Abstract: The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

Abstract: A system and method for web-based checkout in an e-commerce system using a secret pin received via Short Message Service (SMS) and using an identifier are disclosed. The system and method include receiving a customer payment request and email address of a customer from a vendor, transmitting a pin to an SMS account of the customer, receiving the pin from the customer to confirm payment, authenticating the IP address and the pin and processing the payment. The system and method include receiving a payment request from a customer and a phone number of the customer, authenticating an IP address of the customer, looking up an account of the customer based on the received phone number, generating a link and token associated with the customer, transmitting the mailto link and token to the customer, receiving an email response from the customer, and processing the payment.

Abstract: An anti-submarining seat cushion for a vehicle includes a main body constructed of an anisotropic material. The anisotropic material includes a primary material including a primary stiffness and a plurality of inserts that are dispersed throughout the primary material. The plurality of inserts exert an axial compressive force in response to the main body of the anti-submarining seat cushion experiencing a submarining load, where the axial compressive force is exerted in a direction that opposes the submarining load to increase an overall stiffness of the main body in a direction that aligns with the submarining load.

Abstract: Disclosed are techniques for characterizing variants of interest and predicting assignments of individuals to communities based on obtained genetic information. To characterize a variant, DNA datasets of reference individuals are accessed and used to generate a cluster with additional individuals. Reference individuals carry a variant at a genetic locus and the additional individuals share IBD with reference individuals. Statistics of genealogical data of the cluster are generated. A result summarizing the characterization of the variant is generated based on the statistics. To determine if an individual belongs to a community, a subset of the individual's haplotypes are inputted into a community-specific model. The model is trained using the training samples that each include haplotypes of reference individuals and a label identifying whether the reference individual belongs to the community. Based on the output of the model, it is determined whether the individual is a member of the community.

Abstract: A system and method for locating a portable electronic device that is paired with a vehicle that uses a plurality of antennas located on an exterior of a body of the vehicle, within an interior cabin of the vehicle, or located on the exterior of the body and within the interior cabin of the vehicle to communicate with the portable electronic device, and displays a location of the portable electronic device within or near the vehicle based on the communication between the plurality of antennas and the portable electronic device on a graphic display interface of the vehicle.

Abstract: A semiconductor device may include a plurality of single-photon avalanche diodes. The single-photon avalanche diodes may be arranged in microcells. Each microcell may be a split microcell with first and second independent microcell segments. Each microcell segment in the split microcell may have a respective single-photon avalanche diode that is coupled to an output line. The single-photon avalanche diode of each microcell segment may also be coupled to a respective resistor that is used to quench avalanches in the single-photon avalanche diode. Splitting the microcell may reduce the recovery time of each microcell. The segments of the split microcell may be positioned close together, even if susceptible to optical crosstalk. Intra-microcell isolation structures may be formed between the microcell segments. Inter-microcell isolation structures may be formed around a perimeter of the split microcell. The intra-microcell and inter-microcell isolation structures may be different.

Abstract: This technology relates to rasterizing and compositing vector graphics in parallel on a data-parallel computing device. For example, vector data of the vector graphics, may be loaded into local memory accessible by the one or more parallel processors. The vector data may include one or more paths comprised of one or more path segments of the vector graphics. The one or more parallel processors may rasterize the one or more path segments into respective rasters and assign each of the rasters into groups based on pixel coordinates of the respective rasters. Each group may have an associated key and the rasters within each group represent a portion of the same vector graphic. The rasters may be placed onto subpixels according to their respective pixel coordinates and rendered onto a display by the one or more parallel processors.

Abstract: A machine comprising a frame supported on a movable carrier. A first actuator is adapted to actuate a boom coupled to the frame. A first sensor generates signals indicative of a spatial orientation of the boom. At least one second actuator actuates a drilling work device coupled to the boom. A second sensor generates signals indicative of a spatial orientation of the drilling work device. A controller receives signals indicative of the spatial orientation of the boom and the drilling work device and actuates at least one of the first actuator and the second actuator through predetermined sequential steps to automatically position the machine in a default configuration. The controller further receives signals indicative of data corresponding to at least one drilling hole and automatically positions the machine in an operating configuration.

Abstract: The present disclosure describes a module for a telecommunications pole. The module may include a main base plate configured such that telecommunications equipment can be mounted thereto, a top frame member and a bottom frame member coupled to opposing ends of the main base plate and extending outwardly from, and generally perpendicularly to, the main base plate; and a plurality of side frame members coupled to the top and bottom frame members, each side frame member extending collinearly with the main base plate. The top, bottom and side frame members each include a plurality of recesses and protrusions configured and/or positioned such that the top, bottom, and side frame members may be aligned and assembled within the telecommunications pole. Module assemblies and methods of assembling the modules are also described herein.

