Patents Assigned to Optinose AS
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Publication number: 20250090778Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: ApplicationFiled: April 23, 2024Publication date: March 20, 2025Applicant: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Patent number: 11291626Abstract: A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.Type: GrantFiled: September 14, 2011Date of Patent: April 5, 2022Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 11083858Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device including a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which the substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: February 26, 2019Date of Patent: August 10, 2021Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake
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Patent number: 11052204Abstract: A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.Type: GrantFiled: November 19, 2015Date of Patent: July 6, 2021Assignee: OptiNose ASInventors: Per Gisle Djupesland, Ramy A. Mahmoud, Ole A Andreassen, Lars T. Westlye, Daniel S. Quintana, Knut T. Smerud, Colin David Sheldrake
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Publication number: 20210187216Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: ApplicationFiled: July 27, 2020Publication date: June 24, 2021Applicant: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Patent number: 11033696Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: GrantFiled: October 12, 2018Date of Patent: June 15, 2021Assignee: OptiNose ASInventors: Per Gisle Djupesland, Michael Leclerc, Ramy A Mahmoud, Shane Siwinski, Joseph Gordon, Justin Fisk
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Patent number: 10940277Abstract: A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.Type: GrantFiled: November 19, 2015Date of Patent: March 9, 2021Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake
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Patent number: 10864334Abstract: A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject. The delivery device includes a nosepiece unit for insertion into a nasal cavity of a subject and an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject. The delivery device also includes a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle.Type: GrantFiled: March 19, 2018Date of Patent: December 15, 2020Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 10765829Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.Type: GrantFiled: January 12, 2018Date of Patent: September 8, 2020Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Patent number: 10737045Abstract: A delivery device for and method of delivering substance, the delivery device comprising: an outlet member through which substance is in use delivered in an entraining gas flow; and a substance supply unit for supplying substance to be entrained by an entraining gas flow as one or both of a vapor or a fine aerosol mist, wherein the substance supply unit comprises a flow channel which is fluidly connected to the outlet member, and a substance supporting element for supporting substance, at least a surface of which is in use disposed in the flow channel.Type: GrantFiled: September 24, 2015Date of Patent: August 11, 2020Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 10722667Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.Type: GrantFiled: April 7, 2017Date of Patent: July 28, 2020Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Patent number: 10639437Abstract: A delivery device for and method of delivering a metered amount of substance, the delivery device comprising: a mouthpiece through which a user in use exhales; an outlet through which substance is in use delivered; a housing fluidly connected to the mouthpiece and the outlet, such that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.Type: GrantFiled: April 23, 2015Date of Patent: May 5, 2020Assignee: OptiNose ASInventors: Per Gisle Djupesland, Rune Harald Gaarder, Sébastien Lamolle
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Patent number: 10639438Abstract: A delivery device for delivering a metered amount of substance (L) in response to exhalation by a user, the delivery device comprising: a mouthpiece (5) through which the user in use exhales; an outlet (45) from which substance Is delivered; and a dispensing unit (35) which is operable to dispense a metered amount of substance through the outlet in response to exhalation by the user through the mouthpiece, wherein the dispensing unit comprises a body member (37) which includes a cavity (39) for containing a metered amount of substance, an outlet nozzle (43) which is fluidly connected to the cavity from which substance is in use delivered, and a dispensing (41) member which is movably disposed in the cavity and configured to be driven through the cavity by a driving pressure created by exhalation of the user, such as to cause substance to be delivered from the outlet nozzle.Type: GrantFiled: March 26, 2018Date of Patent: May 5, 2020Assignee: OptiNose ASInventors: Per Gisle Djupesland, Erik Andreassen, Rune Harald Gaarder, Christophe Péricé, Andreas Nilsson
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Patent number: 10525218Abstract: A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject. The delivery device includes a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject. The body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.Type: GrantFiled: March 31, 2015Date of Patent: January 7, 2020Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake, Simon Smith, Rachel Striebig, Andy Pidgeon, Tom St. Quintin
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Patent number: 10478574Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.Type: GrantFiled: January 19, 2006Date of Patent: November 19, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20190269867Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasal valve, and expand the same in the sagittal plane; and a delivery unit for delivering substance through the nozzle of the nosepiece.Type: ApplicationFiled: October 8, 2018Publication date: September 5, 2019Applicant: OptiNose ASInventor: Per Gisle DJUPESLAND
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Patent number: 10398859Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pType: GrantFiled: July 13, 2015Date of Patent: September 3, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Patent number: 10300229Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: GrantFiled: February 25, 2013Date of Patent: May 28, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Michael Leclerc, Ramy A. Mahmoud, Shane Siwinski, Joseph Gordon, Justin Fisk
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Patent number: 10286164Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.Type: GrantFiled: December 29, 2016Date of Patent: May 14, 2019Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 10252010Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device including: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: May 26, 2015Date of Patent: April 9, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake