Patents Assigned to Oregon Health Sciences University
  • THERAPEUTIC CONSTRUCTS FOR CO-DELIVERY OF MITOTIC KINASE INHIBITOR AND IMMUNE CHECKPOINT INHIBITOR
    Publication number: 20220071906
    Abstract: Disclosed herein are therapeutic constructs including a delivery particle, at least one mitotic kinase inhibitor, and at least one immune checkpoint inhibitor. Also disclosed are therapeutic constructs including a mitotic kinase inhibitor, an immune checkpoint inhibitor, and a chemical linker. These therapeutic constructs cause cancer death by both therapeutic and immune effects and promote targeted delivery of more therapeutics to the surviving cancer cells in a positive feed-back loop. They enhance therapeutic index of free drugs and can be used intratumorally or systemically. This strategy can treat broad cancer types and is particular useful for cancer without obvious receptors for cancer-targeted delivery of otherwise toxic therapeutics.
    Type: Application
    Filed: November 23, 2021
    Publication date: March 10, 2022
    Applicants: Oregon Health & Science University, PDX Pharmaceuticals, Inc.
    Inventors: Wassana Yantasee, Moataz Reda, Worapol Ngamcherdtrakul
  • Recombinant HCMV and RHCMV vectors and uses thereof
    Patent number: 11266732
    Abstract: The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 8, 2022
    Assignee: Oregon Health & Science University
    Inventors: Louis Picker, Jay A. Nelson, Klaus Frueh, Michael A. Jarvis, Scott G. Hansen
  • Detecting avascular areas using neural networks
    Patent number: 11263747
    Abstract: An example method includes generating, using a multi-scale block of a convolutional neural network (CNN), a first output image based on an optical coherence tomography (OCT) reflectance image of a retina and an OCT angiography (OCTA) image of the retina. The method further includes generating, using an encoder of the CNN, at least one second output image based on the first output image and generating, using a decoder of the CNN, a third output image based on the at least one second output image. An avascular map is generated based on the third output image. The avascular map indicates at least one avascular area of the retina depicted in the OCTA image.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: March 1, 2022
    Assignee: Oregon Health & Science University
    Inventors: Yali Jia, Yukun Guo
  • TRANSLATION OF IMAGES OF STAINED BIOLOGICAL MATERIAL
    Publication number: 20220058839
    Abstract: Techniques and systems for translating images of biological samples stained according to a first staining technique into images representing the biological samples stained according to a second staining technique. In various implementations, the first staining technique can include a histopathological staining technique and the second staining technique can include an immunofluorescence staining technique or an immunohistochemistry staining technique.
    Type: Application
    Filed: December 30, 2019
    Publication date: February 24, 2022
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Young Hwan Chang, Erik Burlingame, Geoffrey Schau, Joe W. Gray
  • NEAR-INFRARED NERVE-SPARING BENZO[C]PHENOXAZINE FLUOROPHORES
    Publication number: 20220041619
    Abstract: Provided are near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.
    Type: Application
    Filed: September 11, 2019
    Publication date: February 10, 2022
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Summer L. Gibbs, Lei G. Wang, Connor W. Barth
  • Immunotherapeutic constructs and methods of their use
    Patent number: 11235058
    Abstract: Disclosed herein are immunotherapeutic constructs comprising a delivery particle, at least one adjuvant, and one or more therapeutic agents/compounds that cause antigen release and/or modulate immunosuppressive tumor microenvironment. These immunotherapeutic constructs create adaptive immunity or anti-cancer immune response(s) that can be used, for instance, to prevent and treat broad types of cancer. Further disclosed are uses of the immunotherapeutic constructs, including to prevent and treat cancer in humans and animals.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: February 1, 2022
    Assignees: Oregon Health & Science University, PDX Pharmaceuticals, Inc.
