Patents Assigned to Okayama University
  • Method for assessment of potential for development of dravet syndrome and use thereof
    Patent number: 8916743
    Abstract: Provided is a method of assessing a potential for development of Dravet syndrome with high accuracy, and use thereof. The method according to the present invention of assessing a potential for development of Dravet syndrome includes, with use of a sample taken from a subject, detecting whether or not a mutation is on ?-subunit type 1 of voltage-gated sodium ion channel NaV1.1, and detecting whether or not a mutation is on ?-subunit type 1 of voltage-gated calcium ion channel CaV2.1.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: December 23, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Iori Ohmori, Mamoru Ouchida
  • Negative Electrode Active Material and Use of Same
    Publication number: 20140361226
    Abstract: This invention relates to an anode active material comprising at least one iron oxide selected from the group consisting of amorphous iron oxides, ferrihydrite, and lepidocrocite. The invention also relates to a lithium ion secondary battery anode material comprising the anode active material as a constituent component, a lithium ion secondary battery anode comprising the lithium ion secondary battery anode material, and a lithium ion secondary battery comprising the lithium ion secondary battery anode.
    Type: Application
    Filed: December 27, 2012
    Publication date: December 11, 2014
    Applicants: National University Corporation Okayama University, Kyoto University, Tokyo Institute of Technology
    Inventors: Jun Takada, Hideki Hashimoto, Tatsuo Fujii, Makoto Nakanishi, Ryoji Kanno, Genki Kobayashi, Mikio Takano
  • Protein production method, fusion protein, and antiserum
    Patent number: 8865428
    Abstract: Disclosed are a highly efficient method for production of heterologous proteins performed by utilizing microorganisms, as well as fusion proteins, and an antiserum. The method includes a method for production of a protein (A) in the form of a fusion protein, comprising the steps of (a) preparing a DNA which codes for a fusion protein comprising the peptide chain forming the protein (A) and the C-terminal peptide or its fragment (B) of the Cry proteins produced by Bacillus thuringiensis, and (b) introducing the DNA into a host bacterium to transform the same, and (c) allowing the fusion protein to be expressed in the transformed host bacterium, as well as a method for production of the protein (A) itself comprising a further step of removing the peptide chain (B) from the fusion protein obtained.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: October 21, 2014
    Assignees: National University Corporation Okayama University, Japan Lamb Co., Ltd.
    Inventors: Hiroshi Sakai, Toru Hayakawa
  • DNA fragment and use thereof
    Patent number: 8865669
    Abstract: The invention relates to a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1, or a nucleotide sequence the same or substantially the same as a partial nucleotide sequence thereof containing at least one HRE consensus sequence, which transiently has a transcription promoting activity in a vascular endothelial cell-specific manner in a hypoxic state, or a vector containing a promoter containing the DNA, and the like. The prophylaxis and/or treatment, as well as diagnosis, of acute ischemic diseases are enabled by connecting a prophylactic and/or therapeutic gene or a reporter gene to the downstream of the vector and administering same to mammals.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: October 21, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Satoshi Hirohata, Yoshifumi Ninomiya, Shozo Kusachi, Faruk Hatipoglu Omer
  • SELF-ASSEMBLING PEPTIDE AND PEPTIDE GEL WITH HIGH STRENGTH
    Publication number: 20140286888
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3 db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Application
    Filed: March 26, 2014
    Publication date: September 25, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, MENICON CO., LTD.
    Inventors: Yusuke NAGAI, Hidenori Yokoi, Koji Uesugi, Keiji Naruse
  • Organic-inorganic composite material and process for producing same
    Patent number: 8841105
    Abstract: Disclosed is an organic-inorganic composite material obtained by chemically modifying a microorganism-derived ceramic material with an organic group, and a process for producing the organic-inorganic composite material. The process is characterized by reacting a microorganism-derived ceramic material with at least one compound selected from the group consisting of silane coupling agents represented by formula (1), silane coupling agents represented by formula (2), and titanate coupling agents represented by formula (3). The organic-inorganic complex can be used in applications for immobilized catalysts and immobilized enzyme catalysts.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: September 23, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Takashi Sakai, Tadashi Ema, Jun Takada, Tatsuo Fujii, Makoto Nakanishi, Hideki Hashimoto
  • EXTERMINATION TECHNIQUES UTILIZING TERMITE EGG VOLATILE CALLING PHEROMONE AND QUEEN PHEROMONE
    Publication number: 20140259881
    Abstract: The present invention provides a termite attractant comprising 1-butanol, 2-butanol, or esters, ketones, ethers, carboxylic acids thereof, or salts thereof; a mimic termite-egg comprising the attractant; and a method for exterminating and controlling termites using the attractant or mimic termite-egg.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 18, 2014
    Applicant: National University Corporation Okayama University
    Inventors: Kenji MATSUURA, Chihiro HIMURO, Tomoyuki YOKOI
  • NOVEL ANTI-HCV AGENT
    Publication number: 20140242030
    Abstract: Provided is a novel anti-HCV agent including as an active ingredient a peroxide derivative represented by the general formula (I). In the general formula (I), C represents an alicyclic hydrocarbon ring group which may be substituted, n represents an integer of from 1 to 6, and R represents a hydrogen atom or a hydroxyalkyl group. The peroxide derivative exhibits potent anti-HCV activity by remarkably suppressing HCV-RNA replication.
