Abstract: A technique for generating a mapping relating values of a scan parameter of an ocular imaging apparatus that are indicative of scan locations in an eye at which the apparatus acquires digital images of imaged regions of the eye, to respective values of a conversion factor for calculating a distance between designated ocular features in the imaged regions, by: simulating light ray propagation to relate each value of the scan parameter in a sequence of scan parameter values to a corresponding location in a model eye; calculating, for each scan parameter value, a distance between the corresponding location in the model eye and a location in the model eye corresponding to an adjacent value in the sequence; and using the calculated distances to generate a respective value of the conversion factor for each scan parameter value.

Abstract: A computer-implemented method of searching for a region indicative of a pathology in an image of a portion of an eye acquired by an ocular imaging system, the method comprising: receiving image data defining the image; searching for the region in the image by processing the received image data using a learning algorithm; and in case a region in the image that is indicative of the pathology is found: determining a location of the region in the image; generating an instruction for an eye measurement apparatus to perform a measurement on the portion of the eye to generate measurement data, using a reference point based on the determined location for setting a location of the measurement on the portion of the eye; and receiving the measurement data from the eye measurement apparatus.

Abstract: A Fourier-domain optical coherence tomography imaging system (10) comprising an Fourier-domain optical coherence tomography scanner (20) arranged to generate complex optical coherence tomography data (25) by performing a scan of an imaging target (30) to acquire samples whose complex values are indicative of an optical property of the imaging target at respective scan locations in the imaging target. The imaging system (10) further comprises a controller (40) arranged to calculate a two-dimensional cross-correlation using phase information of the acquired samples, and control the scanner (20), based on the calculated cross-correlation, to compensate for relative movement between the imaging target (30) and the scanner (20) during the scan.

Abstract: There is provided a control system for controlling two or more illuminates of a multi-modality ophthalmic imaging system that are arranged to generate light for imaging an eye, the control system comprising: a processor which selects, from the illuminates and based on a selected imaging modality of the ophthalmic imaging system, one or more illuminates that are to be used to image the eye, and to generate an input signal identifying the selected one or more illuminates. The control system further comprises a logic block, which receives the input signal and comprises logic that determines a respective operating power for each illuminate of the selected one or more illuminates, based on the received input signal. The logic block also generates a respective control signal for each illuminate of the selected one or more illuminates, each control signal indicating the respective operating power determined for the respective illuminate.

Abstract: A movement mechanism (110) for an ophthalmic imaging apparatus (100) for imaging an eye (120) using light propagating along a first optical path and a second optical path, the movement mechanism arranged to move a first optical element into and out of the first optical path, and concurrently move a second optical element into and out of the second optical path, the movement mechanism arranged to rotate the optical elements between a first rotational position and a second rotational position such that the first and second optical element are: in the first and second optical path, respectively, when the optical elements are at the first rotational position and the imaging apparatus is operating in a first imaging mode; and out of the first and second optical path, respectively, when the optical elements are at the second rotational position and the imaging apparatus is operating in a second imaging mode.

Abstract: An optical assembly for optically coupling a light source and a photodetector to an optical system of an ophthalmic imaging apparatus, the optical assembly comprising: a housing through which a light beam from the light source propagates towards the optical system along an optical path, and light from an eye collected by the optical system propagates towards the photodetector along the optical path; an arm which extends into the housing and supports a reflective surface to reflect the light beam towards the optical system; and an adjustable mechanism attaching the arm to the housing and allowing the reflective surface to be adjusted by: rotation about a first axis passing through a point on the reflective surface and perpendicular to the optical path; rotation about a second axis passing through the point and perpendicular to the first axis and the optical path; and/or translation along the optical path.

Abstract: An imaging system for generating an image of a region of an eye, comprising: an ocular imaging device controlled by a control module to acquire, from a first viewpoint, a first ocular image of the region having an image artefact caused by obstruction from imaging of a part of the region by an object, and a second ocular image from a predetermined second viewpoint, which shows at least a portion of the part of the region that was obstructed from imaging during acquisition of the first ocular image; and an image data processing module for combining the first and second ocular images to generate an enhanced ocular image having an image artefact caused by obstruction from imaging by the object which is smaller in relation to the image artefact in the first or second ocular image, or no such image artefact.

