Abstract: Provided here are therapeutically effective pharmaceutical compositions containing one or more TREX2 inhibitors, and more specifically methods of administering TREX2 inhibitors to increase the effectiveness of a chemotherapeutic agent. Also provided here are methods of identifying agents that inhibit the exonuclease activity of TREX2.

Abstract: An embodiment includes a platform shape memory polymer system. Such an embodiment exhibits a blend of tunable, high performance mechanical attributes in combination with advanced processing capabilities and good biocompatibility. A post-polymerization crosslinking synthetic approach is employed that combines polyurethane and thiol-ene synthetic processes. Other embodiments are described herein.

Abstract: Disclosed herein are systems and methods for iteratively training artificial intelligence models using reinforcement learning techniques. With each iteration, a training agent applies a random radiation therapy treatment attribute corresponding to the radiation therapy treatment attribute associated with previously performed radiation therapy treatments when an epsilon value indicative of a likelihood of exploration and exploitation training of the artificial intelligence model satisfies a threshold. When the epsilon value does not satisfy the threshold, the agent generates, using an existing policy, a first predicted radiation therapy treatment attribute, and generates, using a predefined model, a second predicted radiation therapy treatment attribute. The agent applies one of the first predicted radiation therapy treatment attribute or the second predicted radiation therapy treatment attribute that is associated with a higher reward.

Abstract: A system and method for flexible writing of internal data of a regulated system can include generating a flexible write instruction, providing the flexible write instruction to the regulated system, and storing or committing data changes to the regulated system outside of the normal system operations, during runtime.

Abstract: A bi-directional buffer for applications using in an I2C or SMBUS or other bus systems. The bi-directional buffer has an input terminal to receive an input voltage signal and an output terminal for providing an output voltage signal, and the output voltage signal follows the input voltage signal. The output voltage signal is regulated to have a first bias voltage greater than the input voltage signal by a first operational amplifier, or to have a second bias voltage greater than the input voltage signal by a second operational amplifier, the second bias voltage is smaller than the first bias voltage.

Abstract: Draw compounds and draw solutions comprising said draw compounds for use in forward osmosis solvent purification systems. The draw compound may be a linear random, sequential, or block molecular chain consisting of at least one oxide monomer or diol monomer and have a temperature-dependent affinity with a feed solvent. The draw compound may further include a first terminal group and a second terminal group, at least one of the first terminal group and the second terminal group selected from the group consisting of a hydroxyl group, an amine group, a carboxylic group, an allyl group, and a C1 to C14 substituted and unsubstituted alky group. The draw compound may also be a branched random, sequential, or block molecular chain consisting of at least one oxide monomer or diol monomer.

Abstract: The claimed invention is an apparatus and method for performing impedance spectroscopy with a handheld measuring device. Conformal analyte sensor circuits comprising a porous nanotextured substrate and a conductive material situated on the top surface of the solid substrate in a circuit design may be used alone or in combination with a handheld potentiometer. Also disclosed are methods of detecting and/or quantifying target analytes in a sample using a handheld measuring device.

Abstract: A tether actuation unit includes an actuator configured to form a connection with a tether that is releasable in response to actuation of the actuator, and a housing configured to receive the actuator. The housing includes a tether channel configured to allow the tether to extend therethrough. The tether channel includes sidewalls configured to receive and engage the tether along a portion of its length when the tether extends at an angle from the housing. The sidewalls of the tether channel are configured to limit movement of the tether in response to airbag deployment in order to limit tension applied to the actuator by the tether to a predetermined range of non-orthogonal directions with respect to a central axis of the actuator.

Abstract: A suspension system in a vehicle is provided. The suspension system includes, in one example, a hub carrier mounting structure and a hub carrier designed to couple to a wheel hub. The hub carrier mounting structure includes a mounting flange removably attached to the hub carrier and an upper case and a lower case coupled to a support beam, the upper and lower cases are coupled via a first set of attachment devices and a second set of attachment devices that are positioned on opposing sides of the upper and lower cases, where the first and second sets of attachment devices have varying vertical heights.

Abstract: Devices and methods enable optimizing a signal of interest based on identifying and analyzing the signal of interest based on radio frequency energy measurements. Signal data is compared with stored data to identify the signal of interest. Signal degradation data is calculated based on noise figure parameters, hardware parameters and environment parameters. The signal of interest is optimized based on the signal degradation data. Terrain data may also be used for optimizing the signal of interest.

Abstract: The present invention relates to an air conditioner for a vehicle, which can improve a gear ratio of a power transmission means in order to operate a sliding door with more torque. The air conditioner for a vehicle includes: an air-conditioning case having a heat exchanger; a first door and a second door disposed inside the air-conditioning case to adjust the degree of opening of an air passageway; a first driving part for operating the first door; a power transmission part connected to the first driving part; a second driving part for operating the second door; and a third driving part for connecting the power transmission part with the second driving part.

