  • Method and system for determining properties of an asphalt material
    Patent number: 8364425
    Abstract: A method for determining properties of an asphalt material include measuring respective current deformations of a plurality of samples of the asphalt material, repeating the measuring step over a plurality of temperatures that change at a predetermined rate, calculating a plurality of measured total strain values as a function of the deformations and the temperatures, calculating respective creep strains, at different ones of the plurality of temperatures, based on the total strains as a function of applied stresses, calculating respective creep stiffnesses as a function of the temperatures, determining a combined creep curve based on the respective creep stiffnesses, deriving a theoretical creep curve, and fitting the theoretical creep curve with the combined creep curve to determine a master creep curve function and a time-temperature shift function.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: January 29, 2013
    Assignee: Ohio University
    Inventor: Sang-Soo Kim
  • PGG separation and purification
    Patent number: 8357796
    Abstract: A simple, inexpensive, and efficient method for separation and purification of the ?-and ?-forms of penta-O-galloyl-D-glucose (PGG) without the need for HPLC. The methods provided herein are useful for separation ?-PGG or ?-PGG from a mixture containing ?-PGG and ?-PGG and other chemicals. The method for separation of ?-PGG from a mixture of ?-PGG and ?-PGG comprises the steps of: adding water to a sample containing 50% or more ?-PGG and 50% or less ?-PGG; mixing the PGG and water to dissolve the PGG; filtering out any undissolved particles; and allowing the filtered solution to stand undisturbed until crystals form.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: January 22, 2013
    Assignee: Ohio University
    Inventors: Yulin Ren, Klaus B. Himmeldirk, Xiaozhou Chen
  • LAYERED ELECTROCATALYST FOR OXIDATION OF AMMONIA AND ETHANOL
    Publication number: 20120325682
    Abstract: A layered electrocatalyst for oxidizing ammonia, ethanol, or combinations thereof, comprising: a carbon support integrated with a conductive metal; at least one first metal plating layer at least partially deposited on the carbon support, wherein the at least one first metal plating layer is active to OH adsorption and inactive to a target species, and wherein the at least one first metal plating layer has a thickness ranging from 10 nanometers to 10 microns; and at least one second metal plating layer at least partially deposited on the at least one first metal plating layer, wherein the at least one second metal plating layer is active to the target species, and wherein the at least one second metal plating layer has a thickness ranging from 10 nanometers to 10 microns, forming a layered electrocatalyst.
    Type: Application
    Filed: July 9, 2012
    Publication date: December 27, 2012
    Applicant: OHIO UNIVERSITY
    Inventor: Gerardine G. Botte
  • COMPOSITE MEMBRANE FOR POLYMER ELECTROLYTE MEMBRANE FUEL CELL
    Publication number: 20120312695
    Abstract: The present invention relates generally to conducting polymer composites for use in electrochemical applications and electrolysis applications, and methods of making the same. A composite material is provided that includes a conducting polymer; and a silsesquioxane compound. The composite material is used to prepare ion conducting membranes and membrane electrode assemblies (MEA).
    Type: Application
    Filed: December 3, 2010
    Publication date: December 13, 2012
    Applicant: OHIO UNIVERSITY
    Inventor: Anima B. Bose
  • On-line and off-line coupling of EC with DESI-MS
    Patent number: 8330119
    Abstract: An apparatus for direct analysis of the redox products, or intermediates, of an electrochemical reaction by coupling an electrochemical cell to desorption electrospray ionization mass spectrometry.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: December 11, 2012
    Assignee: Ohio University
    Inventors: Hao Chen, Jiwen Li, Zhixin Miao, Yun Zhang
  • Systems and Methods For Promoting Wound Healing
    Publication number: 20120296266
    Abstract: In various embodiments, provided are topical gas delivery systems and methods for promoting wound healing. A provided gas delivery system comprises a gas reservoir comprising at least one chamber adapted to contain one or more therapeutic gases selected from NO, CO, O2, air, or combinations thereof, and at least one gas permeable membrane operably coupled to the reservoir. A provided method comprises using a provided gas delivery system to deliver the one or more therapeutic gases to a wound site such that a NO/ONOO? ratio suitable for promoting wound healing is achieved at the wound site.