Abstract: A method of generating a segmentation confidence map by processing classification values each indicating a respective classification of a respective voxel of a retinal C-scan into a respective retinal layer class of a predefined set of retinal layer classes, the method comprising: generating, for each voxel, a respective confidence value which indicates a level of confidence in the classification of the voxel; for a retinal layer class of the predefined set, identifying a subset of the voxels such that the classification value generated for each voxel indicates a classification of the voxel into the retinal layer class; calculating, for each A-scan having voxels in the identified subset, a respective average of the confidence indicator values generated for the voxels; and using the calculated averages to generate the map, which indicates a spatial distribution of a level of confidence in the classification of the voxels.

Abstract: A method of processing functional OCT image data, acquired by an OCT scanner scanning a retina that is being repeatedly stimulated by a light stimulus, to obtain a response of the retina to the light stimulus, comprising: receiving OCT image data generated by the OCT scanner repeatedly scanning the retina over a time period, and a sequence of stimulus indicators each indicative of a stimulation of the retina by the light stimulus in a respective time interval of a sequence of time intervals spanning the time period; calculating, for each stimulus indicator, a product of the stimulus indicator and a respective windowed portion of the sequence of B-scans comprising a B-scan based on a portion of the OCT image data generated while the retina was being stimulated in accordance with the stimulus indicator; and combining the calculated products to generate the indication of the response.

Abstract: An apparatus, method, computer-readable medium, and computer program product, for designating an OCT scan location to be performed on a retina. The apparatus comprises a display device for displaying an image comprising a background image of the retina and a planning element designating the location; a touch-sensitive input device that generates touch interaction data indicative of touch interaction of a user with the input device; an image manipulation module determines, based on the touch interaction data, a manipulation to be performed on the displayed image, and applies the image manipulation to the image in response to each touch interaction to generate an updated image to display; and a scan location designation module generates data indicative of the location of the OCT scan to be performed, based on a location of the planning element on the background image in at least one updated image.

Abstract: A non-confocal point-scan Fourier-domain optical coherence tomography, OCT, imaging system, comprising: a scanning system arranged to perform a two-dimensional point scan of a light beam across an imaging target, and collect light scattered by the imaging target; a light detector arranged to generate a detection signal based on an interference between a reference light and the light collected by the scanning system. The OCT imaging system further comprises hardware arranged to: generate complex volumetric OCT data of the imaging target based on the detection signal, the OCT data including a component which, when the OCT data is processed to generate an enface projection of the OCT data, provides a defocusing and/or distortion in the enface projection; and generate corrected OCT data by executing a correction algorithm which uses phase information in the OCT data to remove at least some of the component from the OCT data.

Abstract: A method of processing optical coherence tomography angiography, OCTA, data comprising an array of columns of data elements to generate corrected OCTA data showing reduced projection artefacts in enface projection, the OCTA data having been generated from repeat B-scans, the method comprising: (i) calculating a correlation value indicative of a correlation between a first sequence of the data elements, whose respective locations within respective B-scans correspond to a location of a first data element within the array, and a second sequence of the data elements, whose respective locations within respective B-scans correspond to a location of a second data element within the array; (ii) calculating a correction for the second data element based on the first data element and the calculated correlation value; and (iii) applying the calculated correction to the second data element, wherein processes (i) to (iii) are performed multiple times to generate the corrected OCTA data.

Abstract: Aspects of the present invention relate to an ophthalmic imaging system for imaging a target on a posterior segment of a patient's eye, the imaging system comprising: a light source configured to emit a light beam for imaging the target; an imaging device for tracking a position of an anterior segment of the patient's eye; and a controller configured to determine a movement of the target in dependence on the tracked position of the anterior segment of the patient's eye; wherein the controller is further configured to adjust an angle of incidence of the light beam that contacts the posterior segment in dependence on the determined movement of the target.

