Patents Assigned to Ohio University
  • CARBON FIBER-ELECTROCATALYSTS FOR THE OXIDATION OF AMMONIA AND ETHANOL IN ALKALINE MEDIA AND THEIR APPLICATION TO HYDROGEN PRODUCTION, FUEL CELLS, AND PURIFICATION PROCESSES
    Publication number: 20100252422
    Abstract: Electrocatalysts useful for the oxidation of ammonia and ethanol in alkaline media. The electrocatalysts include a carbon support, a first plating layer having a strong affinity for OH, and a second plating layer having a strong affinity for oxidation of ammonia or ethanol. The carbon support may be selected from such materials as carbon fibers, carbon tubes, carbon microtubes, and carbon microspheres. The first plating layer is selected from rhodium, ruthenium, nickel and palladium and combinations thereof. The second plating layer is selected from platinum, indium, and combinations thereof. Also provided are electrolytic cells for the production of hydrogen including one or more electrocatalysts described herein, a basic electrolyte, and ammonia or ethanol. Also provided are ammonia fuel cells and ethanol fuel cells utilizing the electrocatalysts described herein.
    Type: Application
    Filed: October 16, 2006
    Publication date: October 7, 2010
    Applicant: OHIO UNIVERSITY
    Inventor: Gerardine G. Botte
  • Flow-Controlling Header
    Publication number: 20100248330
    Abstract: An apparatus and method for holding a membrane, screen or other flexible planar body in tension, while providing a conduit for water or other liquid to flow to the membrane being held. The membrane extends from inside a manifold body that carries the liquid, and the manifold body supports the membrane at one edge while the membrane is pulled in tension. Liquid pressure builds up inside the manifold body, preferably by entering a pressure chamber at the top of the manifold body. At a feeding pressure in the pressure chamber the liquid is distributed to the membrane for microbe growth. The liquid can be elevated to a higher, microbe-harvesting pressure by increasing the pressure in the pressure chamber, thereby deflecting a shim separating the pressure chamber from the membrane. The change in pressure is carried out by manually or automatically opening and closing a conventional water valve.
    Type: Application
    Filed: May 19, 2008
    Publication date: September 30, 2010
    Applicant: OHIO UNIVERSITY
    Inventors: David J. Bayless, Morgan LeFay Vis-Chiasson, Gregory G. Kremer, Ben Stuart
  • Electro-catalysts for the oxidation of ammonia in alkaline media
    Patent number: 7803264
    Abstract: An electro-catalyst for the oxidation of ammonia in alkaline media; the electrocatalyst being a noble metal co-deposited on a support with one or more other metals that are active to ammonia oxidation. In some embodiments, the support is platinum, gold, tantalum, or iridium. In some embodiments, the support has a layer of Raney metal deposited thereon prior to the deposition of the catalyst. Also provided are electrodes having the electro-catalyst deposited thereon, ammonia electrolytic cells, ammonia fuel cells, ammonia sensors, and a method for removing ammonia contaminants from a contaminated effluent.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: September 28, 2010
    Assignee: Ohio University
    Inventor: Gerardine G. Botte
  • PHOSPHAPLATINS AND THEIR USE IN THE TREATMENT OF CANCERS RESISTANT TO CISPLATIN AND CARBOPLATIN
    Publication number: 20100233293
    Abstract: The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 16, 2010
    Applicant: OHIO UNIVERSITY
    Inventor: Rathindra N. Bose
  • Portable loeb-eiber mass spectrometer
    Patent number: 7772546
    Abstract: A portable mass spectrometer including an ion source, an ion detector, and a Loeb-Eiber style high-pass ion separator comprising an array of wires. The array can have first and second sets of wires where the distance between adjacent wires is less than the diameter of each of the wires. An electrical generator can be configured to create an electrical current and supply the electrical current to the first set of wires while the second set of wires remains grounded.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: August 10, 2010
    Assignee: Ohio University
    Inventor: Glen P. Jackson
  • Efficient method to synthesize benzyl group-protected alpha-pentagalloylglucose (?-PGG) and its analogues
    Patent number: 7772381
    Abstract: A method to synthesize benzyl group protected alpha-pentagalloylglucose (?-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an acylating catalyst in a donor solvent; adding ?-D-glucose or an analogue thereof to the mixture; reacting the mixture at room temperature for a time sufficient for reaction to occur; evaporating the solvent; taking up the residue in an appropriate solvent; filtering the residue and solvent mixture; and evaporating off the solvent.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: August 10, 2010
    Assignee: Ohio University
    Inventors: Klaus B. Himmeldirk, Xiaozhou Chen
  • Apparatus and method associated with cable robot system
    Patent number: 7753642
    Abstract: An apparatus associated with a cable robot system is provided. In one embodiment, the apparatus includes: an end-effector platform adapted to be positioned and maneuvered within a three-dimensional (3D) workspace, three vertical support members adapted to be positioned outside the 3D workspace, and three adjustable cables adapted to be routed from each vertical support member and releasably secured to the end-effector platform to apply upward and downward tension to the end-effector platform. The adjustable cables are adapted to be adjustably extended and retracted in a coordinated fashion to maneuver the end-effector platform such that an adjustable portion of each adjustable cable spans from the corresponding vertical support member to the end-effector platform. At least two of the adjustable portions associated with each vertical support member are generally in parallel relation to each other.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: July 13, 2010