Abstract: An IC package structure and an IC package unit are disclosed. The IC package includes an array of metal wall grids formed into a panel, each one of the metal wall grids having a continuous and closed metal wall to surround an IC package unit with at least one IC chip/IC die disposed therein. Each IC chip/IC die has a top surface with a plurality of metal pads formed thereon. A panel-shaped metal layer is formed on entire back side of the panel of the array of metal wall grids and bonded to the metal wall of each metal wall grid. A panel-shaped rewiring substrate having a plurality of metal pillars is connected to each IC chip/IC die with each one of the plurality of metal pillars soldered with a corresponding one of the plurality of metal pads.

Abstract: A radio frequency (RF) summer circuit having a characteristic impedance Zo comprises first and second ports coupled by first and second resistances, respectively, to a junction. The circuit further comprises a series combination of a third resistance and a switch movable between open and closed positions and an amplifier having input and output terminals and operable in an off state and an on state wherein the series combination is coupled across the input and output terminals of the amplifier between the junction and a third port. The first resistance, second resistance, and the third resistance are all substantially equal to Z0/3. Further, when the switch is moved to the closed position and the amplifier is switched to the off state a passive mode of operation is implemented and when the switch is moved to the open position and the amplifier is switched to the on state an active mode of operation is implemented.

Abstract: The systems and methods described herein dynamically allocate streams when restoring data from databases. In some embodiments, the system and methods restore data from a database by determining a number of streams to allocate to the database for restoring files of data from the database. The determined number of streams may be based on a total amount of data within the database, and/or may be based, at least in part, on the previous number of streams used during backup operations, in order to balance the benefit of allocating streams to a restoration of data with any detriments associated with changing the number of streams from the number used during previous backup operations.

Abstract: A distributed data storage system using erasure coding (EC) provides advantages of EC data storage while retaining high resiliency for EC data storage architectures having fewer data storage nodes than the number of EC data-plus-parity fragments. An illustrative embodiment is a three-node data storage system with EC 4+2. Incoming data is temporarily replicated to ameliorate the effects of certain storage node outages or fatal disk failures, so that read and write operations can continue from/to the storage system. The system is equipped to automatically heal failed EC write attempts in a manner transparent to users and/or applications: when all storage nodes are operational, the distributed data storage system automatically converts the temporarily replicated data to EC storage and reclaims storage space previously used by the temporarily replicated data. Individual hardware failures are healed through migration techniques that reconstruct and re-fragment data blocks according to the governing EC scheme.

Abstract: A system that handles delivery of service(s) through a client device, includes an interactive service provider, a video service provider, and a client device. The interactive service provider inserts at least one of digital watermarks and digital fingerprints in non-programming media content. The video service provider transmits a media stream of the media content that includes programming media content and the non-programming media content. The client device detects at least one of the inserted digital watermarks and the digital fingerprints in the playback duration of the media content and renders overlay graphics on the media content. The client device activates at least one of input devices paired with the client device and the rendered overlay graphics. The client device further receives trigger responses over activated overlay graphics and displays an interactive view to enable delivery of service(s) in response to the trigger responses.

Abstract: In general, a smart door alarm and locking mechanism and methods for use thereof are provided for maintaining security while providing ease of access to a fuel dispenser. In an exemplary embodiment, the methods and devices are used in fuel dispensing devices for providing fuel to a vehicle. However, the methods and devices can be utilized in any device having a payment system where security and access are both required. In some embodiments, the described methods and systems include a door alarm and door lock kit that allow unlocking one or more doors in a housing of a fuel dispenser and simultaneously disabling or de-activating respective door alarm sensor(s). In a similar manner, the door can be locked and the door alarm sensor activated or re-activated substantially simultaneously.

Abstract: A medical image processing apparatus of an embodiment includes processing circuitry. The processing circuitry is configured to acquire medical image data on the basis of tomosynthesis imaging of a test object, and input the acquired medical image data of the test object to a trained model to acquire a two-dimensional image data, the trained model being generated by learning of two-dimensional image data on the basis of X-ray imaging of a person and image data on the basis of tomosynthesis imaging of the person who is subjected to the X-ray imaging.

Abstract: A system for applying a first coating composition and a second coating composition. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a substrate defining a target area. The first high transfer efficiency applicator is configured to expel the first coating composition through the first nozzle orifice to the target area of the substrate to form a first coating layer. The second high transfer efficiency applicator is configured to expel the second coating composition through the second nozzle orifice to the first coating layer to form a second coating layer.

Abstract: A dispenser capable of dispensing a fluid via a vertically-oriented piezo device comprises a reservoir in the form of a replaceable cartridge containing a fluid to be dispensed, a planar piezo element having front and rear surfaces and which in use is oriented with its plane vertical and which is drivable to vibrate and thereby dispense fluid from the front surface, and a pump to draw a predetermined amount, or dose, of fluid from the reservoir and to drive the dose of fluid at a predetermined above-atmospheric pressure to the rear surface of the piezo element for dispensing.