Abstract: The invention provides novel compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be the same or different are H or OH, R.sub.3 is ##STR2## wherein R.sub.4 and R.sub.5, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds include metabolites of toremifene and exhibit valuable pharmacological properties as oestrogenic, anti-oestrogenic, and progestanic agents.

Abstract: Known and new catechol derivates may be used as medicinal antioxidants in the prevention or treatment of tissue damage induced by lipid peroxidation. The conditions and diseases to be treated are for example heart disease, rheumatoid arthritis, cancer, inflammatory disease, a rejection reaction in organ transplants, ischemia, cancer and aging.

Abstract: The invention relates to an image plate (1) for intra-oral dental X-ray photography, the plate being placed in a shield (3) enveloping it for the duration of photography. According to the invention the shield has been made pervious to X-rays but impervious to visible light, and it comprises a closed shielding bag of plastic membrane. The shield may be made up of an inner shielding bag (3) impervious to light and a surrounding closed outer shielding bag which may be of transparent plastic membrane. After photography, the possible outer bag is first removed, the patient's saliva being removed along with it. Thereafter the image plate (1) and the surrounding shielding bag (3), one end (6) of which has been opened or, if an outer bag is used, is possibly already open, are introduced into the read-out apparatus, in which a pulling device grips the end of the plate in the bag, whereafter the bag can be pulled out while the plate remains in the read-out apparatus for the reading out of the image.

Abstract: This invention relates to a transdermal preparation comprising a therapeutically active compound of the formula: ##STR1## where R.sub.1, R.sub.2, and R.sub.3, which can be the same or different are H, CH.sub.3, C.sub.2 H.sub.5 or Cl; X is CH.dbd.CH or (CH.sub.2).sub.n where n is 1 to 3 or X is --C(OR.sub.5)H-- where R.sub.5 is methyl or ethyl; and R.sub.4 is hydrogen or a straight alkyl of 1 to 4 carbon atoms. The transdermal administration of the compounds can be accomplished by preparations in the form of ointments, emulsions, lotions, solutions, creams or transdermal patches.

Abstract: A compound according to formula 1 ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms or which is substituted with hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable esters and salts thereof, and a pharmaceutically acceptable carrier therefor, as well as pharmaceutical compositions containing said compounds as COMT inhibitors.

Abstract: Novel 4(5)-imidazole derivatives of specified formula and their non-toxic salts possess selective aromatase inhibiting properties, which are valuable in the treatment of estrogen dependent diseases e.g. breast cancer.

Abstract: Salts of medetomidine and optically active enantiomers, thereof, particularly the d-enantiomer are disclosed. These salts may be used to regulate the rate of the transdermal administration of active drugs. The transdermal delivery system comprises a drug impermeable backing layer and an adhesive layer wherein the medetomidine is dispersed throughout the adhesive layer.

Abstract: This invention relates to the use of a compound of formula ##STR1## wherein X is --CH.sub.2 -- or ##STR2## R.sub.1 is H, C.sub.1-5 -alkyl or benzyl, which can be substituted of unsubstituted; R.sub.2 is H, C.sub.1-4 -alkyl, C.sub.1-4 -alkenyl, OH, or C.sub.1-3 -alkoxy; R.sub.3 is H, CH.sub.3, C.sub.2 CH.sub.3, OCH.sub.3, or Hal; R.sub.4 H, CH.sub.3, C.sub.2 CH.sub.3, OCH.sub.3, or Hal, and Hal is halogen, provided that when R.sub.2 is OH or C.sub.1-3 -alkoxy then X cannot be CO or a non-toxic pharmaceutically acceptable salt thereof for the use in the treatment of age related memory impairment or cognitive disorders, particularly Alzheimer's Disease.

Abstract: Optically substantially pure (-) enantiomer of [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono)prop anedinitrile or pharmaceutically acceptable salt thereof, intermediates and a process for the preparation are described. The product is useful as a cardiotonic agent, antihypertensive and vasodilator for the treatment of congestive heart failure.

Abstract: A radiation image read-out apparatus which comprises an optical system for exposing a stimulable phosphor plate (1) which contains a latent radiation image to a stimulating beam, and a light collector (3) for directing the stimulated light generated in the phosphor plate (1) to a photodetector (4), for example, a photomultiplier tube. Such read-out apparatuses often have the disadvantage that sufficient light cannot be collected into the photodetector. This problem has been solved by using a shiny mirror tube as the light collector.

