Patents Assigned to Orion-yhtyma Oy
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Patent number: 5622251Abstract: The invention relates to a transfer device for performing a regular, linear transfer movement including a body (1), provided with a threaded bar (2), a stepping motor (3) for driving the threaded bar (2), two guide bars (4, 5), a slide (6), and a follower (7) connected to it. The slide (6) is moved along the guide bars (4, 5) by the follower (7), which transforms the rotational movement of the threaded bar (2) into a linear transfer movement. The object to be transferred with the transfer bar (2) is attachable to the slide (6). The invention is characterized by the fact that the slide (6) includes an opening (8), through which the threaded bar (2) is fitted to pass with some play, and in connection with the opening (8) there is a follower (7), having a tongue (9), which is fitted to follow the threaded groove (10) of the threaded bar (2), so that the rotational movement (A, B) of the threaded bar is transformed into a linear movement of the slide (6) via the follower (7).Type: GrantFiled: January 12, 1995Date of Patent: April 22, 1997Assignee: Orion-Yhtyma OYInventor: Matti Rantanen
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Patent number: 5620697Abstract: An ultrasonic processing method by which polymer/drug composites can be quickly and efficiently molded to form matrix-type drug delivery systems is disclosed. The advantages of the method include speed and good control of the process. It also causes less degradation in polymers and/or drugs than most conventional processing methods.Type: GrantFiled: June 30, 1995Date of Patent: April 15, 1997Assignees: Orion-Yhtyma Oy, Leiras OyInventors: Pertti O. Tormala, Saila S. Miettinen-Lahde
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Patent number: 5605700Abstract: Transdermal preparations containing as active ingredient toremifene or one of its metabolites N-demethyltoremifene or 4-hydroxy-toremifene or their pharmaceutically acceptable non-toxic salts are useful for the treatment of cancers localized in the skin or on a short distance form the skin such as metastatic lesions of breast cancer. They may also be used in adjuvant therapy of breast cancer and in the reversal of multidrug resistance of cancer cells to cytotoxic drugs. Such transdernal preparations are of particular interest in the treatment of melanoma, lymphoma, Kaposi's sarcoma and fungoides mycosis.Type: GrantFiled: October 31, 1994Date of Patent: February 25, 1997Assignee: Orion-Yhtyma OyInventors: Michael W. DeGregorio, Kauko O. A. Kurkela
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Patent number: 5576552Abstract: The invention relates to an image plate (1) for intraoral dental radiography which can be closed within a cover through which X-rays can pass, where the plate is retained during the X-raying and from where the plate can be removed after the X-raying in order to read the picture. According to the invention the edges of the image plate (1) are equipped with a protective frame (2) projecting from the plane of the plate surface at least on the image side of the plate. The frame may be formed as a continuous cover frame (2) surrounding the edges of the frame, consisting of two opposite frame-like portions (7) pressed together and optionally identical. The purpose of the frame (2) is to protect the image plate (1) against scratches or similar damages as the plate is being handled and read.Type: GrantFiled: April 10, 1995Date of Patent: November 19, 1996Assignee: Orion-Yhtyma OYInventor: Matti Rantanen
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Patent number: 5571534Abstract: This invention relates to parenteral preparations of antiestrogens such as toremifene, desmethyl toremifene, tamoxifen or desmethyltamoxifen. The preparations can be emulsions, liposomes or aqueous solutions of cyclodextrin-drug complexes. Particularly the invention relates to a parenteral drug formulation comprising a complex having a 2-hydroxypropyl cyclodextrin component and including an active drug substance selected from the group consisting of toremifene, desmethyl toremifene, tamoxifen and desmethyltamoxifen or a pharmaceutically acceptable non-toxic salt thereof, said complex being present either in an aqueous solution or emulsion or loaded into a liposome.Type: GrantFiled: July 7, 1994Date of Patent: November 5, 1996Assignee: Orion-yhtyma OyInventors: Harry G. Jalonen, Terttu M. Heikkila, Hannu U. Jalonen, Lauri V. M. Kangas, Risto A. S. Lammintausta, Kauko O. A. Kurkela
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Patent number: 5569657Abstract: The compound (-)-[[4-(1,4,5,6 tetrahydro-4-methyl-6-oxo-3 pyridazinyl) phenyl]-hydrazono] propane dinitrile and its salts are prepared and used for treating congestive heart failure.Type: GrantFiled: May 31, 1995Date of Patent: October 29, 1996Assignee: Orion-yhtyma OyInventors: Pentti Nore, Erkki Honkanen, Reijo B ackstr om, Tom Wikberg, Heimo Haikala, Jorma Haarala