    Inventors: Wassana Yantasee, Amanda Lund, Worapol Ngamcherdtrakul, Moataz Reda
  • Therapeutic constructs for co-delivery of mitotic kinase inhibitor and immune checkpoint inhibitor
    Patent number: 11224573
    Abstract: Disclosed herein are therapeutic constructs including a delivery particle, at least one mitotic kinase inhibitor, and at least one immune checkpoint inhibitor. Also disclosed are therapeutic constructs including a mitotic kinase inhibitor, an immune checkpoint inhibitor, and a chemical linker. These therapeutic constructs cause cancer death by both therapeutic and immune effects and promote targeted delivery of more therapeutics to the surviving cancer cells in a positive feed-back loop. They enhance therapeutic index of free drugs and can be used intratumorally or systemically. This strategy can treat broad cancer types and is particular useful for cancer without obvious receptors for cancer-targeted delivery of otherwise toxic therapeutics.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: January 18, 2022
    Assignees: Oregon Health & Science University, PDX Pharmaceuticals, Inc.
    Inventors: Wassana Yantasee, Moataz Reda, Worapol Ngamcherdtrakul
  • Enteral feeding tube housing and fixation devices
    Patent number: 11213461
    Abstract: Enteric feeding tube housings configured to secure a feeding tube to the body are disclosed. The housing includes a disc having a hole configured to accommodate the feeding tube and two or more holes configured to accommodate fasteners. Also disclosed are enteric feeding tube housings that include a disc having a hole configured to accommodate the feeding tube and two or more holes configured to accommodate fasteners, and a plurality of fasteners. Also disclosed are surgical kits that include a housing, a plurality of fasteners, and a plurality of locking devices configured to adjustably secure the fasteners in the fastener receiving holes, and method of using the disclosed devices.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: January 4, 2022
    Assignee: Oregon Health & Science University
    Inventors: James P. Dolan, Younes Jahangiri Noudeh, Niloy Ghosh
  • Cross-linked polymer modified nanoparticles
    Patent number: 11207428
    Abstract: Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: December 28, 2021
    Assignees: Oregon Health & Science University, PDX Pharmaceuticals, Inc.
    Inventors: Wassana Yantasee, Worapol Ngamcherdtrakul, Jingga Morry, David Castro, Joe Gray
  • CROSS-LINKED POLYMER MODIFIED NANOPARTICLES
    Publication number: 20210393806
    Abstract: Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.
    Type: Application
    Filed: August 10, 2021
    Publication date: December 23, 2021
    Applicants: OREGON HEALTH & SCIENCE UNIVERSITY, PDX Pharmaceuticals, Inc.
    Inventors: Wassana Yantasee, Worapol Ngamcherdtrakul, Jingga Morry, David Castro, Joe William Gray
  • Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
    Patent number: 11197889
    Abstract: Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: December 14, 2021
    Assignees: ABT Holding Company, Oregon Health & Science University
    Inventors: Richard Maziarz, Magdalena Kovacsovics, Philip Streeter, Robert Deans, Wouter Van't Hof
  • METHODS FOR INCREASING YIELD OF SEQUENCING LIBRARIES
    Publication number: 20210380972
    Abstract: The present disclosure is concerned with compositions, methods, and kits for preparing a sequencing library. In one embodiment, methods include producing a library of target nucleic acids having the same adapter at each end and then switching the identity of one adapter to result in target nucleic acids flanked by distinct adapters.
    Type: Application
    Filed: June 10, 2021
    Publication date: December 9, 2021
    Applicants: Illumina, Inc., Illumina Cambridge Limited, Oregon Health & Science University
    Inventors: Andrew C. Adey, Ryan Mulqueen, Frank Steemers, Dmitry K Pokholok, Fan Zhang, Esther Musgrave-Brown
  • RECOMBINANT POLYPEPTIDES COMPRISING MODIFIED MHC CLASS II DRa1 DOMAINS AND METHODS OF USE
    Publication number: 20210380660
    Abstract: Recombinant polypeptides comprising a modified DR?1 domain are provided. In some embodiments, the polypeptides include the modified DR?1 domain, an antigenic peptide, and optionally a linker sequence. Pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said recombinant polypeptides or pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides are also provided.
