Patents Assigned to Oxford University Innovation Limited
  • Beverage composition comprising nanoencapsulated oxygen
    Patent number: 10864160
    Abstract: The invention relates to a beverage composition comprising: water; oxygen bubbles; a surfactant in an amount of between about 0.1% (v/v) and about 0.5% (v/v); one or more viscosity modifying agent(s) in an amount of between about 0.5% (v/v) and about 2.5% (v/v); and optionally citric acid in an amount of between about 0.1% (v/v) and about 0.5% (v/v). The invention further relates to compositions, methods of treatment for cancer, the composition for use in treatment of cancer, and the manufacture of the composition.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: December 15, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Eleanor Stride, Joshua Owen, Ray Averre
  • Method for diagnosing a brain tumour in a human
    Patent number: 10859576
    Abstract: An in vitro method for diagnosing a brain tumour in a human test subject comprising: determining the concentration of at least two metabolites comprised in a biofluid sample obtained from the human test subject; comparing the concentration of the at least two metabolites in the biofluid sample with the concentration of the same at least two metabolites in at least one reference standard obtained from a non-tumour bearing subject and/or a tumour bearing subject; and identifying a concentration difference for each of the at least two metabolites in the biofluid sample relative to the reference standard; wherein the concentration difference for each of the at least two metabolites in the biofluid sample correlates with the presence of a brain tumour. The invention also relates to a data-storage medium comprising data obtained by a method of the invention.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: December 8, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: Nicola R. Sibson, Daniel C. Anthony, Alex M. Dickens, James R. Larkin
  • Treatment of retinitis pigmentosa
    Patent number: 10836803
    Abstract: A polynucleotide comprising a nucleotide sequence encoding the retinitis pigmentosa GTPase regulator ORF15 isoform (RPGRORF15), wherein the RPGRORF15-encoding nucleotide sequence has been codon optimised to increase fidelity of replication of the sequence.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: November 17, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Robert MacLaren, Dominik Fischer
  • Electrode and use thereof
    Patent number: 10830727
    Abstract: The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm?2 to 95 megaohms cm?2.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: November 10, 2020
    Assignees: Universidade Estadual Paulista “Julio de Mequita Filho”, Oxford University Innovation Limited
    Inventors: Jason Davis, Paulo Roberto Bueno
  • Method for treating chronic intestinal inflammation and inflammatory bowel disease by administering antagonists of Oncostatin-M (OSM) and/or antagonists of OSM receptor-beta (OSMR)
    Patent number: 10822406
    Abstract: The invention relates to methods of treating chronic intestinal inflammation and/or inflammatory bowel disease by administering an antagonist of oncostatin-M (OSM) and/or OSM receptor-? (OSMR). The invention also relates to methods for diagnosing or prognosing chronic intestinal inflammation and/or inflammatory bowel disease in an individual and for predicting whether or not an individual will respond to an anti-TNF? therapy. The methods comprise measuring OSM and/or OSMR in the individual.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: November 3, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: Nathaniel Richard West, Benjamin Michael Joseph Owens, Ahmed Nabil Hegazy, Fiona Margaret Powrie
  • Measurement of analytes with membrane channel molecules, and bilayer arrays
    Patent number: 10822655
    Abstract: The invention relates to a method for detection of analyte interaction with a channel molecule held in a membrane, comprising the optical detection of a modification in the flux of a signal molecule as it passes through the channel molecule by the action of a membrane potential, wherein the modification in the flux is caused by at least partial blockage of the channel molecule by the analyte. The invention further relates to bilayer arrays, components, methods of manufacture and use.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: November 3, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Mark Wallace, Hagan Bayley, Shuo Huang, Oliver Kieran Castell, Mercedes Romero-Ruiz
  • Reactance measurement
    Patent number: 10816509
    Abstract: Apparatus and methods for reactance measurements are disclosed. The apparatus and methods are particularly suitable for eddy current proximity sensors in turbo-machine assemblies. In one arrangement, there is provided an apparatus comprising a circuit for receiving a sensing component of a sensor. The circuit has a unit having fixed reactance. An electrical source is provided for driving an alternating current through the circuit. An analysis unit measures the phase of a signal in the circuit that is dependent on the reactance of the sensing component. A measure of the reactance of the sensing component is output based on the measured phase.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: October 27, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Kamaljit Singh Chana, Jonathan Shamus Sullivan
  • Proximal tibial osteotomy system
