Patents Assigned to Ortho Pharmaceutical Corporation
  • Substituted hydroxyureas
    Patent number: 5066658
    Abstract: The present invention relates to substituted hydroxyureas. These compounds inhibit the enzyme 5-lipoxygenase. In addition, certain of the compounds also inhibit the enzyme-cyclooxygenase. The compounds are useful for treating asthma, allergies, arthritis, posoriasis, ischemia, dermatitis, inflammation and/or broncho-constriction and/or inflammatory diseases of the eye.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: November 19, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: James P. Demers, Richard B. Sulsky
  • Methods and reagents for staining intracellular components
    Patent number: 5053054
    Abstract: Reagents and methods for intracellular staining of anionic materials as provided. The inherent staining characteristics of a fluorescent molecule may be suitably altered by covalently linking a plurality of said molecules to a nonimmunoglobulin derived cationic polymer having the desired staining specificity. By careful selection of the net charge and size of the dye polymer complex, diffusion through the cellular membrane can be enhanced and an enhanced fluorescent signal obtained by localization of a plurality of fluorescent molecules at the site of interest.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: October 1, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Stefan J. Kirchanski, A. R. M. Azad, Peter J. Natale
  • Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides
    Patent number: 5051518
    Abstract: 2- and 3-substituted (1',5'-diaryl-3'-pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviating inflammatory and cardiovascular disorders in mammals.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: September 24, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: William V. Murray, Michael P. Wachter
  • 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
    Patent number: 5030635
    Abstract: Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.
    Type: Grant
    Filed: August 8, 1990
    Date of Patent: July 9, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Donald W. Combs, Robert Falotico, David M. Ritchie
  • Substituted thienopyrans
    Patent number: 5030736
    Abstract: Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.
    Type: Grant
    Filed: November 5, 1990
    Date of Patent: July 9, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Jeffery B. Press, Pauline Sanfilippo, James J. McNally, Robert Falotico
  • 6-substituted purinyl piperazine derivatives
    Patent number: 5021574
    Abstract: 6-Substituted purinyl piperazine derivatives and a method of synthesis for the derivatives are described. The 6-substituted purinyl piperazine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: June 4, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Ramesh M. Kanojia, Jeffery B. Press
  • Reversal of glucocorticoid-induced skin atrophy
    Patent number: 5019569
    Abstract: The present invention is directed to the topical administration of a retinoid-containing pharmaceutical composition for reversing the effects of glucocorticoid-induced skin atrophy.
    Type: Grant
    Filed: August 31, 1989
    Date of Patent: May 28, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Albert M. Kligman, James A. Mezick, Robert J. Capetola
  • 4-substituted pyrazolo[3,4-d]pyrimidine derivatives
    Patent number: 5001127
    Abstract: 4-Substituted pyrazolo[3,4-d]pyrimidine derivatives and a method of synthesis for the derivatives are described. The 4-substituted pyrazolopyrimidine derivatives are useful as cardiotonic agents and antiarrhythmic agents.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: March 19, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Jeffery B. Press, Zoltan G. Hajos
  • Long lasting contraceptive suppository composition and methods of use
    Patent number: 4999342
    Abstract: Compositions and methods for providing long lasting contraceptive protection comprising a mixture of a contraceptive effective amount of spermicidal agent, a polymeric gum, a dispersing agent, and a water miscible polyethylene glycol polymer suppository base; and mammalian contraceptive methods utilizing the compositions of the invention in suppository form to provide up to 12 hours of contraceptive protection after initial insertion of the suppository.
    Type: Grant
    Filed: August 16, 1988
    Date of Patent: March 12, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Nawaz Ahmad, George A. Ziets, Sudeb Das
  • Substituted thienopyrans as antihypertensive agents
    Patent number: 4992435
    Abstract: Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: February 12, 1991
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Jeffery B. Press, Pauline Sanfilippo, James J. McNally, Robert Falotico
  • 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
    Patent number: 4963554
    Abstract: Novel 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides and their synthesis are described. These novel compounds are cardiotonic agents and bronchodilating agents, and as such are useful for the treatment of heart failure and asthma.