Abstract: A vehicle configured to operate in an autonomous mode is provided. The vehicle is configured to obtain an indication of a final destination, and, if the final destination is not on a pre-approved road for travel by the vehicle, the vehicle is configured to determine a route from the vehicle's current location to an intermediary destination. The vehicle is further configured to determine a means for the vehicle user to reach the final destination from the intermediate destination.

Abstract: A method and apparatus for decoding a video sequence using a discrete sine transform (DST) type-VII transform core includes generating a set of tuples of transform core elements associated with an n-point DST-VII transform core. A first sum of a first subset of transform core elements of a first tuple is equal to a second sum of a second subset of remaining transform core elements of the first tuple. The n-point DST-VII transform core is generated based on generating the set of tuples of transform core elements. A transform on a block is performed using the n-point DST-VII transform core.

Abstract: A query operator execution flow includes: identifying an OR operator of the query expression; generating a plurality of parallel sub-flows based on a plurality predicates of the OR operator; and generating a plurality of serial sub-flows of the query operator execution flow based on the OR operator of the query expression. A first consecutive one of the plurality of serial sub-flows includes an identifier appending operator, a second consecutive one of the plurality of serial sub-flows includes a tee operator, a third consecutive one of the plurality of serial sub-flows includes the plurality of parallel sub-flows from the tee operator, and a fourth consecutive one of the plurality of serial sub-flows includes a union distinct operator applied to the plurality of parallel sub-flows. Execution of the query is facilitated by applying the query operator execution flow to a plurality of rows indicated by the query.

Abstract: A system and method that enable data processing and dynamic recombination of data by software on a device to be enhanced without requiring a replacement of the main software image on the device. Runtime management objects are generated at a network management platform including an interpreted application. The runtime management objects, KPIs, and interpreted application are downloaded network access devices. Data is collected at the interpreted application and analytics is performed on the collected data. First new runtime management objects are dynamically created at the interpreted application. The first new runtime management objects are presented to the network management platform. Analytics on the first new runtime management objects is performed at the network management platform to generate second new runtime management objects to provide to the plurality of network access devices for processing by the downloaded interpreted applications.

Abstract: A beverage product including a mixture having a dissolved oxygen content of less than 500 parts per billion, the mixture including hops flavor, and water and no sweeteners and no calories. The beverage product has the hoppy flavor is infused from hops in the water 2-3 hours. The oxygen content is less than 100 parts per billion. The mixture is carbonated. An anaerobic environment in the mixture does not include alcohol. The beverage does not include yeast. A ratio of floral flavors to earthy flavors is increased as compared to longer infusion times.

Abstract: One example method includes receiving, by a backup appliance, a request concerning a dataset, performing, by the backup appliance, an inquiry to determine if end-to-end encryption is enabled for a volume of a target storage array, receiving, by the backup appliance, confirmation from the storage array that end-to-end encryption is enabled for the volume, and based on the confirmation that end-to-end encryption is enabled for the volume, storing the dataset in the volume without performing encryption, compression, or deduplication, of the dataset prior to storage of the dataset in the volume.

Abstract: A system for cooling and lubricating a rotor shaft bearing of an electric machine is provided. In one example, the system includes a plurality of oil passages that extend axially through a rotor shaft and open into a sealed cavity near a housing interface between an electric machine housing and gearbox housing to route oil to the rotor shaft bearing for cooling and lubrication thereof.

Abstract: An all-in-one osteotomy fixation device, along with various related components, systems, and methods. The various embodiments include a device body, a bone attachment structure, a removable slot body, and a movable cutting guide moveably attached to the body via a guide coupling structure. The various methods include using any single device embodiment herein to perform all of the steps of the osteotomy procedure.

Abstract: Systems and methods for controlling autonomous vehicle test trips are provided. In one example embodiment, a computer implemented method includes obtaining, by a computing system, data indicative of a test trip index associated with an autonomous vehicle. The test trip index includes a plurality of test trips for the autonomous vehicle and each test trip is associated with one or more test trip parameters. The method includes obtaining, by the computing system, data indicating that the autonomous vehicle is available to travel in accordance with at least one of the test trips of the test trip index. The method includes selecting, by the computing system and from the test trip index, at least one selected test trip for the autonomous vehicle. The method includes causing, by the computing system, the autonomous vehicle to travel in accordance with the test trip parameters associated with the at least one selected test trip.