    Patent number: 10806496
    Abstract: A support plate, for supporting the two parts of a tibia after a tibial osteotomy, is generally in the shape of a T with a stem having top and bottom ends and a cross piece extending across the top end of the stem. The support plate has a rear surface arranged to contact the tibia. The rear surface of the stem is convex in its central longitudinal plane over a first region of the plate, and the rear surface of the cross piece is concave in its transverse plane.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: October 20, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Andrew Paul Monk, Andrew Price, William Jackson, Cameron Peter Brown
  • Method for detecting GABAA receptor autoantibodies
    Patent number: 10802019
    Abstract: The invention relates to methods of determining whether or not an individual has or is likely to develop a neurological disease and related methods and kits.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: October 13, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: Angela Vincent, Philippa Pettingill, Patrick Waters
  • Cofactor regeneration system
    Patent number: 10801052
    Abstract: The present invention relates to cofactor regeneration systems, components and uses thereof and methods for generating and regenerating cofactors. The cofactor regeneration system comprises a first electron transfer component selected from a polypeptide comprising a NADH:acceptor oxido-reductase or NADPH:acceptor oxido-reductase, a second electron transfer component selected from a hydrogenase moiety and/or non-biological nanoparticles and an electronically conducting surface. The first and second electron transfer components are immobilised on the electrically conducting surface, and the first and second electron transfer components do not occur together in nature as an enzyme complex.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: October 13, 2020
    Assignees: OXFORD UNIVERSITY INNOVATION LIMITED, HUMBOLDT-UNIVERSITAT ZU BERLIN
    Inventors: Kylie Vincent, Lars Lauterbach, Oliver Lenz
  • Material production process with alkylamine
    Patent number: 10797255
    Abstract: The present invention relates to a process for producing a layer of crystalline A/M/X material, wherein the process comprises disposing on a substrate a precursor composition comprising: (a) a first precursor compound comprising a first cation (M), which first cation is a metal or metalloid cation; and (b) a solvent, wherein the solvent comprises; (i) acetonitrile, propionitrile, acetone or a mixture thereof; and (ii) an alkylamine. The invention also relates to a composition comprising: (i) a compound of formula MXn, (ii) a compound of formula AX, (iii) acetonitrile, propionitrile, acetone or a mixture thereof; and (iv) an alkylamine of formula RANH2, wherein RA is a C1-8 alkyl group.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: October 6, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Henry James Snaith, Pabitra Nayak, Bernard Wenger, Nakita Noel, Severin Habisreutinger, David Moore
  • Photovoltaic device comprising a metal halide perovskite and a passivating agent
    Patent number: 10777693
    Abstract: The present invention relates to devices comprising metal halide perovskites and organic passivating agents. In particular, the invention relates to photovoltaic and optoelectronic devices comprising passivated metal halide perovskites. The device according to the invention comprises: (a) a metal halide perovskite; and (b) a passivating agent which is an organic compound; wherein molecules of the passivating agent are chemically bonded to anions or cations in the metal halide perovskite.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: September 15, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Henry J. Snaith, Antonio Abate, Nakita K. Noel
  • Interferometric scattering microscopy
    Patent number: 10775597
    Abstract: An interferometric scattering microscope is adapted by performing spatial filtering of output light, which comprises both light scattered from a sample location and illuminating light reflected from the sample location, prior to detection of the output light. The spatial filtering passes the reflected illumination light but with a reduction in intensity that is greater within a predetermined numerical aperture than at larger numerical apertures. This enhances the imaging contrast for coherent illumination, particularly for objects that are weak scatterers.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: September 15, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: Philipp Kukura, Alexander Weigel, Justin Benesch
  • Method of determining risk of 5-fluorouracil toxicity
    Patent number: 10774385
    Abstract: The invention provides an assay useful in predicting risk of 5-fluorouracil (FU) toxicity in a subject. The subject may be screened for the presence of at least one TYMS polymorphism and/or at least one DPYD polymorphism. Suitable TYMS and DPYD polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing FU toxicity; a negative result may indicate a decreased risk of developing FU toxicity.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: September 15, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: David Kerr, Ian Tomlinson, Dan Rosmarin, Claire Palles
  • System and method for structures detection and multi-class image categorization in medical imaging
    Patent number: 10762630