    Type: Grant
    Filed: February 14, 1990
    Date of Patent: October 16, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Donald W. Combs, Robert Falotico, David M. Ritchie
  • Hybrid cell line for producing monoclonal antibody to a human monocyte antigen, antibody, and methods
    Patent number: 4959458
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: September 25, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • HIV peptide-inducted T cell stimulation
    Patent number: 4943628
    Abstract: The present invention provides peptides derived from HIV-1 which are capable of stimulating T cell proliferation. Such peptides are useful for immunizing human subjects against HIV infection.
    Type: Grant
    Filed: June 13, 1988
    Date of Patent: July 24, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Jonathan I. Rosen, John F. Warner
  • Dosing cap
    Patent number: 4941598
    Abstract: Apparatus for dispensing predetermined amounts of viscous product. The apparatus has a conduit which is telescopically received with a cap. The cap and conduit define an expandable dosing chamber which expands to a predetermined maximum volume when product is introduced into the chamber through the conduit. A check valve prevents back flow of product through the conduit. Collapsing the chamber from its maximum volume to a minimum volume dispenses the product from the dosing chamber.
    Type: Grant
    Filed: November 8, 1988
    Date of Patent: July 17, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Lawrence E. Lambelet, Jr., Thomas A. Frazier
  • Ring-fused thienopyrimidinedione derivatives
    Patent number: 4939137
    Abstract: The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and as such are useful as cardiovascular agents.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: July 3, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ronald K. Russell, Richard A. Rampulla
  • Human splenin
    Patent number: 4923964
    Abstract: The present invention is directed to the protein human splenin (hsP), substantially free of material associated with the protein in its natural environment in the human spleen. In particular, the present invention relates to such isolated or synthesized human splenin having the amino acid residue sequence:-GLY-LEU-PRO-LYS-GLU-VAL-PRO-ALA-VAL-LEU-THR-LYS-GLN-LYS -LEU-LYS-SER-GLU-LEU-VAL-ALA-ASN-ASN-VAL-THR-LEU-PRO-ALA -GLY-GLU-MET-ARG-LYS-ALA-VAL-TYR-VAL-GLU-LEU-TYR-LEU-GLY -SER-LEU-THR-ALA-GLU-HIS-.Additionally, the present invention relates to a therapeutic composition of matter comprising a therapeutically effective amount of the hsP having the above sequence and a pharmaceutically acceptible carrier.
    Type: Grant
    Filed: May 22, 1987
    Date of Patent: May 8, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Gideon Goldstein, Tapan Audhya
  • Dispenser
    Patent number: 4915256
    Abstract: A dispenser for dispensing a series of different pills over a prescribed period. The dispenser is provided with an indicator that is adjustable to preset the start of the pill regimen on whatever day desired. The pill package and dispenser are constructed and arranged so that after the indicator has been preset the pill package can be fixedly positioned in the dispenser with the first pill of the regimen in position to be taken by the user on the first preselected day.
    Type: Grant
    Filed: June 28, 1985
    Date of Patent: April 10, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventor: Dereck Tump
  • Hybrid cell line for producing monoclonal antibody to a human monocyte, antigen, antibody and methods
    Patent number: 4912045
    Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on normal human monocytes and granulocytes. The hybrid is formed by fusing splenocytes from immunized BALB/cJ mice with P3X63Ag8Ul myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
    Type: Grant
    Filed: August 8, 1985
    Date of Patent: March 27, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Patrick C. Kung, Gideon Goldstein
  • Antifungal dermatological solution
    Patent number: 4912124
    Abstract: Alcohol/aqueous solutions of certain relatively insoluble imidazole derivatives, particularly micronazole and miconazole nitrate, are prepared to concentrations of at least 1.0 percent by weight active agent. The solutions are pharmacologically acceptable for topical application as the treatment of fungal skin infections and are readily applied by means of a pump sprayer.
    Type: Grant
    Filed: February 23, 1984
    Date of Patent: March 27, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Sudeb Das, Darius D. Dubash
  • 1,5-epoxy-2,3,4,5-tetrahydro-1H-3-benzazepins
    Patent number: 4910198
    Abstract: The synthesis of epoxybenzazepin compounds is described. The novel compounds have anti-ulcer activity.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: March 20, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Michael P. Wachter, Donald S. Karanewsky