Abstract: The invention includes methods and systems for identifying targets for therapeutic intervention for various diseases and conditions; and provides specific materials and methods for treatment of specific diseases and conditions.

Abstract: Automated CPR systems incorporating biological feedback can include an automated compression piston system, a data acquisition system, computer systems for running various control algorithms, ventilation control systems, and/or drug delivery systems. Automated CPR systems can be used as stand-alone systems for treating patients in cardiac arrest, or they can be used to administer pretreatment to a patient prior to defibrillation.

Abstract: An axle system is provided herein. In one example, the axle system includes a gearbox housing at least partially enclosing a gearbox and a planetary gearset that is rotationally coupled to an output of the gearbox and positioned co-axial with a rotational axis of an axle shaft in a differential. The planetary gearset includes a ring gear grounded by a planetary support that is attached to the gearbox housing.

Abstract: Systems, methods, and apparatuses for providing optimization of network resources. The system is operable to monitor the electromagnetic environment, analyze the electromagnetic environment, and extract environmental awareness of the electromagnetic environment. The system extracts the environmental awareness of the electromagnetic environment by including customer goals. The system is operable to use the environmental awareness with the customer goals and/or user defined policies and rules to extract actionable information to help the customer optimize the network resources.

Abstract: This invention provides a composition comprising Formula I, or salt thereof, wherein X is chlorine, Y is a methyl group, and R is an alkyl group having a carbon chain length of three carbon atoms. A method of inhibiting osteoclast development and a method for preventing bone erosion in a patient using the compositions of Formula I are disclosed.

Abstract: Disclosed methods and systems describe an analytics server that generates an inter-related nodal data structure. The analytics server receives an electronic template having a set of input fields, the electronic template identifying at least a portion of data stored within a database and its corresponding domain data table and a display attribute, the electronic template further identifying a database storing the data; retrieves the data from the database; parses the data into a set of unique domain data tables having a first criterion and a set of unique dimension tables having a second criterion; generates a nodal network comprising a set of nodes where each node represents at least a portion of the retrieved data, each node having metadata comprising a unique identifier corresponding to a unique domain table and a unique dimension table corresponding to data associated with each node; links one or more nodes based their respective metadata.

Abstract: Techniques for enabling the configuration of a voting block for use in a process control system of a process plant are described. According to certain aspects, the voting block may have a voting scheme that dictates an output based on a set of inputs, where the voting block may be configured parametrically using various control selections that direct the behavior of the voting scheme. In particular, a bypass degrade selection may be specified for one or more inputs that controls whether a “bypass” input degrades the voting scheme, a status degrade selection may be specified for one or more inputs that controls whether a “bad” input degrades the voting scheme, and a trip enable selection may be specified that controls whether a trip occurs automatically under certain conditions. The control selections enable the voting blocks to be configured to conform with various specifications and other requirements.

Abstract: A cavitation seed for drug delivery, and a drug delivery method using the same are disclosed. The cavitation seed according to the present invention comprises: a shell which forms the outer surface thereof to maintain the outer shape thereof within a fluid; and a core which is located inside the shell to determine buoyancy of the cavitation seed within the fluid. The cavitation seed can improve an effect of delivering a drug into a body since cavitation is induced by ultrasound at a position close to the epidermis. In addition, the cavitation seed can be applied in the delivery of various drugs as well as skin cosmetics, such as skin tone lightening agents, depilatories, hair restorers and skin fillers, skin analgesics, local anesthetics, agents for genetic diseases such as psoriasis, and agents for treatment of skin disease such as skin cancer.

Abstract: The disclosed embodiments relate to systems and methods for securely associating an application installation with an account of a service. The computer implemented method may include an inviting device with authenticated access to an account provided by a service having data stored therein. An invite code may be generated in response to a request to enable another device to have access to the service account without identifying the other device. The inviting device may provide the invite code to an invited device. The disclosed embodiments enable an inviting device to provide secure and convenient authenticated account access to multiple devices.

Abstract: A nonlinear converter may comprise: alternating layers of a dielectric material and a metal material; a first refractive index of the nonlinear converter for a first wavelength (i.e., input wavelength or pump wavelength) between 207 nm and 237 nm, the first refractive index being less than 0.5, the first refractive index corresponding to metal fill ratio; and a second refractive index of the nonlinear converter for a second wavelength (i.e., output wavelength or SHG wavelength), the second wavelength being approximately double the first wavelength, the second refractive index corresponding to the metal fill ratio.

Abstract: A scanner is provided and includes a load bearing element, a scan assembly, a transparent plate and a casing. The load bearing element includes a support element and a base. The support element is disposed on the base and surrounds the base. The scan assembly is configured to perform a scan operation and is disposed on the base. The transparent plate is disposed on the support element and is configured to bear an object. The casing includes a first casing part and a second casing part. The second casing part includes a bottom plate and at least one cylinder. The at least one cylinder is disposed on the bottom plate. The load bearing element is disposed on the at least one cylinder, and is located between the first casing part and the second casing part. A first buffer space is formed between the base and the bottom plate.