    Assignee: Ohio University
    Inventors: Paul M. Bosscher, Robert L. Williams, II
  • Phosphaplatins and their use in the treatment of cancers resistant to cisplatin and carboplatin
    Patent number: 7700649
    Abstract: The present invention provides phosphaplatins, stable isolated monomeric phosphate complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: April 20, 2010
    Assignee: Ohio University
    Inventor: Rathindra N. Bose
  • Cognitive and Linguistic Assessment Using Eye Tracking
    Publication number: 20100092929
    Abstract: Methods for assessing cognitive and linguistic abilities by tracking and recording the eye movements of a patient in response to predetermined verbal and visual stimuli. The methods incorporate conventional eye-tracking technology to acquire eye-fixation location and duration measures for testing linguistic comprehension, working memory, attention allocation, and the effect of semantic associative priming. Visual stimuli presented in the methods are carefully designed to reduce visually distracting features. Verbal stimuli are carefully designed to control for numerous linguistic features.
    Type: Application
    Filed: October 14, 2009
    Publication date: April 15, 2010
    Applicant: Ohio University
    Inventors: Brooke Hallowell, Hans Kruse
  • Methods and compositions for treating hyperglycemic, hyperlipidemic, or hyperinsulinemic disorders
    Patent number: 7687472
    Abstract: Methods of treating hyperglycemic, hyperlipidemic, and hyperinsulinemic disorders are provided. Compositions for treating such disorders are also provided. The compositions can include hexose and pentose variants having acid moieties and a substituent Y linked to the six position of a hexose or the five position of the pentose.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: March 30, 2010
    Assignee: Ohio University
    Inventors: Xiaozhuo Chen, Klaus Himmeldirk, Yulin Ren
  • PORTABLE LOEB-EIBER MASS SPECTROMETER
    Publication number: 20100072358
    Abstract: A portable mass spectrometer including an ion source, an ion detector, and a Loeb-Eiber style high-pass ion separator comprising an array of wires. The array can have first and second sets of wires where the distance between adjacent wires is less than the diameter of each of the wires. An electrical generator can be configured to create an electrical current and supply the electrical current to the first set of wires while the second set of wires remains grounded.
    Type: Application
    Filed: September 23, 2008
    Publication date: March 25, 2010
    Applicant: OHIO UNIVERSITY
    Inventor: Glen P. Jackson
  • MICRO-CHANNEL TUBES AND APPARATUS AND METHOD FOR FORMING MICRO-CHANNEL TUBES
    Publication number: 20100064756
    Abstract: An apparatus and method are provided for extruding a micro-channel tube (402) from a non-aluminum metal or alloy such as copper. The micro-channel tube is formed by simultaneously extruding two rectangular shaped billets (404; 406) to form a top portion of the micro-channel tube and a bottom portion of the micro-channel tube in parallel. The top and bottom portions are then joined during the extrusion process (e.g., within a die assembly) to form the micro-channel tube (402).
    Type: Application
    Filed: December 11, 2007
    Publication date: March 18, 2010
    Applicant: OHIO UNIVERSITY
    Inventor: Frank F. Kraft
  • METHOD AND APPARATUS OF LIQUID SAMPLE-DESORPTION ELECTROSPRAY IONIZATION-MASS SPECROMETRY (LS-DESI-MS)
    Publication number: 20100059674
    Abstract: An apparatus and method for direct analysis of continuous-flow liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) including a sample stage that is adapted to receive a liquid sample and a nebulizing ionizer that is configured to generate a charged, nebulized solvent and thereby desorb at least a portion of the liquid sample from the sample stage.
    Type: Application
    Filed: September 5, 2008
    Publication date: March 11, 2010
    Applicant: Ohio University
    Inventors: Hao Chen, Zhixin Miao
  • SYNTHESIS OF METHYL NONACTATE DERIVATIVES
    Publication number: 20100056779
    Abstract: Methyl nonactate is converted into a variety of different triazoloamide antibacterial agents by a reaction scheme involving (1) inversion of the secondary alcohol of the methyl nonactate to produce the corresponding azidoester, (2) converting the azido ester to the corresponding azidoamide, and (3) converting the azido group of the azidoamide to a triazole to produce the corresponding triazoloamide.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 4, 2010
    Applicant: OHIO UNIVERSITY
    Inventors: Stephen C. Bergmeier, Nigel D. Priestley
  • METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF BONE LOSS
    Publication number: 20100056483
    Abstract: Disclosed herein are methods and compositions for the treatment and prevention of bone loss. The methods comprise providing a therapeutically effective amount of at least one chelating agent to a subject. The methods further comprise providing a therapeutically effective amount of estrogen or at least one estrogen analogue to a subject. Compositions disclosed herein for the treatment and prevention of bone loss comprise a chelator and estrogen or at least one estrogen analogue. The compositions further comprise at least one of a bisphosphonate, a selective estrogen receptor modulator, or a hormone.