    Type: Application
    Filed: December 31, 2010
    Publication date: November 22, 2012
    Applicant: OHIO UNIVERSITY
    Inventor: Tadeusz Malinski
  • TRANSDERMAL DELIVERY OF METFORMIN
    Publication number: 20120283332
    Abstract: Provided is a transdermal metformin that is an effective alternative treatment modality in patients with insulin resistance. Transdermal metformin can be used in conditions where oral metformin is indicated such as Type 2 diabetes mellitus, pre-diabetes, polycystic ovarian syndrome, and other known diabetes associated disorders. One advantage of using transdermal metformin is its ability to bypass the gastrointestinal system. This allows the drug to not have the gastrointestinal side-effects associated with oral metformin. A surprising advantage of using transdermal metformin in accordance with this disclosure is a 90% decrease in dosage from the oral preparation.
    Type: Application
    Filed: May 12, 2010
    Publication date: November 8, 2012
    Applicant: OHIO UNIVERSITY
    Inventors: Chase A. Scarbrough, Stanley S. Scarbrough, Jay Shubrook
  • Electrolytic cells and methods for the production of ammonia and hydrogen
    Patent number: 8303781
    Abstract: A method using an electrolytic cell to electrolyze urea to produce at least one of H2 and NH3 is described. An electrolytic cell having a cathode with a first conducting component, an anode with a second conducting component, urea and an alkaline electrolyte composition in electrical communication with the anode and the cathode is used to electrolyze urea. The alkaline electrolyte composition has a hydroxide concentration of at least 0.01 M.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: November 6, 2012
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • CARBON FIBER COMPOSITE DISCHARGE ELECTRODE
    Publication number: 20120227588
    Abstract: A discharge electrode using carbon fibers, nanofibers and/or nanotubes to generate the corona discharge. The invention contemplates carbon fiber electrodes with or without a polymer matrix to form a composite, and a supporting configuration in which the fibers are wrapped helically around a supporting rod that extends along the length of the electrode. Another supporting configuration includes the fibers stretched across the gas flow path. Yet another supporting configuration includes mounting the fibers along the length of the support rod substantially parallel to the rod.
    Type: Application
    Filed: July 8, 2010
    Publication date: September 13, 2012
    Applicant: OHIO UNIVERSITY
    Inventor: M. Khairul Alam
  • Electrochemical method for providing hydrogen using ammonia and ethanol
    Patent number: 8221610
    Abstract: An electrochemical method for providing hydrogen using ammonia, ethanol, or combinations thereof, comprising: forming an anode comprising a layered electrocatalyst, the layered electrocatalyst comprising at least one active metal layer deposited on a carbon support; providing a cathode comprising a conductor; disposing a basic electrolyte between the anode and the cathode; disposing a fuel within the basic electrolyte; and applying a current to the anode causing the oxidation of the fuel, forming hydrogen at the cathode.
    Type: Grant
    Filed: May 4, 2008
    Date of Patent: July 17, 2012
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • Electrochemical cell for oxidation of ammonia and ethanol
    Patent number: 8216437
    Abstract: An electrochemical cell for causing a reaction that produces hydrogen, the electrochemical cell comprising: a first electrode comprising: at least one layered electrocatalyst formed of at least one active metal layer deposited on a carbon support, wherein the at least one active metal layer is active to a target species; a second electrode comprising a conductor; a basic electrolyte; ammonia, ethanol, or combinations thereof; and electrical current in communication with the first electrode.
    Type: Grant
    Filed: May 4, 2008
    Date of Patent: July 10, 2012
    Assignee: Ohio University
    Inventor: Gerardine G. Botte