Abstract: A computer system comprises a memory, a network interface, and at least one processor is provided. The memory stores a plurality of user profile records and a plurality of skill profile records. The at least one processor is configured to receive a request to recommend a skill to improve mental health of a user; retrieve, from the plurality of user profile records, a user profile record associated with the user and the skill, the user profile record including a first weight; retrieve, from the plurality of skill profile records, a skill profile record associated with the skill, the skill profile record including a second weight; determine a third weight based on the first weight and the second weight; generate a response to the request, the response including an identifier of the skill and the third weight; and transmit the response to a virtual assistant.

Abstract: An insulated electric wire includes a conductor comprising twisted elemental wires and an insulation covering. The insulated electric wire includes an exposed portion in which the insulation covering is removed from the outer surface of the conductor, and a covered portion in which the insulation covering covers the outer surface of the conductor. The exposed portion and the covered portion are adjacent with each other along a longitudinal axis of the insulated electric wire. A density of the conductive material per unit length is higher in the exposed portion than in the covered portion. The elemental wires are twisted in both the exposed portion and the covered portion including an area that is positioned away from the exposed portion by at least a distance corresponding to a length of the exposed portion. Gaps between the elemental wires of the exposed portion are filled with a sealant.

Abstract: A biomarker panel for a urine test for detecting lung cancer detects a biomarker selected from the group of biomarkers consisting of DMA, C5:1, C10:1, ADMA, C5-OH, SDMA, and kynurenine, or a combination thereof. A biomarker panel for a serum test for detecting lung cancer detects a biomarker selected from the group of biomarkers consisting of valine, arginine, ornithine, methionine, spermidine, spermine, diacetylspermine, C10:2, PC aa C32:2, PC ae C36:0, and PC ae C44:5; and lysoPC a C18:2, or a combination thereof.

Abstract: This disclosure relates to a distributed data center that includes resources carried by a fleet of vehicles. The system includes sensors configured to generate output signals conveying information related to the vehicles and/or the surroundings of vehicles. The system includes a remote computing server configured to maintain map data and distribute it to the fleet, including local map data to individual vehicles pertaining to their surroundings. Individual vehicles may compare the local map data with the information related to their individual surroundings. Based on such comparisons, individual vehicles may detect discrepancies between the local map data and the information related to their individual surroundings. The remote computing server may modify and/or update the map data based on the detected discrepancies.

Abstract: In one embodiment, a system of detecting seat belt operation in a vehicle includes at least one light source configured to emit a predetermined wavelength of light onto structures within the vehicle, wherein at least one of the structures is a passenger seat belt assembly having a pattern that reflects the predetermined wavelength at a preferred luminance. At least one 3-D time of flight camera is positioned in the vehicle to receive reflected light from the structures in the vehicle and provide images of the structures that distinguish the preferred luminance of the pattern from other structures in the vehicle. A computer processor connected to computer memory and the camera includes computer readable instructions causing the processor to reconstruct 3-D information in regard to respective images of the structures and calculate a depth measurement of the distance of the reflective pattern on the passenger seat belt assembly from the camera.

Abstract: The present disclosure relates to sealed isocyanate resin compositions. The resin compositions may be used for additive manufacturing. One embodiment of the invention includes a photopolymerizable resin for additive manufacturing, the resin comprising: a blocked isocyanate; at least one monomer or oligomer; and a multifunctional nucleophile.

Abstract: A pressure sensor receptacle for the fastening of a pressure sensor to a motor vehicle tank, and a tank device that includes a pressure sensor receptacle. The pressure sensor receptacle includes a receptacle body having a substantially cylindrical shape with a first axial end forming a fastening portion of the receptacle body, the fastening portion configured for being plugged through an opening of the motor vehicle tank until a first bearing surface of the receptacle body bears against an edge of the opening, wherein the first bearing surface is configured to bound the fastening portion; and a locking body having a second bearing surface, the locking body configured for mounting and locking onto the fastening portion such that the second bearing surface bears against an opposite side of the edge of the opening to thereby clamp the pressure sensor receptacle to the edge of the opening by the receptacle body at one side and by the locking body at another side.

Abstract: Described herein are computer-implemented methods for analysis of a tissue sample. An example method includes: annotating the whole tumor regions or set of tumorous sub-regions either on a biomarker image or an H&E image (e.g. from an adjacent serial section of the biomarker image); registering at least a portion of the biomarker image to the H&E image; detecting different cellular and regional tissue structures within the registered H&E image; computing a probability map based on the different detected structures within the registered H&E image; deriving nuclear metrics from each of the biomarker and H&E images; deriving probability metrics from the probability map; and classifying tumor nuclei in the biomarker image based on the computed nuclear and probability metrics.

Abstract: A system for applying a coating composition to a substrate utilizing a high transfer efficiency applicator is provided herein. The system includes a high transfer efficiency applicator defining a nozzle orifice. The coating composition comprises a carrier and a binder. The coating composition has a viscosity of from about 0.002 Pa*s to about 0.2 Pa*s, a density of from about 838 kg/m3 to about 1557 kg/m3, a surface tension of from about 0.015 N/m to about 0.05 N/m, and a relaxation time of from about 0.0005 s to about 0.02 s. The high transfer efficiency applicator is configured to expel the coating composition through the nozzle orifice to the substrate to form a coating layer. At least 80% of the droplets of the coating composition expelled from the high transfer efficiency applicator contact the substrate.