    Type: Application
    Filed: April 24, 2009
    Publication date: March 4, 2010
    Applicant: OHIO UNIVERSITY
    Inventors: Yang V. Li, Caleb O. Molokwu
  • DEVICE IMPROVING THE DETECTION OF A LIGAND
    Publication number: 20100047920
    Abstract: A device and method is disclosed for improving the detection of a ligand by a receptor by concentrating microbes by removing particulates from fluid-borne samples and/or causing selective aggregation of concentrated microbes. The device may be configured as a multipath valve capable purifying/concentrating a sample in one orientation and delivering the concentrated sample in another orientation. In one embodiment, the device includes a body that defines a plurality of chambers and pathways and supports a pathogen capture unit that houses a receptor that exhibits specificity for a ligand. In another embodiment, the capture unit houses a plurality of antibody coated generally spherical particles capable of binding to a ligand.
    Type: Application
    Filed: August 20, 2008
    Publication date: February 25, 2010
    Applicant: NORTHEASTERN OHIO UNIVERSITIES COLLEGE OF MEDICINE
    Inventor: Gary D. Niehaus
  • ELECTROCHEMICAL TECHNIQUE TO MEASURE CONCENTRATION OF MULTIVALENT CATIONS SIMULTANEOUSLY
    Publication number: 20100032320
    Abstract: Methods and systems for simultaneously measuring concentration of two or more different cations in solution. The methods include the steps of applying a steady state polarization technique to a solution comprising two or more different cations; measuring the limiting currents of the solution; and correlating the limiting currents with the concentration of the different cations. The system includes a working electrode; a potentiostat; a counter electrode; a reference electrode; a solution comprising different cations to be analyzed; and a model for correlating the limiting currents with the concentration of the pair cations. The working electrode may be any electrode compatible with the media, including noble metals, carbon, or combinations thereof. In some embodiments, the working electrode is a rotating disk electrode (RDE).
    Type: Application
    Filed: May 8, 2007
    Publication date: February 11, 2010
    Applicant: OHIO UNIVERSITY
    Inventors: Gerardine G. Botte, Xin Jin
  • DIAGNOSIS OF HYPERINSULINEMIA AND TYPE II DIABETES AND PROTECTION AGAINST SAME BASED ON PROTEINS DIFFERENTIALLY EXPRESSED IN SERUM
    Publication number: 20100028326
    Abstract: Mouse proteins differentially expressed in serum, in comparisons of normal vs. hyperinsulinemic, hyperinsulinemic vs. type 2 diabetic, and normal vs. type 2 diabetic white adipose tissue have been identified, as have corresponding human proteins. The human molecules, or antagonists thereof, may be used for protection against hyperinsulinemia or type 2 diabetes, or their sequalae.
    Type: Application
    Filed: December 7, 2005
    Publication date: February 4, 2010
    Applicant: Ohio University
    Inventors: John J. Kopchick, Shigeru Okada, Sudha Sankaran
  • METHODS OF PRODUCING PEPTIDES IN PLANTS AND PEPTIDES PRODUCED THEREBY
    Publication number: 20100028993
    Abstract: Methods of increasing the yield in plant expression of recombinant proteins comprising engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion are present. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are also present.
    Type: Application
    Filed: May 16, 2008
    Publication date: February 4, 2010
    Applicant: OHIO UNIVERSITY
    Inventors: Marcia J. Kieliszewski, Jianfeng Xu, Gary D. Meyer
  • GLYCOPROTEINS PRODUCED IN PLANTS AND METHODS OF THEIR USE
    Publication number: 20100029548
    Abstract: Methods of increasing the yield in plant expression of recombinant proteins comprising: engineering glycosylation sites into cloned genes or cDNAs for proteins using codons that drive post-translational modifications in plants; and engineering the cloned genes or cDNAs to contain a plant secretory signal sequence that targets the gene products (protein) for secretion. The methods result in increased recombinant glycosylated protein yields. Proteins produced according to these methods are disclosed.
    Type: Application
    Filed: May 8, 2008
    Publication date: February 4, 2010
    Applicant: Ohio University
    Inventors: Marcia J. Kieliszewski, Jianfeng Xu, John Kopchick, Shigeru Okada, Gary D. Meyer