Abstract: A device (200) for mixing first and second substances. The device comprises a first container (100) for storage of the first substance and a second container (150) received in the first container (100) and for storage of the second substance. An outlet (112) is disposed at the distal end of the first container (100). Valve means (180) are provided for closing a distal end of the second container (150) and a proximal end of the first container (100). A stopper means (166) closes a proximal end of the second chamber (152) and is movable with respect to the second container (150). An operating mechanism drives relative movement between the first and second containers for causing displacement of the second substance into the first chamber (102) through the valve means (180) when the outlet (112) is closed, for mixing the first and second substances in a mixing stroke of the device.

Abstract: A device for delivery of a medicament from a container (10) having an outlet (16) at a distal end of the container (10) and a stopper (22) for containing the medicament in the container (10).

Abstract: A needle protection device (10) for protecting a needle has a needle carrier (12) for carrying said needle (14) and being translatable along a longitudinal axis X between a first, deployed, position (D) and a second, protected, position (P); a shuttle (16) surrounding said needle (14); a hub (24) for receiving the needle carrier (12); a sleeve (26) being rotatable around each of said needle carrier (12), said shuttle (16) and said hub (24); a first driving mechanism (30) between said needle carrier (12) and said shuttle (16) to cause axial displacement of said shuttle (16) in a first direction (A) between a first, retracted position R and a second, deployed position Ds upon axial displacement of the needle carrier (12) along axis X; and a second driving mechanism (32) between said needle carrier (12) and said sleeve (26) to cause axial displacement of the carrier (12) in said first direction (A) upon rotational displacement of the sleeve (26).

Abstract: A safety syringe (100; 700; 1200) comprising: a barrel (104; 704; 1204) having an opening at an end thereof; a syringe plunger (108; 708; 1208) configured to move within the barrel such that an inward stroke of the syringe plunger causes a substance within the barrel to be expelled from the opening; and a sheath (112; 712; 1212) configured to cover at least partially the opening in the barrel after use of the syringe, wherein the sheath is coupled to the syringe plunger and is configured to decouple from the syringe plunger at a point on the inward stroke such that the sheath is moveable independently of the syringe plunger and further movement of the sheath after decoupling at least partially covers the opening in the barrel.

Abstract: A medicament delivery device (100) for delivery of medicament through a cannula (132) from a cartridge (10), the device comprising a first container (11) for storage of a first substance, a second container (12), and valve means for closing a distal end of the second chamber (12), the second container (12) being arranged coaxially with respect to the first container (11), a mixing element (304) being provided for causing displacement of the second substance into the first container (11) through the valve means in a mixing stroke, a release element being provided for holding the mixing element (304) in an initial position and being operable to release the mixing element (304) to initiate the mixing stroke, there being a needle shroud (400) for shrouding the cannula, and removal of the needle shroud (400) from the cannula (132) causing operation of the release element.

Abstract: An injection device (1) for the delivery of medicament has an indicator (50) for providing an end of dose indication. The device comprises a housing (10), an extendable plunger (40), an actuation mechanism (30), a trigger arrangement (15), and an indicator (50). The extendable plunger (40) comprises a leading portion (42) and a trailing portion (48) configured to allow the plunger (40) to extend from an initial length to a maximum extended length, the plunger portions ((42),48) being slidably mounted within the housing (10). The actuation mechanism (30) is configured to move the leading portion (42) of the plunger (40) forwardly relative to a syringe (20) so as to express medicament from the syringe (20). The trigger arrangement (15) is moveable in use to release the actuation mechanism (30).

Abstract: A medicament delivery device (100) for a delivery of a medicament from a container (12) through a cannula (16). The device comprises a chassis (300), a carriage (200), and an insertion spring (70) for biasing the carriage (200) for movement in an insertion direction with respect to the chassis (300) from a starting position in which the cannula (16) is shrouded to an insertion position in which the cannula (16) is extended. A drive mechanism (400) is provided for driving a stopper (22) of the container (12) to expel the medicament. The drive mechanism (400) is carriage by the carriage (200) and comprises a movable drive member (404), a drive means (40) for applying a driving force to the drive member (404), and a force transmission means (406) for transmitting the driving force to the stopper (22). The drive means (40) is arranged around or alongside at least part of the force transmission means (406).

Abstract: A medicament delivery device (100; 300; 400) comprises a chassis (124), a drive element (166) for driving a stopper (22) to expel the medicament through a cannula (144). A carrier (126) is arranged for movement with respect to the chassis (124). Insertion means (130, 202) biases the carrier (126) in an insertion direction. A control part (132) is biased for rotation with respect to the carrier (126). A locking element (176) prevents rotation of the control part (132) in an initial state. The locking element (176) is coupled to the drive element (166) such that the control part (132) is released for rotation when the drive element (166) reaches an activation position during a delivery stroke. Rotation of the control part (132) through a predetermined angle causes decoupling of the insertion means (130, 202) from the carrier (126) to allow movement of the carrier (126) in a retraction direction after the end of the delivery stroke.

Abstract: An apparatus for use with a syringe to provide a safety syringe, the apparatus including: a sheath deployable for at least partially covering a needle of the syringe; a sheath actuator for deploying the sheath; and a ratioed mechanism linking the sheath and the sheath actuator and configured such that a magnitude of movement of the sheath is greater than a magnitude of movement of the sheath actuator during deployment of the sheath.