    Type: Application
    Filed: October 2, 2012
    Publication date: August 28, 2014
    Applicant: National University Corporation Okayama University
    Inventors: Nobuyuki Kato, Masanori Ikeda, Yusuke Wataya, Hye-Sook Kim, Hiroyuki Doi
  • pH or concentration measuring device and pH or concentration measuring method
    Patent number: 8815078
    Abstract: Disclosed are a pH or concentration measuring device and a pH or concentration measuring method which enable measurement in the shortest possible time even in an object to be measured having low buffer capacity.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: August 26, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Akira Yamada, Michihiro Nakamura, Satoshi Mohri, Keiji Naruse
  • METALLOPORPHYRIN COMPLEX, MANUFACTURING PROCESS THEREFOR AND CARBON DIOXIDE FIXATION CATALYST THEREFROM, AS WELL AS PROCESS FOR MANUFACTURING CYCLIC CARBONATE
    Publication number: 20140228561
    Abstract: There is provided a metalloporphyrin complex represented by general formula (1): wherein M is a metal; A1 to A4 are independently of each other a substituent represented by general formula (2): -D-E+X???(2) wherein D is a divalent organic group having 1 to 20 carbon atoms; E+ is a quaternary ammonium group or quaternary phosphonium group having 3 to 60 carbon atoms; and X is a halogen atom. There is thus provided a metalloporphyrin complex which, when used as a carbon dioxide fixation catalyst, exhibits high catalytic activity, has a small environmental burden and can be easily synthesized.
    Type: Application
    Filed: September 19, 2012
    Publication date: August 14, 2014
    Applicant: National University Corporation Okayama University
    Inventors: Tadashi Ema, Takashi Sakai, Yuki Miyazaki
  • Magnetic ceramic and process for production thereof
    Patent number: 8795546
    Abstract: This invention relates to a magnetic ceramic material comprising, as main components, (a) at least one magnetic iron oxide selected from the group consisting of Fe3O4 and ?-Fe2O3, and (b) an amorphous phase, and a process for producing a magnetic ceramic material, comprising (1) heating a microorganism-derived iron oxide ceramic material containing an iron atom, and (2) reducing the iron oxide ceramic material obtained in Step (1) by heating in the presence of hydrogen gas.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: August 5, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Jun Takada, Hideki Hashimoto, Tatsuo Fujii, Makoto Nakanishi
  • Compound, novel ligand, novel transition metal complex, and catalyst including novel transition metal complex
    Patent number: 8779133
    Abstract: Provided are novel ligands for transition metal complexes which exhibit high coordination power with respect to metals by being free of substituents at the positions ortho to phosphorus or arsenic and which have electron-withdrawing power comparable to the highest level known in conventional ligands. One ligand includes a compound represented by General Formula (1): R1R2R3A or General Formula (2): R1R2A-Y-AR3R4 and having a total of 15 to 110 carbon atoms. In the formulae, A is phosphorus or arsenic; R1, R2, R3 and R4 are each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C2-20, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: July 15, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Toshinobu Korenaga, Takashi Sakai, Aram Ko
  • DYNAMO
    Publication number: 20140167418
    Abstract: The dynamo of the present invention is provided in the flow field of a fluid, and has: a columnar oscillating body, one end of the oscillating body being supported in the flow field of the fluid by a shaft that is parallel to the flow direction of the fluid, and the oscillating body being moved reciprocally by self-excited oscillation about the shaft; and an electricity generation unit for generating electrical energy in response to the reciprocal oscillation of the oscillating body.
