Patents Assigned to Ohio University
  • Neural stem cells and use thereof for brain tumor therapy
    Patent number: 7655224
    Abstract: The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: February 2, 2010
    Assignees: Children's Medical Center Corp., The General Hospital Corp., Northeastern Ohio Universities COM
    Inventors: Evan Y. Snyder, Xandra O. Breakefield, Karen S. Aboody, Ulrich Herrlinger, William P. Lynch
  • Room temperature synthesis of GaN nanopowder
    Patent number: 7641880
    Abstract: In the direct production of GaN by the metathesis of Li3N and GaCl3 or GaBr3 or GaI3, the reaction rate and yields can be greatly enhanced by including diethyl ether in the reaction system.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: January 5, 2010
    Assignee: Ohio University
    Inventors: Paul Gregory Van Patten, Guiquan Pan
  • Solid Oxide Fuel Cell Process and Apparatus
    Publication number: 20090252999
    Abstract: Conveying gas containing sulfur through a sulfur tolerant planar solid oxide fuel cell (PSOFC) stack for sulfur scrubbing, followed by conveying the gas through a non-sulfur tolerant PSOFC stack. The sulfur tolerant PSOFC stack utilizes anode materials, such as LSV, that selectively convert H2S present in the fuel stream to other non-poisoning sulfur compounds. The remaining balance of gases remaining in the completely or near H2S-free exhaust fuel stream is then used as the fuel for the conventional PSOFC stack that is downstream of the sulfur-tolerant PSOFC. A broad range of fuels such as gasified coal, natural gas and reformed hydrocarbons are used to produce electricity.
    Type: Application
    Filed: March 28, 2007
    Publication date: October 8, 2009
    Applicant: OHIO UNIVERSITY
    Inventors: Matthew Ellis Cooper, David J. Bayless, Jason P. Trembly
  • METHODS AND SYSTEMS FOR IDENTIFYING INSULIN MIMETICS
    Publication number: 20090203150
    Abstract: Methods are provided for identifying and selecting candidate molecules that activate glucose transport through binding of the insulin receptor at a site other than the insulin binding site. The methods include analyzing the properties of one or more candidate molecules in terms of the ability to bind the insulin receptor and activate glucose transport. Optionally the methods include, competitive assays in the presence of the glucose receptor, a candidate molecule, and one or more of insulin, alpha PGG and beta PGG.
    Type: Application
    Filed: August 31, 2006
    Publication date: August 13, 2009
    Applicant: OHIO UNIVERSITY
    Inventor: Xiaozhuo Chen
  • POLYCYCLIC COMPOUNDS FOR USE IN TREATING OCULAR NEURODEGENERATIVE DISEASES
    Publication number: 20090143457
    Abstract: Described herein are various compounds for treatment of ocular neurodegenerative diseases, including but not limited to glaucoma and diabetic retinopathy. The compounds described herein can act to attenuate and/or block calcium release from external neuronal environments as well as intracellular stores.
    Type: Application
    Filed: December 4, 2008
    Publication date: June 4, 2009
    Applicant: NORTHEASTERN OHIO UNIVERSITIES COLLEGE OF MEDICINE
    Inventors: Cornelis J. Van der Schyf, Randolph B. Schiffer, Paula Grammas, Masao Roy Wilson, Werner J. Geldenhuys, Lois-May Bezuidenhout
  • ELECTRO-CATALYSTS FOR THE OXIDATION OF AMMONIA IN ALKALINE MEDIA
    Publication number: 20090127094
    Abstract: An electro-catalyst for the oxidation of ammonia in alkaline media; the electrocatalyst being a noble metal co-deposited on a support with one or more other metals that are active to ammonia oxidation. In some embodiments, the support is platinum, gold, tantalum, or iridium. In some embodiments, the support has a layer of Raney metal deposited thereon prior to the deposition of the catalyst. Also provided are electrodes having the electro-catalyst deposited thereon, ammonia electrolytic cells, ammonia fuel cells, ammonia sensors, and a method for removing ammonia contaminants from a contaminated effluent.
    Type: Application
    Filed: December 16, 2008
    Publication date: May 21, 2009
    Applicant: OHIO UNIVERSITY
    Inventor: Gerardine G. Botte
  • NANOPARTICLE ASSEMBLIES WITH MOLECULAR SPRINGS
    Publication number: 20090117002
    Abstract: A nanoscale sensing device from different types of nanoparticles (NPs) and nanowires (NWs) connected by molecular springs. The distance between the nanoscale colloids reversibly changes depending on conditions or analyte concentration and can be evaluated by fluorescence measurements.