    Type: Application
    Filed: October 4, 2019
    Publication date: December 9, 2021
    Applicants: Oregon Health & Science University, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Roberto Meza-Romero, Arthur A. Vandenbark, Halina Offner
  • Real time monitoring and prediction of motion in MRI
    Patent number: 11181599
    Abstract: Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: November 23, 2021
    Assignees: Washington University, Oregon Health and Science University
    Inventors: Nico Dosenbach, Jonathan Koller, Andrew Van, Abraham Snyder, Amy Mirro, Damien Fair, Eric Earl, Rachel Klein, Oscar Miranda Dominguez, Anders Perrone
  • IMMUNOMODULATORY PROPERTIES OF MULTIPOTENT ADULT PROGENITOR CELLS AND USES THEREOF
    Publication number: 20210346429
    Abstract: Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.
    Type: Application
    Filed: July 12, 2021
    Publication date: November 11, 2021
    Applicants: ABT Holding Company, Oregon Health & Science University
    Inventors: Richard MAZIARZ, Magdalena KOVACSOVICS, Philip STREETER, Robert DEANS, Wouter VAN'T HOF
  • AUXETIC STENTS FOR MANAGING VENOUS STENOSIS
    Publication number: 20210346180
    Abstract: Stents useable for treating venous stenosis are disclosed. In embodiments, a stent is configured to be auxetic, expanding axially as it is expanded radially, to prevent the imposition of tension on portions of a blood vessel adjacent to the stented portion of the blood vessel, and thereby prevent a narrowing of the adjacent portions and improving luminal gain. The stent may include one or more cross members that are deformable axially, to allow the axial length of the stent to be adjusted while maintaining a constant diameter, and further to allow the stent to be curved to conform to vessel curvature.
    Type: Application
    Filed: January 10, 2020
    Publication date: November 11, 2021
    Applicant: Oregon Health & Science University
    Inventors: Ramsey Al-Hakim, Khashayar Farsad, John Kaufman, Craig Bonsignore
  • BIOABSORBABLE CLIPS AND APPLICATOR FOR TISSUE CLOSURE
    Publication number: 20210322010
    Abstract: Surgical clips and surgical applicators used in performing rapid tissue closure in either minimally invasive surgeries or traditional open procedures are provided. In one example approach, a surgical clip comprises opposing sides extending from a top portion and terminating at tips positioned below the top portion. The resting position of the clip is its closed position, and in the closed position, the tips are set at a first distance apart. Each side has a cut-out (or hole or aperture) opposite one another. Each cut-out is fully surrounded by the side and does not extend to the top or tips. Each cut-out is configured to engage an inwardly turned hook at the end of a clip array or clip applicator such that the sides bend outwardly away from each other when pressure is applied on the top portion of the clip, thereby placing the clip in an open position.
    Type: Application
    Filed: July 1, 2021
    Publication date: October 21, 2021
    Applicant: Oregon Health & Science University
    Inventors: Neil Roundy, Rachel Dreilinger
  • NEAR-INFRARED NERVE-SPARING FLUOROPHORES
    Publication number: 20210317137
    Abstract: Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.
    Type: Application
    Filed: July 26, 2019
    Publication date: October 14, 2021
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Summer L. Gibbs, Lei G. Wang, Connor W. Barth
  • ACTIVITY MRI
    Publication number: 20210304899
    Abstract: Methods, computer-readable storage media and systems are described for constructing a three-dimensional electronic library of simulated decays of the diffusion-weighted 1H2O MR signal in b-space. Methods, computer-readable media, and systems are described for preparing a parametric tissue map for tissue in a subject. Computer readable media, having an electronic library of simulated decays of the diffusion-weighted 1H2O signal in b-space and method of using such a library.
    Type: Application
    Filed: April 6, 2018
    Publication date: September 30, 2021
    Applicants: Oregon Health & Science University, University of Washington
    Inventors: Charles Springer, Gregory Wilson, Jeffrey Maki, Thomas Barbara, Xin Li, William Rooney, Wei Huang, Brendan Moloney, Eric Baker
  • AMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
    Publication number: 20210284599
    Abstract: Amide compounds are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds as well as methods of treating neurodegenerative diseases that involve administering the compounds or pharmaceutical compositions to a subject.
    Type: Application
    Filed: August 14, 2017
    Publication date: September 16, 2021
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Thomas S. SCANLAN, James Matthew MEINIG, Skylar J. FERRARA, Tapasree BANERJI, Tania BANERJI