Patents Assigned to Optinose AS
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Patent number: 10478574Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit (17) for insertion into a nasal airway (1) of a subject and comprising an outlet unit (21) which includes a nozzle (25) for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle: wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.Type: GrantFiled: January 19, 2006Date of Patent: November 19, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20190269867Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasal valve, and expand the same in the sagittal plane; and a delivery unit for delivering substance through the nozzle of the nosepiece.Type: ApplicationFiled: October 8, 2018Publication date: September 5, 2019Applicant: OptiNose ASInventor: Per Gisle DJUPESLAND
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Patent number: 10398859Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pType: GrantFiled: July 13, 2015Date of Patent: September 3, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Patent number: 10300229Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: GrantFiled: February 25, 2013Date of Patent: May 28, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Michael Leclerc, Ramy A. Mahmoud, Shane Siwinski, Joseph Gordon, Justin Fisk
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Patent number: 10286164Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.Type: GrantFiled: December 29, 2016Date of Patent: May 14, 2019Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 10252010Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device including: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: May 26, 2015Date of Patent: April 9, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake
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Patent number: 10179216Abstract: A nasal delivery device comprising: a housing (15); a nosepiece (17) for fitting to a nasal cavity of a subject; a mouthpiece (19) through which the subject in use exhales; and a substance supply unit (21) including an actuation member (23) which extends from one end of the housing and is manually actuated to deliver substance to the nasal cavity of the subject; wherein the housing includes a grip section (27) which is disposed at the one end of the housing from which the actuation member extends, said grip section comprising a first, distal part (28) including at least one projecting grip element (29) by which the subject grips the housing in actuating the actuation member, and a second, proximal part (31) providing a recess (33) in which fingers of the subject are located, said recess promoting proper orientation of the delivery device in a hand of the subject.Type: GrantFiled: February 25, 2013Date of Patent: January 15, 2019Assignee: OptiNose ASInventors: Per Gisle Djupesland, Kate Dudgeon, Joseph Gordon, Mark Guarraia, Michael Leclerc, Ramy A Mahmoud
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Patent number: 10124132Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasal valve, and expand the same in the sagittal plane; and a delivery unit for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: February 23, 2016Date of Patent: November 13, 2018Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 10112021Abstract: Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.Type: GrantFiled: March 2, 2015Date of Patent: October 30, 2018Assignee: OptiNose ASInventor: Roderick Peter Hafner
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Patent number: 10076614Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.Type: GrantFiled: February 25, 2013Date of Patent: September 18, 2018Assignee: OptiNose ASInventors: Per Gisle Djupesland, Joseph Gordon, Michael Leclerc, Ramy A Mahmoud, Shane Siwinski
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Patent number: 10076615Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: February 10, 2015Date of Patent: September 18, 2018Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake
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Patent number: 9949923Abstract: A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.Type: GrantFiled: March 15, 2012Date of Patent: April 24, 2018Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9649456Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece (47) for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit (16) which is operable to deliver the powdered substance through the nosepiece (47).Type: GrantFiled: April 7, 2008Date of Patent: May 16, 2017Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner
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Patent number: 9566402Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.Type: GrantFiled: August 10, 2015Date of Patent: February 14, 2017Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9522243Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.Type: GrantFiled: August 3, 2015Date of Patent: December 20, 2016Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9468727Abstract: A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a delivery unit for delivering a flow entraining a substance to one nostril of a subject, the delivery unit including a nosepiece for fitting to a nostril of the subject; and a flow resistor unit for fitting to the other nostril of the subject, the flow resistor unit including a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.Type: GrantFiled: December 2, 2013Date of Patent: October 18, 2016Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9452272Abstract: A breath-actuated delivery device includes a mouthpiece through which a subject in use exhales, an air channel which is in fluid communication with the mouthpiece, and a flexible diaphragm which is disposed in the air channel. The diaphragm provides for at least a restricted air flow through the air channel until a predeterminable actuation pressure is developed in the mouthpiece, and, on generation of the predeterminable actuation pressure in the mouthpiece, provides for an air flow through the air channel.Type: GrantFiled: May 16, 2012Date of Patent: September 27, 2016Assignee: OptiNose ASInventors: Per Gisle Djupesland, Martin Joseph Murphy, Stuart Brian William Kay, Andrew Gordon Pocock
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Patent number: D761951Type: GrantFiled: May 23, 2013Date of Patent: July 19, 2016Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: D773644Type: GrantFiled: February 11, 2015Date of Patent: December 6, 2016Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: D809128Type: GrantFiled: June 10, 2016Date of Patent: January 30, 2018Assignee: OPTINOSE ASInventor: Per Gisle Djupesland