    Type: Application
    Filed: May 30, 2006
    Publication date: May 7, 2009
    Applicant: Ohio University
    Inventors: Nicholas Kotov, Joebeom Lee, Alexander Govorov
  • Storm water runoff treatment system
    Patent number: 7527731
    Abstract: A hydrodynamic device for removing sediment and other materials from storm water runoff is provided. An exemplary embodiment of this device includes: a first substantially cylindrical chamber a second substantially cylindrical chamber concentrically disposed within the upper portion of the first chamber, a first baffle concentrically disposed within the second chamber, and a second baffle disposed within the lower portion of the first chamber. A water inlet is attached to or formed integrally with the second chamber; a water outlet is attached to or formed integrally with the first chamber; and an optional bypass outlet is attached to or formed integrally with the first chamber.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: May 5, 2009
    Assignee: Ohio University
    Inventors: Yuming Su, Gayle F Mitchell
  • Electrolytic Cells and Methods for the Production of Ammonia and Hydrogen
    Publication number: 20090095636
    Abstract: A method using an electrolytic cell to electrolyze urea to produce at least one of H2 and NH3 is described. An electrolytic cell having a cathode with a first conducting component, an anode with a second conducting component, urea and an alkaline electrolyte composition in electrical communication with the anode and the cathode is used to electrolyze urea. The alkaline electrolyte composition has a hydroxide concentration of at least 0.01 M.
    Type: Application
    Filed: October 14, 2008
    Publication date: April 16, 2009
    Applicant: Ohio University
    Inventor: Gerardine G. Botte
  • FUEL CELL UTILIZING AMMONIA, ETHANOL OR COMBINATIONS THEREOF
    Publication number: 20090081500
    Abstract: An fuel cell utilizing ammonia, ethanol, or combinations thereof, comprising: a housing; an anode disposed within the housing, the anode comprising at least one layered electrocatalyst, wherein the at least one layered electrocatalyst comprises at least one active metal layer and at least one second metal layer deposited on a carbon support; a basic electrolyte disposed adjacent the anode; a cathode disposed adjacent the basic electrolyte, wherein the cathode comprises a conductor; and an oxidant in communication with the cathode for connecting with a power conditioner, a load, or combinations thereof, wherein the power conditioner, the load, or combinations thereof is in communication with the anode, which oxidizes the ammonia, ethanol, or combinations thereof, causing the fuel cell to form an electric current.
    Type: Application
    Filed: May 4, 2008
    Publication date: March 26, 2009
    Applicant: Ohio University
    Inventor: Gerardine G. Botte
  • Method for Sequencing Peptides and Proteins Using Metastable-Activated Dissociation Mass Spectrometry
    Publication number: 20090050798
    Abstract: Methods for fragmentation of large molecular ions, including proteins, nucleic acids, dendromers, and nanomaterials, compatible with several mass spectrometric techniques. The methods involve providing a gas-phase ion and allowing the gas phase ion to undergo collisions with metastable states of noble gases or nitrogen gas.
    Type: Application
    Filed: June 5, 2006
    Publication date: February 26, 2009
    Applicant: Ohio University
    Inventors: Glen P. Jackson, Olivier Collin
  • ELECTROCHEMICAL METHOD FOR PROVIDING HYDROGEN USING AMMONIA AND ETHANOL
    Publication number: 20090050489
    Abstract: An electrochemical method for providing hydrogen using ammonia, ethanol, or combinations thereof, comprising: forming an anode comprising a layered electrocatalyst, the layered electrocatalyst comprising at least one active metal layer deposited on a carbon support; providing a cathode comprising a conductor; disposing a basic electrolyte between the anode and the cathode; disposing a fuel within the basic electrolyte; and applying a current to the anode causing the oxidation of the fuel, forming hydrogen at the cathode.
    Type: Application
    Filed: May 4, 2008
    Publication date: February 26, 2009
    Applicant: Ohio University
    Inventor: Gerardine G. Botte
  • PHOSPHAPLATINS AND THEIR USE IN THE TREATMENT OF CANCERS RESISTANT TO CISPLATIN AND CARBOPLATIN
    Publication number: 20090042838
    Abstract: The present invention provides phosphaplatins, stable isolated monomeric phosphate complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes-unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents-do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art.