    Type: Application
    Filed: June 20, 2012
    Publication date: June 19, 2014
    Applicant: National University Corporation Okayama University
    Inventors: Shinji Hiejima, Kenichi Hayashi
  • Self-assembling peptide and peptide gel with high strength
    Patent number: 8729032
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: May 20, 2014
    Assignees: Menicon Co., Ltd., National University Corporation Okayama University
    Inventors: Yusuke Nagai, Hidenori Yokoi, Koji Uesugi, Keiji Naruse
  • IRON OXIDE RED PIGMENT
    Publication number: 20140134216
    Abstract: Disclosed are a hematite composite formed by aggregation of fine particles, each of the fine particles comprising a crystalline hematite particle and phosphorus-containing amorphous silicate covering the surface of the crystalline hematite particle; a pigment comprising the hematite composite; a cosmetic composition comprising a cosmetic pigment containing the hematite composite and a cosmetic base; and a method for producing the hematite composite, comprising the step of heat-treating an amorphous and/or microcrystalline iron oxide containing silicon and phosphorus.
    Type: Application
    Filed: November 14, 2012
    Publication date: May 15, 2014
    Applicant: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
    Inventor: National University Corporation Okayama University
  • Metal complex compound and process for producing amides utilizing the metal complex compound
    Patent number: 8722912
    Abstract: A catalyst contains a metal complex compound represented by the following general formula (I). In the formula (I), M is a metal ion such as ruthenium, L1 is a cyclic or acyclic, neutral or minus 1-valent unsaturated hydrocarbon group of 1 to 30 carbon atoms which may have a substituent, L2 and L3 are each independently chlorine or the like, and L4 is a compound bonded to M through phosphorus or arsenic and represented by the following general formula (IIa) or (IIb). In the formulas (IIa) and (IIb), E is phosphorus or arsenic, Y1 is oxygen or sulfur, Y2, Y3 and Y4 are each independently a hydrogen atom, an aryl group or the like, and H is a hydrogen atom.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: May 13, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Toshiyuki Oshiki, Makoto Muranaka
  • Measuring device and measuring method that use pulsed electromagnetic wave
    Patent number: 8710440
    Abstract: Provided are a measuring device and a measuring method that use terahertz light, by which a substance to be detected can be detected with high sensitivity and high accuracy. A measuring device using a pulsed electromagnetic wave is provided with a substance detection plate, a means for generating the pulsed electromagnetic wave having amplitude intensity dependent on the amount of a substance to be detected at an irradiation position by irradiating the substance detection plate with a pulsed laser beam, and a detection means for detecting the amplitude intensity of the pulsed electromagnetic wave, and measures the change of the state of a solution containing the substance to be detected on the basis of the amplitude intensity.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: April 29, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Toshihiko Kiwa, Keiji Tsukada
  • CELL CULTURING VESSEL
    Publication number: 20140113365
    Abstract: A cell culture vessel supplies cells close to the center of gel and deeper down to the bottom with sufficient nutrients for attaining an enhanced survival rate of the cultivated cells. The cell culturing vessel comprises a culture tray capable of holding a liquid culture medium and a cell mixture container fixed to inner walls of the culture tray for retaining the cell mixture. Once the culture tray is filled with the liquid culture medium, the cell mixture retained in the cell mixture container has its opposite outer parts exposed to the liquid culture medium.
    Type: Application
    Filed: April 26, 2012
    Publication date: April 24, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, MENICON CO., LTD.
    Inventors: Yusuke Nagai, Keiji Naruse, Ken Takahashi, Eijiro Tokuyama
  • Cell cultivation method and cell culture
    Patent number: 8697438
    Abstract: Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: April 15, 2014
    Assignees: National University Corporation Okayama University, 3-D Matrix, Ltd.
    Inventors: Naoya Kobayashi, Noriaki Tanaka
  • Vermin extermination using lysozyme, salt or biological fragment thereof, or lysozyme-related peptide as an egg recognition pheromone
    Patent number: 8691218
    Abstract: The present invention provides a mimetic egg comprising lysozyme, a salt or biological fragment thereof or a lysozyme-related peptide and an active ingredient in its base material mimicking an egg of a vermin; and a vermin exterminating method using the mimetic egg.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: April 8, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Kenji Matsuura, Takashi Tamura, Norimasa Kobayashi