Abstract: Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture.

Abstract: Provided are a pairing computation device, a pairing computation method, and a pairing computation program all of which enable fast pairing computation.

Abstract: Provided is an ion sensor with which the concentration of ions in a solution can be determined without any reference electrode. The ion sensor is equipped with: a first electrode plate; a second electrode plate which has been disposed opposite the first electrode plate and has one or multiple openings; an ion-sensitive film continuously formed so that the film is interposed between the first electrode plate and the second electrode plate, blocks up one side of each opening of the second electrode plate, and extends from the end of that side of the opening to the outer surface of the second electrode plate through the inner wall surface of the opening; and a sensor support which supports the second electrode plate so that when the ion concentration of a test solution to be examined is determined, the ion-sensitive film comes into contact with the test solution only in the portions thereof that have been formed in each opening and on the outer surface of the second electrode plate.

Abstract: The invention provides novel ligands for transition metal complexes which exhibit high coordination power with respect to metals by being free of substituents at the positions ortho to phosphorus or arsenic and which have electron-withdrawing power comparable to the highest level known in conventional ligands. A ligand of the invention includes a compound represented by General Formula (1): R1R2R3A or General Formula (2): R1R2A-Y-AR3R4 and having a total of 15 to 110 carbon atoms. In the formulae, A is phosphorus or arsenic; R1, R2, R3 and R4 are each independently a substituted pyridyl group having optionally different electron-withdrawing groups bonded to the positions meta to the atom A as well as hydrogen atoms bonded to the positions ortho to the atom A; and Y is a divalent group derived from a C2-20, optionally substituted and optionally heteroatom-containing, aliphatic, alicyclic or aromatic compound or from ferrocene.

Abstract: An object of the present invention is to provide a composition for local anesthesia to be added to a local anesthetic drug, the composition showing a sustained local anesthetic effect and having high safety. The object is achieved by a composition for local anesthesia including a drug antagonistic to a systemic action of adrenaline, i.e., an ?2 receptor agonist. The ?2 receptor agonist can be added to a local anesthetic agent together with adrenaline or a salt thereof to reduce the amount of adrenaline to be added as compared to that of adrenaline or a salt thereof alone. As a result, a sustained local anesthetic effect is obtained and local anesthesia can be performed with high safety.

Abstract: The present invention provides a mimetic egg comprising ?-glucosidase, a salt thereof, a biological fragment thereof or a ?-glucosidase-related peptide as an egg recognition pheromone in its base material mimicking an egg of a insect pests, particularly a termite, a method for exterminating and controlling insect pests, and a tool for a biological study using the same.

Abstract: From antibodies that can be used to immunostain atherosclerotic tissue sections, the present inventors selected antibodies applicable to in vivo imaging, and analyzed their specificities. The result showed that fluorescently labeled anti-oxidized LDL/?2GPI complex antibodies that are specific to a particular epitope were effective for imaging.

Abstract: Provided is a device which obtains information for verifying onset of dementia while suppressing individual differences between subjects. The device includes a stimulus provision unit 12 which provides a subject H with one of two alternatively selectable selection items as a stimulus including at least one of audio information and visual information a plurality of times, a measurement unit 13 which measures a response time from the provision of the stimulus to the reception of the responses from the subject H, an average time computation unit 14 which calculates an average value of the response times, and a data creation unit 17 which creates data in which the average value of the response times for the specified subject H is compared with the previously prepared average value of the response times.

Abstract: An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.

Abstract: It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c): (wherein R1, R2 and R6 are same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously).

Abstract: There is provided a filter for filtering gas or liquid, wherein a constituent material of the filter contains a protein that absorbs iron, radium, or heavy metal (except iron), the constituent material is an iron-containing fiber body 4, the iron-containing fiber body 4 is a fiber body including iron or a fiber body 41 on which iron is supported, and the protein is ferritin or hemosiderin and bound to iron of the iron-containing fiber body 4.

Abstract: A brain cooling apparatus includes a tube body 2 which can maintain an airway in the respiratory tract of a living body; a pharyngeal cuff 5 which is provided in the peripheral part of this tube body 2 and can store a cooled fluid; and an injection and discharge portion 6 which can inject and discharge a fluid into and from this pharyngeal cuff 5, in which the pharyngeal cuff 5 is flexible enough to inflate and deflate when a fluid is injected and discharged, and when a fluid is injected in a state where an airway in the respiratory tract of a living body is maintained by the tube body 2, the inflated pharyngeal cuff adheres closely to the pharyngeal part T of the living body.