    Type: Application
    Filed: August 6, 2008
    Publication date: February 12, 2009
    Applicant: Ohio University
    Inventor: Rathindra N. Bose
  • Direct pyrolysis route to GaN quantum dots
    Patent number: 7488384
    Abstract: Colloidal nanocrystals or “quantum dots” of GaN are directly produced by heating amidogallium dimer, i.e., (Ga2[N(CH3)2]6), in the presence of a functional amine. The GaN quantum dots obtained, which comprise isolated particles 2-3 nm in diameter with a relative broad size distribution (e.g., 20% standard deviation) exhibit strong exciton confinement.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: February 10, 2009
    Assignee: Ohio University
    Inventors: Paul Gregory Van Patten, Guiquan Pan
  • Electro-catalysts for the oxidation of ammonia in alkaline media
    Patent number: 7485211
    Abstract: An electro-catalyst for the oxidation of ammonia in alkaline media; the electrocatalyst being a noble metal co-deposited on a support with one or more other metals that are active to ammonia oxidation. In some embodiments, the support is platinum, gold, tantalum, or iridium. In some embodiments, the support has a layer of Raney metal deposited thereon prior to the deposition of the catalyst. Also provided are electrodes having the electro-catalyst deposited thereon, ammonia electrolytic cells, ammonia fuel cells, ammonia sensors, and a method for removing ammonia contaminants from a contaminated effluent.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: February 3, 2009
    Assignee: Ohio University
    Inventors: Gerardine G. Botte, Frederic Vitse, Matt Cooper
  • SYNTHETIC GENES FOR PLANT GUMS AND OTHER HYDROXYPROLINE-RICH GLYCOPROTEINS
    Publication number: 20090030185
    Abstract: A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabino-galactan proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.
    Type: Application
    Filed: May 15, 2008
    Publication date: January 29, 2009
    Applicant: OHIO UNIVERSITY
    Inventor: Marcia J. Kieliszewski
  • ELECTROCHEMICAL CELL FOR OXIDATION OF AMMONIA AND ETHANOL
    Publication number: 20080318097
    Abstract: An electrochemical cell for causing a reaction that produces hydrogen, the electrochemical cell comprising: a first electrode comprising: at least one layered electrocatalyst formed of at least one active metal layer deposited on a carbon support, wherein the at least one active metal layer is active to a target species; a second electrode comprising a conductor; a basic electrolyte; ammonia, ethanol, or combinations thereof; and electrical current in communication with the first electrode.
    Type: Application
    Filed: May 4, 2008
    Publication date: December 25, 2008
    Applicant: Ohio University
    Inventor: Gerardine G. Botte
  • LAYERED ELECTROCATALYST FOR OXIDATION OF AMMONIA AND ETHANOL
    Publication number: 20080314755
    Abstract: A layered electrocatalyst for oxidizing ammonia, ethanol, or combinations thereof, comprising: a carbon support integrated with a conductive metal; at least one first metal plating layer at least partially deposited on the carbon support, wherein the at least one first metal plating layer is active to OH adsorption and inactive to a target species, and wherein the at least one first metal plating layer has a thickness ranging from 10 nanometers to 10 microns; and at least one second metal plating layer at least partially deposited on the at least one first metal plating layer, wherein the at least one second metal plating layer is active to the target species, and wherein the at least one second metal plating layer has a thickness ranging from 10 nanometers to 10 microns, forming a layered electrocatalyst.
    Type: Application
    Filed: May 4, 2008
    Publication date: December 25, 2008
    Applicant: Ohio University
    Inventor: Gerardine G. Botte
  • Efficient Method To Synthesize Benzyl Group-Protected Alpha-Pentagalloylglucose (Alpha-Pgg) And Its Analogues
    Publication number: 20080319185
    Abstract: A method to synthesize benzyl group protected alpha-pentagalloylglucose (?-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an acylating catalyst in a donor solvent; adding ?-D-glucose or an analogue thereof to the mixture; reacting the mixture at room temperature for a time sufficient for reaction to occur; evaporating the solvent; taking up the residue in an appropriate solvent; filtering the residue and solvent mixture; and evaporating off the solvent.
    Type: Application
    Filed: January 24, 2005
    Publication date: December 25, 2008
    Applicant: Ohio University
    Inventors: Klaus B. Himmeldirk, Xiaozhuo Chen
  • Cross-Linkable Glycoproteins and Methods of Making the Same
    Publication number: 20080262198
    Abstract: Non-naturally occurring peptides/polypeptides/proteins comprising the crosslinking motif, Tyr-X-Tyr, wherein X is any amino acid, and methods of preparing the same.
    Type: Application
    Filed: April 19, 2005
    Publication date: October 23, 2008
    Applicant: OHIO UNIVERSITY
    Inventors: Marcia J. Kieliszewski, Michael Held, Li Tan