Abstract: The invention relates to a method for imaging a desired object by using a panoramic X-ray radiography apparatus equipped with exposure automatics, the apparatus including an X-ray generator (5), an X-ray tube (6), and an image receptor (8) with its holder (10). The detecting of the cone of rays (7) which has passed through the object, for the purpose of determining the exposure value, is carried out during the imaging at points positioned in each given case at different heights (17) in the cone of rays, by using one or more detectors (1). The positioning can be done either by moving the detector or by activating a certain detector in an arrangement of a number of detectors.

Abstract: The invention relates to a method used in the panoramic X-ray photography of a patient's set of teeth and a device for carrying out constant enlargement also in those spots (21) of the dental arch where the X-ray beam (12) is not perpendicular to the tangent (23) of the dental arch (20). Constant enlargement is achieved by selecting, on the film (13), a speed profile which follows the formula: v.sub.f =((A+B/A).times.v1.times.1/ cos (b), where v.sub.f is the speed of the film, v.sub.1 is a component of the propagation speed of the intersection of the X-ray beam and the spot to be photographed which is perpendicular to the X-ray beam, A is the distance between the focus of the X-ray source and the spot to be photographed, B is the distance between the spot to be photographed and the film, and b is the angle between the tangent (23) of the spot in question of the dental arch and the normal (22) of the X-ray beam.

Abstract: A method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde by reacting 4-hydroxy-3-methoxy-5-nitrobenzaldehyde with a strong nucleophilic agent which may be created by reacting an aromatic mercapto compound with a strong organic or inorganic alkali metal base such as lithium hydroxide. The reaction is performed at elevated temperatures using an aprotic polar solvent. It is preferably carried out in an inert atmosphere.

Abstract: A method for detecting and quantifying mutans streptococci in the saliva of an individual is provided comprising the steps of(a) collecting a sample of saliva on the surface of a solid carrier strip;(b) introducing the sample on the solid carrier strip into a liquid medium which is selective for mutans streptococci and incubating in the liquid medium for a period of time sufficient to allow growth of visible colonies of mutans streptococci; and(c) detecting and counting colonies of mutans streptococci on the surface of the solid carrier strip. The invention further provides a kit for carrying out the method of the invention. The kit includes a solid carrier strip for obtaining a sample, an incubation vessel sized to accept the solid carrier strip, and a selective medium for growth of mutans streptococci.

Abstract: The invention relates to a panoramic X-ray photography apparatus having a rotatably mounted supporting arm (1) which has at one end an X-ray source (2) and at the opposite end an image receptor (3), in which case the object is placed between the X-ray source (2) and the image receptor (3) and the imaging is carried out by rotating the supporting arm. The idea of the invention is that a simple panoramic X-ray photography apparatus can also be used for tomography, since the object to be imaged, i.e. the denture, contains mainly vertical surfaces and a horizontal oscillating movement suffices for blurring them. An additional idea is that by moving the bearing shaft (4) of the supporting arm along a circle arc portion during blurring, the fulcrum can be shifted to outside the bearing shaft, thus eliminating certain limitations imposed by the mechanics of a conventional X-ray photography apparatus with respect to the area to be imaged and the location of the supporting arm.

Abstract: Compounds of formula(I) ##STR1## wherein R.sub.1 is nitro, halo, cyano and R.sub.2 is a group selected from ##STR2## wherein Y is oxygen or sulfur; X.sub.1 is NR wherein R is hydrogen, C.sub.1-8 alkyl or phenyl and pharmaceutically acceptable salts thereof are useful in the prevention or treatment of tissue damage induced by lipid peroxidation.

Abstract: 4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, known as medetomidine, and in particular its d-enantiomer and salts thereof are useful in perioperative care, in particular in reducing the amount of anaesthetic it is necessary to administer.

Abstract: The degradation of type III collagen in the body is quantitatively determined by measuring the concentration of the liberated aminoterminal telopeptide region of the type III collagen molecule in the body fluid by a specific immunological method. This degredation product is resistant to further degradation and can thus be found in body fluids e.g. in serum or urine. For the determination the telopeptide region must be isolated from a human source e.g. from uterine leiomyoma.

Abstract: Compounds of formula: ##STR1## where X is --CH.sub.2 --, --CH(CH.sub.3)--, --CHR.sub.3 --CH.sub.2 -- or --CR.sub.3 .dbd.CH-- and R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, are each H or CH.sub.3 or a stereoisomer or pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing them, are useful for lowering intraocular pressure in a mammal, e.g. in the treatment of glaucoma.