Patents Assigned to Orion-yhtyma Oy
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Patent number: 5185370Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.Type: GrantFiled: January 31, 1991Date of Patent: February 9, 1993Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Erkki J. Honkanen, Jarmo J. Pystynen, Anne M. Luiro, Paivi A. Aho, Inge-Britt Y. Linden, Erkki A. O. Nissinen, Pentti Pohto
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Patent number: 5185332Abstract: New heterocyclic compounds of formula I ##STR1## In which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 --group; R.sub.1 and R.sub.2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrgen or lower alkyl or R.sub.1 and R.sub.2 together form a susbtituted or unsubstituted 5 or 6 membered ring which may contain 1 to 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 means independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.Type: GrantFiled: March 15, 1991Date of Patent: February 9, 1993Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Erkki J. Honkanen, Kari K. Lonnberg, Pentti T. Nore, Jarmo J. Pystynen, Anne M. Luiro, Aino K. Pippuri
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Patent number: 5166437Abstract: An improved process for the preparation of fluoxetine. The invention is concerned with an improved process for the preparation of the antidepressant, fluoxetine hydrochloride, or N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride, by simultaneous debenzylation and catalytic hydrogenation of 2-benzoyl-1-(N-benzyl-N-methyl)ethylamine base with the aid of Pd/C, Pt/C or Pd-Pt/C at a hydrogen pressure of 5 bar at 50.degree. C. with ethyl acetate as a solvent to obtain 1-phenyl-3-(N-methylamino)-propan-1-ol. This compound is then selectively etherified with 1-chloro-4-trifluoromethylbenzene in N-methylpyrrolidone at 80.degree. C. in the presence of potassium t-butoxide to form N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, or fluoxetine base, which is transformed in a known manner to fluoxetine hydrochloride, or N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride. The yield of fluoxetine hydrochloride is 85-87% of the theoretical.Type: GrantFiled: November 23, 1990Date of Patent: November 24, 1992Assignee: Orion-Yhtyma OyInventors: Pekka J. Kairisalo, Petri J. Hukka, Anitta H. Jarvinen
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Patent number: 5157264Abstract: The invention relates to a supporting system of a sliding plate of a magazine comprising a magazine case and a sliding plate which travels in a linear direction inside the magazine case. The system is comprised of a guide bar that is secured to the lower cover of the magazine, parallel to the longitudinal axis of the lower cover. The sliding plate rests upon the guide bar and upon support screws arranged on the end part of the magazine case against the front portion of the sliding plate.Type: GrantFiled: July 30, 1991Date of Patent: October 20, 1992Assignee: Orion-Yhtyma OYInventors: Ilmari Kinanen, Matti Rantanen, Pertti Sormunen
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Patent number: 5135950Abstract: Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).Type: GrantFiled: October 31, 1990Date of Patent: August 4, 1992Assignee: Orion-yhtyma OyInventors: Aino K. Pippuri, Erkki J. Honkanen, Jorma V. Haarala
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Patent number: 5122524Abstract: New heterocyclic compounds of formula I ##STR1## in which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 -- group; R.sub.1 and R.sub.2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrogen or lower alkyl or R.sub.1 and R.sub.2 together form a substituted or unsubstituted 5 or 6 membered ring which may contain 1 or 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 mean independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.Type: GrantFiled: March 15, 1991Date of Patent: June 16, 1992Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Erkki J. Honkanen, Kari K. Lonnberg, Pentti T. Nore, Jarmo J. Pystynen, Anne M. Luiro, Aino K. Pippuri
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Patent number: 5112861Abstract: The invention concerns a method for the treatment of Parkinson's Disease. The method comprises administering a catechol-O-methyl-transferase inhibiting amount of a compound having the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkylcarbamoyl of 2 to 5 carbon atoms or alkylcarbonyl of 2 to 5 carbon atoms, X represents nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano; alkylcarbonyl of 2 to 5 carbon atoms; or carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, or hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable salts or esters thereof; and a sufficient amount of levodopa to treat Parkinson's Disease. A peripheral decarboxylase inhibitor such as carbidopa or benzerazide is also preferably administered.Type: GrantFiled: September 25, 1990Date of Patent: May 12, 1992Assignee: Orion-yhtyma OyInventors: Reijo Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka I. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo Pystynen
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Patent number: 5107843Abstract: The invention relates to a method for thin needle biopsy in connection with mammography, wherein a stationary target is radiographed from two angles by means of a rotating picture head, the pictures are placed on a separate measurement table, and the x-, y-, and z-coordinates of the desired site in the target are calculated on the basis of the two pictures in a known manner.Type: GrantFiled: April 5, 1991Date of Patent: April 28, 1992Assignee: Orion-Yhtyma OyInventors: Jaakko A. Aarnio, Terho Turkumaki
