Abstract: An ophthalmic device including an illumination module which scans light across a region of the retina of an eye when the pupil is disposed at a focal point of the illumination module. The ophthalmic device further comprises components (2, 3-1, 4-1) for: aligning the pupil with the focal point; monitoring a position of the pupil relative to the focal point and maintaining the alignment based on the monitored position; aligning a scan location of the illumination module on the retina to a target scan location while the alignment of the pupil with the focal point is being maintained, wherein the illumination module performs a scan at the target scan location. The ophthalmic device further maintains the scan location at the target scan location while the alignment of the pupil with the focal point is being maintained, using scan location correction information based on retinal feature information.

Abstract: A method may include illuminating a region of a choroid of an eye of a patient with off-axis illumination from a first imaging channel, the first imaging channel being off-axis with respect to an axis of a focus of the eye. The method may also include capturing an image of the choroid, where the off-axis illumination from the first imaging channel is off-set within the first imaging channel from the image sensor. A second off-axis illumination from a second imaging channel that is off-axis from both the first imaging channel and the off-axis illumination may illuminate the same or a different region of the choroid. The captured image of the choroid may be provided to a machine learning system. Indices associated with the image to may be identified based on an output of the machine learning system.

Abstract: A method, system, and computer-readable medium, for detecting whether an eye blink or non-blink is captured in the image. The method includes filtering, from the image, one or more objects that are predicted to be unsuitable for determining whether an eye blink or no-blink is captured in the image, to provide a filtered image. The method also includes correlating the filtered image with a reference image, and determining, based on the correlating, whether the eye blink or non-blink is captured in the image. The eye blink is a full eye blink or a partial eye blink, and the images may be sequentially captured IR SLO images, in one example embodiment herein. Images determined to include an eye blink can be omitted from inclusion in a final (e.g., OCT) image.

Abstract: A method of processing a sequence of images of a retina acquired by an ophthalmic device to generate retinal position tracking information indicative of retina movement during acquisition. The method includes (i) receiving one or more images of the retina; (ii) calculating a cross-correlation between a reference image and an image based on the received image(s) to acquire an offset between the image and reference image; and repeating processes (i) and (ii) to acquire, as the tracking information, respective offsets for images that are based on the respective received image(s). Another step includes modifying the reference image during the repeating, by determining a measure of similarity between correspondingly located regions of pixels in two or more received images and accentuating features in the reference image representing structures of the imaged retina in relation to other features in the reference image based on the determined measure of similarity.

Abstract: A computer-implemented method of searching for a region indicative of a pathology in an image of a portion of an eye acquired by an ocular imaging system, the method comprising: receiving image data defining the image; searching for the region in the image by processing the received image data using a learning algorithm; and in case a region in the image that is indicative of the pathology is found: determining a location of the region in the image; generating an instruction for an eye measurement apparatus to perform a measurement on the portion of the eye to generate measurement data, using a reference point based on the determined location for setting a location of the measurement on the portion of the eye; and receiving the measurement data from the eye measurement apparatus.

Abstract: A method of processing functional OCT image data, acquired by an OCT scanner scanning a retina that is being repeatedly stimulated by a light stimulus, to obtain a response of the retina to the light stimulus, comprising: receiving OCT image data generated by the OCT scanner repeatedly scanning the retina over a time period, and a sequence of stimulus indicators each indicative of a stimulation of the retina by the light stimulus in a respective time interval of a sequence of time intervals spanning the time period; calculating, for each stimulus indicator, a product of the stimulus indicator and a respective windowed portion of the sequence of B-scans comprising a B-scan based on a portion of the OCT image data generated while the retina was being stimulated in accordance with the stimulus indicator; and combining the calculated products to generate the indication of the response.

Abstract: A computer-implemented method of searching for a region indicative of a pathology in an image of a portion of an eye acquired by an ocular imaging system, the method comprising: receiving image data defining the image; searching for the region in the image by processing the received image data using a learning algorithm; and in case a region in the image that is indicative of the pathology is found: determining a location of the region in the image; generating an instruction for an eye measurement apparatus to perform a measurement on the portion of the eye to generate measurement data, using a reference point based on the determined location for setting a location of the measurement on the portion of the eye; and receiving the measurement data from the eye measurement apparatus.

