Abstract: A method is provided for supplying the desired optical isomer of a derivative of epoxypropionic acid from a racemix mixture. A representative derivative of epoxypropionic acid is an ester of (p-methoxyphenyl)epoxypropionic acid. The racemic mixture initially is dissolved in carbon dioxide and the resulting solution is passed through a chromatographic column. The desired isomer is subsequently separated from the resulting eluant. In a preferred embodiment the chromatographic column is packed with microcrystallized cellulosetriacetate, cellulose-tris-(3,5-dimethylphenylcarbamate), or cellulose-tris-(p-methylphenylcarbamate).

Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.

Abstract: The invention relates to a pulling device for providing a smooth linear pulling movement. The device comprises a shaft (8) rotatable around its longitudinal axis, a pulling nut moving linearly on the shaft and driven by the rotational movement of the shaft and arranged to have the member to be pulled to be attached to, and a motor (9) providing the rotational movement of the shaft. The linear movement of the pulling nut is advantageously provided with the aid of pulling bearings set against the shaft (8) at a pitch angle. It is essential to the invention that the rotational movement of the motor (9) is transmitted to the shaft (8) through the intermediary of a flexible O-ring (25) between mutually nested parts (8, 22) associated with the motor and the shaft. The O-ring (25) forms between said parts (8, 22) a narrow contact surface closing a circular line, the purpose of which is to keep the rotational movement of the shaft as smooth as possible.

Abstract: Catechol compounds of formula I ##STR1## where R.sub.1, R.sub.2, R.sub.3 and X are as described herein are effective Catechol-O-methyltransferase inhibitors.

Abstract: A bacterial preparation useful for the prophylaxis of intestinal bacterial infections, especially Campylobacter infections, in poultry comprises bacteria derived from an adult bird from the same microecological niche, especially in the caecum, where the pathogenic bacteria tend to propagate in newly hatched chickens.

Abstract: The invention relates to a cassette holder intended for a mammography apparatus, the holder being suitable for cassettes of different sizes and having means by which the holder can be widened or narrowed to a suitable size by the moving of a detachable cassette retainer (4, 4").

Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.

Abstract: New heterocyclic compounds of formula I ##STR1## In which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 --group; R.sub.1 and R.sub.2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrgen or lower alkyl or R.sub.1 and R.sub.2 together form a susbtituted or unsubstituted 5 or 6 membered ring which may contain 1 to 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 means independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.

Abstract: An improved process for the preparation of fluoxetine. The invention is concerned with an improved process for the preparation of the antidepressant, fluoxetine hydrochloride, or N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride, by simultaneous debenzylation and catalytic hydrogenation of 2-benzoyl-1-(N-benzyl-N-methyl)ethylamine base with the aid of Pd/C, Pt/C or Pd-Pt/C at a hydrogen pressure of 5 bar at 50.degree. C. with ethyl acetate as a solvent to obtain 1-phenyl-3-(N-methylamino)-propan-1-ol. This compound is then selectively etherified with 1-chloro-4-trifluoromethylbenzene in N-methylpyrrolidone at 80.degree. C. in the presence of potassium t-butoxide to form N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine, or fluoxetine base, which is transformed in a known manner to fluoxetine hydrochloride, or N-methyl-3-(p-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride. The yield of fluoxetine hydrochloride is 85-87% of the theoretical.

Abstract: The invention relates to a supporting system of a sliding plate of a magazine comprising a magazine case and a sliding plate which travels in a linear direction inside the magazine case. The system is comprised of a guide bar that is secured to the lower cover of the magazine, parallel to the longitudinal axis of the lower cover. The sliding plate rests upon the guide bar and upon support screws arranged on the end part of the magazine case against the front portion of the sliding plate.

Abstract: Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).

Abstract: New heterocyclic compounds of formula I ##STR1## in which Het means one of following groups; ##STR2## wherein R.sub.11, R.sub.13 and R.sub.14 mean independently hydrogen, hydroxymethyl or lower alkyl group, Z means S, O or NH; A means valency bond, --CH.dbd.CH--, or --CH.sub.2 --CH.sub.2 -- group; R.sub.1 and R.sub.2 independently mean nitro, cyano, halogen, amino, carboxamido, aryl, aroyl, pyridyl, alkoxycarbonyl, acyl or one of following groups; ##STR3## wherein R.sub.6 means hydrogen or lower alkyl group, R.sub.8 means lower alkyl, R.sub.7 means cyano or COOR.sub.10, wherein R.sub.10 means hydrogen or lower alkyl or R.sub.1 and R.sub.2 together form a substituted or unsubstituted 5 or 6 membered ring which may contain 1 or 2 heteroatom N; R.sub.3, R.sub.4, and R.sub.5 mean independently hydrogen, hydroxy or lower alkyl group; Y means N or CH. The compounds may be used in the treatment of congestive heart failure.

Abstract: The invention concerns a method for the treatment of Parkinson's Disease. The method comprises administering a catechol-O-methyl-transferase inhibiting amount of a compound having the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkylcarbamoyl of 2 to 5 carbon atoms or alkylcarbonyl of 2 to 5 carbon atoms, X represents nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano; alkylcarbonyl of 2 to 5 carbon atoms; or carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, or hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable salts or esters thereof; and a sufficient amount of levodopa to treat Parkinson's Disease. A peripheral decarboxylase inhibitor such as carbidopa or benzerazide is also preferably administered.

Abstract: The invention relates to a method for thin needle biopsy in connection with mammography, wherein a stationary target is radiographed from two angles by means of a rotating picture head, the pictures are placed on a separate measurement table, and the x-, y-, and z-coordinates of the desired site in the target are calculated on the basis of the two pictures in a known manner.

Abstract: This invention relates to local epidural or intraspinal use of compounds of the formula: ##STR1## where X is H or CH.sub.3 and R.sub.1 and R.sub.2, which can be the same or different, are each H or CH.sub.3 and their stereoisomers and their non-toxic, pharmaceutically acceptable salts. Especially useful are the compounds known under the generic names medetomidine ((.+-.)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole), dexmedetomidine (+)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole and detomidine 4-(2,3-dimethylbenzyl)-1H-imidazole.

Abstract: A method for treating alcoholism. The alcohol-drinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.

Abstract: A method is provided for the treatment of postmenopausal disorders which comprises administering to a woman in single, oral, daily dose form during an uninterrupted consecutive sequence of 90 days.(a) a daily, oral, dose in an uninterrupted consecutive sequence for 69 days starting on the first day of a naturally occurring or synthetic estrogenic compound effective in the prevention of climacteric symptoms;(b) a daily, oral dose in an uninterrupted consecutive sequence from the 70th day to the 83rd day following said first day, of a naturally occurring or synthetic estrogenic compound and a compound having progestational activity effective in preventing the development of endometrial hyperplasia; and optionally(c) a daily, oral dose in an uninterrupted consecutive sequence from the 84th to the 90th day following said first day, of a compound free of estrogen and progestogen.

Abstract: A panoramic method for the radiography of the dental arch and jaws, in which method by means of movable radiographing and/or imaged elements, several subsequent exposure sweep sequences are performed so that the moving elements are transferred to a new position betwen the subsequent exposure sequences. In order to achieve a perfectly jointed X-ray picture, the movement of the moving elements is started before the switch-on instant of the X-ray beam in the latter exposure sequence and the starting positions of said elements is selected so as to obtain desired positions and velocities for the elements at the switch-on instant of the X-ray beam. The coincidence of the X-ray beam orientation at the start of the latter exposure sequence with the X-ray beam orientation at the end of the preceding sequence is characterizing to an embodiment of the invention.