Abstract: There is provided a pairing computation device provided with a CPU which computes pairing e(S,Q) with S?G1, Q?G2, ? being a given integer variable, and F being a rational function calculated using Miller's algorithm with respect to multi-pairing (MMA). An order r, a trace t of the Frobenius endomorphism ?p are specified preliminarily using the integer variable ? according to an embedding degree k. The CPU performs pairing computation by means of: an input unit which inputs the integer variable ?, the rational point S, and the rational point Q into respective predetermined registers; a computation unit which computes F; a computation unit which computes a value at a rational point Q(xQ, yQ) of a straight line passing through given rational points; a computation unit which computes f? ?,S(Q) using the aforementioned F and the value; and a computation unit which computes the pairing e(S,Q) using aforementioned f? ?,S(Q) as [F83]. [F83] e(S,Q)=f??,S(Q)(pk?1)/r.

Abstract: In a surface treating method of the present invention, a fluid suction passage 26 communicating with a fluid supply passage 25 via only a narrowed portion 27 is provided, so as to approximately concentrically surround the periphery of the fluid supply passage 25 having the narrowed portion 27 at one end thereof, and the sucking cavitation flow 5 is generated at the direct downstream of the narrowed portion 27, by sucking the processing fluid 8 into the fluid suction passage 26 using a suction pump 17, as well as a surface treating is performed on the treated surface 6a, by crushing the sucking cavitation flow 5 approximately perpendicular to the treated surface 6a.

Abstract: Disclosed are a high-strength, high-toughness hot-pressed steel plate member and a manufacturing method therefor. A specified hot-press process is performed on a steel plate member that, with respect to the chemical composition of the steel plate, includes: 0.15 to 0.4 wt % of C; 1.0 to 5.0 wt % of Mn or of a total of Mn and at least one of Cr, Mo, Cu, and Ni; 0.02 to 2.0 wt % of at least any one of Si and Al; and the remainder being Fe and unavoidable impurities, thus providing the physical properties of a martensite phase average grain diameter of 5 ?m or less and a tensile strength of 1200 MPa or higher.

Abstract: Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). ArnR3-nP?O (1) ArnR3-nP (2) In formulae (1) and (2), Ar represents an aryl group such as a phenyl group, a phenyl group having a substituent, a heteroaromatic ring group, and a heteroaromatic ring group having a substituent; R represents an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having a substituent; and n represents an integer of 0 to 3.

Abstract: The present inventors carried out immunization using renal/urinary calculus-derived calcified globules or carotid artery-derived arteriosclerotic plaques, and then obtained antibodies specific to calcified globules (NLO) via screening with NLO. The present inventors demonstrated that the antibodies reacted specifically to arteriosclerotic lesions (calcified lesions) and visualized arteriosclerotic plaques (in particular, calcified lesions) by using fluorescently labeled antibodies. Accordingly, the present inventors completed the present invention.

Abstract: A method of conducting an endoscopic observation of an inner wall of a gastrointestine by applying a diagnostic agent to the inner wall of the gastrointestine, the diagnostic agent being an acidic aqueous solution of pH 1 to 5 containing a colorant, and conducting the endoscopic observation of the inner wall. The acidic aqueous solution can contain at least one acid selected from a carboxylic acid, hydrochloric acid, sulfuric acid and phosphoric acid. By applying the diagnostic agent to the inner wall of the gastrointestine in the endoscopic observation, it is possible to clearly observe a lesion which is difficult to be determined. In particular, the method can be used for observing lesions having cancer cells in the stomach or the Barrett's esophagus.

Abstract: Disclosed is a compound represented by the general formula shown below, which can bind to a retinoid X receptor (RXR), which is one of nuclear receptors, and exhibit an agonistic or antagonistic action. [Wherein, R1 is selected from the group consisting of an alkyl group, an alkenyl group, an alkynyl group and an aryl group. R2 is selected from the group consisting of an alkoxy group, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. W is NR3 or CR3; and R3 is selected from a hydrogen, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. X1 and Y1 are selected from CH or N. X2 and Y2 are selected from CH, CR4 or N. R4 is selected from an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a halogen, a nitro group and an amino group. Z is selected from a carboxylic acid, a carboxylate ester or a hydroxamic acid, which is bound directly or via an alkyl group, an alkenyl group or an alkynyl group.

Abstract: Provided are a scalar multiplier and a scalar multiplication program for performing a scalar multiplication at a high speed. In computing a scalar multiplication [s]P of a rational point P of an additive group E(Fp) including rational points on an elliptic curve where a characteristic p, an order r, and a trace t of a Frobenius endomorphism at an embedding degree k=12 using an integer variable ? are given by: p(?)=36?4?36?3+24?2?6?+1, r(?)=36?4?36?3+18?2?6?+1=p(?)+1?t(?), t(?)=6?2+1, the scalar multiplication [s]P is computed as: [s]P=([A]??2+[B])P, using a Frobenius map ??2 given by: [p2]P=??2(P) assuming that a twist degree d is 6 and a positive integer e is 2 where k=d×e.