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Patent number: 5559141Abstract: New 4(5)-imidazole derivatives of formula (Ia) and (Ib) wherein one of R.sub.1 and R.sub.2 is CN and the other one is H, CH.sub.3, OCH.sub.3, NO.sub.2, NH.sub.2, CN, CF.sub.3, CHF.sub.2, CH.sub.2 F or halogen; R' is H or (II) where R.sub.3 is H, CH.sub.3 or halogen; R.sub.4 is H and R.sub.5 is H or R.sub.4 and R.sub.5 together form a bond, n is 1 or 2 and y is 0 to 2, their stereoisomers and their non-toxic pharmaceutically acceptable acid addition salts exhibit selective aromatase inhibiting properties, compared with their desmolase inhibiting properties. The compounds of the invention are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).Type: GrantFiled: May 9, 1994Date of Patent: September 24, 1996Assignee: Orion-yhtyma OyInventors: Arto J. Karjalainen, Marja-Liisa Sodervall, Arja M. Kalapudas, Reino O. Pelkonen, Aire M. Laine, Risto A. Lammintausta, Jarmo S. Salonen
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Patent number: 5541211Abstract: The present invention is in the art of eliciting a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic neurotransmission male sexual activity response in penile erection. The improvement involves a more rapid onset of action and improved effect than that of yohimbine, consisting essentially of the step of administering the compound atipamezole or a pharmaceutically acceptable acid addition salt thereof to a male in need thereof. Atipamezole or pharmaceutically acceptable acid salt thereof may be administered perorally, intravenously, intramuscularly, transmucosally or transdermally.Type: GrantFiled: March 16, 1995Date of Patent: July 30, 1996Assignee: Orion-yhtyma OyInventors: Antti Pertovaara, Ilkka Linnankoski, Raimo Virtanen
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Patent number: 5518737Abstract: This invention describes a device for peroral administration of a therapeutic agent which is capable of existing in an unionized therapeutically active form. The device comprises a reservoir comprising the therapeutic agent in ionized form, which reservoir has a wall permeable to un-ionized material and impermeable to ionized material; and a solid material which upon uptake of water is converted to a buffer; the solid material having, on uptake of water, a pH which determines the rate of permeation of the therapeutic agent in un-ionized form through the reservoir wall. The device enables the release of the therapeutic agent to be controlled by the pH of the buffer and, if desired, the composition of the reservoir walls. The composition of the surrounding aqueous medium does not affect the rate of release.Type: GrantFiled: May 5, 1994Date of Patent: May 21, 1996Assignee: Orion-yhtyma OyInventors: Arto O. Urtti, Marja R. Sutinen, Timo P. Paronen
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Chiral resolution of an intermediate in diltiazem synthesis using lipase PS immobilized with sucrose
Patent number: 5514589Abstract: An enzymatic method for the preparation of (2S,3S)-threo-alkyl-2-hydroxy-3-(4-methoxyphenyl)-3-(2-X-phenylthio)propio nate, where X=NO.sub.2, NH.sub.2, NHCOCH.sub.3, NHCOCF.sub.3, NHCO.sub.2 CH.sub.3, NHCO.sub.2 C(CH.sub.3).sub.3 or NHCHO and R is an alkyl group, e.g., CH.sub.3, or CH.sub.2 CH.sub.3 in an essentially anhydrous organic solvent is described. In this method a lipase which stereospecifically acylates the (2R,3R)-enantiomer of the racemic mixture is used. After enzymatic reaction, the (2S,3S)-enantiomer and the acylated (2R,3R)-compound are separated, e.g., by flash-chromatography or by fraction crystallization of the (2S,3S)-compound from the reaction mixture.Type: GrantFiled: March 22, 1994Date of Patent: May 7, 1996Assignee: Orion-yhtyma Oy FermionInventors: Liisa Kanerva, Oskari Sundholm, Pekka Kairisalo, Martti Hytonen -
Patent number: 5512572Abstract: A method for preventing or treating myocardial ischemia in a mammalian organism is disclosed. The compound 4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl!hydrazono!prop anedinitrile or its enantiomer or a pharmaceutically acceptable salt there is administered to a mammalian organism in need of such prevention or treatment. The compound may be administered in its racemic form or in a form which is substantially free of the (+)-enantiomer or substantially free of the (-)-enantiomer.Type: GrantFiled: November 22, 1994Date of Patent: April 30, 1996Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Juoko M. Levijoki, Reijo J. Backstrom, Pentti T. Nore, Erkki J. Honkanen
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Patent number: 5512571Abstract: Diastereomeric intermediate salts of formulae (IIIa) or (IIIb) ##STR1## are prepared.Type: GrantFiled: May 31, 1995Date of Patent: April 30, 1996Assignee: Orion-yhtyma OyInventors: Pentti Nore, Erkki Honkanen, Reijo Backstrom, Tom Wikberg, Heimo Haikala, Jorma Haarala
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Patent number: 5498623Abstract: The invention provides compounds of the formula ##STR1## wherein Y is --CH.sub.2 -- or --CO--;R.sub.1 is F, Cl or OH; R.sub.2 is H, F or Cl; and R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3, excluding 4-(5-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole and 4-(4-chloro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole; and their non-toxic acid addition salts and mixtures thereof. Processes for the preparation of these compounds are described, as are pharmaceutical compositions comprising at least one of the compounds or its salt. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are highly selective and long acting antagonists at .alpha..sub.2 -adrenoceptors. Their peroral bioavailability is good. The compounds are especially useful in the treatment of cognitive disorders.Type: GrantFiled: September 19, 1994Date of Patent: March 12, 1996Assignee: Orion-yhtyma OyInventors: Arto J. Karjalainen, Raimo E. Virtanen, Arja L. Karjalainen, Maire M. Eloranta, Jarmo S. Salonen, Hannu T. Sipila, Antti S. Haapalinna