    Abstract: A system and method are provided to automatically categorize biological and medical images. The new system and method can incorporate a machine learning classifier in which novel ideas are provided to guide the classifier to focus on regions of interest (ROI) within medical images for categorizing or classifying the images. The system and method can ignore regions when misleading structures exist. The detection and classification of one or more features of interest within a discriminative region of interest within an image are rendered invariant to differences in translation, orientation and/or scaling of the one or more features of interest within the medical image(s). The system and method allow a processor to more quickly, efficiently and accurately process and categorize medical images.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: September 1, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Mohammad Yaqub, J. Alison Noble, Aris Papageorghiou
  • Wireless power transfer system
    Patent number: 10756580
    Abstract: A wireless power transfer system (1) includes a primary coil (2) for generating an oscillating electromagnetic field for wirelessly transferring power to a secondary coil. The system also includes emitting coils (6) arranged to generate an electromagnetic field for exciting a nuclear quadrupole resonance in the biological material of an animal (7) exposed to the electromagnetic field generated by the emitting coils. The system also includes detecting coils (6) for detecting the absorption and/or emission of electromagnetic radiation by and/or from the excitation of the nuclear quadrupole resonance. The system is arranged, when the detecting coils detect the absorption or emission of electromagnetic radiation, to prevent the primary coil from generating, or to cause the primary coil to reduce the amplitude of, the oscillating electromagnetic field.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: August 25, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: Arzhang Ardavan, James Semple
  • Apparatus and methods for providing tactile sensation
    Patent number: 10747319
    Abstract: Apparatus and methods for providing tactile sensation are provided. In one disclosed arrangement, there is provided a first magnet module comprising one or more magnetic elements. A mounting arrangement mounts the first magnet module to a human or animal body. A controller controls a tactile sensation applied by the first magnet module to the human or animal body by controlling a magnetic field applied to the first magnet module. The one or more magnetic elements are rotatably mounted and the controller controls the applied tactile sensation by rotating one or more of the magnetic elements using the applied magnetic field.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: August 18, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventor: Jeroen Henricus Maria Bergmann
  • Sensor, controller and system
    Patent number: 10739210
    Abstract: The present invention relates to a sensor for measuring temperature of a fluid within a vessel, the vessel having a first region and a second region and the fluid having a temperature profile extending between the first region and the second region, the sensor comprising an array of elements, each element having a temperature-dependent parameter, the array being capable of deployment within or adjacent the vessel such that the array extends along the vessel for measuring the temperature profile, the elements of the array being coupled together between an input and an output, the input being coupled or capable of being coupled to a driving source for driving the sensors, and the output being coupled or capable of being coupled to a detector for measuring an aggregate of the temperature-dependent parameter from the array of elements.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: August 11, 2020
    Assignee: Oxford University Innovation Limited
    Inventors: Malcolm Duncan McCulloch, Peter Michael Armstrong
  • Optical device
    Patent number: 10718987
    Abstract: An optical device comprising a stack of the following layers: a capping layer (16) having a high refractive index for guiding incident light; a layer of light absorber material (10), preferably a phase-changing material; and a reflective layer (12), wherein the refractive index of the capping layer is at least 1.6.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: July 21, 2020
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Peiman Hosseini, Harish Bhaskaran, Ben Broughton
  • DETECTING COMPOSITION OF A SAMPLE BASED ON THERMAL PROPERTIES
    Publication number: 20200225181
    Abstract: The invention relates to detecting a composition of a sample or contamination in liquids by detecting corresponding changes in their thermal properties. In a disclosed arrangement, an apparatus is provided comprising a first probe element configured to provide a first surface in direct contact with the sample and a second surface that is not in direct contact with the sample. A measurement system measures a rate of heat transfer through the first surface. A processing unit analyses the measured rate of heat transfer in order to detect a heat transfer characteristic of the sample that is indicative of a composition of the sample.
    Type: Application
    Filed: January 28, 2020
    Publication date: July 16, 2020
    Applicant: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Kamaljit Singh CHANA, Jonathan Shamus SULLIVAN