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Patent number: 5091402Abstract: This invention relates to local epidural or intraspinal use of compounds of the formula: ##STR1## where X is H or CH.sub.3 and R.sub.1 and R.sub.2, which can be the same or different, are each H or CH.sub.3 and their stereoisomers and their non-toxic, pharmaceutically acceptable salts. Especially useful are the compounds known under the generic names medetomidine ((.+-.)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole), dexmedetomidine (+)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole and detomidine 4-(2,3-dimethylbenzyl)-1H-imidazole.Type: GrantFiled: October 17, 1990Date of Patent: February 25, 1992Assignee: Orion-Yhtyma OYInventors: Eija Kalso, Risto Lammintausta
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Patent number: 5086058Abstract: A method for treating alcoholism. The alcohol-drinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.Type: GrantFiled: June 4, 1990Date of Patent: February 4, 1992Assignees: Alko Ltd., Orion-Yhtyma OyInventors: John D. Sinclair, Harry Scheinin, Risto Lammintausta
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Patent number: 5043331Abstract: A method is provided for the treatment of postmenopausal disorders which comprises administering to a woman in single, oral, daily dose form during an uninterrupted consecutive sequence of 90 days.(a) a daily, oral, dose in an uninterrupted consecutive sequence for 69 days starting on the first day of a naturally occurring or synthetic estrogenic compound effective in the prevention of climacteric symptoms;(b) a daily, oral dose in an uninterrupted consecutive sequence from the 70th day to the 83rd day following said first day, of a naturally occurring or synthetic estrogenic compound and a compound having progestational activity effective in preventing the development of endometrial hyperplasia; and optionally(c) a daily, oral dose in an uninterrupted consecutive sequence from the 84th to the 90th day following said first day, of a compound free of estrogen and progestogen.Type: GrantFiled: June 15, 1989Date of Patent: August 27, 1991Assignee: Orion-yhtyma OyInventors: Erkki Hirvonen, Ariel Gordin
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Patent number: 5033070Abstract: A panoramic method for the radiography of the dental arch and jaws, in which method by means of movable radiographing and/or imaged elements, several subsequent exposure sweep sequences are performed so that the moving elements are transferred to a new position betwen the subsequent exposure sequences. In order to achieve a perfectly jointed X-ray picture, the movement of the moving elements is started before the switch-on instant of the X-ray beam in the latter exposure sequence and the starting positions of said elements is selected so as to obtain desired positions and velocities for the elements at the switch-on instant of the X-ray beam. The coincidence of the X-ray beam orientation at the start of the latter exposure sequence with the X-ray beam orientation at the end of the preceding sequence is characterizing to an embodiment of the invention.Type: GrantFiled: January 9, 1990Date of Patent: July 16, 1991Assignee: Orion-Yhtyma OyInventors: Heikki K. J. Kanerva, Erkki H. Tammisalo, Pasi T. Mustalahti, Olli J. Ojala
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Patent number: 5019575Abstract: New heterocyclic compounds of formula I ##STR1## in which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 --group; R.sub.1 and R.sub.2 independently means nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrogen or lower alkyl or R.sub.1 and R.sub.2 together form a substituted or unsubstituted 5 or 6 membered ring which may contain 1 or 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 mean independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.Type: GrantFiled: February 9, 1990Date of Patent: May 28, 1991Assignee: Orion-yhtyma OyInventors: Heimo O. Haikala, Erkki J. Honkanen, Kari K. Lonnberg, Pentti T. Nore, Jarmo J. Pystynen, Anne M. Luiro, Aino K. Pippuri
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Patent number: 5000645Abstract: The invention concerns an apparatus (10) for handling containers, load pallets or similar load units comprising an auxiliary body (12) on which the container or similar load object can be disposed to be movable, the auxiliary body being turnable relative to a body or chassis (11). The apparatus comprises a coupler connected to the auxiliary body (12), by the aid of which coupler the container or equivalent can be moved higher on the auxiliary body and off of the auxiliary body. The coupler comprises a tilting cylinder (17) between the body or chassis (11) and the auxiliary body (12) and a lifting cylinder (16) between the body or chassis (11) and the auxiliary body (12), and an intermediate lever (13). The intermediate lever (13) is at one end with a pivot (21) turnably connected to the auxiliary body (12) and at the other end with a pivot (20) to the body (11).Type: GrantFiled: June 20, 1989Date of Patent: March 19, 1991Assignee: Orion-Yhtyma Oy NormetInventor: Raimo J. Polojarvi