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Patent number: 5491173Abstract: The invention provides novel compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be the same or different are H or OH, R.sub.3 is ##STR2## wherein R.sub.4 and R.sub.5, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds include metabolites of toremifene and exhibit valuable pharmacological properties as oestrogenic, anti-oestrogenic, and progestanic agents.Type: GrantFiled: January 24, 1994Date of Patent: February 13, 1996Assignee: Orion-yhtyma OyInventors: Reijo J. Toivola, Arto J. Karjalainen, Kauko O. A. Kurkela, Marja-Liisa Soderwall, Lauri V. M. Kangas, Guillermo L. Blanco, Hannu K. Sundquist, Arja Kalapudas
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Patent number: 5489614Abstract: Known and new catechol derivates may be used as medicinal antioxidants in the prevention or treatment of tissue damage induced by lipid peroxidation. The conditions and diseases to be treated are for example heart disease, rheumatoid arthritis, cancer, inflammatory disease, a rejection reaction in organ transplants, ischemia, cancer and aging.Type: GrantFiled: June 5, 1995Date of Patent: February 6, 1996Assignee: Orion-yhtyma OyInventors: Tapio J. Korkolainen, Erkki A. O. Nissinen, Reijo J. Backstrom, Aino K. Pippuri
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Patent number: 5466561Abstract: The invention relates to an image plate (1) for intra-oral dental X-ray photography, the plate being placed in a shield (3) enveloping it for the duration of photography. According to the invention the shield has been made pervious to X-rays but impervious to visible light, and it comprises a closed shielding bag of plastic membrane. The shield may be made up of an inner shielding bag (3) impervious to light and a surrounding closed outer shielding bag which may be of transparent plastic membrane. After photography, the possible outer bag is first removed, the patient's saliva being removed along with it. Thereafter the image plate (1) and the surrounding shielding bag (3), one end (6) of which has been opened or, if an outer bag is used, is possibly already open, are introduced into the read-out apparatus, in which a pulling device grips the end of the plate in the bag, whereafter the bag can be pulled out while the plate remains in the read-out apparatus for the reading out of the image.Type: GrantFiled: September 2, 1994Date of Patent: November 14, 1995Assignee: Orion-Yhtyma OyInventor: Matti Rantanen
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Patent number: 5464628Abstract: This invention relates to a transdermal preparation comprising a therapeutically active compound of the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3, which can be the same or different are H, CH.sub.3, C.sub.2 H.sub.5 or Cl; X is CH.dbd.CH or (CH.sub.2).sub.n where n is 1 to 3 or X is --C(OR.sub.5)H-- where R.sub.5 is methyl or ethyl; and R.sub.4 is hydrogen or a straight alkyl of 1 to 4 carbon atoms. The transdermal administration of the compounds can be accomplished by preparations in the form of ointments, emulsions, lotions, solutions, creams or transdermal patches.Type: GrantFiled: November 12, 1993Date of Patent: November 7, 1995Assignee: Orion-yhtyma OyInventors: Harry Jalonen, Risto Lammintausta
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Patent number: 5446194Abstract: A compound according to formula 1 ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms or which is substituted with hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable esters and salts thereof, and a pharmaceutically acceptable carrier therefor, as well as pharmaceutical compositions containing said compounds as COMT inhibitors.Type: GrantFiled: September 16, 1993Date of Patent: August 29, 1995Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 5439928Abstract: Novel 4(5)-imidazole derivatives of specified formula and their non-toxic salts possess selective aromatase inhibiting properties, which are valuable in the treatment of estrogen dependent diseases e.g. breast cancer.Type: GrantFiled: May 19, 1993Date of Patent: August 8, 1995Assignee: Orion-yhtyma OyInventors: Arto J. Karjalainen, Reino O. Pelkonen, Marja-Liisa Sodervall, Matti A. Lahde, Risto A. S. Lammintausta, Arja L. Karjalainen, Arja M. Kalapudas
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Patent number: 5438067Abstract: Salts of medetomidine and optically active enantiomers, thereof, particularly the d-enantiomer are disclosed. These salts may be used to regulate the rate of the transdermal administration of active drugs. The transdermal delivery system comprises a drug impermeable backing layer and an adhesive layer wherein the medetomidine is dispersed throughout the adhesive layer.Type: GrantFiled: November 12, 1993Date of Patent: August 1, 1995Assignee: Orion-yhtyma OyInventors: Harry Jalonen, Arto Karjalainen