Abstract: Aspects of the present invention relate to a method of detecting clipping of retinal image content in an optical coherence tomography, OCT, image of a patient’s retina. The method comprises detecting a boundary of the retinal image content in the OCT image and calculating a distance between the boundary and an edge of the OCT image. The method further comprises determining if clipping of the retinal image content in the OCT image has occurred by comparing the calculated distance between the boundary and the edge of the OCT image with a clipping threshold distance. Clipping of the retinal image content is determined to have occurred when the calculated distance between the boundary and the edge of the OCT image is equal to, or less than, the clipping threshold distance.

Abstract: A computer-implemented method of processing repeat B-scans of an imaged region of a body part, the imaged region including an anatomical feature in a first subregion and vasculature of interest in a second subregion of the imaged region, to generate cropped B-scans for use in generating OCT angiography data which provides a representation of the vasculature of interest, the method comprising processing each B-scan of the repeat B-scans by: selecting a subset of the data elements of the B-scan such that the selected data elements are distributed along a representation of the anatomical feature in the B-scan; using the selected data elements to define a respective subregion of interest in the B-scan, which includes OCT data acquired from the second subregion containing the vasculature of interest; and cropping the B-scan to leave the subregion of interest in the B-scan.

Abstract: Method of aligning an imaging device with respect to an object, the imaging device comprising two or more optical channels, is disclosed. The method may include aiming the two or more optical channels at corresponding overlapping zones of the object such that the two or more optical channels are oriented at different angles relative to each other and off-axis relative to a central axis of the imaging device. The method may additionally include guiding or focusing the imaging device relative to the object using composite images created by combining separate images from the two or more optical channels.

Abstract: An ophthalmic device for imaging an eye, wherein a scanning element scans a first portion of light beam across a region of an eye via a light guiding component and a second portion of the light beam is reflected back by the light guiding component. The ophthalmic device further comprises: a light detector to detect light reflected from eye and guided to the light detector by the light guiding component; and a dynamic amplitude mask which receives the light reflected from the eye and the light reflected back by the light guiding component, and has an unmasked portion to allow light reflected from the eye to reach the light detector, and a masked portion whose spatial distribution varies with a scan angle such that the masked portion prevents light reflected back by the light guiding component from reaching the light detector during the scan.

Abstract: An apparatus for providing temperature-dependent movement of an optical element, the apparatus comprising: a moveable mount for the optical element; a mount moving component attached to the moveable mount; and a guide attached to the mount moving component and configured to guide a movement of the moveable mount. The apparatus is configured such that a difference in thermal contraction or thermal expansion between the mount moving component and the guide in response to a change in temperature of the apparatus causes the mount moving component to move the moveable mount relative to the guide.

Abstract: An imaging system may include a panoramic gonioscopic imaging apparatus that includes a disposable component configured to rest against a cornea of a patient, and an objective optical device configured to direct a continuous panoramic image of an entire circumference of an iridocorneal angle of the patient on an intermediate imaging plane, and a relay lens configured to direct the continuous panoramic image from the intermediate imaging plane to a sensor such that the sensor captures the entire circumference of the iridocorneal angle at once. The imaging system may also include a computing device in communication with the panoramic gonioscopic imaging apparatus, where the computing device configured to display an image of the entire circumference of the iridocorneal angle.

Abstract: An apparatus for generating an alert indicating an unreliability in a location of a landmark feature in a retinal image predicted by a machine learning algorithm, comprising: a receiver module which receives the predicted location; a probability indication determining module which uses the predicted location and a mixture model, which comprises a probability distribution of a landmark feature location and is based on determined locations of the landmark feature in retinal images having a plurality of retinal image classes, to determine, for each class, a respective probability indication indicating a probability that the retinal image belongs to the class; an outlier detector module which uses the probability indications to determine whether the retinal image is an outlier belonging to none of the classes; and an alert generator module which generates, when the retinal image belongs to none of the classes, an alert indicating unreliability of the predicted location.