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Patent number: 4991672Abstract: The invention concerns an automatic control system for the transfer of the drive power between a tractor (10) and a trailer (11), which system comprises a closed hydraulic circuit (43) that operates the drive wheels of the tractor (10) and an open hydraulic circuit (25) that operates the drive wheels (17a,17b) of the trailer. In the system, the closed hydraulic circuit (43) of the tractor (10) includes a pump (15) and a hydraulic motor (16) driven by the pump and, in a corresponding way, the open hydraulic circuit (25) of the trailer (11) comprises a motor or motors (21a,21b) driven by a pump (20). The control system comprises a line (42) that transmits a control pressure (P.sub.2) from the closed circuit (43) of the tractor (10) to the open circuit (25) of the trailer (11). When the resistance to traction increases, e.g. when driving up a steep hill, the pressure (P.sub.2) in the transmitting line (42) increases and, because of this pressure (P.sub.Type: GrantFiled: October 25, 1989Date of Patent: February 12, 1991Assignee: Orion-Yhtyma Oy NormetInventor: Reijo Leino
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Patent number: 4963590Abstract: Pharmacologically active catechol derivatives of formula I ##STR1## wherein R.sub.1 and R.sub.2 independently comprise hydrogen, alkyl, acyl, optionally substituted aroyl, lower alkylsulfonyl or alkylcabamoyl or taken together form a lower alkylidene or cycloalkylidene, X comprises an electronegative substituent such as halogen, nitro, cyano, lower alkylsulfonyl, sulfonamido, aldehyde, caboxyl or trifluoromethyl and R.sub.3 comprises hydrogen, halogen, hydroxy alkyl, amino, nitro, cyano, trifluoromethyl, lower alkylsulfonyl, sulfonamide, aldehyde, alkyl carbonyl, aralkylidene carbonyl or carboxyl or a group selected from ##STR2## wherein R.sub.4 comprises hydrogen, alkyl, cyano, carboxyl or acyl and R.sub.5 comprises hydrogen, cyano, carboxyl, alkoxycarbonyl, carboxyalkenyl, nitro, acyl, optionally substituted aroyl or heteroaroyl, hydroxyalkyl or carboxyalkyl or R.sub.4 and R.sub.5 together form a five to seven membered substituted cycloalkanone ring;--(CO).sub.n (CH.sub.2).sub.Type: GrantFiled: November 27, 1987Date of Patent: October 16, 1990Assignee: Orion-yhtyma OyInventors: Reijo J. Backstrom, Kalevi E. Heinola, Erkki J. Honkanen, Seppo K. Kaakkola, Pekka J. Kairisalo, Inge-Britt Y. Linden, Pekka T. Mannisto, Erkki A. O. Nissinen, Pentti Pohto, Aino K. Pippuri, Jarmo J. Pystynen
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Patent number: 4935247Abstract: The invention relates to a new composition for use on a pharmaceutical granule. The composition is three-layered, comprising as the innermost layer a substantially pure fat, as the middle layer a mixture of fat and polymer, and as the outermost layer again a substantially pure fat.The composition according to the invention produces a preparation which is tasteless, especially when administered in the form of a powder or a mixture, even if the phrmaceutical to be dosed has a bad taste. Also, the preparation keeps well in mixture, and it enables a pharmaceutical to be transported past the stomach for release/absorption at the beginning of the small intestine.Type: GrantFiled: May 6, 1988Date of Patent: June 19, 1990Assignee: Orion-Yhtyma OyInventors: Esko Marttila, Ilkka Larma, Kari Vahervuo, Jaakko Uotila
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Patent number: 4910756Abstract: The invention relates to a mammography device, having a frame column (3) comprising a slide (2) mounted vertically (Z) slidingly onto bearings, into the horizontal axis of which the photography head (1) is pivotally mounted onto bearings. According to the invention, the control device (10), the photography head (1) being tilted, guides the hoisting mechanism (M1) of the slide (2) according to a preset program and to the observed angle of inclination (.OMEGA.) in such a way that the center point of the support plate (6) in the photography head is at essentially the same height above the support (20) at the end of the tilting movement.Type: GrantFiled: January 10, 1989Date of Patent: March 20, 1990Assignee: Orion - Yhtyma OyInventors: Hannu Mikkonen, Tuomas Kyllonen
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A process for the preparation of anhydrous, stable, crystalline delta-form of prazosin hydrochloride
Patent number: 4873330Abstract: Anhydrous, stable, crystalline .delta.-form of prazosin hydrochloride, having an infrared spectrum in potassium bromide of FIG. 1 having the following sharp absorption bands at 7.95.mu., 13.3.mu., and a triplet at 9.95.mu. and the x-ray diffractogram of FIG. 2 having sharp bands in 10.5.degree., 12.0.degree., 16.9.degree., and doublets in 24.5.degree. and 26.5.degree.. The .delta.-form of prazosin hydrochloride is prepared by removing the water of crystallization of prazosin hydrochloride hydrate by azeotropic distillation with selected organic solvents having a boiling point in the range of 55.degree.-160.degree. C. The .delta.-form of prazosin hydrochlorie is useful as a hypotensive agent.Type: GrantFiled: February 8, 1988Date of Patent: October 10, 1989Assignee: Orion-yhtyma OyInventor: Stig O. E. Lindholm -
Patent number: D323892Type: GrantFiled: April 11, 1988Date of Patent: February 11, 1992Assignee: Orion-Yhtyma OyInventor: Davor Spoljaric