Abstract: An autoinjector has a main body (10, 12) containing a syringe (13) or cartridge with a needle at its front end for being moved forwardly in the body to extend the needle from the body for an injection, the body housing in a forward region a shroud (24) having a forward portion of generally tubular form (32), the shroud being moveable longitudinally between a rearward retracted position and a forward extended position, the autoinjector further including a spring arrangement for biasing the shroud forwardly, the spring arrangement (44) including two springs disposed alongside and spaced from the longitudinal axis.

Abstract: A plunger rod for use in a syringe barrel for driving a bung through the syringe barrel to expel a substance therefrom, the plunger rod including: a bung fixing configured to be received within a recess of a bung and including at least one laterally extending lug including a thread engagement surface configured to engage with a point on a track portion of a thread on a sidewall of the recess, wherein the lug is further configured to cross the thread on relative rotation between the plunger rod and the bung under a force applied by a user, such that the thread engagement surface of the lug engages the point of the track portion every full rotation of the syringe plunger relative to the bung.

Abstract: An injection device is disclosed comprising a plunger for expressing medicament from a syringe and a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe. A latch arrangement is provided that releasably holds the plunger against the force of the delivery mechanism. The latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position. A trigger is provided for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger. A method of manufacturing the injection device is also enclosed.

Abstract: A cartridge (100) for packaging a medicament and being suitable for use with multiple different types of dosing device is described, together with dosing devices and adaptors for dosing devices. The cartridge includes a generally tubular body (102) having an interior cavity (104), a closure member (106) disposed at a distal end of the body and comprising a sealing element (128), a piston member (108) disposed in the cavity to contain the medicament between the piston member and the sealing element (128), a coupling element (114) disposed at the distal end of the body for coupling the cartridge to a dosing device (200) or to an adaptor for a dosing device, and a seal arrangement (126, 129) for receiving a sealing element release member (214) of the dosing device or adaptor.

Abstract: An injector apparatus includes a housing (101, 102) for a cartridge or syringe, a plunger (40) for cooperating in use with the cartridge or syringe to express successive doses, a dose setting arrangement (16, 20) to select a dose volume, and a drive mechanism (22, 24) releasable to advance the plunger in respective predetermined increments of magnitude to express the successive doses. The drive mechanism includes a drive spring (22) for imparting movement directly or indirectly to the plunger (40), and the dose setting arrangement includes a dose setting element (16) moveable in a dose setting routine to define a magnitude of an increment of movement of the plunger for a given dose. The drive mechanism further includes a clutch arrangement (56) operable during the dose setting routine to inhibit forward movement of the plunger and/or to isolate the dose setting element from the force of the drive spring.

Abstract: An injection device is disclosed which comprises a housing (140, 240, 440, 740) for a plurality of cartridges (110,310,410,810) each containing a medicament to be administered to a patient. A plurality of needles (120, 220, 320, 420, 720, 820) may be provided in communication with the plurality of cartridges. A delivery mechanism is arranged to deliver medicament through the plurality of cartridges via the plurality of needles. An injection device may comprise a drive member (130) having a cam surface (136) configured to engage a surface of a carrier (150) and rotate the carrier about a pivot (152) and at least one plunger (134) arranged to engage a cylinder in the cartridge.

Abstract: The invention relates to an injection device comprising an elongate housing and a cap removably mounted over a forward end of the housing. The cap comprising at least one slot extending forwardly from its rear edge; the at least one slot being configured to engage with an outwardly projecting protrusion on an outer surface of the housing when the cap is mounted on the housing. A rearward portion of the cap includes rearwardly extending engagement features provided on each side of the at least one slot, the engagement features being configured to locate within a cavity in the housing when the cap is mounted on the housing. The cavity is provided with corresponding surfaces which align with the cap engagement features so as to hold the outwardly projecting protrusion within the cut-out.

Abstract: A syringe plunger, bung and/or syringe is disclosed. The syringe plunger includes an elongate shaft for insertion into a barrel of a syringe, wherein an end of the shaft is configured for slidable engagement within a recess in a bung of the syringe such that the end of the shaft abuts a surface of the recess, and wherein the end of the shaft is further configured such that, after engagement between the end of the shaft and the recess, a relative force therebetween longitudinally deforms the bung.

Abstract: An autoinjector device is disclosed which comprises a body portion and a syringe carrier, for supporting a syringe with a needle at its forward end. The syringe carrier is moveably mounted within the housing such that forward movement relative to the housing may extend the needle from a forward end of the body. The syringe carrier has a latch element arranged to cooperate with a corresponding retention feature of the body portion to releasably hold the syringe carrier in a rearward position within the body potion. A delivery mechanism is arranged to forwardly displace the syringe carrier relative to the housing and to deliver a dose of medicament from the syringe. A shroud assembly is provided at a forward end of the device. The shroud further comprises a locking arrangement which blocks releasing movement of the latch element from the retention feature when the shroud is in a first, forward position and is unlocked when the shroud is in a second, rearward position.

Abstract: A skin pricking device includes a housing having an opening formed in a proximal end thereof; a spring mounted lancet including a needle within a casing having body and cap parts, interconnected by a separable coupling. The cap part has a cap projecting through the opening allow a user to grip and remove the cap. The device further includes a trigger for firing the lancet. Turning the cap part moves the entire lancet, engaging a trigger stop surface on the distal body part of the lancet with a trigger catch and further biasing the trigger to block the lancet. Further turning of the cap part over a second angle relative to the housing causes the cap part to move in a proximal direction by a further, second distance, thereby axially separating the cap part from the body part, whereby the cap part can then be removed from the device.