Patents Assigned to Optinose AS
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Publication number: 20160074603Abstract: A delivery device for and method of delivering a metered amount of substance, the delivery device comprising: a mouthpiece through which a user in use exhales; an outlet through which substance is in use delivered; a housing fluidly connected to the mouthpiece and the outlet, such that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.Type: ApplicationFiled: April 23, 2015Publication date: March 17, 2016Applicant: OptiNose ASInventors: Per Gisle Djupesland, Rune Harald Gaarder, Sébastien Lamolle
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Patent number: 9272104Abstract: A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal cavity of a subject and comprising an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject; and a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle.Type: GrantFiled: March 23, 2007Date of Patent: March 1, 2016Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Publication number: 20160051778Abstract: A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.Type: ApplicationFiled: March 31, 2015Publication date: February 25, 2016Applicant: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake, Simon Smith, Rachel Striebig, Andy Pidgeon, Tom St. Quintin
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Patent number: 9205209Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.Type: GrantFiled: December 21, 2012Date of Patent: December 8, 2015Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9205208Abstract: A nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.Type: GrantFiled: July 11, 2011Date of Patent: December 8, 2015Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9168341Abstract: A delivery device for and method of delivering substance, the delivery device having an outlet member through which substance is in use delivered in an entraining gas flow, and a substance supply unit for supplying substance to be entrained by an entraining gas flow as one or both of a vapor or a fine aerosol mist, wherein the substance supply unit has a flow channel which is fluidly connected to the outlet member, and a substance supporting element for supporting substance, at least a surface of which is in use disposed in the flow channel.Type: GrantFiled: August 11, 2014Date of Patent: October 27, 2015Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9144652Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: GrantFiled: September 19, 2014Date of Patent: September 29, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Patent number: 9132249Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.Type: GrantFiled: March 5, 2013Date of Patent: September 15, 2015Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9119932Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.Type: GrantFiled: June 2, 2006Date of Patent: September 1, 2015Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9108015Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pType: GrantFiled: October 21, 2013Date of Patent: August 18, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Patent number: 9072857Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.Type: GrantFiled: June 2, 2006Date of Patent: July 7, 2015Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 9067034Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: October 3, 2008Date of Patent: June 30, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake
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Publication number: 20150165139Abstract: Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.Type: ApplicationFiled: March 2, 2015Publication date: June 18, 2015Applicant: OptiNose ASInventor: Roderick Peter HAFNER
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Patent number: 9038630Abstract: A delivery device for delivering a metered amount of substance, the delivery device comprising: a mouthpiece (17) through which a user in use exhales; an outlet (19) through which substance is in use delivered; a housing (21) fluidly connected to the mouthpiece and the outlet, such, that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit (25) which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.Type: GrantFiled: November 28, 2007Date of Patent: May 26, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Rune Harald Gaarder, Sébastien Lamolle
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Patent number: 9010325Abstract: A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly (3) including a mouthpiece unit (9) which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit (5) which includes a nosepiece and contains a container containing particulate substance.Type: GrantFiled: November 28, 2007Date of Patent: April 21, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Colin David Sheldrake, Simon Smith, Rachel Striebig, Andy Pidgeon, Tom St. Quintin
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Patent number: 8978647Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: April 7, 2008Date of Patent: March 17, 2015Assignee: Optinose, ASInventors: Per Gisle Djupesland, Colin David Sheldrake
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Publication number: 20150053201Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: ApplicationFiled: March 26, 2014Publication date: February 26, 2015Applicant: OPTINOSE ASInventors: Per Gisle DJUPESLAND, Ramy A. MAHMOUD, John MESSINA
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Patent number: D723156Type: GrantFiled: May 23, 2013Date of Patent: February 24, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Kate Dudgeon, Justin Fisk, Joseph Gordon, Mark Guarraia, Michael Leclerc, Ramy A Mahmoud, Shane Siwinski
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Patent number: D725769Type: GrantFiled: May 23, 2013Date of Patent: March 31, 2015Assignee: OptiNose ASInventors: Per Gisle Djupesland, Kate Dudgeon, Justin Fisk, Joseph Gordon, Mark Guarraia, Michael Leclerc, Ramy A Mahmoud, Shane Siwinski
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Patent number: D759805Type: GrantFiled: February 11, 2015Date of Patent: June 21, 2016Assignee: OptiNose ASInventor: Per Gisle Djupesland