Abstract: A method of generating a segmentation confidence map by processing classification values each indicating a respective classification of a respective voxel of a retinal C-scan into a respective retinal layer class of a predefined set of retinal layer classes, the method comprising: generating, for each voxel, a respective confidence value which indicates a level of confidence in the classification of the voxel; for a retinal layer class of the predefined set, identifying a subset of the voxels such that the classification value generated for each voxel indicates a classification of the voxel into the retinal layer class; calculating, for each A-scan having voxels in the identified subset, a respective average of the confidence indicator values generated for the voxels; and using the calculated averages to generate the map, which indicates a spatial distribution of a level of confidence in the classification of the voxels.

Abstract: A medical imaging device comprising: an optical imaging module which generates an image of a region of a body part by acquiring image samples at respective sample locations in the region and mapping the samples to corresponding image pixels; a control module which controls the optical imaging module to acquire a first sequence of samples whose corresponding pixel locations follow a path which is spanned by pixels corresponding to the first sequence of samples and extends over a greater portion of the image than an arrangement in an array of a sequence of pixels corresponding to a second sequence of samples that the optical imaging module is operable to acquire, wherein a sum of distances between adjacent pixels in the sequence of pixels is equal to a length of the path; and a registration module which registers the image against a reference image.

Abstract: A multimode optical coherence tomography (OCT) imaging system comprises a light source arranged to emit coherent light in a path to scan a sample. An optical parameter unit is arranged in the path and is operable in at least one selected mode from among a plurality of available operating modes, including at least a first mode, a second mode and a third mode. A detector is arranged to detect reflected light, the reflected light being light reflected in the path as a result of the coherence light scanning the sample. A controller is arranged to control at least one of the light source or the optical parameter unit. The first, second and third modes include a retina mode, anterior segment mode, and biometry mode, respectively. Also provided are a method for operating a multimode OCT imaging system, and a computer-readable storage medium storing a program for performing the method.

Abstract: An information processing system comprises: an image acquisition device acquiring subject eye image data of a patient; a first information processing device storing the image data; a second information processing device obtaining the image data as a first diagnosis result using artificial intelligence; and a third information processing device obtaining the image data as a second diagnosis result by a radiologist, the image acquisition device: generates diagnosis method information indicating a diagnosis by artificial intelligence and/ or a radiologist; and transmits first transmission data including the image data and the diagnosis method information to the first information processing device, the first processing device: stores the image data when receiving the first transmission data from the image acquisition device; and transmits, based on the diagnosis method information, second transmission data including the image data to the second and/ or the third information processing.

Abstract: An ophthalmic optical coherence tomography instrument, method, and computer-readable medium. The instrument includes a scanner defining an apparent point source for scanning sample light across a subject position and an objective having a posterior imaging configuration to project the apparent point source onto a pivot point between the objective and the subject position. The objective is settable between the posterior imaging configuration for scanning the sample light across a retina of an eye at the subject position and an anterior imaging configuration for scanning the sample light across a pivot plane. An axial region from which an interferogram is detectable extends across the pivot plane while the objective is in the anterior imaging configuration. A pupil alignment method uses the anterior imaging modality to obtain a structure position of a structure of an eye's anterior segment and then an offset between the structure position and a reference position.

Abstract: An information processing apparatus that is communicably connected with another information processing apparatus, the information processing apparatus comprises: a processor configured to execute a program; and a storage device configured to store the program, the processor being configured to execute: acquisition processing of acquiring agreement information relating to the usage of subject eye image data of a patient by the other information processing apparatus; and transmission processing of transmitting the subject eye image data to the other information processing apparatus on the basis of the agreement information acquired by the acquisition processing.

Abstract: An ophthalmic scanning system includes a first imaging modality, a second imaging modality different from the first imaging modality, and a control system that maps the first imaging modality to the second imaging modality by compensating for at least one of an optical-mechanical and an electro-mechanical projection difference between the first and second imaging modalities. The control system provides a scan location for the second imaging modality based on a scan location of the first imaging modality.

Abstract: An information processing system comprises: an image acquisition device acquiring subject eye image data of a patient; and a first information processing device communicating with the image acquisition device and storing the image data, the image acquisition device transmits, to the first information processing device, the image data and first transmission data including additional information used to identify an image diagnosis device performing image diagnosis on the image data, the first information processing device: stores the image data when receiving the first transmission data from the image acquisition device; identifies, based on the additional information, a first image diagnosis device performing a first image diagnosis on the image data and/or a second image diagnosis device performing a second image diagnosis differing from the first image diagnosis on the image data; and transmits second transmission data including the image data to the identified image diagnosis device.

Abstract: An optical coherence tomography instrument suitable for imaging a retina is disclosed. In the instrument, an adjustable optical frequency shifter, which can be or include an acousto-optic modulator or electro-optic modulator, is arranged either (i) between a coupler and a reference optical system, (ii) in a reference optical system, (iii) between the coupler and a front-end optical system, or (iv) in a front-end optical system. The optical frequency of reference light or signal light may adjustably be increased or decreased. In operation, a subject is arranged such that its retina is in the focal depth of the front-end optical system. The increase or decrease in the optical frequency of the reference light or the sample light can be adjusted. Thereby, an interferogram representing a depth structure at the retina obtained between returning signal light and returning reference light may be brought to lie within a detection bandwidth of the instrument.

Abstract: A method of processing B-scans acquired by an OCT imaging system to generate correction data for compensating for axial displacements between B-scans caused by a variation in distance between the OCT imaging system and an imaging target, and to generate a reliability indicator indicative of a reliability of the correction data. The correction data is generated by determining, for each pair of adjacent B-scans, a respective indicator of an axial shift between respective representations of a common ocular feature in the adjacent B-scans. The reliability indicator is generated by: calculating values indicative of speeds or accelerations of the imaging target relative to the OCT imaging system when pairs of B-scans were acquired; where at least a predetermined number of calculated values exceed a threshold, setting the reliability indictor to indicate that the correction data is unreliable, and otherwise to indicate that the correction data is reliable.

Abstract: A method of processing C-scan data, which comprises a sequence of B-scans of an imaging target acquired by an OCT imaging system, to generate correction data for compensating for axial displacements between B-scans in the sequence caused by a relative motion of the OCT imaging system and the imaging target that varies a distance therebetween during acquisition of the B-scans, the correction data being generated by determining, for each pair of adjacent B-scans of a plurality of pairs of adjacent B-scans in the sequence, a respective indicator of an axial shift between respective representations of a common ocular feature in the adjacent B-scans; and determining, from a variation of the determined indicators with locations of the corresponding pairs of adjacent B-scans in the sequence, a first frequency component of the variation which is indicative of the relative motion during acquisition of the B-scans.

Abstract: An ophthalmic device includes a scanning member, an objective lens, and an optical element. The objective lens includes a first lens group and a second lens group in order from the scanning member side. The optical element is capable of being inserted into and removed from an optical path between the second lens group of the objective lens and the scanning member. In a case in which the optical element is not inserted into the optical path, the objective lens configures a first observation optical system. In a case in which the optical element has been inserted into the optical path, the objective lens and the optical element configure a second observation optical system.

Abstract: A method of determining a geometrical measurement of a retina of an eye, comprising obtaining a two dimensional representation of at least a portion of the retina of the eye (34), deriving a geometrical remapping which converts the two dimensional representation of the retinal portion to a three dimensional representation of the retinal portion (36), using one or more coordinates of the two dimensional representation of the retinal portion to define the geometrical measurement to be taken of the retina on the two dimensional representation (38), using the geometrical remapping to convert the or each coordinate of the two dimensional representation of the retinal portion to an equivalent coordinate of the three dimensional representation of the retinal portion (40), and using the or each equivalent coordinate of the three dimensional representation of the retinal portion to determine the geometrical measurement of the retina of the eye (42).